<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.sec.gov/edgar/nport eis_NPORT_Filer.xsd">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0001100663</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000004350</seriesId>
        <classId>C000012080</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>iShares Trust</regName>
      <regFileNumber>811-09729</regFileNumber>
      <regCik>0001100663</regCik>
      <regLei>5493000860OXIC4B5K91</regLei>
      <regStreet1>400 Howard Street</regStreet1>
      <regCity>San Francisco</regCity>
      <regStateConditional regCountry="US" regState="US-CA"/>
      <regZipOrPostalCode>94105</regZipOrPostalCode>
      <regPhone>800-474-2737</regPhone>
      <seriesName>iShares Biotechnology ETF</seriesName>
      <seriesId>S000004350</seriesId>
      <seriesLei>549300S7IVD88MPK0066</seriesLei>
      <repPdEnd>2025-03-31</repPdEnd>
      <repPdDate>2025-03-31</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>6597430169.74</totAssets>
      <totLiabs>790940029.15</totLiabs>
      <netAssets>5806490140.59</netAssets>
      <assetsAttrMiscSec>0.00000000</assetsAttrMiscSec>
      <assetsInvested>0.00000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.00000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.00000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.00000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.00000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.00000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.00000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.00000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.00000000</amtPayAftOneYrOther>
      <delayDeliv>0.00000000</delayDeliv>
      <standByCommit>0.00000000</standByCommit>
      <liquidPref>0.00000000</liquidPref>
      <cshNotRptdInCorD>0.00000000</cshNotRptdInCorD>
      <borrowers>
        <borrower aggrVal="2266.88000000" lei="RUC0QBLBRPRCU4W1NE59" name="BMO Capital Markets"/>
        <borrower aggrVal="117374091.85000000" lei="RCNB6OTYUAMMP879YW96" name="BNP PARIBAS SECURITIES CORP"/>
        <borrower aggrVal="18910935.36360000" lei="BFM8T61CT2L1QCEMIK50" name="UBS AG"/>
        <borrower aggrVal="64657.00000000" lei="OXTKY6Q8X53C9ILVV871" name="NOMURA SECURITIES INTERNATIONAL INC."/>
        <borrower aggrVal="9948931.98000000" lei="MP6I5ZYZBEU3UXPYFY54" name="HSBC BANK PLC"/>
        <borrower aggrVal="2964613.46620000" lei="T6FIZBDPKLYJKFCRVK44" name="UBS SECURITIES LLC"/>
        <borrower aggrVal="26349802.34500000" lei="G5GSEF7VJP5I7OUK5573" name="BARCLAYS BANK PLC"/>
        <borrower aggrVal="19521252.94000000" lei="58PU97L1C0WSRCWADL48" name="Jefferies LLC"/>
        <borrower aggrVal="782233.00000000" lei="549300BLWPABP1VNME36" name="Scotia Capital (USA) Inc"/>
        <borrower aggrVal="43810575.97500000" lei="9R7GPTSO7KV3UQJZQ078" name="MORGAN STANLEY &amp; CO. LLC (US EQUITY SEC LENDING)"/>
        <borrower aggrVal="1654601.11000000" lei="549300L8G1E7ZHVEOG75" name="Natixis Securities Americas LLC"/>
        <borrower aggrVal="81892.00000000" lei="549300LCO2FLSSVFFR64" name="RBC Capital Markets LLC"/>
        <borrower aggrVal="3606804.00000000" lei="5493001I7IJ4CW6Q9N27" name="CITADEL CLEARING LLC"/>
        <borrower aggrVal="11241111.60000000" lei="571474TGEMMWANRLN572" name="STATE STREET BANK &amp; TRUST COMPANY"/>
        <borrower aggrVal="14417609.81000000" lei="549300JRHF1MHHWUAW04" name="National Financial Services LLC"/>
        <borrower aggrVal="73741548.94000000" lei="KB1H1DSPRFMYMCUFXT09" name="Wells Fargo Bank, National Association"/>
        <borrower aggrVal="146566035.33316800" lei="ZBUT11V806EZRVTWT807" name="JP MORGAN SECURITIES LLC"/>
        <borrower aggrVal="37191711.87520000" lei="MBNUM2BPBDO7JBLYG310" name="CITIGROUP GLOBAL MARKETS INC."/>
        <borrower aggrVal="18272644.12000000" lei="FOR8UP27PHTHYVLBNG30" name="GOLDMAN SACHS &amp; CO."/>
        <borrower aggrVal="3593150.28000000" lei="549300ZBQI1JB1844X09" name="TD Prime Services LLC"/>
        <borrower aggrVal="1391522.50000000" lei="549300RA02N3BNSWBV74" name="VIRTU AMERICAS, LLC"/>
        <borrower aggrVal="3724412.00000000" lei="549300F35UE0BOM1WJ55" name="SG AMERICAS SECURITIES LLC"/>
        <borrower aggrVal="3819505.42000000" lei="AC28XWWI3WIBK2824319" name="BARCLAYS CAPITAL INC."/>
        <borrower aggrVal="27557741.73000000" lei="549300KUN9K9K32C6D97" name="BNP PARIBAS PRIME BROKERAGE INTERNATIONAL LIMITED"/>
        <borrower aggrVal="121439263.60410000" lei="549300HN4UKV1E2R3U73" name="BofA Securities, Inc."/>
        <borrower aggrVal="17420855.89000000" lei="VYVVCKR63DVZZN70PB21" name="Wells Fargo Securities LLC"/>
      </borrowers>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000012080" rtn1="4.92897200" rtn2="-1.19612700" rtn3="-6.58329300"/>
        </monthlyTotReturns>
        <monthlyReturnCats>
          <commodityContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </commodityContracts>
          <creditContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </creditContracts>
          <equityContracts>
            <mon1 netRealizedGain="-3135.85000000" netUnrealizedAppr="413241.42000000"/>
            <mon2 netRealizedGain="219414.12000000" netUnrealizedAppr="-365504.05000000"/>
            <mon3 netRealizedGain="-195666.09000000" netUnrealizedAppr="-67851.86000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="-3135.85000000" netUnrealizedAppr="413241.42000000"/>
              <instrMon2 netRealizedGain="219414.12000000" netUnrealizedAppr="-365504.05000000"/>
              <instrMon3 netRealizedGain="-195666.09000000" netUnrealizedAppr="-67851.86000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </equityContracts>
          <foreignExchgContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </foreignExchgContracts>
          <interestRtContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </interestRtContracts>
          <otherContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <forwardCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </forwardCategory>
            <futureCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </futureCategory>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </optionCategory>
            <swaptionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swaptionCategory>
            <swapCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </swapCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </otherCategory>
          </otherContracts>
        </monthlyReturnCats>
        <othMon1 netRealizedGain="31584715.71999999" netUnrealizedAppr="280185748.36000000"/>
        <othMon2 netRealizedGain="12086593.02999999" netUnrealizedAppr="-96570197.90000000"/>
        <othMon3 netRealizedGain="34375102.72999999" netUnrealizedAppr="-441409515.44000000"/>
      </returnInfo>
      <mon1Flow redemption="653638331.29999995" reinvestment="0.00000000" sales="432799612.25000000"/>
      <mon2Flow redemption="350187389.19999999" reinvestment="0.00000000" sales="195348434.00000000"/>
      <mon3Flow redemption="815489952.75000000" reinvestment="0.00000000" sales="714935994.79999995"/>



      <varInfo>

        <fundsDesignatedInfo>
          <nameDesignatedIndex>N/A</nameDesignatedIndex>
          <indexIdentifier>N/A</indexIdentifier>

        </fundsDesignatedInfo>

      </varInfo>
    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>Applied Therapeutics, Inc.</name>
        <lei>549300KL3IJPHZM2GR04</lei>
        <title>Applied Therapeutics, Inc.</title>
        <cusip>03828A101</cusip>
        <identifiers>
          <isin value="US03828A1016"/>
          <other otherDesc="Inhouse Asset ID" value="03828A101"/>
        </identifiers>
        <balance>645115.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>315396.72000000</valUSD>
        <pctVal>0.005431796358</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="112609.08446800"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MannKind Corp.</name>
        <lei>213800GFBCNY1ZFST722</lei>
        <title>MannKind Corp.</title>
        <cusip>56400P706</cusip>
        <identifiers>
          <isin value="US56400P7069"/>
          <other otherDesc="Inhouse Asset ID" value="56400P706"/>
        </identifiers>
        <balance>1903903.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9576632.09000000</valUSD>
        <pctVal>0.164929791631</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1271081.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurogene, Inc.</name>
        <lei>529900A7VIY892SZVW73</lei>
        <title>Neurogene, Inc.</title>
        <cusip>64135M105</cusip>
        <identifiers>
          <isin value="US64135M1053"/>
          <other otherDesc="Inhouse Asset ID" value="64135M105"/>
        </identifiers>
        <balance>111749.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1308580.79000000</valUSD>
        <pctVal>0.022536519624</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="143213.30000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apogee Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Apogee Therapeutics, Inc.</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
          <other otherDesc="Inhouse Asset ID" value="03770N101"/>
        </identifiers>
        <balance>233376.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8718927.36000000</valUSD>
        <pctVal>0.150158308184</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7101874.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Enliven Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Enliven Therapeutics, Inc.</title>
        <cusip>29337E102</cusip>
        <identifiers>
          <isin value="US29337E1029"/>
          <other otherDesc="Inhouse Asset ID" value="29337E102"/>
        </identifiers>
        <balance>203924.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4013224.32000000</valUSD>
        <pctVal>0.069116182458</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2708420.64000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bicycle Therapeutics plc</name>
        <lei>213800XKUI6R7GKC3E43</lei>
        <title>Bicycle Therapeutics plc</title>
        <cusip>088786108</cusip>
        <identifiers>
          <isin value="US0887861088"/>
          <other otherDesc="Inhouse Asset ID" value="088786108"/>
        </identifiers>
        <balance>190644.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1618567.56000000</valUSD>
        <pctVal>0.027875145239</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1218315.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ionis Pharmaceuticals, Inc.</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>Ionis Pharmaceuticals, Inc.</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
          <other otherDesc="Inhouse Asset ID" value="462222100"/>
        </identifiers>
        <balance>1000235.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30177089.95000000</valUSD>
        <pctVal>0.519713100674</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="18780825.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>United Therapeutics Corp.</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>United Therapeutics Corp.</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
          <other otherDesc="Inhouse Asset ID" value="91307C102"/>
        </identifiers>
        <balance>284967.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87846777.09000000</valUSD>
        <pctVal>1.512906677924</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Solid Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>Solid Biosciences, Inc.</title>
        <cusip>83422E204</cusip>
        <identifiers>
          <isin value="US83422E2046"/>
          <other otherDesc="Inhouse Asset ID" value="83422E204"/>
        </identifiers>
        <balance>380029.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1406107.30000000</valUSD>
        <pctVal>0.024216131707</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="222000.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>uniQure NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
          <other otherDesc="Inhouse Asset ID" value="BRSM5K8D6"/>
        </identifiers>
        <balance>306444.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3248306.40000000</valUSD>
        <pctVal>0.055942683468</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1857522.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORIC Pharmaceuticals, Inc.</name>
        <lei>54930033FJRNEYBW0L25</lei>
        <title>ORIC Pharmaceuticals, Inc.</title>
        <cusip>68622P109</cusip>
        <identifiers>
          <isin value="US68622P1093"/>
          <other otherDesc="Inhouse Asset ID" value="68622P109"/>
        </identifiers>
        <balance>276800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1544544.00000000</valUSD>
        <pctVal>0.026600303498</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1460319.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tango Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Tango Therapeutics, Inc.</title>
        <cusip>87583X109</cusip>
        <identifiers>
          <isin value="US87583X1090"/>
          <other otherDesc="Inhouse Asset ID" value="87583X109"/>
        </identifiers>
        <balance>381873.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>523166.01000000</valUSD>
        <pctVal>0.009010021498</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Madrigal Pharmaceuticals, Inc.</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>Madrigal Pharmaceuticals, Inc.</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
          <other otherDesc="Inhouse Asset ID" value="558868105"/>
        </identifiers>
        <balance>120360.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>39866842.80000000</valUSD>
        <pctVal>0.686591070245</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5056557.18000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>4D Molecular Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>4D Molecular Therapeutics, Inc.</title>
        <cusip>35104E100</cusip>
        <identifiers>
          <isin value="US35104E1001"/>
          <other otherDesc="Inhouse Asset ID" value="35104E100"/>
        </identifiers>
        <balance>255599.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>825584.77000000</valUSD>
        <pctVal>0.014218310029</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Savara, Inc.</name>
        <lei>5493002JO0WM3YMJXG33</lei>
        <title>Savara, Inc.</title>
        <cusip>805111101</cusip>
        <identifiers>
          <isin value="US8051111016"/>
          <other otherDesc="Inhouse Asset ID" value="SBYXGN810"/>
        </identifiers>
        <balance>565037.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1565152.49000000</valUSD>
        <pctVal>0.026955225137</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="372709.04000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stoke Therapeutics, Inc.</name>
        <lei>549300RD25SS2DIJHJ67</lei>
        <title>Stoke Therapeutics, Inc.</title>
        <cusip>86150R107</cusip>
        <identifiers>
          <isin value="US86150R1077"/>
          <other otherDesc="Inhouse Asset ID" value="86150R107"/>
        </identifiers>
        <balance>263924.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1755094.60000000</valUSD>
        <pctVal>0.030226428660</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1722217.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACELYRIN, Inc.</name>
        <lei>N/A</lei>
        <title>ACELYRIN, Inc.</title>
        <cusip>00445A100</cusip>
        <identifiers>
          <isin value="US00445A1007"/>
          <other otherDesc="Inhouse Asset ID" value="00445A100"/>
        </identifiers>
        <balance>470702.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1162633.94000000</valUSD>
        <pctVal>0.020023007218</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="192907.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioMarin Pharmaceutical, Inc.</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BioMarin Pharmaceutical, Inc.</title>
        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
          <other otherDesc="Inhouse Asset ID" value="09061G101"/>
        </identifiers>
        <balance>1217992.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>86099854.48000000</valUSD>
        <pctVal>1.482820988158</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lexeo Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Lexeo Therapeutics, Inc.</title>
        <cusip>52886X107</cusip>
        <identifiers>
          <isin value="US52886X1072"/>
          <other otherDesc="Inhouse Asset ID" value="52886X107"/>
        </identifiers>
        <balance>164037.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>569208.39000000</valUSD>
        <pctVal>0.009802968337</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="673.18000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cybin, Inc.</name>
        <lei>549300NTYWN4CVYSCN32</lei>
        <title>Cybin, Inc.</title>
        <cusip>23256X407</cusip>
        <identifiers>
          <isin value="CA23256X4075"/>
          <other otherDesc="Inhouse Asset ID" value="SBP4YFH45"/>
        </identifiers>
        <balance>126416.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>801477.44000000</valUSD>
        <pctVal>0.013803130989</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="133774.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kymera Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Kymera Therapeutics, Inc.</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
          <other otherDesc="Inhouse Asset ID" value="501575104"/>
        </identifiers>
        <balance>349163.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9556591.31000000</valUSD>
        <pctVal>0.164584647155</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7292709.13000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alumis, Inc.</name>
        <lei>N/A</lei>
        <title>Alumis, Inc.</title>
        <cusip>022307102</cusip>
        <identifiers>
