Income Taxes (Tables)

12 Months Ended

Dec. 31, 2019

Schedule of Deferred Tax Assets and Liabilities

The tax effect of temporary differences and net operating loss and tax credit carryforwards that give rise to significant portions of the deferred tax assets and deferred tax liabilities as of December 31, 2019 and 2018 are presented below (in thousands).

	2019			2018
Deferred tax assets:
U.S. Federal and State net operating loss carryforwards	$	143,126		$	182,557
Foreign net operating loss carryforwards		4,096			1,524
Research and development tax credits		16,364			18,507
Share-based compensation		4,774			4,824
Intangible Assets		38,710			36,217
Interest expense carryforward		3,893			6,555
Deferred Revenue		47,456			—
Lease Liability		2,002			—
Other		3,974			4,882
Total deferred tax assets		264,395			255,066
Less: valuation allowance		(262,228	)		(254,315	)
Net deferred tax assets		2,167			751
Foreign intangible assets		(1,009	)		(1,063	)
Right of use asset		(1,599	)		—
Other		(165	)		(406	)
Deferred tax liabilities		(2,773	)		(1,469	)
Net deferred tax liability	$	(606	)	$	(718	)

Schedule of Effective Income Tax Rate Reconciliation

Income tax benefit was nil for the years ended December 31, 2019, 2018 and 2017. Income taxes recorded differed from the amounts computed by applying the U.S. Federal income tax rate of 21% in 2019 and 2018 and 34% in 2017 to loss before income taxes as a result of the following (in thousands).

	2019			2018			2017
Computed “expected” Federal tax benefit	$	(23,413	)	$	(34,029	)	$	(41,035	)
(Increase) reduction in income taxes benefit resulting from:
Change in valuation allowance		7,913			24,233			(63,868	)
(Decrease) increase due to uncertain tax positions		(64	)		7			—
Foreign income inclusion		—			11,089			—
State and local income benefit, net of Federal income tax benefit		4,144			(11,708	)		(4,561	)
Change in federal tax rate		—			—			104,764
Foreign rate differential		(564	)		956			2,084
Change in fair value contingent consideration		1,219			(280	)		(1,084	)
Other, net		10,765			9,732			3,700
Income tax benefit	$	—		$	—		$	—

Summary of Income Tax Contingencies

A reconciliation of the beginning and ending amount of gross unrecognized tax benefits is as follows (in thousands):

	2019			2018		2017
Balance, January 1	$	4,356		$	4,349	$	5,278
Increase related to current year positions		122			—		—
Increase (decrease) related to previously recognized positions		(186	)		7		—
Decrease related to change in federal tax rate		—			—		(929	)
Balance, December 31	$	4,292		$	4,356	$	4,349