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Income Taxes
12 Months Ended
Dec. 31, 2019
Income Tax Disclosure [Abstract]  
Income Taxes Income taxes:On December 22, 2017, the United States enacted major tax reform legislation, Public Law No. 115-97, commonly referred to as the Tax Cuts and Jobs Act (or 2017 Tax Act). The 2017 Tax Act, among other changes, lowers the general corporate income tax rate to 21% for tax years beginning after December 31, 2017, transitions U.S. international taxation from a worldwide tax system to a territorial system and provides for a one-time transition tax on the mandatory deemed repatriation of cumulative foreign earnings as of December 31, 2017, which is not applicable to the Company. The
Company has calculated the impact of the 2017 Tax Act in its income tax provision during the years ended December 31, 2019, 2018 and 2017 based on the provisions of the Act.

Reconciliation of the Federal statutory income tax rate of 21% to the effective rate is as follows:
201920182017
Federal statutory income (benefit) tax rate21.00 %21.00 %(34.00)%
2017 Tax Act, net deferred tax remeasurement—  —  (626.73) 
State taxes, net of federal benefit(0.18) (0.11) (2.01) 
Stock compensation(5.39) (4.74) (5.18) 
Permanent differences-other(7.67) (1.33) (13.39) 
North Carolina tax rate change—  —  (32.75) 
Research and development (“R&D”) credit—  —  5.54  
Valuation release for bargain purchase gain—  —  (302.23) 
Other1.71  (2.07) (1.36) 
Decrease (increase) in valuation allowance(9.44) (12.65) 709.88  
0.03 %0.10 %(302.23)%
The tax effects of temporary differences and net operating losses that give rise to significant components of deferred tax assets and liabilities consist of the following:
December 31,
Deferred tax assets (liabilities)20192018
Basis difference in equipment$(438)$(459)
Basis difference in intangibles(5,356) (6,045) 
Accrued liabilities and other3,942  2,246  
R&D credit10,980  10,980  
Stock options4,416  4,360  
Net operating loss carry-forward62,535  64,376  
76,079  75,458  
Less: valuation allowance(76,079) (75,458) 
$—  $—  
The Company is required to reduce any deferred tax asset by a valuation allowance if, based on an assessment of positive and negative evidence, including estimates of future taxable income necessary to realize future deductible amounts, it is more likely than not (a likelihood of more than 50 percent) that some portion or all of the deferred tax assets will not be realized. As a result, the Company recorded a valuation allowance with respect to all of the Company’s deferred tax assets for the years ended December 31, 2019 and 2018.
The Company has a federal net operating loss carry forward (“NOLs”) of approximately $271 million as of December 31, 2019. Under Section 382 and 383 of the Internal Revenue Code, if an ownership change occurs with respect to a “loss corporation”, as defined, there are annual limitations on the amount of the NOLs and other deductions, which are available to the Company. The Company has determined that the portion of the NOLs incurred prior to May 16, 2006 is subject to this limitation. As such, the use of these NOLs to offset taxable income is limited to approximately $1.5 million per year. The Company has state NOLs of approximately $261 million as of December 31, 2019. These state NOLs expire in various years through 2037 and certain state NOLs generated in 2018 have an indefinite carryforward period. The federal NOLs incurred through December 31, 2017 expire between 2024 and 2037. The federal NOL generated in 2018 has an indefinite carryforward life due to tax reform.
Management has evaluated all other tax positions that could have a significant effect on the financial statements and determined that the Company has no uncertain income tax positions at December 31, 2019.
One or more of the Company’s legal entities file income tax returns in the U.S. federal jurisdiction and various U.S. state jurisdictions. The Company’s income tax returns are subject to audit by the tax authorities in those jurisdictions. Significant disputes may arise with authorities involving issues of the timing and amount of deductions, the use of tax credits and allocations of income and expenses among various tax jurisdictions because of differing interpretations of tax laws, regulations and the interpretation of the relevant facts. The Company is no longer subject to U.S. federal or state tax examinations for years ended on or before December 31, 2015.