<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2025-10-01</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001671584</issuerCik>
        <issuerName>Aptevo Therapeutics Inc.</issuerName>
        <issuerTradingSymbol>APVO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000070858</rptOwnerCik>
            <rptOwnerName>BANK OF AMERICA CORP /DE/</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>BANK OF AMERICA CORPORATE CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>100 N TRYON ST</rptOwnerStreet2>
            <rptOwnerCity>CHARLOTTE</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>28255</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001102113</rptOwnerCik>
            <rptOwnerName>BANK OF AMERICA NA</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>100 NORTH TRYON STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>CHARLOTTE</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>28255</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001675365</rptOwnerCik>
            <rptOwnerName>BOFA SECURITIES, INC.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>150 N COLLEGE ST</rptOwnerStreet1>
            <rptOwnerStreet2>NC1-028-28-04</rptOwnerStreet2>
            <rptOwnerCity>CHARLOTTE</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>28255</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <remarks>This statement is jointly filed by Bank of America Corporation (&quot;Bank of America&quot;), Bank of America N.A. (&quot;BANA&quot;), and BofA Securities, Inc. (&quot;BOFAS&quot;). Bank of America, BANA and BOFAS are submitting this form to indicate they are no longer subject to Section 16 as their beneficial ownership has decreased below 10 percent.</remarks>

    <ownerSignature>
        <signatureName>/s/ Andres Ortiz, Authorized Signatory for Bank of America Corporation</signatureName>
        <signatureDate>2025-10-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Andres Ortiz, Authorized Signatory for Bank of America N.A</signatureName>
        <signatureDate>2025-10-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Andres Ortiz, Authorized Signatory for BofA Securities, Inc.</signatureName>
        <signatureDate>2025-10-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
