Consolidated Statements of Convertible Preferred Stock and Stockholders' Deficit - USD ($) $ in Thousands	Total	Amendment to 2013 Warrants [Member]	SECANT Yeast Display Acquisition [Member]	Common Stock [Member]	Common Stock [Member] SECANT Yeast Display Acquisition [Member]	Additional Paid-in Capital [Member]	Additional Paid-in Capital [Member] Amendment to 2013 Warrants [Member]	Additional Paid-in Capital [Member] SECANT Yeast Display Acquisition [Member]	Treasury Stock [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Non-controlling Interest [Member]	Accumulated Deficit [Member]	Series C-1 Convertible Preferred Stock [Member]	Series A-1 convertible preferred stock [Member]
Stockholders' Equity, Beginning Balance at Dec. 31, 2016	$ (39,126)			$ 878		$ 866,854				$ (1,529)		$ (905,329)		$ 0
Balance, shares at Dec. 31, 2016				87,795,000										32,000
Net loss	(120,692)											(120,692)
Other comprehensive loss	(640)									(640)
Adoption of ASC	(82)					1,211						(1,293)
Shares sold under Stock Purchase Agreement, values	60,000			$ 100		59,900
Shares sold under Stock Purchase Agreement, shares				10,000,000
Share-based compensation	10,924					10,924
Reclassification of liability	2,016					2,016
Vesting of nonvested shares, value	(527)			$ 11		(11)			$ (527)
Vesting of nonvested shares, shares				1,097,000					(156,000)
Shares sold at the market, value	5,560			$ 13		5,547
Shares sold at the market, shares				1,315,000
Issuance of warrants		$ 731					$ 731
Retirement of treasury shares, value				$ (2)		(1,364)			$ 527			839
Retirement of treasury shares, share				(156,000)					156,000
Issuance of shares related to milestone achievement, values	1,486			$ 4		1,482
Issuance of shares related to milestone achievement, shares				373,000
Issuance of stock for acquisition, value			$ 3,548		$ 10			$ 3,538
Issuance of stock for acquisition, share					999,000
Exercise of stock options and employee share purchases, value	987			$ 3		984
Exercise of stock options and employee share purchases, shares				283,000
Stockholders' Equity, Ending Balance at Dec. 31, 2017	(75,815)			$ 1,017		951,812				(2,169)		(1,026,475)		$ 0
Balance, shares at Dec. 31, 2017				101,706,000										32,000
Net loss	(162,044)										$ (2,352)	(159,692)
Other comprehensive loss	630									630
Adoption of ASC | ASC 606 [Member]	8,856											8,856
AgenTus share distribution	274										274
Share-based compensation	7,351					7,351
Vesting of nonvested shares, value				$ 1		(1)
Vesting of nonvested shares, shares				53,000
Shares sold at the market, value	44,919			$ 178		44,741
Shares sold at the market, shares				17,799,000
Issuance of Series C-1 convertible preferred stock, net of issuance costs, value													$ 39,879
Issuance of Series C-1 convertible preferred stock, net of issuance costs, shares													18,000
Payment of consultant in shares	50			$ 0		50
Payment of consultant in shares, shares				26,000
Exercise of stock options and employee share purchases, value	1,234			$ 4		1,230
Exercise of stock options and employee share purchases, shares				413,000
Stockholders' Equity, Ending Balance at Dec. 31, 2018	(174,545)			$ 1,200		1,005,183				(1,539)	(2,078)	(1,177,311)		$ 0
Temporary Equity, shares at Dec. 31, 2018													18,459
Temporary Equity, Ending Balance at Dec. 31, 2018													$ 39,879
Balance, shares at Dec. 31, 2018				119,997,000										32,000
Net loss	(111,560)										(3,903)	(107,657)
Other comprehensive loss	215									215
Adoption of ASC	(25)											(25)
Shares sold under Stock Purchase Agreement, values	30,000			$ 111		29,889
Shares sold under Stock Purchase Agreement, shares				11,111,000
Share-based compensation	9,892					9,892
Vesting of nonvested shares, value				$ 1		(1)
Vesting of nonvested shares, shares				130,000
Conversion of Series C-1 convertible preferred stock	12,962			$ 60		12,902							$ (12,962)
Conversion of Series C-1 convertible preferred stock, shares				6,000,000									(6,000)
Payment of consultant in shares	81			$ 0		81
Payment of consultant in shares, shares				29,000
Exercise of stock options and employee share purchases, value	1,643			$ 6		1,637
Exercise of stock options and employee share purchases, shares				552,000
Stockholders' Equity, Ending Balance at Dec. 31, 2019	$ (231,337)			$ 1,378		$ 1,059,583				$ (1,324)	$ (5,981)	$ (1,284,993)		$ 0
Temporary Equity, shares at Dec. 31, 2019													12,459
Temporary Equity, Ending Balance at Dec. 31, 2019													$ 26,917
Balance, shares at Dec. 31, 2019				137,819,000										32,000