144 0001141722 XXXXXXXX LIVE 0001100682 CHARLES RIVER LABORATORIES INTERNATIONAL, INC. 001-15943 251 BALLARDVALE ST WILMINGTON MA 01887 781-222-6000 FOSTER JAMES C Director Common UBS Financial Services, Inc.

Eleven Madison Avenue 4th Floor New York NY 10010

33561 10065950.73 47738872 08/25/2026 NYSE Common 08/25/2026 Exercise of stock options Issuer N 33561 08/25/2026 Cash N James Foster

251 BALLARDVALE ST WILMINGTON MA 01887

Common 06/29/2026 75000 16875000.00 James Foster

251 BALLARDVALE ST WILMINGTON MA 01887

Common 08/10/2026 28733 7901575.00 08/25/2026 03/06/2026 /s/ UBS Financial Services Inc, as attorney-in-fact for James Foster