Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020
Cash flows from operating activities:
Net income (loss)	$ 38,883	$ (145,161)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
Depreciation and amortization	5,133	5,341
Share-based compensation	14,379	7,673
Non-cash royalty revenue	(28,903)	(29,950)
Non-cash interest expense	48,295	44,109
Donation of assets		622
Loss on disposal of assets	83	14
Change in fair value of contingent obligations	13,531	4,652
Gain on extinguishment of debt	(6,197)
Loss on modification of debt		2,720
Changes in operating assets and liabilities:
Accounts receivable	(20,596)	15,883
Prepaid expenses	(7,612)	(822)
Accounts payable	4,885	6,291
Deferred revenue	(20,384)	(8,741)
Accrued liabilities and other current liabilities	(11,181)	(8,748)
Other operating assets and liabilities	2,756	2,611
Net cash provided by (used in) operating activities	33,072	(103,506)
Cash flows from investing activities:
Purchases of plant and equipment	(24,852)	(2,632)
Purchases of available-for-sale securities	(4,999)
Cash paid for business acquisition, net		(975)
Net cash used in investing activities	(29,851)	(3,607)
Cash flows from financing activities:
Net proceeds from sale of equity	147,437	151,431
Proceeds from employee stock purchases and option exercises	8,829	4,408
Proceeds from issuance of long-term debt		6,197
Repayments of debt	(462)	(1,231)
Payment of contingent purchase price consideration	(1,542)
Payment of finance lease obligation	(603)	(1,597)
Net cash provided by financing activities	153,659	159,208
Effect of exchange rate changes on cash	(187)	241
Net increase in cash, cash equivalents and restricted cash	156,693	52,336
Cash, cash equivalents and restricted cash, beginning of period	102,505	61,808
Cash, cash equivalents and restricted cash, end of period	259,198	114,144
Supplemental cash flow information:
Cash paid for interest	862	892
Supplemental disclosures - non-cash activities:
Purchases of plant and equipment in accounts payable and accrued liabilities	3,481	166
Issuance of subsidiary shares to noncontrolling interest	10,000
Insurance financing agreement	987
Contingent purchase price consideration in connection with business acquisition		144
Lease right-of-use assets obtained in exchange for new operating lease liabilities	898	8,600
Lease right-of-use assets obtained in exchange for new finance lease liabilities	762	2,434
Payment for services [Member]
Supplemental disclosures - non-cash activities:
Issuance of common stock	75	62
Business Acquisition Related [Member]
Supplemental disclosures - non-cash activities:
Issuance of common stock		$ 900
Employee bonus [Member]
Supplemental disclosures - non-cash activities:
Issuance of common stock	3,126
Series C-1 Convertible Preferred Stock [Member]
Supplemental disclosures - non-cash activities:
Conversion of series C-1 convertible preferred stock to common stock, $0.01 par value	$ 26,917