          <isin value="US0223071020"/>
          <other otherDesc="Inhouse Asset ID" value="022307102"/>
        </identifiers>
        <balance>163093.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1001391.02000000</valUSD>
        <pctVal>0.017246064244</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="997940.34000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merus NV</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>Merus NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0011606264"/>
          <other otherDesc="Inhouse Asset ID" value="SBZBY0056"/>
        </identifiers>
        <balance>395683.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16654297.47000000</valUSD>
        <pctVal>0.286822108825</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6570249.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>89bio, Inc.</name>
        <lei>N/A</lei>
        <title>89bio, Inc.</title>
        <cusip>282559103</cusip>
        <identifiers>
          <isin value="US2825591033"/>
          <other otherDesc="Inhouse Asset ID" value="SBK1K4846"/>
        </identifiers>
        <balance>896167.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6515134.09000000</valUSD>
        <pctVal>0.112204342593</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="106142.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Waters Corp.</name>
        <lei>5T547R1474YC9HOD8Q74</lei>
        <title>Waters Corp.</title>
        <cusip>941848103</cusip>
        <identifiers>
          <isin value="US9418481035"/>
          <other otherDesc="Inhouse Asset ID" value="941848103"/>
        </identifiers>
        <balance>383315.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>141278409.55000000</valUSD>
        <pctVal>2.433112019986</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="72469707.68000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fusion Pharmaceuticals, Inc.</name>
        <lei>N/A</lei>
        <title>Fusion Pharmaceuticals, Inc., CVR</title>
        <cusip>361CVR012</cusip>
        <identifiers>
          <isin value="US361CVR0124"/>
          <other otherDesc="Inhouse Asset ID" value="361CVR012"/>
        </identifiers>
        <balance>1880.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1034.00000000</valUSD>
        <pctVal>0.000017807659</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Right"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="88000.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amylyx Pharmaceuticals, Inc.</name>
        <lei>N/A</lei>
        <title>Amylyx Pharmaceuticals, Inc.</title>
        <cusip>03237H101</cusip>
        <identifiers>
          <isin value="US03237H1014"/>
          <other otherDesc="Inhouse Asset ID" value="03237H101"/>
        </identifiers>
        <balance>402072.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1423334.88000000</valUSD>
        <pctVal>0.024512826949</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="63720.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mineralys Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Mineralys Therapeutics, Inc.</title>
        <cusip>603170101</cusip>
        <identifiers>
          <isin value="US6031701013"/>
          <other otherDesc="Inhouse Asset ID" value="603170101"/>
        </identifiers>
        <balance>158780.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2521426.40000000</valUSD>
        <pctVal>0.043424277643</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1411620.84000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Medpace Holdings, Inc.</name>
        <lei>549300H8TYEUVTW14A54</lei>
        <title>Medpace Holdings, Inc.</title>
        <cusip>58506Q109</cusip>
        <identifiers>
          <isin value="US58506Q1094"/>
          <other otherDesc="Inhouse Asset ID" value="58506Q109"/>
        </identifiers>
        <balance>161587.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49233943.03000000</valUSD>
        <pctVal>0.847912281566</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4082846.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Repligen Corp.</name>
        <lei>54930006QJ0T5AUO1E71</lei>
        <title>Repligen Corp.</title>
        <cusip>759916109</cusip>
        <identifiers>
          <isin value="US7599161095"/>
          <other otherDesc="Inhouse Asset ID" value="759916109"/>
        </identifiers>
        <balance>342273.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43550816.52000000</valUSD>
        <pctVal>0.750036863329</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16925464.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurocrine Biosciences, Inc.</name>
        <lei>549300FECER0XBN49756</lei>
        <title>Neurocrine Biosciences, Inc.</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
          <other otherDesc="Inhouse Asset ID" value="64125C109"/>
        </identifiers>
        <balance>626237.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>69261812.20000000</valUSD>
        <pctVal>1.192834406379</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MeiraGTx Holdings plc</name>
        <lei>54930007YV6NYIOGFZ57</lei>
        <title>MeiraGTx Holdings plc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="KYG596651029"/>
          <other otherDesc="Inhouse Asset ID" value="SBFYQFJ21"/>
        </identifiers>
        <balance>339380.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2300996.40000000</valUSD>
        <pctVal>0.039628008388</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="701730.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Absci Corp.</name>
        <lei>N/A</lei>
        <title>Absci Corp.</title>
        <cusip>00091E109</cusip>
        <identifiers>
          <isin value="US00091E1091"/>
          <other otherDesc="Inhouse Asset ID" value="00091E109"/>
        </identifiers>
        <balance>602230.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1511597.30000000</valUSD>
        <pctVal>0.026032891874</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="659981.91000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insmed, Inc.</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>Insmed, Inc.</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <other otherDesc="Inhouse Asset ID" value="457669307"/>
        </identifiers>
        <balance>1143180.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87213202.20000000</valUSD>
        <pctVal>1.501995182775</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6576198.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Dyne Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Dyne Therapeutics, Inc.</title>
        <cusip>26818M108</cusip>
        <identifiers>
          <isin value="US26818M1080"/>
          <other otherDesc="Inhouse Asset ID" value="26818M108"/>
        </identifiers>
        <balance>542788.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5677562.48000000</valUSD>
        <pctVal>0.097779593911</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="956044.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vera Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Vera Therapeutics, Inc., Class A</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
          <other otherDesc="Inhouse Asset ID" value="92337R101"/>
        </identifiers>
        <balance>313845.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7538556.90000000</valUSD>
        <pctVal>0.129829840703</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1208206.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rhythm Pharmaceuticals, Inc.</name>
        <lei>529900JPNWXQ8DPLA551</lei>
        <title>Rhythm Pharmaceuticals, Inc.</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
          <other otherDesc="Inhouse Asset ID" value="76243J105"/>
        </identifiers>
        <balance>363341.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19246172.77000000</valUSD>
        <pctVal>0.331459665030</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="540294.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biogen, Inc.</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>Biogen, Inc.</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
          <other otherDesc="Inhouse Asset ID" value="09062X103"/>
        </identifiers>
        <balance>941689.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>128860722.76000000</valUSD>
        <pctVal>2.219253277624</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OmniAb, Inc.</name>
        <lei>N/A</lei>
        <title>OmniAb, Inc., 15.00 Earnout Shares</title>
        <cusip>68218J301</cusip>
        <identifiers>
          <isin value="US68218J3014"/>
          <other otherDesc="Inhouse Asset ID" value="68218J301"/>
        </identifiers>
        <balance>46839.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.47000000</valUSD>
        <pctVal>0.000000008094</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Design Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Design Therapeutics, Inc.</title>
        <cusip>25056L103</cusip>
        <identifiers>
          <isin value="US25056L1035"/>
          <other otherDesc="Inhouse Asset ID" value="25056L103"/>
        </identifiers>
        <balance>202614.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>782090.04000000</valUSD>
        <pctVal>0.013469239093</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kura Oncology, Inc.</name>
        <lei>5493005QORQTZCZYOP39</lei>
        <title>Kura Oncology, Inc.</title>
        <cusip>50127T109</cusip>
        <identifiers>
          <isin value="US50127T1097"/>
          <other otherDesc="Inhouse Asset ID" value="50127T109"/>
        </identifiers>
        <balance>467441.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3085110.60000000</valUSD>
        <pctVal>0.053132107784</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="279180.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mettler-Toledo International, Inc.</name>
        <lei>5493000BD5GJNUDIUG10</lei>
        <title>Mettler-Toledo International, Inc.</title>
        <cusip>592688105</cusip>
        <identifiers>
          <isin value="US5926881054"/>
          <other otherDesc="Inhouse Asset ID" value="592688105"/>
        </identifiers>
        <balance>133167.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>157258241.97000000</valUSD>
        <pctVal>2.708318418913</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="9919644.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tarsus Pharmaceuticals, Inc.</name>
        <lei>N/A</lei>
        <title>Tarsus Pharmaceuticals, Inc.</title>
        <cusip>87650L103</cusip>
        <identifiers>
          <isin value="US87650L1035"/>
          <other otherDesc="Inhouse Asset ID" value="87650L103"/>
        </identifiers>
        <balance>213764.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10981056.68000000</valUSD>
        <pctVal>0.189116943525</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="213853.31000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Charles River Laboratories International, Inc.</name>
        <lei>549300BSQ0R4UZ5KX287</lei>
        <title>Charles River Laboratories International, Inc.</title>
        <cusip>159864107</cusip>
        <identifiers>
          <isin value="US1598641074"/>
          <other otherDesc="Inhouse Asset ID" value="159864107"/>
        </identifiers>
        <balance>327019.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49222899.88000000</valUSD>
        <pctVal>0.847722095244</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="18279148.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nurix Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Nurix Therapeutics, Inc.</title>
        <cusip>67080M103</cusip>
        <identifiers>
          <isin value="US67080M1036"/>
          <other otherDesc="Inhouse Asset ID" value="67080M103"/>
        </identifiers>
        <balance>480369.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5706783.72000000</valUSD>
        <pctVal>0.098282845261</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="624888.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pliant Therapeutics, Inc.</name>
        <lei>5493002Q5LITR7VHZH02</lei>
        <title>Pliant Therapeutics, Inc.</title>
        <cusip>729139105</cusip>
        <identifiers>
          <isin value="US7291391057"/>
          <other otherDesc="Inhouse Asset ID" value="729139105"/>
        </identifiers>
        <balance>362767.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>489735.45000000</valUSD>
        <pctVal>0.008434276785</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Phathom Pharmaceuticals, Inc.</name>
        <lei>N/A</lei>
        <title>Phathom Pharmaceuticals, Inc.</title>
        <cusip>71722W107</cusip>
        <identifiers>
          <isin value="US71722W1071"/>
          <other otherDesc="Inhouse Asset ID" value="71722W107"/>
        </identifiers>
        <balance>246029.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1542601.83000000</valUSD>
        <pctVal>0.026566855236</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1513715.94000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Entrada Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Entrada Therapeutics, Inc.</title>
        <cusip>29384C108</cusip>
        <identifiers>
          <isin value="US29384C1080"/>
          <other otherDesc="Inhouse Asset ID" value="29384C108"/>
        </identifiers>
        <balance>143492.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1297167.68000000</valUSD>
        <pctVal>0.022339961811</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4529.04000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alpha Teknova, Inc.</name>
        <lei>N/A</lei>
        <title>Alpha Teknova, Inc.</title>
        <cusip>02080L102</cusip>
        <identifiers>
          <isin value="US02080L1026"/>
          <other otherDesc="Inhouse Asset ID" value="02080L102"/>
        </identifiers>
        <balance>74971.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>389099.49000000</valUSD>
        <pctVal>0.006701113419</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="519.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Editas Medicine, Inc.</name>
        <lei>5299000AON4Q9NT2JE42</lei>
        <title>Editas Medicine, Inc.</title>
        <cusip>28106W103</cusip>
        <identifiers>
          <isin value="US28106W1036"/>
          <other otherDesc="Inhouse Asset ID" value="28106W103"/>
        </identifiers>
        <balance>560178.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>649806.48000000</valUSD>
        <pctVal>0.011191037343</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="278623.88000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ironwood Pharmaceuticals, Inc.</name>
        <lei>549300PC8MR6QHH6P296</lei>
        <title>Ironwood Pharmaceuticals, Inc., Class A</title>
        <cusip>46333X108</cusip>
        <identifiers>
          <isin value="US46333X1081"/>
          <other otherDesc="Inhouse Asset ID" value="46333X108"/>
        </identifiers>
        <balance>1002418.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1473554.46000000</valUSD>
        <pctVal>0.025377713977</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Allogene Therapeutics, Inc.</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
          <other otherDesc="Inhouse Asset ID" value="019770106"/>
        </identifiers>
        <balance>871251.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1272026.46000000</valUSD>
        <pctVal>0.021906977006</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1076087.16000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Edgewise Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Edgewise Therapeutics, Inc.</title>
        <cusip>28036F105</cusip>
        <identifiers>
          <isin value="US28036F1057"/>
          <other otherDesc="Inhouse Asset ID" value="28036F105"/>
        </identifiers>
        <balance>431902.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9501844.00000000</valUSD>
        <pctVal>0.163641783072</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1931600.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Argenx SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>Argenx SE</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
          <other otherDesc="Inhouse Asset ID" value="04016X101"/>
        </identifiers>
        <balance>272509.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>161288539.29000000</valUSD>
        <pctVal>2.777728634420</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2840952.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BlackRock Funds III</name>
        <lei>549300JDHS1T46VWOG19</lei>
        <title>BlackRock Cash Funds: Institutional, SL Agency Shares</title>
        <cusip>066922519</cusip>
        <identifiers>
          <isin value="US0669225197"/>
          <other otherDesc="Inhouse Asset ID" value="066922519"/>
        </identifiers>
        <balance>786401314.32500000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>786794514.98000000</valUSD>
        <pctVal>13.55026006984</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <cashCollateralCondition cashCollateralVal="786794514.98000002" isCashCollateral="Y"/>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aura Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>Aura Biosciences, Inc.</title>
        <cusip>05153U107</cusip>
        <identifiers>
          <isin value="US05153U1079"/>
          <other otherDesc="Inhouse Asset ID" value="05153U107"/>
        </identifiers>
        <balance>287088.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1682335.68000000</valUSD>
        <pctVal>0.028973366685</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5262.28000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SpringWorks Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>SpringWorks Therapeutics, Inc.</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
          <other otherDesc="Inhouse Asset ID" value="SBGMGM899"/>
