X0306 4 2018-08-01 0 0001103021 BIODELIVERY SCIENCES INTERNATIONAL INC BDSI 0001748462 Smith Thomas B C/O BIODELIVERY SCIENCES INTL, INC., 4131 PARKLAKE AVE. SUITE 225 RALEIGH NC 27612 0 1 0 0 Chief Medical Officer Stock Options (right to buy) 2.93 2018-08-01 4 A 0 117691 0.00 A 2028-08-01 Common Stock 117691 117691 D The exercise price of the stock options issued to the Reporting Person is the volume-weighted average price of the Company's Common Stock for the 30-day period preceding August 1, 2018. The stock options were issued to the Reporting Person on August 1, 2018, pursuant to a grant under the Company's Equity Incentive Plan. The award is subject to time-based vesting and will vest in equal portions on: (i) August 1, 2019; (ii) August 1, 2020; and (iii) August 1, 2021. /s/ Thomas Smith, MD. 2018-08-01