X0306 4 2022-05-27 0001100682 CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CRL 0001924996 Pease Flavia 251 BALLARDAVALE STREET WILMINGTON MA 01887 1 Corporate Executive VP & CFO Common Stock 2022-05-27 4 A 0 1637 0 A 6822 D Stock Options (Right to Buy) 244.41 2022-05-27 4 A 0 4423 244.41 A 2023-05-27 2032-05-27 Common Stock 4423 4423 D Unvested restricted stock units vest as follows: 409 on May 27, 2023, 409 on May 27, 2024, 409 on May 27, 2025 and 410 on May 27, 2026. Stock Options vest as follows: 1,105 on May 27, 2023, 1,106 on May 27, 2024, 1,106 on May 27, 2025 and 1,106 on May 27, 2026. /s/ Flavia Pease 2022-06-01