Equity [Abstract]
Equity [Table]
Equity [Table]
Equity [Table]
Scenario [Axis]
Scenario [Axis]
Scenario, Unspecified [Domain]
Scenario, Unspecified [Domain]
Registered direct offering [Member]
Registered direct offering [Member]
Registered direct [Member]
Statement, Equity Components [Axis]
Equity Components [Axis]
Equity Component [Domain]
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Class of Stock [Axis]
Class of Stock [Axis]
Class of Stock [Domain]
Class of Stock [Domain]
Series A convertible preferred stock
Series A Preferred Stock [Member]
Series A-1 convertible preferred stock [Member]
Series A-1 convertible preferred stock [Member]
Series A-1 convertible preferred stock [Member]
Series B-1 convertible preferred stock [Member]
Series B-1 convertible preferred stock [Member]
Series B-1 convertible preferred stock [Member]
Series B-2 convertible preferred stock [Member]
Series B-2 convertible preferred stock [Member]
Series B-2 convertible preferred stock [Member]
Series B2 convertible preferred stock
Series B Preferred Stock [Member]
Warrants issued in private placements, shares [Axis]
Class of Warrant or Right [Axis]
Class of Warrant or Right [Domain]
Class of Warrant or Right [Domain]
10-year warrants [Member]
10-year warrants [Member]
10-year warrants [Member]
10-year Unit warrants [Member]
10-year Unit warrants [Member]
10-year Unit warrants [Member]
Unit warrants [Member]
Unit warrants [Member]
Unit warrants [Member]
5-year warrants [Member]
5-year warrants [Member]
5-year warrants [Member]
July 2009 6-month warrants [Member]
July 2009 6-month warrants [Member]
July 2009 6-month warrants [Member]
July 2009 4-year warrants [Member]
July 2009 4-year warrants [Member]
July 2009 4-year warrants [Member]
August 2009 6-month warrants [Member]
August 2009 6-month warrants [Member]
August 2009 6-month warrants [Member]
August 2009 4-year warrants [Member]
August 2009 4-year warrants [Member]
August 2009 4-year warrants [Member]
Equity Issuance Program, By Type [Axis]
Equity Issuance Profram, By Type [Axis]
Equity Issuance Profram, By Type [Axis]
Equity Issuance Program By Type [Domain]
Equity Issuance Profram By Type [Domain]
Equity Issuance Profram, By Type [Domain]
Old ATM Program [Member]
Old Atm Program [Member]
Old ATM Program [Member]
New ATM Program [Member]
New Atm Program [Member]
New ATM Program [Member]
Amended New ATM program [Member]
Amended New ATM program [Member]
Amended New ATM program [Member]
Equity [Line Items]
Equity [Line Items]
Equity [Line Items]
Common stock, shares authorized
Common Stock, Shares Authorized
Common stock, par value
Common Stock, Par or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
Proceeds from Issuance of Convertible Preferred Stock
Proceeds from Issuance of Convertible Preferred Stock
Preferred Stock, Dividend Rate, Percentage
Preferred Stock, Dividend Rate, Percentage
Preferred Stock, Redemption Price Per Share
Preferred Stock, Conversion Price Per Share
Preferred Stock, Conversion Price Per Share
Preferred Stock, Redemption Amount
Preferred Stock, Redemption Amount
Preferred Stock, Liquidation Preference Per Share
Preferred Stock, Liquidation Preference Per Share
Preferred Stock, Amount of Preferred Dividends in Arrears
Preferred Stock, Amount of Preferred Dividends in Arrears
Preferred Stock, Per Share Amounts of Preferred Dividends in Arrears
Preferred Stock, Per Share Amounts of Preferred Dividends in Arrears
Common stock, shares issued
Common Stock, Shares, Issued
Stock Issued During Period, Price Per Share
Stock Issued During Period, Price Per Share
Stock Issued During Period, Price Per Share
Sale of Stock, Price Per Share
Sale of Stock, Price Per Share
Proceeds from Issuance of Private Placement
Proceeds from Issuance of Private Placement
Preferred stock, shares issued, Series A
Preferred Stock, Shares Issued
Stock, Convertible, Conversion Price is Equal to a Stated Percentage of the Total Dollar Amount Previously Invested , Stated Percentage
Convertible Preferred Stock, Conversion Threshold as a Stated Percentage of the Total Dollar Amount Previously Invested, Maximum
Stock, Convertible, Conversion Price is Equal to a Stated Percentage of the Total Dollar Amount Previously Invested , Stated Percentage
Convertible Preferred Stock, Right to Purchase Common Share, Price per Share, Maximum
Convertible Preferred Stock, Right to Purchase Common Share, Price per Share, Maximum
