144 0001767215 XXXXXXXX LIVE 0001100682 Charles River Laboratories 001-15943 251 Balardvale Street Wilmington MA 01887 781-222-6000 Joseph LaPlume Officer Common UBS Financial Services Inc

1000 Harbor Blvd 3rd Floor Weehawken NJ 07086

800 125600 49120000 08/18/2025 NYSE COMMON 01/27/2023 PERFORMANCE STOCK UNIT CHARLES RIVER LABORATORIES N 8342 08/18/2025 CASH N Joseph LaPlume

c/o Charles River Laboratories 251 Balardvale Street Wilmington MA 01887

Common 08/07/2025 400 59991 08/18/2025 /s/JOSEPH CASSIDY, for UBS Financial Services Inc, as attorney-in-fact for Joseph LaPlume