X0306 4 2021-05-28 0001100682 CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CRL 0001632780 Creamer Victoria L 251 BALLARDVALE STREET WILMINGTON MA 01887 1 EVP & Chief People Officer Common Stock 2021-05-28 4 A 0 1006 0 A 6513 D Common Stock 2021-05-29 4 F 0 127 337.99 D 6386 D Stock Options (Right to Buy) 337.99 2021-05-28 4 A 0 3110 337.99 A 2022-05-28 2031-05-28 Common Stock 3110 3110 D Unvested restricted stock units vest as follows: 251 on May 28, 2022, 252 on May 28, 2023, 251 on May 28, 2024 and 252 on May 28, 2025. Stock Options vest as follows: 777 on May 28, 2022, 778 on May 28, 2023, 777 on May 28, 2024 and 778 on May 28, 2025. /s/ Victoria L. Creamer 2021-06-01