X0306 4 2018-01-02 0001100682 CHARLES RIVER LABORATORIES INTERNATIONAL INC CRL 0001650274 Smith David Ross 251 BALLARDVALE STREET WILMINGTON MA 01887 1 Corporate Executive VP & CFO Common Stock 2018-01-02 4 S 0 200 109.74 D 22802 D Common Stock 2018-01-02 4 S 0 200 109.745 D 22602 D Common Stock 2018-01-02 4 S 0 500 109.75 D 22102 D Common Stock 2018-01-02 4 S 0 400 109.755 D 21702 D Common Stock 2018-01-02 4 S 0 300 109.79 D 21402 D Common Stock 2018-01-02 4 S 0 300 109.795 D 21102 D Common Stock 2018-01-02 4 S 0 100 109.81 D 21002 D Common Stock 2018-01-02 4 S 0 200 109.83 D 20802 D Common Stock 2018-01-02 4 S 0 500 109.91 D 20302 D Common Stock 2018-01-02 4 S 0 202 110.02 D 20100 D Common Stock 2018-01-02 4 S 0 200 110.03 D 19900 D Common Stock 2018-01-02 4 S 0 48 110.05 D 19852 D Common Stock 2018-01-02 4 S 0 100 110.06 D 19752 D Common Stock 2018-01-02 4 S 0 200 110.07 D 19552 D Common Stock 2018-01-02 4 S 0 98 110.075 D 19454 D Common Stock 2018-01-02 4 S 0 200 110.08 D 19254 D Common Stock 2018-01-02 4 S 0 100 110.085 D 19154 D Common Stock 2018-01-02 4 S 0 908 110.09 D 18246 D Common Stock 2018-01-02 4 S 0 300 110.095 D 17946 D Common Stock 2018-01-02 4 S 0 199 110.10 D 17747 D Common Stock 2018-01-02 4 S 0 400 110.11 D 17347 D Common Stock 2018-01-02 4 S 0 55 110.115 D 17292 D Common Stock 2018-01-02 4 S 0 500 110.12 D 16792 D Common Stock 2018-01-02 4 S 0 672 110.14 D 16120 D Common Stock 2018-01-02 4 S 0 700 110.15 D 15420 D Common Stock 2018-01-02 4 S 0 200 110.16 D 15220 D Common Stock 2018-01-02 4 S 0 100 110.18 D 15120 D Common Stock 2018-01-02 4 S 0 100 110.22 D 15020 D Common Stock 2018-01-02 4 S 0 200 110.23 D 14820 D Common Stock 2018-01-02 4 S 0 49 110.28 D 14771 D This sale occurred pursuant to a 10b5-1 Trading Plan. /s/ David R. Smith 2018-01-02