CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Cash flows from operating activities
Net income	$ 4,169.7	$ 1,399.4	$ 1,521.9
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	155.2	144.9	139.6
Non-cash operating lease cost	27.8	28.2	27.2
Stock-based compensation (Notes 2 and 16)	162.3	139.4	126.8
Gain on sale of product group (Note 5)	(3,348.2)	0.0	0.0
Impairment charges (Note 4)	0.0	0.0	55.1
Change in fair value of contingent consideration liabilities (Note 13)	0.0	(26.2)	(35.8)
(Gain) loss on investments, net	(5.2)	0.1	51.5
Deferred income taxes	(323.4)	(272.1)	(254.5)
Gain on remeasurement of previously held equity interest upon acquisition (Note 10)	(55.0)	0.0	0.0
Other	18.4	8.4	7.8
Changes in operating assets and liabilities:
Accounts and other receivables, net	121.2	(141.2)	(84.1)
Inventories	(256.1)	(289.0)	(213.4)
Prepaid expenses and other current assets	22.7	(81.8)	0.1
Accounts payable and accrued liabilities	89.5	146.0	(21.4)
Intellectual property agreement accrual	(36.8)	(33.0)	(45.0)
Income taxes	(186.7)	(5.8)	(5.6)
Long-term prepaid royalties (Note 3)	8.3	(109.9)	0.0
Other	(21.4)	(11.6)	(52.0)
Net cash provided by operating activities	542.3	895.8	1,218.2
Cash flows from investing activities
Capital expenditures	(252.4)	(253.0)	(244.6)
Purchases of held-to-maturity investments (Note 8)	(45.9)	(66.4)	(353.5)
Proceeds from sales and maturities of held-to-maturity investments (Note 8)	57.5	97.9	419.5
Purchases of available-for-sale investments (Note 8)	(899.9)	(9.1)	(315.8)
Proceeds from sales and maturities of available-for-sale investments (Note 8)	800.1	617.9	939.6
Business combinations, net of cash (Note 10)	(1,061.8)	(95.2)	0.0
Payments for acquisition options (Note 9)	(46.2)	(30.0)	(109.6)
Issuances of notes receivable	(63.0)	(62.5)	(52.3)
Collections of notes receivable	0.0	0.0	18.0
Investments in intangible assets	(30.0)	(13.3)	(20.2)
Proceeds from sale of product group	3,927.4	0.0	0.0
Other	(72.9)	(12.5)	(28.8)
Net cash provided by investing activities	2,312.9	173.8	252.3
Cash flows from financing activities
Purchases of treasury stock	(1,159.4)	(879.6)	(1,727.1)
Proceeds from stock plans	179.5	169.9	146.4
Other	(3.1)	(1.3)	(3.8)
Net cash used in financing activities	(983.0)	(711.0)	(1,584.5)
Effect of currency exchange rate changes on cash, cash equivalents, and restricted cash	38.6	16.8	19.2
Net increase (decrease) in cash, cash equivalents, and restricted cash	1,910.8	375.4	(94.8)
Cash, cash equivalents, and restricted cash at beginning of year	1,148.0	772.6	867.4
Cash, cash equivalents, and restricted cash at end of year (Note 6)	$ 3,058.8	$ 1,148.0	$ 772.6