<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001100397</cik>
        <entityName>Advaxis, Inc.</entityName>
        <issuerAddress>
            <street1>TECHNOLOGY CENTRE OF NEW JERSEY</street1>
            <street2>675 ROUTE 1</street2>
            <city>NORTH BRUNSWICK</city>
            <stateOrCountry>NJ</stateOrCountry>
            <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
            <zipCode>08902</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>732 545 1590</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>GREAT EXPECTATIONS AND ASSOCIATES, INC.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>GREAT EXPECTATIONS &amp; ASSOCIATES INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>THOMAS</firstName>
                <lastName>MOORE</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>TECHNOLOGY CENTRE OF NEW JERSEY</street1>
                <street2>675 Route 1</street2>
                <city>NORTH BRUNSWICK</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>JAMES</firstName>
                <lastName>PATTON</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>TECHNOLOGY CENTRE OF NEW JERSEY</street1>
                <street2>675 Route 1</street2>
                <city>NORTH BRUNSWICK</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>RONI</firstName>
                <middleName>A.</middleName>
                <lastName>APPEL</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>TECHNOLOGY CENTRE OF NEW JERSEY</street1>
                <street2>675 Route 1</street2>
                <city>NORTH BRUNSWICK</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>THOMAS</firstName>
                <lastName>MCKEARN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>TECHNOLOGY CENTRE OF NEW JERSEY</street1>
                <street2>675 Route 1</street2>
                <city>NORTH BRUNSWICK</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>RICHARD</firstName>
                <lastName>BERMAN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>TECHNOLOGY CENTRE OF NEW JERSEY</street1>
                <street2>675 Route 1</street2>
                <city>NORTH BRUNSWICK</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>JOHN</firstName>
                <lastName>ROTHMAN</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>TECHNOLOGY CENTRE OF NEW JERSEY</street1>
                <street2>675 Route 1</street2>
                <city>NORTH BRUNSWICK</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>MARK</firstName>
                <middleName>J.</middleName>
                <lastName>ROSENBLUM</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>TECHNOLOGY CENTRE OF NEW JERSEY</street1>
                <street2>675 Route 1</street2>
                <city>NORTH BRUNSWICK</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-11-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Common Stock issuable upon conversion of notes.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Matthew D. Eitner</recipientName>
                <recipientCRDNumber>3267261</recipientCRDNumber>
                <associatedBDName>Laidlaw &amp; Company (UK) Ltd.</associatedBDName>
                <associatedBDCRDNumber>119037</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>546 5th Avenue</street1>
                    <street2>5th Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10036</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>NJ</state>
                    <description>NEW JERSEY</description>
                    <state>NC</state>
                    <description>NORTH CAROLINA</description>
                    <state>OK</state>
                    <description>OKLAHOMA</description>
                    <state>PA</state>
                    <description>PENNSYLVANIA</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>Evan Greenberg</recipientName>
                <recipientCRDNumber>None</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>11 Hunters Lane</street1>
                    <city>Roslyn</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>11576</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>IA</state>
                    <description>IOWA</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>835000</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>10</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>50250</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>No amount of the gross proceeds is anticipated to pay named executive officers, except that the issuer may use the gross proceeds or other available funds for payments to the chief executive officer for the amounts owed to him of not less than $538,791.00</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Advaxis, Inc.</issuerName>
                <signatureName>Mark J. Rosenblum</signatureName>
                <nameOfSigner>MARK J. ROSENBLUM</nameOfSigner>
                <signatureTitle>Chief Financial Officer, Senior Vice President and Secretary</signatureTitle>
                <signatureDate>2010-11-12</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
