X0306 4 2021-01-25 0001100682 CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CRL 0001650274 Smith David Ross 251 BALLARDVALE STREET WILMINGTON MA 01887 1 Corporate Executive VP & CFO Common Stock 2021-01-25 5 G 0 E 8656 0 D 7111 D Common Stock 2021-01-25 5 G 0 E 8656 0 A 8656 I By Spouse Common Stock 2021-01-29 4 A 0 14234 0 A 21345 D Common Stock 2021-01-29 4 F 0 3795 260.88 D 17550 D On 1/25/2021 8,656 shares were gifted to Mr. Smith's spouse. Reflects shares of common stock issued following the achievement of performance goals set forth in performance share unit awards originally granted on February 23, 2018. /s/ David R. Smith 2021-02-02