        </identifiers>
        <balance>454665.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20064366.45000000</valUSD>
        <pctVal>0.345550684909</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="15369464.01000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Genmab A/S</name>
        <lei>529900MTJPDPE4MHJ122</lei>
        <title>Genmab A/S</title>
        <cusip>372303206</cusip>
        <identifiers>
          <isin value="US3723032062"/>
          <other otherDesc="Inhouse Asset ID" value="372303206"/>
        </identifiers>
        <balance>2984897.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58444283.26000000</valUSD>
        <pctVal>1.006533755244</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1433256.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Recursion Pharmaceuticals, Inc.</name>
        <lei>N/A</lei>
        <title>Recursion Pharmaceuticals, Inc., Class A</title>
        <cusip>75629V104</cusip>
        <identifiers>
          <isin value="US75629V1044"/>
          <other otherDesc="Inhouse Asset ID" value="75629V104"/>
        </identifiers>
        <balance>1918383.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10148246.07000000</valUSD>
        <pctVal>0.174774189299</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7469908.49000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zai Lab Ltd.</name>
        <lei>549300P2UYQ9U5LY1T58</lei>
        <title>Zai Lab Ltd.</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
          <other otherDesc="Inhouse Asset ID" value="98887Q104"/>
        </identifiers>
        <balance>489043.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17674014.02000000</valUSD>
        <pctVal>0.304383777326</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Olema Pharmaceuticals, Inc.</name>
        <lei>N/A</lei>
        <title>Olema Pharmaceuticals, Inc.</title>
        <cusip>68062P106</cusip>
        <identifiers>
          <isin value="US68062P1066"/>
          <other otherDesc="Inhouse Asset ID" value="68062P106"/>
        </identifiers>
        <balance>352870.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1326791.20000000</valUSD>
        <pctVal>0.022850141270</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7512.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Revolution Medicines, Inc.</name>
        <lei>549300JU3X0LBCQ65892</lei>
        <title>REVOLUTION Medicines, Inc.</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
          <other otherDesc="Inhouse Asset ID" value="76155X100"/>
        </identifiers>
        <balance>1044620.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36937763.20000000</valUSD>
        <pctVal>0.636146145186</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Blueprint Medicines Corp.</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>Blueprint Medicines Corp.</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
          <other otherDesc="Inhouse Asset ID" value="09627Y109"/>
        </identifiers>
        <balance>405668.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35905674.68000000</valUSD>
        <pctVal>0.618371405283</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="486805.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Standard BioTools, Inc.</name>
        <lei>549300GX8Y96GSB6YP89</lei>
        <title>Standard BioTools, Inc.</title>
        <cusip>34385P108</cusip>
        <identifiers>
          <isin value="US34385P1084"/>
          <other otherDesc="Inhouse Asset ID" value="34385P108"/>
        </identifiers>
        <balance>2328471.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2514748.68000000</valUSD>
        <pctVal>0.043309273228</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MacroGenics, Inc.</name>
        <lei>5493001KJQUA83L8MH79</lei>
        <title>MacroGenics, Inc.</title>
        <cusip>556099109</cusip>
        <identifiers>
          <isin value="US5560991094"/>
          <other otherDesc="Inhouse Asset ID" value="556099109"/>
        </identifiers>
        <balance>384653.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>488509.31000000</valUSD>
        <pctVal>0.008413160070</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="216154.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>10X Genomics, Inc.</name>
        <lei>5493003Z6741WNLG7H43</lei>
        <title>10X Genomics, Inc., Class A</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
          <other otherDesc="Inhouse Asset ID" value="88025U109"/>
        </identifiers>
        <balance>654858.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5716910.34000000</valUSD>
        <pctVal>0.098457247004</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="28870.11000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Myriad Genetics, Inc.</name>
        <lei>52990044IHUOUMETT163</lei>
        <title>Myriad Genetics, Inc.</title>
        <cusip>62855J104</cusip>
        <identifiers>
          <isin value="US62855J1043"/>
          <other otherDesc="Inhouse Asset ID" value="62855J104"/>
        </identifiers>
        <balance>566075.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5021085.25000000</valUSD>
        <pctVal>0.086473672191</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intra-Cellular Therapies, Inc.</name>
        <lei>5299002U2KGF193IJA20</lei>
        <title>Intra-Cellular Therapies, Inc.</title>
        <cusip>46116X101</cusip>
        <identifiers>
          <isin value="US46116X1019"/>
          <other otherDesc="Inhouse Asset ID" value="46116X101"/>
        </identifiers>
        <balance>640093.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>84441068.56000000</valUSD>
        <pctVal>1.454253197981</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Disc Medicine, Inc.</name>
        <lei>N/A</lei>
        <title>Disc Medicine, Inc.</title>
        <cusip>254604101</cusip>
        <identifiers>
          <isin value="US2546041011"/>
          <other otherDesc="Inhouse Asset ID" value="254604101"/>
        </identifiers>
        <balance>137065.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6803906.60000000</valUSD>
        <pctVal>0.117177613933</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bio-Techne Corp.</name>
        <lei>54930073RLKQ51TILZ35</lei>
        <title>Bio-Techne Corp.</title>
        <cusip>09073M104</cusip>
        <identifiers>
          <isin value="US09073M1045"/>
          <other otherDesc="Inhouse Asset ID" value="09073M104"/>
        </identifiers>
        <balance>1010941.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>59271470.83000000</valUSD>
        <pctVal>1.020779668868</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1330901.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Theravance Biopharma, Inc.</name>
        <lei>5493007VTSXP4Z6MIW52</lei>
        <title>Theravance Biopharma, Inc.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="KYG8807B1068"/>
          <other otherDesc="Inhouse Asset ID" value="SBMNDK095"/>
        </identifiers>
        <balance>293405.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2620106.65000000</valUSD>
        <pctVal>0.045123759561</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2369727.31000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ADC Therapeutics SA</name>
        <lei>N/A</lei>
        <title>ADC Therapeutics SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0499880968"/>
          <other otherDesc="Inhouse Asset ID" value="SBK6H4Z72"/>
        </identifiers>
        <balance>508383.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>716820.03000000</valUSD>
        <pctVal>0.012345151935</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="229529.67000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tempus AI, Inc.</name>
        <lei>N/A</lei>
        <title>Tempus AI, Inc.</title>
        <cusip>88023B103</cusip>
        <identifiers>
          <isin value="US88023B1035"/>
          <other otherDesc="Inhouse Asset ID" value="88023B103"/>
        </identifiers>
        <balance>395231.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19065943.44000000</valUSD>
        <pctVal>0.328355736053</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="15366128.40000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fortrea Holdings, Inc.</name>
        <lei>5493000FIVFABOVCDU97</lei>
        <title>Fortrea Holdings, Inc.</title>
        <cusip>34965K107</cusip>
        <identifiers>
          <isin value="US34965K1079"/>
          <other otherDesc="Inhouse Asset ID" value="34965K107"/>
        </identifiers>
        <balance>550013.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4152598.15000000</valUSD>
        <pctVal>0.071516493603</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WaVe Life Sciences Ltd.</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WaVe Life Sciences Ltd.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
          <other otherDesc="Inhouse Asset ID" value="SBYZG9R07"/>
        </identifiers>
        <balance>788904.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6374344.32000000</valUSD>
        <pctVal>0.109779645976</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1103728.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Q32 Bio, Inc.</name>
        <lei>549300RWKPJEFTM3K452</lei>
        <title>Q32 Bio, Inc.</title>
        <cusip>746964105</cusip>
        <identifiers>
          <isin value="US7469641051"/>
          <other otherDesc="Inhouse Asset ID" value="746964105"/>
        </identifiers>
        <balance>27586.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45516.90000000</valUSD>
        <pctVal>0.000783896965</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="848.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics, Inc.</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>Sage Therapeutics, Inc.</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
          <other otherDesc="Inhouse Asset ID" value="78667J108"/>
        </identifiers>
        <balance>349418.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2777873.10000000</valUSD>
        <pctVal>0.047840830393</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ideaya Biosciences, Inc.</name>
        <lei>549300ULW08F62IJML11</lei>
        <title>Ideaya Biosciences, Inc.</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
          <other otherDesc="Inhouse Asset ID" value="45166A102"/>
        </identifiers>
        <balance>521601.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8543824.38000000</valUSD>
        <pctVal>0.147142665760</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cytek Biosciences, Inc.</name>
        <lei>549300K2J28BOC6FBO89</lei>
        <title>Cytek Biosciences, Inc.</title>
        <cusip>23285D109</cusip>
        <identifiers>
          <isin value="US23285D1090"/>
          <other otherDesc="Inhouse Asset ID" value="23285D109"/>
        </identifiers>
        <balance>754384.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3025079.84000000</valUSD>
        <pctVal>0.052098251555</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bruker Corp.</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
        <title>Bruker Corp.</title>
        <cusip>116794108</cusip>
        <identifiers>
          <isin value="US1167941087"/>
          <other otherDesc="Inhouse Asset ID" value="116794108"/>
        </identifiers>
        <balance>666374.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27814450.76000000</valUSD>
        <pctVal>0.479023473501</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="813930.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roivant Sciences Ltd.</name>
        <lei>549300DL466NY5J6U724</lei>
        <title>Roivant Sciences Ltd.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="BMG762791017"/>
          <other otherDesc="Inhouse Asset ID" value="SBMW4NZ91"/>
        </identifiers>
        <balance>2859815.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28855533.35000000</valUSD>
        <pctVal>0.496953110249</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BM</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="12427671.38000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Praxis Precision Medicines, Inc.</name>
        <lei>N/A</lei>
        <title>Praxis Precision Medicines, Inc.</title>
        <cusip>74006W207</cusip>
        <identifiers>
          <isin value="US74006W2070"/>
          <other otherDesc="Inhouse Asset ID" value="74006W207"/>
        </identifiers>
        <balance>111176.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4210235.12000000</valUSD>
        <pctVal>0.072509123722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Twist Bioscience Corp.</name>
        <lei>549300T23BL59LCOH584</lei>
        <title>Twist Bioscience Corp.</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
          <other otherDesc="Inhouse Asset ID" value="90184D100"/>
        </identifiers>
        <balance>364023.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14291542.98000000</valUSD>
        <pctVal>0.246130495944</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2756052.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cytokinetics, Inc.</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>Cytokinetics, Inc.</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
          <other otherDesc="Inhouse Asset ID" value="23282W605"/>
        </identifiers>
        <balance>746494.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30001593.86000000</valUSD>
        <pctVal>0.516690688067</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1036902.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sutro Biopharma, Inc.</name>
        <lei>5493005U6P15VD25P851</lei>
        <title>Sutro Biopharma, Inc.</title>
        <cusip>869367102</cusip>
        <identifiers>
          <isin value="US8693671021"/>
          <other otherDesc="Inhouse Asset ID" value="869367102"/>
        </identifiers>
        <balance>461423.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>300201.80000000</valUSD>
        <pctVal>0.005170107805</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcturus Therapeutics Holdings, Inc.</name>
        <lei>N/A</lei>
        <title>Arcturus Therapeutics Holdings, Inc.</title>
        <cusip>03969T109</cusip>
        <identifiers>
          <isin value="US03969T1097"/>
          <other otherDesc="Inhouse Asset ID" value="03969T109"/>
        </identifiers>
        <balance>157224.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1665002.16000000</valUSD>
        <pctVal>0.028674846933</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="655160.94000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illumina, Inc.</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>Illumina, Inc.</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
          <other otherDesc="Inhouse Asset ID" value="452327109"/>
        </identifiers>
        <balance>1019357.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>80875784.38000000</valUSD>
        <pctVal>1.392851488968</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exelixis, Inc.</name>
        <lei>254900PJQB59O2O95R37</lei>
        <title>Exelixis, Inc.</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
          <other otherDesc="Inhouse Asset ID" value="30161Q104"/>
        </identifiers>
        <balance>1761729.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>65043034.68000000</valUSD>
        <pctVal>1.120178164521</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Quanterix Corp.</name>
        <lei>N/A</lei>
        <title>Quanterix Corp.</title>
        <cusip>74766Q101</cusip>
        <identifiers>
          <isin value="US74766Q1013"/>
          <other otherDesc="Inhouse Asset ID" value="74766Q101"/>
        </identifiers>
        <balance>216824.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1411524.24000000</valUSD>
        <pctVal>0.024309422832</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="199206.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prothena Corp. plc</name>
        <lei>5299009ZXQ8NIIJ8OL30</lei>
        <title>Prothena Corp. plc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
          <other otherDesc="Inhouse Asset ID" value="SB91XRN21"/>
        </identifiers>
        <balance>275416.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3408273.00000000</valUSD>
        <pctVal>0.058697645522</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2505739.50000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fate Therapeutics, Inc.</name>
        <lei>549300L14Q4UHOODLA90</lei>
        <title>Fate Therapeutics, Inc.</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
          <other otherDesc="Inhouse Asset ID" value="31189P102"/>
        </identifiers>
        <balance>659791.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>521300.87000000</valUSD>
        <pctVal>0.008977899856</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="60442.65000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Day One Biopharmaceuticals, Inc.</name>
        <lei>N/A</lei>
        <title>Day One Biopharmaceuticals, Inc.</title>
        <cusip>23954D109</cusip>
        <identifiers>
          <isin value="US23954D1090"/>
          <other otherDesc="Inhouse Asset ID" value="23954D109"/>
        </identifiers>
        <balance>479077.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3799080.61000000</valUSD>
        <pctVal>0.065428176368</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1227984.29000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Galapagos NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>Galapagos NV</title>
        <cusip>36315X101</cusip>
        <identifiers>
          <isin value="US36315X1019"/>
          <other otherDesc="Inhouse Asset ID" value="36315X101"/>
        </identifiers>
        <balance>215173.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5405145.76000000</valUSD>
