X0306 4 2022-05-27 0001100682 CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CRL 0001141722 FOSTER JAMES C 251 BALLARDVALE STREET WILMINGTON MA 01887 1 1 Chairman, President and CEO Common Stock 2022-05-29 4 F 0 1311 244.41 D 213711 D Common Stock 8000 I 2021 GRAT Common Stock 17579 I 2020 GRAT Common Stock 750 I By Trust Common Stock 2250 I By Trust Common Stock 340 I By Trust Common Stock 10000 I Held By Spouse Stock Options (Right to Buy) 244.41 2022-05-27 4 A 0 24042 244.41 A 2023-05-27 2032-05-27 Common Stock 24042 24042 D Stock Options vest as follows: 6,010 on May 27, 2023, 6,011 on May 27, 2024, 6,010 on May 27, 2025 and 6,011 on May 27, 2026. /s/ James C. Foster 2022-06-01