X0306 4 2016-08-11 0 0001103021 BIODELIVERY SCIENCES INTERNATIONAL INC BDSI 0001314000 Bramlage Charles C/O BIODELIVERY SCIENCES INTL, INC. 4131 PARKLAKE AVE., SUITE 225 RALEIGH NC 27612 1 0 0 0 Common Stock 2016-08-11 4 M 0 10000 0.00 A 38150 D Common Stock 2016-08-11 4 M 0 15000 0.00 A 53150 D Restricted Stock Units 0.00 2016-08-11 4 M 0 10000 0.00 D 2016-08-11 2016-08-11 Common Stock 10000 0 D Restricted Stock Units 0.00 2016-08-11 4 M 0 15000 0.00 D 2016-08-11 Common Stock 15000 15000 D The shares of common stock were acquired by the Reporting Person as a result of the vesting of 10,000 Restricted Stock Units ("RSUs") granted to the Reporting Person on July 16, 2015 under the Issuer's 2011 Equity Incentive Plan, as amended. The shares of common stock were acquired by the Reporting Person as a result of the vesting of one-half of the RSUs granted to the Reporting Person on June 30, 2016 under the Issuer's 2011 Equity Incentive Plan, as amended. The remaining RSUs under this grant will vest in the first open window following the Company's 2017 Annual Meeting of Stockholders. /s/ Charles J. Bramlage 2016-08-12