        <pctVal>0.093088003753</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1685552.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Replimune Group, Inc.</name>
        <lei>549300AY704NEIRC4K64</lei>
        <title>Replimune Group, Inc.</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
          <other otherDesc="Inhouse Asset ID" value="76029N106"/>
        </identifiers>
        <balance>397439.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3875030.25000000</valUSD>
        <pctVal>0.066736189267</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="428532.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Janux Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Janux Therapeutics, Inc.</title>
        <cusip>47103J105</cusip>
        <identifiers>
          <isin value="US47103J1051"/>
          <other otherDesc="Inhouse Asset ID" value="47103J105"/>
        </identifiers>
        <balance>310647.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8387469.00000000</valUSD>
        <pctVal>0.144449896528</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8230437.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centessa Pharmaceuticals plc</name>
        <lei>213800GIDAARDSKOI827</lei>
        <title>Centessa Pharmaceuticals plc</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
          <other otherDesc="Inhouse Asset ID" value="152309100"/>
        </identifiers>
        <balance>359666.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5171997.08000000</valUSD>
        <pctVal>0.089072692018</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2469046.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novocure Ltd.</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>Novocure Ltd.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
          <other otherDesc="Inhouse Asset ID" value="SBYSS4X46"/>
        </identifiers>
        <balance>638408.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11376430.56000000</valUSD>
        <pctVal>0.195926115166</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="334570.50000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fulgent Genetics, Inc.</name>
        <lei>549300CL6P01M68QJ404</lei>
        <title>Fulgent Genetics, Inc.</title>
        <cusip>359664109</cusip>
        <identifiers>
          <isin value="US3596641098"/>
          <other otherDesc="Inhouse Asset ID" value="359664109"/>
        </identifiers>
        <balance>127851.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2160681.90000000</valUSD>
        <pctVal>0.037211496923</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="10140.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Castle Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>Castle Biosciences, Inc.</title>
        <cusip>14843C105</cusip>
        <identifiers>
          <isin value="US14843C1053"/>
          <other otherDesc="Inhouse Asset ID" value="14843C105"/>
        </identifiers>
        <balance>178684.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3577253.68000000</valUSD>
        <pctVal>0.061607849034</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xenon Pharmaceuticals, Inc.</name>
        <lei>549300XV44Q9Z1MIPQ03</lei>
        <title>Xenon Pharmaceuticals, Inc.</title>
        <cusip>98420N105</cusip>
        <identifiers>
          <isin value="CA98420N1050"/>
          <other otherDesc="Inhouse Asset ID" value="98420N105"/>
        </identifiers>
        <balance>479296.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16080380.80000000</valUSD>
        <pctVal>0.276938053981</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3052479.65000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Enanta Pharmaceuticals, Inc.</name>
        <lei>529900SSN4DODDQSN594</lei>
        <title>Enanta Pharmaceuticals, Inc.</title>
        <cusip>29251M106</cusip>
        <identifiers>
          <isin value="US29251M1062"/>
          <other otherDesc="Inhouse Asset ID" value="29251M106"/>
        </identifiers>
        <balance>128680.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>710313.60000000</valUSD>
        <pctVal>0.012233097496</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amicus Therapeutics, Inc.</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>Amicus Therapeutics, Inc.</title>
        <cusip>03152W109</cusip>
        <identifiers>
          <isin value="US03152W1099"/>
          <other otherDesc="Inhouse Asset ID" value="03152W109"/>
        </identifiers>
        <balance>1915505.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15630520.80000000</valUSD>
        <pctVal>0.269190516500</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="14688.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cullinan Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Cullinan Therapeutics, Inc.</title>
        <cusip>230031106</cusip>
        <identifiers>
          <isin value="US2300311063"/>
          <other otherDesc="Inhouse Asset ID" value="230031106"/>
        </identifiers>
        <balance>231186.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1750078.02000000</valUSD>
        <pctVal>0.030140032577</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1717284.78000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Perspective Therapeutics, Inc.</name>
        <lei>5493005LRKM6BCABC605</lei>
        <title>Perspective Therapeutics, Inc.</title>
        <cusip>46489V302</cusip>
        <identifiers>
          <isin value="US46489V3024"/>
          <other otherDesc="Inhouse Asset ID" value="46489V302"/>
        </identifiers>
        <balance>318506.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>678417.78000000</valUSD>
        <pctVal>0.011683784240</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="139581.03000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC Therapeutics, Inc.</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC Therapeutics, Inc.</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
          <other otherDesc="Inhouse Asset ID" value="69366J200"/>
        </identifiers>
        <balance>497131.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25333795.76000000</valUSD>
        <pctVal>0.436301365310</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2063880.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ultragenyx Pharmaceutical, Inc.</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>Ultragenyx Pharmaceutical, Inc.</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
          <other otherDesc="Inhouse Asset ID" value="90400D108"/>
        </identifiers>
        <balance>560143.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20282778.03000000</valUSD>
        <pctVal>0.349312192717</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="155703.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nuvalent, Inc.</name>
        <lei>N/A</lei>
        <title>Nuvalent, Inc., Class A</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
          <other otherDesc="Inhouse Asset ID" value="670703107"/>
        </identifiers>
        <balance>287231.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20370422.52000000</valUSD>
        <pctVal>0.350821615584</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Astria Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Astria Therapeutics, Inc.</title>
        <cusip>04635X102</cusip>
        <identifiers>
          <isin value="US04635X1028"/>
          <other otherDesc="Inhouse Asset ID" value="04635X102"/>
        </identifiers>
        <balance>301609.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1610592.06000000</valUSD>
        <pctVal>0.027737790317</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="224814.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Codexis, Inc.</name>
        <lei>N/A</lei>
        <title>Codexis, Inc.</title>
        <cusip>192005106</cusip>
        <identifiers>
          <isin value="US1920051067"/>
          <other otherDesc="Inhouse Asset ID" value="192005106"/>
        </identifiers>
        <balance>520395.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1399862.55000000</valUSD>
        <pctVal>0.024108583948</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Natera, Inc.</name>
        <lei>N/A</lei>
        <title>Natera, Inc.</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
          <other otherDesc="Inhouse Asset ID" value="632307104"/>
        </identifiers>
        <balance>826187.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>116831103.67000000</valUSD>
        <pctVal>2.012077879083</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="89243851.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ArriVent Biopharma, Inc.</name>
        <lei>N/A</lei>
        <title>ArriVent Biopharma, Inc.</title>
        <cusip>04272N102</cusip>
        <identifiers>
          <isin value="US04272N1028"/>
          <other otherDesc="Inhouse Asset ID" value="04272N102"/>
        </identifiers>
        <balance>124348.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2299194.52000000</valUSD>
        <pctVal>0.039596976216</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1823798.13000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CareDx, Inc.</name>
        <lei>549300NQOFKL9NON0U06</lei>
        <title>CareDx, Inc.</title>
        <cusip>14167L103</cusip>
        <identifiers>
          <isin value="US14167L1035"/>
          <other otherDesc="Inhouse Asset ID" value="14167L103"/>
        </identifiers>
        <balance>324528.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5760372.00000000</valUSD>
        <pctVal>0.099205748404</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3923389.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UroGen Pharma Ltd.</name>
        <lei>549300C0YCX7CG2G5D50</lei>
        <title>UroGen Pharma Ltd.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IL0011407140"/>
          <other otherDesc="Inhouse Asset ID" value="SBZ7PJQ15"/>
        </identifiers>
        <balance>226135.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2501053.10000000</valUSD>
        <pctVal>0.043073406471</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1498983.92000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirum Pharmaceuticals, Inc.</name>
        <lei>254900YZKR40F7F27K81</lei>
        <title>Mirum Pharmaceuticals, Inc.</title>
        <cusip>604749101</cusip>
        <identifiers>
          <isin value="US6047491013"/>
          <other otherDesc="Inhouse Asset ID" value="604749101"/>
        </identifiers>
        <balance>251467.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11328588.35000000</valUSD>
        <pctVal>0.195102171461</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="666740.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kyverna Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Kyverna Therapeutics, Inc.</title>
        <cusip>501976104</cusip>
        <identifiers>
          <isin value="US5019761049"/>
          <other otherDesc="Inhouse Asset ID" value="501976104"/>
        </identifiers>
        <balance>138812.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>267907.16000000</valUSD>
        <pctVal>0.004613926029</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="15054.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OPKO Health, Inc.</name>
        <lei>529900A4S2D4OGOJLL02</lei>
        <title>OPKO Health, Inc.</title>
        <cusip>68375N103</cusip>
        <identifiers>
          <isin value="US68375N1037"/>
          <other otherDesc="Inhouse Asset ID" value="68375N103"/>
        </identifiers>
        <balance>1992962.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3308316.92000000</valUSD>
        <pctVal>0.056976191122</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2116915.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>N/A</name>
        <lei>N/A</lei>
        <title>Russell 2000 E-Mini Index</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Inhouse Asset ID" value="RTSM52027"/>
          <other otherDesc="Future Ticker" value="RTYM5 Index"/>
        </identifiers>
        <balance>19.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-44902.31000000</valUSD>
        <pctVal>-0.00077331242</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="Future" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <futrDeriv derivCat="FUT">
            <counterparties>
              <counterpartyName>CME Clearing House</counterpartyName>
              <counterpartyLei>LCZ7XYGSLJUHFXXNXD88</counterpartyLei>
            </counterparties>
            <payOffProf>Long</payOffProf>
            <descRefInstrmnt>
              <indexBasketInfo>
                <indexName>Russell 2000 E-Mini Index</indexName>
                <indexIdentifier>US7827001089</indexIdentifier>
              </indexBasketInfo>
            </descRefInstrmnt>
            <expDate>2025-06-20</expDate>
            <notionalAmt>1925745.00000000</notionalAmt>
            <curCd>USD</curCd>
            <unrealizedAppr>-44902.31000000</unrealizedAppr>
          </futrDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pacific Biosciences of California, Inc.</name>
        <lei>529900F1BWRE1M0KZN89</lei>
        <title>Pacific Biosciences of California, Inc.</title>
        <cusip>69404D108</cusip>
        <identifiers>
          <isin value="US69404D1081"/>
          <other otherDesc="Inhouse Asset ID" value="69404D108"/>
        </identifiers>
        <balance>1586072.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1871564.96000000</valUSD>
        <pctVal>0.032232293772</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1864713.88000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MaxCyte, Inc.</name>
        <lei>54930053YHXULRFCU991</lei>
        <title>MaxCyte, Inc.</title>
        <cusip>57777K106</cusip>
        <identifiers>
          <isin value="US57777K1060"/>
          <other otherDesc="Inhouse Asset ID" value="57777K106"/>
        </identifiers>
        <balance>628796.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1716613.08000000</valUSD>
        <pctVal>0.029563695768</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor, Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor, Inc.</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <other otherDesc="Inhouse Asset ID" value="98401F105"/>
        </identifiers>
        <balance>428140.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4555409.60000000</valUSD>
        <pctVal>0.078453755878</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="153216.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics, Inc.</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>Sarepta Therapeutics, Inc.</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
          <other otherDesc="Inhouse Asset ID" value="803607100"/>
        </identifiers>
        <balance>581019.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>37080632.58000000</valUSD>
        <pctVal>0.638606657071</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1212580.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcutis Biotherapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Arcutis Biotherapeutics, Inc.</title>
        <cusip>03969K108</cusip>
        <identifiers>
          <isin value="US03969K1088"/>
          <other otherDesc="Inhouse Asset ID" value="03969K108"/>
        </identifiers>
        <balance>674553.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10550008.92000000</valUSD>
        <pctVal>0.181693392472</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Summit Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Summit Therapeutics, Inc.</title>
        <cusip>86627T108</cusip>
        <identifiers>
          <isin value="US86627T1088"/>
          <other otherDesc="Inhouse Asset ID" value="SBMTVQS73"/>
        </identifiers>
        <balance>742348.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14319892.92000000</valUSD>
        <pctVal>0.246618741671</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="14051491.86000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Corvus Pharmaceuticals, Inc.</name>
        <lei>549300I3AVJ8F75NCX65</lei>
        <title>Corvus Pharmaceuticals, Inc.</title>
        <cusip>221015100</cusip>
        <identifiers>
          <isin value="US2210151005"/>
          <other otherDesc="Inhouse Asset ID" value="221015100"/>
        </identifiers>
        <balance>302127.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>960763.86000000</valUSD>
        <pctVal>0.016546378909</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="283974.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nuvation Bio, Inc.</name>
        <lei>N/A</lei>
        <title>Nuvation Bio, Inc., Class A</title>
        <cusip>67080N101</cusip>
        <identifiers>
          <isin value="US67080N1019"/>
          <other otherDesc="Inhouse Asset ID" value="67080N101"/>
        </identifiers>
        <balance>1460365.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2570242.40000000</valUSD>
        <pctVal>0.044264992065</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="847992.64000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Atea Pharmaceuticals, Inc.</name>
        <lei>N/A</lei>
        <title>Atea Pharmaceuticals, Inc.</title>
        <cusip>04683R106</cusip>
        <identifiers>
          <isin value="US04683R1068"/>
          <other otherDesc="Inhouse Asset ID" value="04683R106"/>
        </identifiers>
        <balance>475161.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1420731.39000000</valUSD>
        <pctVal>0.024467989363</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="57476.77000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CG oncology, Inc.</name>
        <lei>N/A</lei>
        <title>CG oncology, Inc.</title>
        <cusip>156944100</cusip>
        <identifiers>
          <isin value="US1569441009"/>
          <other otherDesc="Inhouse Asset ID" value="156944100"/>
        </identifiers>
        <balance>297938.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7296501.62000000</valUSD>
