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Notes Payable - Additional Information (Detail) - USD ($)
12 Months Ended
May 23, 2019
Dec. 26, 2017
Dec. 31, 2019
Feb. 21, 2017
Debt Instrument [Line Items]        
Loan agreement interest only term     36 months  
Bio Pharma Credit Plc        
Debt Instrument [Line Items]        
Maximum borrowing capacity $ 60,000,000      
Additional facility that can be obtained 20,000,000      
Debt instrument, face amount 60,000,000      
Additional borrowing of face amount 1,800,000      
Bio Pharma Credit Plc | LIBOR        
Debt Instrument [Line Items]        
Loan agreement term     72 months  
Additional interest rate     7.50%  
CRG        
Debt Instrument [Line Items]        
Back end facility fee $ 5,600,000      
CRG | Interest Expense        
Debt Instrument [Line Items]        
Debt issuance costs     $ 5,200,000  
Amortization of discount     3,900,000  
Loan preclosure fees     $ 2,800,000  
CRG | Line of Credit        
Debt Instrument [Line Items]        
Borrowings outstanding       $ 45,000,000.0
CRG | Tranche Two | Line of Credit        
Debt Instrument [Line Items]        
Net proceeds in aggregate amount   $ 15,000,000.0