X0306 4 2021-12-01 0001100682 CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CRL 0001688104 Barbo William D 251 BALLARDVALE STREET WILMINGTON MA 01887 1 Corporate Executive VP & CCO Common Stock 2021-12-01 5 G 0 E 400 0 D 11912 I By Trust Common Stock 2022-01-28 4 A 0 10273 0 A 14644 D Common Stock 2022-01-28 4 F 0 4095 312.24 D 10549 D Reflects shares of common stock issued following the achievement of performance goals set forth in performance share unit awards originally granted on February 22, 2019. /s/ William D. Barbo 2022-02-01