        <pctVal>0.125661138542</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5443612.71000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Iovance Biotherapeutics, Inc.</name>
        <lei>2549002L8WT2ACU5Q878</lei>
        <title>Iovance Biotherapeutics, Inc.</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
          <other otherDesc="Inhouse Asset ID" value="462260100"/>
        </identifiers>
        <balance>1716924.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5717356.92000000</valUSD>
        <pctVal>0.098464938053</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1982881.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biomea Fusion, Inc.</name>
        <lei>N/A</lei>
        <title>Biomea Fusion, Inc.</title>
        <cusip>09077A106</cusip>
        <identifiers>
          <isin value="US09077A1060"/>
          <other otherDesc="Inhouse Asset ID" value="09077A106"/>
        </identifiers>
        <balance>219180.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>466853.40000000</valUSD>
        <pctVal>0.008040199650</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="384081.60000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Annexon, Inc.</name>
        <lei>N/A</lei>
        <title>Annexon, Inc.</title>
        <cusip>03589W102</cusip>
        <identifiers>
          <isin value="US03589W1027"/>
          <other otherDesc="Inhouse Asset ID" value="03589W102"/>
        </identifiers>
        <balance>598335.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1154786.55000000</valUSD>
        <pctVal>0.019887858620</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="86271.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cargo Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Cargo Therapeutics, Inc.</title>
        <cusip>14179K101</cusip>
        <identifiers>
          <isin value="US14179K1016"/>
          <other otherDesc="Inhouse Asset ID" value="14179K101"/>
        </identifiers>
        <balance>193756.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>788586.92000000</valUSD>
        <pctVal>0.013581129062</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="140008.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Syndax Pharmaceuticals, Inc.</name>
        <lei>529900OF94TRHKZVBS87</lei>
        <title>Syndax Pharmaceuticals, Inc.</title>
        <cusip>87164F105</cusip>
        <identifiers>
          <isin value="US87164F1057"/>
          <other otherDesc="Inhouse Asset ID" value="87164F105"/>
        </identifiers>
        <balance>539335.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6625730.48000000</valUSD>
        <pctVal>0.114109045560</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals, Inc.</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>Alnylam Pharmaceuticals, Inc.</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <other otherDesc="Inhouse Asset ID" value="02043Q107"/>
        </identifiers>
        <balance>800605.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>216179362.10000000</valUSD>
        <pctVal>3.723064310207</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Inhibrx Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>Inhibrx Biosciences, Inc.</title>
        <cusip>45720N103</cusip>
        <identifiers>
          <isin value="US45720N1037"/>
          <other otherDesc="Inhouse Asset ID" value="45720N103"/>
        </identifiers>
        <balance>64249.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>898843.51000000</valUSD>
        <pctVal>0.015479979957</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="242027.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vaxcyte, Inc.</name>
        <lei>254900M7NMHTGASX8D95</lei>
        <title>Vaxcyte, Inc.</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
          <other otherDesc="Inhouse Asset ID" value="92243G108"/>
        </identifiers>
        <balance>808266.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30520124.16000000</valUSD>
        <pctVal>0.525620872868</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2077441.92000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Keros Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Keros Therapeutics, Inc.</title>
        <cusip>492327101</cusip>
        <identifiers>
          <isin value="US4923271013"/>
          <other otherDesc="Inhouse Asset ID" value="492327101"/>
        </identifiers>
        <balance>212323.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2163571.37000000</valUSD>
        <pctVal>0.037261259687</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="851568.11000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>Ascendis Pharma A/S</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
          <other otherDesc="Inhouse Asset ID" value="04351P101"/>
        </identifiers>
        <balance>271295.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42284038.70000000</valUSD>
        <pctVal>0.728220278967</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3834156.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novavax, Inc.</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax, Inc.</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
          <other otherDesc="Inhouse Asset ID" value="670002401"/>
        </identifiers>
        <balance>947829.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6075583.89000000</valUSD>
        <pctVal>0.104634361600</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5658651.85000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Beam Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Beam Therapeutics, Inc.</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
          <other otherDesc="Inhouse Asset ID" value="07373V105"/>
        </identifiers>
        <balance>475966.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9295615.98000000</valUSD>
        <pctVal>0.160090101850</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="8468266.59000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Oruka Therapeutics, Inc.</name>
        <lei>529900TG7O4ESUDMGI54</lei>
        <title>Oruka Therapeutics, Inc.</title>
        <cusip>687604108</cusip>
        <identifiers>
          <isin value="US6876041087"/>
          <other otherDesc="Inhouse Asset ID" value="687604108"/>
        </identifiers>
        <balance>191364.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1963394.64000000</valUSD>
        <pctVal>0.033813794434</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1484437.32000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Taysha Gene Therapies, Inc.</name>
        <lei>N/A</lei>
        <title>Taysha Gene Therapies, Inc.</title>
        <cusip>877619106</cusip>
        <identifiers>
          <isin value="US8776191061"/>
          <other otherDesc="Inhouse Asset ID" value="877619106"/>
        </identifiers>
        <balance>1018619.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1415880.41000000</valUSD>
        <pctVal>0.024384445262</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1263175.01000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals, Inc.</name>
        <lei>529900ONJHY8EOGYT555</lei>
        <title>Agios Pharmaceuticals, Inc.</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
          <other otherDesc="Inhouse Asset ID" value="00847X104"/>
        </identifiers>
        <balance>356609.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10448643.70000000</valUSD>
        <pctVal>0.179947669711</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ginkgo Bioworks Holdings, Inc.</name>
        <lei>N/A</lei>
        <title>Ginkgo Bioworks Holdings, Inc.</title>
        <cusip>37611X209</cusip>
        <identifiers>
          <isin value="US37611X2099"/>
          <other otherDesc="Inhouse Asset ID" value="37611X209"/>
        </identifiers>
        <balance>238935.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1361929.50000000</valUSD>
        <pctVal>0.023455296866</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1336433.40000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Verona Pharma plc</name>
        <lei>213800EVI6O6J3TIAL06</lei>
        <title>Verona Pharma plc</title>
        <cusip>925050106</cusip>
        <identifiers>
          <isin value="US9250501064"/>
          <other otherDesc="Inhouse Asset ID" value="925050106"/>
        </identifiers>
        <balance>328858.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20879194.42000000</valUSD>
        <pctVal>0.359583740167</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6418839.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Axsome Therapeutics, Inc.</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>Axsome Therapeutics, Inc.</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
          <other otherDesc="Inhouse Asset ID" value="05464T104"/>
        </identifiers>
        <balance>259007.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30207986.41000000</valUSD>
        <pctVal>0.520245202843</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1632820.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>2seventy bio, Inc.</name>
        <lei>N/A</lei>
        <title>2seventy bio, Inc.</title>
        <cusip>901384107</cusip>
        <identifiers>
          <isin value="US9013841070"/>
          <other otherDesc="Inhouse Asset ID" value="901384107"/>
        </identifiers>
        <balance>304617.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1504807.98000000</valUSD>
        <pctVal>0.025915965472</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="50388.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Humacyte, Inc.</name>
        <lei>N/A</lei>
        <title>Humacyte, Inc.</title>
        <cusip>44486Q103</cusip>
        <identifiers>
          <isin value="US44486Q1031"/>
          <other otherDesc="Inhouse Asset ID" value="SBMYTJP41"/>
        </identifiers>
        <balance>674280.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1149647.40000000</valUSD>
        <pctVal>0.019799351624</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="696613.55500000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ADMA Biologics, Inc.</name>
        <lei>N/A</lei>
        <title>ADMA Biologics, Inc.</title>
        <cusip>000899104</cusip>
        <identifiers>
          <isin value="US0008991046"/>
          <other otherDesc="Inhouse Asset ID" value="000899104"/>
        </identifiers>
        <balance>1475689.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>29277669.76000000</valUSD>
        <pctVal>0.504223189071</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3456128.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alvotech SA</name>
        <lei>222100DCZBOWV5DZ8372</lei>
        <title>Alvotech SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="LU2458332611"/>
          <other otherDesc="Inhouse Asset ID" value="SBPNTJ346"/>
        </identifiers>
        <balance>704920.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6816576.40000000</valUSD>
        <pctVal>0.117395814596</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>LU</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3234615.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Newamsterdam Pharma Co. NV</name>
        <lei>984500B6549TF6E14D36</lei>
        <title>Newamsterdam Pharma Co. NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL00150012L7"/>
          <other otherDesc="Inhouse Asset ID" value="SBP8JSP46"/>
        </identifiers>
        <balance>365956.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7491119.32000000</valUSD>
        <pctVal>0.129012865580</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6195245.50000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Crinetics Pharmaceuticals, Inc.</name>
        <lei>549300Q1CNFXK5P31D28</lei>
        <title>Crinetics Pharmaceuticals, Inc.</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
          <other otherDesc="Inhouse Asset ID" value="22663K107"/>
        </identifiers>
        <balance>561356.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18827880.24000000</valUSD>
        <pctVal>0.324255785924</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4348628.70000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>N/A</name>
        <lei>N/A</lei>
        <title>E-Mini Health Care Select Sector Index</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Inhouse Asset ID" value="IXCM52025"/>
          <other otherDesc="Future Ticker" value="IXCM5 Index"/>
        </identifiers>
        <balance>21.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>-10239.64000000</valUSD>
        <pctVal>-0.00017634818</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="Future" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <futrDeriv derivCat="FUT">
            <counterparties>
              <counterpartyName>CME Clearing House</counterpartyName>
              <counterpartyLei>LCZ7XYGSLJUHFXXNXD88</counterpartyLei>
            </counterparties>
            <payOffProf>Long</payOffProf>
            <descRefInstrmnt>
              <indexBasketInfo>
                <indexName>E-Mini Health Care Select Sector Index</indexName>
                <indexIdentifier>IXV Index</indexIdentifier>
              </indexBasketInfo>
            </descRefInstrmnt>
            <expDate>2025-06-20</expDate>
            <notionalAmt>3120180.00000000</notionalAmt>
            <curCd>USD</curCd>
            <unrealizedAppr>-10239.64000000</unrealizedAppr>
          </futrDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alector, Inc.</name>
        <lei>549300Z8RQOIY1JMHC25</lei>
        <title>Alector, Inc.</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
          <other otherDesc="Inhouse Asset ID" value="014442107"/>
        </identifiers>
        <balance>499976.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>614970.48000000</valUSD>
        <pctVal>0.010591087991</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="204549.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AnaptysBio, Inc.</name>
        <lei>529900HH4WQT03IG1A12</lei>
        <title>AnaptysBio, Inc.</title>
        <cusip>032724106</cusip>
        <identifiers>
          <isin value="US0327241065"/>
          <other otherDesc="Inhouse Asset ID" value="032724106"/>
        </identifiers>
        <balance>182777.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3397824.43000000</valUSD>
        <pctVal>0.058517699121</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1031689.23000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcus Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>Arcus Biosciences, Inc.</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
          <other otherDesc="Inhouse Asset ID" value="03969F109"/>
        </identifiers>
        <balance>377771.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2965502.35000000</valUSD>
        <pctVal>0.051072201591</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="54165.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arvinas, Inc.</name>
        <lei>N/A</lei>
        <title>Arvinas, Inc.</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
          <other otherDesc="Inhouse Asset ID" value="04335A105"/>
        </identifiers>
        <balance>386808.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2715392.16000000</valUSD>
        <pctVal>0.046764776900</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="554580.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Geron Corp.</name>
        <lei>549300T282D7Z2YESL90</lei>
        <title>Geron Corp.</title>
        <cusip>374163103</cusip>
        <identifiers>
          <isin value="US3741631036"/>
          <other otherDesc="Inhouse Asset ID" value="374163103"/>
        </identifiers>
        <balance>3861660.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6140039.40000000</valUSD>
        <pctVal>0.105744421351</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2199790.44000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vanda Pharmaceuticals, Inc.</name>
        <lei>529900AY8VOOQBKJ0O70</lei>
        <title>Vanda Pharmaceuticals, Inc.</title>
        <cusip>921659108</cusip>
        <identifiers>
          <isin value="US9216591084"/>
          <other otherDesc="Inhouse Asset ID" value="921659108"/>
        </identifiers>
        <balance>350345.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1608083.55000000</valUSD>
        <pctVal>0.027694588487</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Autolus Therapeutics plc</name>
        <lei>549300C0KZP8EYROLL02</lei>
        <title>Autolus Therapeutics plc</title>
        <cusip>05280R100</cusip>
        <identifiers>
          <isin value="US05280R1005"/>
          <other otherDesc="Inhouse Asset ID" value="05280R100"/>
        </identifiers>
        <balance>1082269.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1677516.95000000</valUSD>
        <pctVal>0.028890377997</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1469843.30000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACADIA Pharmaceuticals, Inc.</name>
        <lei>529900O3044NO0PEA039</lei>
        <title>ACADIA Pharmaceuticals, Inc.</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
          <other otherDesc="Inhouse Asset ID" value="004225108"/>
        </identifiers>
        <balance>1068942.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17755126.62000000</valUSD>
        <pctVal>0.305780707279</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33220.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lyell Immunopharma, Inc.</name>
        <lei>N/A</lei>
        <title>Lyell Immunopharma, Inc.</title>
        <cusip>55083R104</cusip>
        <identifiers>
          <isin value="US55083R1041"/>
          <other otherDesc="Inhouse Asset ID" value="55083R104"/>
        </identifiers>
        <balance>813841.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>437846.46000000</valUSD>
