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    <testOrLive>LIVE</testOrLive>

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        <entityName>Ayala Pharmaceuticals, Inc.</entityName>
        <issuerAddress>
            <street1>9 DEER PARK DRIVE</street1>
            <street2>SUITE K-1</street2>
            <city>MONMOUTH JUNCTION</city>
            <stateOrCountry>NJ</stateOrCountry>
            <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
            <zipCode>08852</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>732 545 1590</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
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        <edgarPreviousNameList>
            <previousName>Advaxis, Inc.</previousName>
            <previousName>GREAT EXPECTATIONS &amp; ASSOCIATES INC</previousName>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
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    </primaryIssuer>

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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ken</firstName>
                <middleName>A.</middleName>
                <lastName>Berlin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>9 Deer Park Drive, Suite K-1</street1>
                <city>Monmouth Junction</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08852</zipCode>
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                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification>President, Chief Executive Officer and Director</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Roy</firstName>
                <lastName>Golan</lastName>
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                <street1>9 DEER PARK DRIVE</street1>
                <street2>SUITE K-1</street2>
                <city>MONMOUTH JUNCTION</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08852</zipCode>
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            <relationshipClarification>Chief Financial Officer</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Igor</firstName>
                <lastName>Gitelman</lastName>
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            <relatedPersonAddress>
                <street1>9 DEER PARK DRIVE</street1>
                <street2>SUITE K-1</street2>
                <city>MONMOUTH JUNCTION</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08852</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification>SVP Finance and former Interim CFO</relationshipClarification>
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            <relatedPersonName>
                <firstName>Andres</firstName>
                <lastName>Gutierrez</lastName>
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                <street2>SUITE K-1</street2>
                <city>MONMOUTH JUNCTION</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08852</zipCode>
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                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>EVP and Chief Medical Officer</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Sidransky</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>9 DEER PARK DRIVE</street1>
                <street2>SUITE K-1</street2>
                <city>MONMOUTH JUNCTION</city>
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                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08852</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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            <relationshipClarification>Chair of Board</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Roni</firstName>
                <middleName>A.</middleName>
                <lastName>Appel</lastName>
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                <street2>SUITE K-1</street2>
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        <relatedPersonInfo>
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                <lastName>Bisker-Leib</lastName>
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                <street2>SUITE K-1</street2>
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                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08852</zipCode>
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                <firstName>Yuval</firstName>
                <lastName>Cabilly</lastName>
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                <street1>9 DEER PARK DRIVE</street1>
                <street2>SUITE K-1</street2>
                <city>MONMOUTH JUNCTION</city>
                <stateOrCountry>NJ</stateOrCountry>
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                <lastName>Martell</lastName>
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        <relatedPersonInfo>
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                <firstName>Pini</firstName>
                <lastName>Orbach</lastName>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Spiegel</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
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                <city>MONMOUTH JUNCTION</city>
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                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08852</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2023-10-18</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Shares of common stock</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>true</isBusinessCombinationTransaction>
            <clarificationOfResponse>Issuer completed merger where each outstanding target share was exchanged for 1.82285 Issuer common shares. Of shares issued, 466,479 were issued under 506(b) &amp; the remainder under Reg S.</clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>433825</totalOfferingAmount>
            <totalAmountSold>433825</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Amounts above based on $0.93 per share, the closing price of the common stock on OTCQX on date of merger.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>3</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
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        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <signature>
                <issuerName>Ayala Pharmaceuticals, Inc.</issuerName>
                <signatureName>/s/ Ken A. Berlin</signatureName>
                <nameOfSigner>Ken A. Berlin</nameOfSigner>
                <signatureTitle>President and CEO</signatureTitle>
                <signatureDate>2023-11-02</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