        <pctVal>0.007540638998</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="40081.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals, Inc.</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>Vertex Pharmaceuticals, Inc.</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <other otherDesc="Inhouse Asset ID" value="92532F100"/>
        </identifiers>
        <balance>1036110.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>502326850.20000000</valUSD>
        <pctVal>8.651127239302</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cogent Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>Cogent Biosciences, Inc.</title>
        <cusip>19240Q201</cusip>
        <identifiers>
          <isin value="US19240Q2012"/>
          <other otherDesc="Inhouse Asset ID" value="19240Q201"/>
        </identifiers>
        <balance>612442.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3668527.58000000</valUSD>
        <pctVal>0.063179777992</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="311480.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARS Pharmaceuticals, Inc.</name>
        <lei>N/A</lei>
        <title>ARS Pharmaceuticals, Inc.</title>
        <cusip>82835W108</cusip>
        <identifiers>
          <isin value="US82835W1080"/>
          <other otherDesc="Inhouse Asset ID" value="82835W108"/>
        </identifiers>
        <balance>331346.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4168332.68000000</valUSD>
        <pctVal>0.071787475377</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3929841.04000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGENXBIO, Inc.</name>
        <lei>549300EOES47LATSET33</lei>
        <title>REGENXBIO, Inc.</title>
        <cusip>75901B107</cusip>
        <identifiers>
          <isin value="US75901B1070"/>
          <other otherDesc="Inhouse Asset ID" value="75901B107"/>
        </identifiers>
        <balance>288829.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2065127.35000000</valUSD>
        <pctVal>0.035565846147</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="425425.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioCryst Pharmaceuticals, Inc.</name>
        <lei>549300Z0INP1Z5NP6J59</lei>
        <title>BioCryst Pharmaceuticals, Inc.</title>
        <cusip>09058V103</cusip>
        <identifiers>
          <isin value="US09058V1035"/>
          <other otherDesc="Inhouse Asset ID" value="09058V103"/>
        </identifiers>
        <balance>1273310.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9549825.00000000</valUSD>
        <pctVal>0.164468117034</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="95250.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LENZ Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>LENZ Therapeutics, Inc.</title>
        <cusip>52635N103</cusip>
        <identifiers>
          <isin value="US52635N1037"/>
          <other otherDesc="Inhouse Asset ID" value="52635N103"/>
        </identifiers>
        <balance>145867.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3750240.57000000</valUSD>
        <pctVal>0.064587047927</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="379762.41000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tevogen Bio Holdings, Inc.</name>
        <lei>549300AC21G4NBK9D322</lei>
        <title>Tevogen Bio Holdings, Inc.</title>
        <cusip>88165K101</cusip>
        <identifiers>
          <isin value="US88165K1016"/>
          <other otherDesc="Inhouse Asset ID" value="88165K101"/>
        </identifiers>
        <balance>186978.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>201936.24000000</valUSD>
        <pctVal>0.003477767723</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="109923.48000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rapport Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Rapport Therapeutics, Inc.</title>
        <cusip>75383L102</cusip>
        <identifiers>
          <isin value="US75383L1026"/>
          <other otherDesc="Inhouse Asset ID" value="75383L102"/>
        </identifiers>
        <balance>112871.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1132096.13000000</valUSD>
        <pctVal>0.019497081758</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="901997.90000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Climb Bio, Inc.</name>
        <lei>N/A</lei>
        <title>Climb Bio, Inc.</title>
        <cusip>28658R106</cusip>
        <identifiers>
          <isin value="US28658R1068"/>
          <other otherDesc="Inhouse Asset ID" value="28658R106"/>
        </identifiers>
        <balance>356558.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>435000.76000000</valUSD>
        <pctVal>0.007491630046</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Legend Biotech Corp.</name>
        <lei>254900EIUFZTW136H859</lei>
        <title>Legend Biotech Corp.</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
          <other otherDesc="Inhouse Asset ID" value="52490G102"/>
        </identifiers>
        <balance>820310.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27833118.30000000</valUSD>
        <pctVal>0.479344967890</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2052765.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arrowhead Pharmaceuticals, Inc.</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>Arrowhead Pharmaceuticals, Inc.</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
          <other otherDesc="Inhouse Asset ID" value="04280A100"/>
        </identifiers>
        <balance>677858.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8635910.92000000</valUSD>
        <pctVal>0.148728590093</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1403948.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stevanato Group SpA</name>
        <lei>81560033F7E1CD477507</lei>
        <title>Stevanato Group SpA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IT0005452658"/>
          <other otherDesc="Inhouse Asset ID" value="SBNM07529"/>
        </identifiers>
        <balance>319566.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6525537.72000000</valUSD>
        <pctVal>0.112383515032</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IT</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5084682.10000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avidity Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>Avidity Biosciences, Inc.</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
          <other otherDesc="Inhouse Asset ID" value="05370A108"/>
        </identifiers>
        <balance>719257.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21232466.64000000</valUSD>
        <pctVal>0.365667832475</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1567512.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tourmaline Bio, Inc.</name>
        <lei>N/A</lei>
        <title>Tourmaline Bio, Inc.</title>
        <cusip>89157D105</cusip>
        <identifiers>
          <isin value="US89157D1054"/>
          <other otherDesc="Inhouse Asset ID" value="89157D105"/>
        </identifiers>
        <balance>103420.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1573018.20000000</valUSD>
        <pctVal>0.027090689244</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zymeworks, Inc.</name>
        <lei>894500AHOYAGYLYZJL67</lei>
        <title>Zymeworks, Inc.</title>
        <cusip>98985Y108</cusip>
        <identifiers>
          <isin value="US98985Y1082"/>
          <other otherDesc="Inhouse Asset ID" value="98985Y108"/>
        </identifiers>
        <balance>430297.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5124837.27000000</valUSD>
        <pctVal>0.088260500679</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="377654.19000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Inozyme Pharma, Inc.</name>
        <lei>N/A</lei>
        <title>Inozyme Pharma, Inc.</title>
        <cusip>45790W108</cusip>
        <identifiers>
          <isin value="US45790W1080"/>
          <other otherDesc="Inhouse Asset ID" value="SBMVLGY17"/>
        </identifiers>
        <balance>263151.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>239467.41000000</valUSD>
        <pctVal>0.004124133585</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Contra Chinook Therape</name>
        <lei>N/A</lei>
        <title>Contra Chinook Therape, CVR</title>
        <cusip>169CVR016</cusip>
        <identifiers>
          <isin value="US169CVR0169"/>
          <other otherDesc="Inhouse Asset ID" value="169CVR016"/>
        </identifiers>
        <balance>320962.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>272817.70000000</valUSD>
        <pctVal>0.004698495879</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Right"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Artiva Biotherapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Artiva Biotherapeutics, Inc.</title>
        <cusip>04317A107</cusip>
        <identifiers>
          <isin value="US04317A1079"/>
          <other otherDesc="Inhouse Asset ID" value="04317A107"/>
        </identifiers>
        <balance>75251.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>225753.00000000</valUSD>
        <pctVal>0.003887942535</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5994.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunovant, Inc.</name>
        <lei>N/A</lei>
        <title>Immunovant, Inc.</title>
        <cusip>45258J102</cusip>
        <identifiers>
          <isin value="US45258J1025"/>
          <other otherDesc="Inhouse Asset ID" value="45258J102"/>
        </identifiers>
        <balance>447964.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7655704.76000000</valUSD>
        <pctVal>0.131847373794</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3034910.56000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GRAIL, Inc.</name>
        <lei>2549009XSNESW3VE8024</lei>
        <title>GRAIL, Inc.</title>
        <cusip>384747101</cusip>
        <identifiers>
          <isin value="US3847471014"/>
          <other otherDesc="Inhouse Asset ID" value="384747101"/>
        </identifiers>
        <balance>181137.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4626238.98000000</valUSD>
        <pctVal>0.079673587106</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3284009.82000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Silence Therapeutics plc</name>
        <lei>213800SSURRJBX85SQ91</lei>
        <title>Silence Therapeutics plc</title>
        <cusip>82686Q101</cusip>
        <identifiers>
          <isin value="US82686Q1013"/>
          <other otherDesc="Inhouse Asset ID" value="82686Q101"/>
        </identifiers>
        <balance>176623.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>498076.86000000</valUSD>
        <pctVal>0.008577933449</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="104058.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vir Biotechnology, Inc.</name>
        <lei>N/A</lei>
        <title>Vir Biotechnology, Inc.</title>
        <cusip>92764N102</cusip>
        <identifiers>
          <isin value="US92764N1028"/>
          <other otherDesc="Inhouse Asset ID" value="SBK4PZ382"/>
        </identifiers>
        <balance>564421.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3657448.08000000</valUSD>
        <pctVal>0.062988965647</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prime Medicine, Inc.</name>
        <lei>N/A</lei>
        <title>Prime Medicine, Inc.</title>
        <cusip>74168J101</cusip>
        <identifiers>
          <isin value="US74168J1016"/>
          <other otherDesc="Inhouse Asset ID" value="74168J101"/>
        </identifiers>
        <balance>347449.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>691423.51000000</valUSD>
        <pctVal>0.011907770326</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="459932.78000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Third Harmonic Bio, Inc.</name>
        <lei>N/A</lei>
        <title>Third Harmonic Bio, Inc.</title>
        <cusip>88427A107</cusip>
        <identifiers>
          <isin value="US88427A1079"/>
          <other otherDesc="Inhouse Asset ID" value="88427A107"/>
        </identifiers>
        <balance>137186.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>476035.42000000</valUSD>
        <pctVal>0.008198333390</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="16656.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akero Therapeutics, Inc.</name>
        <lei>549300SI3KG74LBE2955</lei>
        <title>Akero Therapeutics, Inc.</title>
        <cusip>00973Y108</cusip>
        <identifiers>
          <isin value="US00973Y1082"/>
          <other otherDesc="Inhouse Asset ID" value="00973Y108"/>
        </identifiers>
        <balance>430234.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17415872.32000000</valUSD>
        <pctVal>0.299938033102</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2266.88000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Maravai LifeSciences Holdings, Inc.</name>
        <lei>N/A</lei>
        <title>Maravai LifeSciences Holdings, Inc., Class A</title>
        <cusip>56600D107</cusip>
        <identifiers>
          <isin value="US56600D1072"/>
          <other otherDesc="Inhouse Asset ID" value="56600D107"/>
        </identifiers>
        <balance>761411.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1682718.31000000</valUSD>
        <pctVal>0.028979956380</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="303875.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intellia Therapeutics, Inc.</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>Intellia Therapeutics, Inc.</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
          <other otherDesc="Inhouse Asset ID" value="45826J105"/>
        </identifiers>
        <balance>631525.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4490142.75000000</valUSD>
        <pctVal>0.077329723142</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2541448.17000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mersana Therapeutics, Inc.</name>
        <lei>529900VWD5VDZ7PVOS22</lei>
        <title>Mersana Therapeutics, Inc.</title>
        <cusip>59045L106</cusip>
        <identifiers>
          <isin value="US59045L1061"/>
          <other otherDesc="Inhouse Asset ID" value="59045L106"/>
        </identifiers>
        <balance>522005.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>179674.12000000</valUSD>
        <pctVal>0.003094367090</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mesoblast Ltd.</name>
        <lei>529900J5ALF3JG921927</lei>
        <title>Mesoblast Ltd.</title>
        <cusip>590717401</cusip>
        <identifiers>
          <isin value="US5907174016"/>
          <other otherDesc="Inhouse Asset ID" value="SBQS74911"/>
        </identifiers>
        <balance>572187.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7140893.76000000</valUSD>
        <pctVal>0.122981243179</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>AU</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="6191976.96000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Precigen, Inc.</name>
        <lei>549300XCWNQU35K64G19</lei>
        <title>Precigen, Inc.</title>
        <cusip>74017N105</cusip>
        <identifiers>
          <isin value="US74017N1054"/>
          <other otherDesc="Inhouse Asset ID" value="74017N105"/>
        </identifiers>
        <balance>1051131.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1566185.19000000</valUSD>
        <pctVal>0.026973010408</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1530772.36000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aurinia Pharmaceuticals, Inc.</name>
        <lei>5299008YP2BW4570ML28</lei>
        <title>Aurinia Pharmaceuticals, Inc.</title>
        <cusip>05156V102</cusip>
        <identifiers>
          <isin value="CA05156V1022"/>
          <other otherDesc="Inhouse Asset ID" value="05156V102"/>
        </identifiers>
        <balance>797859.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6414786.36000000</valUSD>
        <pctVal>0.110476143155</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2695008.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BlackRock Funds III</name>
        <lei>549300JDHS1T46VWOG19</lei>
        <title>BlackRock Cash Funds: Institutional, SL Agency Shares</title>
        <cusip>066922519</cusip>
        <identifiers>
          <isin value="US0669225197"/>
          <other otherDesc="Inhouse Asset ID" value="066922519"/>
        </identifiers>
        <balance>0.20000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.20000000</valUSD>
        <pctVal>0.000000003444</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corp.</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>Scholar Rock Holding Corp.</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <other otherDesc="Inhouse Asset ID" value="80706P103"/>
        </identifiers>
        <balance>471448.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15157053.20000000</valUSD>
        <pctVal>0.261036406383</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4671395.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Altimmune, Inc.</name>
        <lei>549300EOYCQ8SW3NVE64</lei>
        <title>Altimmune, Inc.</title>
        <cusip>02155H200</cusip>
        <identifiers>
          <isin value="US02155H2004"/>
          <other otherDesc="Inhouse Asset ID" value="02155H200"/>
        </identifiers>
        <balance>492333.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2461665.00000000</valUSD>
        <pctVal>0.042395060361</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2415585.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IQVIA Holdings, Inc.</name>
        <lei>549300W3R20NM4KQPH86</lei>
        <title>IQVIA Holdings, Inc.</title>
        <cusip>46266C105</cusip>
        <identifiers>
          <isin value="US46266C1053"/>
          <other otherDesc="Inhouse Asset ID" value="46266C105"/>
        </identifiers>
        <balance>1127560.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>198788828.00000000</valUSD>
        <pctVal>3.423562654664</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="34766360.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rigel Pharmaceuticals, Inc.</name>
        <lei>529900KPTNUS5J8K9K66</lei>
        <title>Rigel Pharmaceuticals, Inc.</title>
        <cusip>766559702</cusip>
        <identifiers>
          <isin value="US7665597024"/>
          <other otherDesc="Inhouse Asset ID" value="766559702"/>
        </identifiers>
        <balance>110696.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1991421.04000000</valUSD>
        <pctVal>0.034296468120</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Protagonist Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Protagonist Therapeutics, Inc.</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
          <other otherDesc="Inhouse Asset ID" value="74366E102"/>
        </identifiers>
        <balance>373289.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18052256.04000000</valUSD>
        <pctVal>0.310897902225</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ImmunityBio, Inc.</name>
        <lei>529900J9XLBR4HFL4B83</lei>
        <title>ImmunityBio, Inc.</title>
        <cusip>45256X103</cusip>
        <identifiers>
          <isin value="US45256X1037"/>
          <other otherDesc="Inhouse Asset ID" value="45256X103"/>
        </identifiers>
        <balance>490621.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1476769.21000000</valUSD>
        <pctVal>0.025433078748</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1092946.05000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Travere Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Travere Therapeutics, Inc.</title>
        <cusip>89422G107</cusip>
        <identifiers>
          <isin value="US89422G1076"/>
          <other otherDesc="Inhouse Asset ID" value="89422G107"/>
        </identifiers>
        <balance>564392.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10113904.64000000</valUSD>
        <pctVal>0.174182757485</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="121856.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TScan Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>TScan Therapeutics, Inc.</title>
        <cusip>89854M101</cusip>
        <identifiers>
          <isin value="US89854M1018"/>
          <other otherDesc="Inhouse Asset ID" value="89854M101"/>
        </identifiers>
        <balance>262908.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>362813.04000000</valUSD>
        <pctVal>0.006248405339</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bridgebio Pharma, Inc.</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>Bridgebio Pharma, Inc.</title>
        <cusip>10806X102</cusip>
        <identifiers>
          <isin value="US10806X1028"/>
          <other otherDesc="Inhouse Asset ID" value="10806X102"/>
        </identifiers>
        <balance>965521.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33378060.97000000</valUSD>
        <pctVal>0.574840569118</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="26743455.71000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BeiGene Ltd.</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BeiGene Ltd.</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
          <other otherDesc="Inhouse Asset ID" value="07725L102"/>
        </identifiers>
        <balance>355399.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>96728945.83000000</valUSD>
        <pctVal>1.665876346776</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11621659.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cartesian Therapeutics, Inc.</name>
        <lei>529900NMN0LACZOL7C43</lei>
        <title>Cartesian Therapeutics, Inc.</title>
        <cusip>816212112</cusip>
        <identifiers>
          <isin value="US8162121128"/>
          <other otherDesc="Inhouse Asset ID" value="816212112"/>
        </identifiers>
        <balance>6098.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2439.20000000</valUSD>
        <pctVal>0.000042008165</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Right"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Adaptive Biotechnologies Corp.</name>
        <lei>549300ZTF7OT1FW66Q96</lei>
        <title>Adaptive Biotechnologies Corp.</title>
        <cusip>00650F109</cusip>
        <identifiers>
          <isin value="US00650F1093"/>
          <other otherDesc="Inhouse Asset ID" value="00650F109"/>
        </identifiers>
        <balance>929145.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6903547.35000000</valUSD>
        <pctVal>0.118893637685</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1462967.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals, Inc.</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>Rocket Pharmaceuticals, Inc.</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
          <other otherDesc="Inhouse Asset ID" value="77313F106"/>
        </identifiers>
        <balance>639251.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4263804.17000000</valUSD>
        <pctVal>0.073431695684</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1356237.78000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Larimar Therapeutics, Inc.</name>
        <lei>529900NCBZHTTJV6HX73</lei>
        <title>Larimar Therapeutics, Inc.</title>
        <cusip>517125100</cusip>
        <identifiers>
          <isin value="US5171251003"/>
          <other otherDesc="Inhouse Asset ID" value="517125100"/>
        </identifiers>
        <balance>250215.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>537962.25000000</valUSD>
        <pctVal>0.009264843941</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcellx, Inc.</name>
        <lei>N/A</lei>
        <title>Arcellx, Inc.</title>
        <cusip>03940C100</cusip>
        <identifiers>
          <isin value="US03940C1009"/>
          <other otherDesc="Inhouse Asset ID" value="03940C100"/>
        </identifiers>
        <balance>260332.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17077779.20000000</valUSD>
        <pctVal>0.294115356893</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4828160.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amgen, Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>Amgen, Inc.</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
          <other otherDesc="Inhouse Asset ID" value="031162100"/>
        </identifiers>
        <balance>1613695.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>502746677.25000000</valUSD>
        <pctVal>8.658357546077</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>C4 Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>C4 Therapeutics, Inc.</title>
        <cusip>12529R107</cusip>
        <identifiers>
          <isin value="US12529R1077"/>
          <other otherDesc="Inhouse Asset ID" value="12529R107"/>
        </identifiers>
        <balance>371217.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>593947.20000000</valUSD>
        <pctVal>0.010229022793</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Halozyme Therapeutics, Inc.</name>
        <lei>529900242I3SV9AGM753</lei>
        <title>Halozyme Therapeutics, Inc.</title>
        <cusip>40637H109</cusip>
        <identifiers>
          <isin value="US40637H1095"/>
          <other otherDesc="Inhouse Asset ID" value="40637H109"/>
        </identifiers>
        <balance>787493.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50249928.33000000</valUSD>
        <pctVal>0.865409690076</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="11575134.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CorMedix, Inc.</name>
        <lei>5299006YIA3L0MBW8358</lei>
        <title>CorMedix, Inc.</title>
        <cusip>21900C308</cusip>
        <identifiers>
          <isin value="US21900C3088"/>
          <other otherDesc="Inhouse Asset ID" value="21900C308"/>
        </identifiers>
        <balance>382716.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2357530.56000000</valUSD>
        <pctVal>0.040601645794</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2273988.64000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Evotec SE</name>
        <lei>529900F9KI6OYITO9B12</lei>
        <title>Evotec SE</title>
        <cusip>30050E105</cusip>
        <identifiers>
          <isin value="US30050E1055"/>
          <other otherDesc="Inhouse Asset ID" value="30050E105"/>
        </identifiers>
        <balance>1518215.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5070838.10000000</valUSD>
        <pctVal>0.087330521144</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1416170.02000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Spyre Therapeutics, Inc.</name>
        <lei>52990017AIJPRH3HQH40</lei>
        <title>Spyre Therapeutics, Inc.</title>
        <cusip>00773J202</cusip>
        <identifiers>
          <isin value="US00773J2024"/>
          <other otherDesc="Inhouse Asset ID" value="00773J202"/>
        </identifiers>
        <balance>330298.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5329358.23000000</valUSD>
        <pctVal>0.091782782730</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4862346.79000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IGM Biosciences, Inc.</name>
        <lei>5493008XCQES2N0VY969</lei>
        <title>IGM Biosciences, Inc.</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
          <other otherDesc="Inhouse Asset ID" value="SBKS3SM88"/>
        </identifiers>
        <balance>105958.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>121851.70000000</valUSD>
        <pctVal>0.002098543131</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="151.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>KalVista Pharmaceuticals, Inc.</name>
        <lei>529900Q7IDA3WUGRZA51</lei>
        <title>KalVista Pharmaceuticals, Inc.</title>
        <cusip>483497103</cusip>
        <identifiers>
          <isin value="US4834971032"/>
          <other otherDesc="Inhouse Asset ID" value="483497103"/>
        </identifiers>
        <balance>247618.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2857511.72000000</valUSD>
        <pctVal>0.049212375304</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Krystal Biotech, Inc.</name>
        <lei>549300YONUY68210OE41</lei>
        <title>Krystal Biotech, Inc.</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
          <other otherDesc="Inhouse Asset ID" value="501147102"/>
        </identifiers>
        <balance>158916.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28652554.80000000</valUSD>
        <pctVal>0.493457391750</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13648710.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BlackRock Funds III</name>
        <lei>5493005PQV5UQG4OSI49</lei>
        <title>BlackRock Cash Funds: Treasury, SL Agency Shares</title>
        <cusip>066922477</cusip>
        <identifiers>
          <isin value="US0669224778"/>
          <other otherDesc="Inhouse Asset ID" value="066922477"/>
        </identifiers>
        <balance>6673221.19000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6673221.19000000</valUSD>
        <pctVal>0.114926935694</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Monte Rosa Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Monte Rosa Therapeutics, Inc.</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
          <other otherDesc="Inhouse Asset ID" value="61225M102"/>
        </identifiers>
        <balance>296768.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1377003.52000000</valUSD>
        <pctVal>0.023714903266</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="335472.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Personalis, Inc.</name>
        <lei>549300EZ2NYFK7H0US48</lei>
        <title>Personalis, Inc.</title>
        <cusip>71535D106</cusip>
        <identifiers>
          <isin value="US71535D1063"/>
          <other otherDesc="Inhouse Asset ID" value="71535D106"/>
        </identifiers>
        <balance>228208.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>801010.08000000</valUSD>
        <pctVal>0.013795082065</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="228501.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Relay Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Relay Therapeutics, Inc.</title>
        <cusip>75943R102</cusip>
        <identifiers>
          <isin value="US75943R1023"/>
          <other otherDesc="Inhouse Asset ID" value="75943R102"/>
        </identifiers>
        <balance>821364.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2151973.68000000</valUSD>
        <pctVal>0.037061523018</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="911843.84000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Regeneron Pharmaceuticals, Inc.</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>Regeneron Pharmaceuticals, Inc.</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
          <other otherDesc="Inhouse Asset ID" value="75886F107"/>
        </identifiers>
        <balance>681678.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>432340637.94000000</valUSD>
        <pctVal>7.445817136892</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cartesian Therapeutics, Inc.</name>
        <lei>529900NMN0LACZOL7C43</lei>
        <title>Cartesian Therapeutics, Inc.</title>
        <cusip>816212302</cusip>
        <identifiers>
          <isin value="US8162123025"/>
          <other otherDesc="Inhouse Asset ID" value="816212302"/>
        </identifiers>
        <balance>55787.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>735272.66000000</valUSD>
        <pctVal>0.012662945121</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="719759.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tectonic Therapeutic, Inc.</name>
        <lei>N/A</lei>
        <title>Tectonic Therapeutic, Inc.</title>
        <cusip>878972108</cusip>
        <identifiers>
          <isin value="US8789721086"/>
          <other otherDesc="Inhouse Asset ID" value="878972108"/>
        </identifiers>
        <balance>55853.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>989156.63000000</valUSD>
        <pctVal>0.017035362259</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="102718.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRISPR Therapeutics AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
        <title>CRISPR Therapeutics AG</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
          <other otherDesc="Inhouse Asset ID" value="SBDHF4K66"/>
        </identifiers>
        <balance>530150.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18041004.50000000</valUSD>
        <pctVal>0.310704126988</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="17700194.05000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pyxis Oncology, Inc.</name>
        <lei>N/A</lei>
        <title>Pyxis Oncology, Inc.</title>
        <cusip>747324101</cusip>
        <identifiers>
          <isin value="US7473241013"/>
          <other otherDesc="Inhouse Asset ID" value="747324101"/>
        </identifiers>
        <balance>305247.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>299111.54000000</valUSD>
        <pctVal>0.005151331230</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="33180.39390000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences, Inc.</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences, Inc.</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
          <other otherDesc="Inhouse Asset ID" value="375558103"/>
        </identifiers>
        <balance>4348831.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>487286513.55000000</valUSD>
        <pctVal>8.392100937942</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sana Biotechnology, Inc.</name>
        <lei>N/A</lei>
        <title>Sana Biotechnology, Inc.</title>
        <cusip>799566104</cusip>
        <identifiers>
          <isin value="US7995661045"/>
          <other otherDesc="Inhouse Asset ID" value="799566104"/>
        </identifiers>
        <balance>802517.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1348228.56000000</valUSD>
        <pctVal>0.023219337798</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1242766.56000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>iTeos Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>iTeos Therapeutics, Inc.</title>
        <cusip>46565G104</cusip>
        <identifiers>
          <isin value="US46565G1040"/>
          <other otherDesc="Inhouse Asset ID" value="46565G104"/>
        </identifiers>
        <balance>204824.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1222799.28000000</valUSD>
        <pctVal>0.021059181198</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PepGen, Inc.</name>
        <lei>N/A</lei>
        <title>PepGen, Inc.</title>
        <cusip>713317105</cusip>
        <identifiers>
          <isin value="US7133171055"/>
          <other otherDesc="Inhouse Asset ID" value="713317105"/>
        </identifiers>
        <balance>189474.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>266210.97000000</valUSD>
        <pctVal>0.004584714062</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="188795.47000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apellis Pharmaceuticals, Inc.</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>Apellis Pharmaceuticals, Inc.</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
          <other otherDesc="Inhouse Asset ID" value="03753U106"/>
        </identifiers>
        <balance>668787.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14626371.69000000</valUSD>
        <pctVal>0.251896952132</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="989726.85000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Incyte Corp.</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>Incyte Corp.</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
          <other otherDesc="Inhouse Asset ID" value="45337C102"/>
        </identifiers>
        <balance>1233288.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>74675588.40000000</valUSD>
        <pctVal>1.286071044502</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="756875.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Structure Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Structure Therapeutics, Inc.</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
          <other otherDesc="Inhouse Asset ID" value="86366E106"/>
        </identifiers>
        <balance>245566.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4250747.46000000</valUSD>
        <pctVal>0.073206831615</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="432750.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Y-mAbs Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Y-mAbs Therapeutics, Inc.</title>
        <cusip>984241109</cusip>
        <identifiers>
          <isin value="US9842411095"/>
          <other otherDesc="Inhouse Asset ID" value="984241109"/>
        </identifiers>
        <balance>224868.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>996165.24000000</valUSD>
        <pctVal>0.017156065297</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="739433.45000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Grifols SA</name>
        <lei>959800HSSNXWRKBK4N60</lei>
        <title>Grifols SA</title>
        <cusip>398438408</cusip>
        <identifiers>
          <isin value="US3984384087"/>
          <other otherDesc="Inhouse Asset ID" value="398438408"/>
        </identifiers>
        <balance>1188825.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8452545.75000000</valUSD>
        <pctVal>0.145570655341</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>ES</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="279423.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Denali Therapeutics, Inc.</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>Denali Therapeutics, Inc.</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
          <other otherDesc="Inhouse Asset ID" value="24823R105"/>
        </identifiers>
        <balance>811982.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11038895.29000000</valUSD>
        <pctVal>0.190113046310</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="851047.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AC Immune SA</name>
        <lei>967600VLQ0ZC2HSOG765</lei>
        <title>AC Immune SA</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="CH0329023102"/>
          <other otherDesc="Inhouse Asset ID" value="SBZC0D707"/>
        </identifiers>
        <balance>393126.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>735145.62000000</valUSD>
        <pctVal>0.012660757225</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="46189.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Ltd.</name>
        <lei>N/A</lei>
        <title>Biohaven Ltd.</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="VGG1110E1079"/>
          <other otherDesc="Inhouse Asset ID" value="SBPLZ7S59"/>
        </identifiers>
        <balance>570695.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13719507.80000000</valUSD>
        <pctVal>0.236278844324</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="3774.28000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AbCellera Biologics, Inc.</name>
        <lei>9845000861BC95FF9F73</lei>
        <title>AbCellera Biologics, Inc.</title>
        <cusip>00288U106</cusip>
        <identifiers>
          <isin value="CA00288U1066"/>
          <other otherDesc="Inhouse Asset ID" value="00288U106"/>
        </identifiers>
        <balance>1446187.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3224997.01000000</valUSD>
        <pctVal>0.055541246638</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2788987.41000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunocore Holdings plc</name>
        <lei>213800IUE3DFS84BVN18</lei>
        <title>Immunocore Holdings plc</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
          <other otherDesc="Inhouse Asset ID" value="45258D105"/>
        </identifiers>
        <balance>199061.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5906139.87000000</valUSD>
        <pctVal>0.101716178396</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="5769865.56000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CureVac NV</name>
        <lei>724500BUT8GAG9LMYN56</lei>
        <title>CureVac NV</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="NL0015436031"/>
          <other otherDesc="Inhouse Asset ID" value="SBN4RD428"/>
        </identifiers>
        <balance>604789.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1675265.53000000</valUSD>
        <pctVal>0.028851603799</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1572806.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OnKure Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>OnKure Therapeutics, Inc.</title>
        <cusip>68277Q105</cusip>
        <identifiers>
          <isin value="US68277Q1058"/>
          <other otherDesc="Inhouse Asset ID" value="68277Q105"/>
        </identifiers>
        <balance>58591.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>251941.30000000</valUSD>
        <pctVal>0.004338960265</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="69264.40000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioNTech SE</name>
        <lei>894500UZJ5LG1F8J1U58</lei>
        <title>BioNTech SE</title>
        <cusip>09075V102</cusip>
        <identifiers>
          <isin value="US09075V1026"/>
          <other otherDesc="Inhouse Asset ID" value="09075V102"/>
        </identifiers>
        <balance>1055343.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>96099533.58000000</valUSD>
        <pctVal>1.655036541063</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="22282382.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zevra Therapeutics, Inc.</name>
        <lei>254900CU6T74V18Y1W18</lei>
        <title>Zevra Therapeutics, Inc.</title>
        <cusip>488445206</cusip>
        <identifiers>
          <isin value="US4884452065"/>
          <other otherDesc="Inhouse Asset ID" value="488445206"/>
        </identifiers>
        <balance>341120.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2554988.80000000</valUSD>
        <pctVal>0.044002292919</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Foghorn Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Foghorn Therapeutics, Inc.</title>
        <cusip>344174107</cusip>
        <identifiers>
          <isin value="US3441741077"/>
          <other otherDesc="Inhouse Asset ID" value="BRWA1Y0T4"/>
        </identifiers>
        <balance>182566.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>666365.90000000</valUSD>
        <pctVal>0.011476225462</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="49041.40000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arbutus Biopharma Corp.</name>
        <lei>25490064CESONAUIAS23</lei>
        <title>Arbutus Biopharma Corp.</title>
        <cusip>03879J100</cusip>
        <identifiers>
          <isin value="CA03879J1003"/>
          <other otherDesc="Inhouse Asset ID" value="03879J100"/>
        </identifiers>
        <balance>950022.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3315576.78000000</valUSD>
        <pctVal>0.057101221214</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2701846.32000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vericel Corp.</name>
        <lei>54930076YM3PLTDR4B91</lei>
        <title>Vericel Corp.</title>
        <cusip>92346J108</cusip>
        <identifiers>
          <isin value="US92346J1088"/>
          <other otherDesc="Inhouse Asset ID" value="92346J108"/>
        </identifiers>
        <balance>319293.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14246853.66000000</valUSD>
        <pctVal>0.245360851651</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="13978999.80000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Trevi Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Trevi Therapeutics, Inc.</title>
        <cusip>89532M101</cusip>
        <identifiers>
          <isin value="US89532M1018"/>
          <other otherDesc="Inhouse Asset ID" value="SBJH9ZN08"/>
        </identifiers>
        <balance>341324.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2146927.96000000</valUSD>
        <pctVal>0.036974625083</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nkarta, Inc.</name>
        <lei>N/A</lei>
        <title>Nkarta, Inc.</title>
        <cusip>65487U108</cusip>
        <identifiers>
          <isin value="US65487U1088"/>
          <other otherDesc="Inhouse Asset ID" value="65487U108"/>
        </identifiers>
        <balance>321596.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>591736.64000000</valUSD>
        <pctVal>0.010190952290</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="405031.84000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Voyager Therapeutics, Inc.</name>
        <lei>54930082S4XVR0ZWCC74</lei>
        <title>Voyager Therapeutics, Inc.</title>
        <cusip>92915B106</cusip>
        <identifiers>
          <isin value="US92915B1061"/>
          <other otherDesc="Inhouse Asset ID" value="92915B106"/>
        </identifiers>
        <balance>288096.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>973764.48000000</valUSD>
        <pctVal>0.016770276990</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="91260.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acrivon Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Acrivon Therapeutics, Inc.</title>
        <cusip>004890109</cusip>
        <identifiers>
          <isin value="US0048901096"/>
          <other otherDesc="Inhouse Asset ID" value="004890109"/>
        </identifiers>
        <balance>143700.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>291711.00000000</valUSD>
        <pctVal>0.005023878331</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="257404.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Erasca, Inc.</name>
        <lei>N/A</lei>
        <title>Erasca, Inc.</title>
        <cusip>29479A108</cusip>
        <identifiers>
          <isin value="US29479A1088"/>
          <other otherDesc="Inhouse Asset ID" value="29479A108"/>
        </identifiers>
        <balance>1055753.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1446381.61000000</valUSD>
        <pctVal>0.024909740221</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1085314.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Emergent BioSolutions, Inc.</name>
        <lei>549300YW6TUOX8BE5103</lei>
        <title>Emergent BioSolutions, Inc.</title>
        <cusip>29089Q105</cusip>
        <identifiers>
          <isin value="US29089Q1058"/>
          <other otherDesc="Inhouse Asset ID" value="29089Q105"/>
        </identifiers>
        <balance>341148.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1657979.28000000</valUSD>
        <pctVal>0.028553898135</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immutep Ltd.</name>
        <lei>529900OL6C5CY5P8BH38</lei>
        <title>Immutep Ltd.</title>
        <cusip>45257L108</cusip>
        <identifiers>
          <isin value="US45257L1089"/>
          <other otherDesc="Inhouse Asset ID" value="45257L108"/>
        </identifiers>
        <balance>655532.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1153736.32000000</valUSD>
        <pctVal>0.019869771446</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>AU</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1124171.84000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Compass Pathways plc</name>
        <lei>213800N7CUZIC6QSTZ31</lei>
        <title>Compass Pathways plc</title>
        <cusip>20451W101</cusip>
        <identifiers>
          <isin value="US20451W1018"/>
          <other otherDesc="Inhouse Asset ID" value="20451W101"/>
        </identifiers>
        <balance>404653.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1157307.58000000</valUSD>
        <pctVal>0.019931276071</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="956664.28000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tyra Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>Tyra Biosciences, Inc.</title>
        <cusip>90240B106</cusip>
        <identifiers>
          <isin value="US90240B1061"/>
          <other otherDesc="Inhouse Asset ID" value="90240B106"/>
        </identifiers>
        <balance>203969.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1896911.70000000</valUSD>
        <pctVal>0.032668818065</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1568352.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Moderna, Inc.</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>Moderna, Inc.</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
          <other otherDesc="Inhouse Asset ID" value="60770K107"/>
        </identifiers>
        <balance>2210104.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>62656448.40000000</valUSD>
        <pctVal>1.079076117980</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="339321.15000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Dynavax Technologies Corp.</name>
        <lei>549300T5URIXWDILX594</lei>
        <title>Dynavax Technologies Corp.</title>
        <cusip>268158201</cusip>
        <identifiers>
          <isin value="US2681582019"/>
          <other otherDesc="Inhouse Asset ID" value="268158201"/>
        </identifiers>
        <balance>765870.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9933333.90000000</valUSD>
        <pctVal>0.171072948708</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="7988223.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes plc</name>
        <lei>N/A</lei>
        <title>Alkermes plc</title>
        <cusip>N/A</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
          <other otherDesc="Inhouse Asset ID" value="SB3P6D269"/>
        </identifiers>
        <balance>1025053.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33847250.06000000</valUSD>
        <pctVal>0.582920994274</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="851916.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Veracyte, Inc.</name>
        <lei>529900ESWZRHXOW27Z37</lei>
        <title>Veracyte, Inc.</title>
        <cusip>92337F107</cusip>
        <identifiers>
          <isin value="US92337F1075"/>
          <other otherDesc="Inhouse Asset ID" value="SBFTWZY08"/>
        </identifiers>
        <balance>494545.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14663259.25000000</valUSD>
        <pctVal>0.252532233672</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="800550.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Anavex Life Sciences Corp.</name>
        <lei>549300K1I5L8COCQ8W36</lei>
        <title>Anavex Life Sciences Corp.</title>
        <cusip>032797300</cusip>
        <identifiers>
          <isin value="US0327973006"/>
          <other otherDesc="Inhouse Asset ID" value="032797300"/>
        </identifiers>
        <balance>532656.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4570188.48000000</valUSD>
        <pctVal>0.078708279345</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="4484439.96000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akouos, Inc.</name>
        <lei>N/A</lei>
        <title>Akouos, Inc., CVR</title>
        <cusip>009CVR036</cusip>
        <identifiers>
          <isin value="US009CVR0361"/>
          <other otherDesc="Inhouse Asset ID" value="009CVR036"/>
        </identifiers>
        <balance>157087.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1.57000000</valUSD>
        <pctVal>0.000000027038</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Right"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1.09890000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Terns Pharmaceuticals, Inc.</name>
        <lei>254900S1ZDQMF4MYP709</lei>
        <title>Terns Pharmaceuticals, Inc.</title>
        <cusip>880881107</cusip>
        <identifiers>
          <isin value="US8808811074"/>
          <other otherDesc="Inhouse Asset ID" value="880881107"/>
        </identifiers>
        <balance>410371.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1132623.96000000</valUSD>
        <pctVal>0.019506172103</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="509220.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OmniAb Operations, Inc.</name>
        <lei>N/A</lei>
        <title>OmniAb, Inc.,</title>
        <cusip>68218J202</cusip>
        <identifiers>
          <isin value="US68218J2024"/>
          <other otherDesc="Inhouse Asset ID" value="68218J202"/>
        </identifiers>
        <balance>46839.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.47000000</valUSD>
        <pctVal>0.000000008094</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neumora Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Neumora Therapeutics, Inc.</title>
        <cusip>640979100</cusip>
        <identifiers>
          <isin value="US6409791000"/>
          <other otherDesc="Inhouse Asset ID" value="640979100"/>
        </identifiers>
        <balance>378568.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>378568.00000000</valUSD>
        <pctVal>0.006519738961</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="313098.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Verve Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>Verve Therapeutics, Inc.</title>
        <cusip>92539P101</cusip>
        <identifiers>
          <isin value="US92539P1012"/>
          <other otherDesc="Inhouse Asset ID" value="92539P101"/>
        </identifiers>
        <balance>427468.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1953528.76000000</valUSD>
        <pctVal>0.033643883184</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>

      <explntrNote note="Monthly returns presented in B.5.a have been calculated without deducting any applicable sales loads or redemption fees." noteItem="B.5.a"/>




    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-03-31</ncom:dateSigned>
      <ncom:nameOfApplicant>iShares Trust</ncom:nameOfApplicant>
      <ncom:signature>Chuck Pulsfort</ncom:signature>
      <ncom:signerName>Chuck Pulsfort</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