Convertible Preferred Stock, Right to Purchase Common Share, Price per Share, Maximum
Series B conversion right term
Series B conversion right term
Series B conversion right term
Common shares issued upon conversion
Conversion of Stock, Shares Issued
Conversion of Stock, Shares Converted
Conversion of Stock, Shares Converted
Preferred stock, shares outstanding, Series A-1
Preferred Stock, Shares Outstanding
Stock, Convertible, Total Number of Shares of Common Stock Issued or Issuable Cannot Exceeed a Stated Percentage of Outstanding Common Stock, Stated Percentage
Convertible Preferred Stock, Common Stock Issued or Issuable as a Percentage of Common Stock Outstanding, Maximum
Stock, Convertible, Total Number of Shares of Common Stock Issued or Issuable Cannot Exceeed a Stated Percentage of Outstanding Common Stock, Stated Percentage
Shares issued in private placements, shares
Shares issued in private placements, shares
Shares issued in private placements, shares
Share-based compensation
Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition
Class of Warrant or Right, Term
Class of Warrant or Right, Term
Class of Warrant or Right, Term
Class of Warrant or Right, Exercisable Term
Class of Warrant or Right, Exercisable Term
Class of Warrant or Right, Exercisable Term
Class of Warrant or Right, Exercise Price of Warrants or Rights
Class of Warrant or Right, Exercise Price of Warrants or Rights
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Class of Warrant or Right, Non Exercisable Term
Class of Warrant or Right, Non Exercisable Term
Class of Warrant or Right, Non Exercisable Term
Shares issued in private placements, value
Shares issued in private placements, value
Shares issued in private placements, value
Subscription Agreement, Terms, Subsequent Period in Whcih Investor Has Right to by a Stated Amount of Common Stock
Subscription Agreement, Terms, Additional Purchase Option, Exercise Period
Period from date of subscription agreements to exercise the right and option to purchase additional shares
Subscription Agreement, Terms, Additional Purchase Option, Number of Shares
Subscription Agreement, Terms, Additional Purchase Option, Number of Shares
Subscription Agreement, Terms, number of additional shares investor can elect to purchase wtihin the exercise period of the additional purchase option
Terms of Private Placement, Subsequent Offering, Potential Proceeds from Issuance of Private Placement
Terms of Private Placement, Subsequent Offering, Potential Proceeds from Issuance of Private Placement
Terms of Private Placement, Subsequent Offering, Potential Proceeds from Issuance of Private Placement
Stock Issued During Period, Shares, New Issues
Stock Issued During Period, Shares, New Issues
warrants issued
warrants issued
warrants issued
Stock Issued During Period, Value, New Issues
Stock Issued During Period, Value, New Issues
Net proceeds from issuance of common stock
Proceeds from Issuance of Common Stock
Payments of stock issuance costs
Payments of Stock Issuance Costs
Shares Available For Sale Through Sales Agent
Shares Available For Sale Through Sales Agent
Shares available for sale through sales agent.
Net operating loss carryforward - federal [Abstract]
Net operating loss carryforward - federal [Abstract]
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Income Tax Authority [Axis]
Income Tax Authority [Axis]
Income Tax Authority [Domain]
Income Tax Authority [Domain]
Internal Revenue Service (IRS) [Member]
Internal Revenue Service (IRS) [Member]
State and Local Jurisdiction [Member]
State and Local Jurisdiction [Member]
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Computed Federal tax benefit
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Deferred Tax Assets, Operating Loss Carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Operating Loss Carryforwards
Operating Loss Carryforwards
Deferred Tax Assets, Tax Credit Carryforwards, Research
Deferred Tax Assets, Tax Credit Carryforwards, Research
Deferred tax assets, contingent royalty consideration
Deferred tax assets, contingent royalty consideration
Deferred tax assets, contingent royalty consideration
Deferred Tax Assets, Other
Deferred Tax Assets, Other
Deferred Tax Assets, Gross
Deferred Tax Assets, Gross
Deferred Tax Assets, Valuation Allowance
Deferred Tax Assets, Valuation Allowance
Deferred Tax Assets, Net
Deferred Tax Assets, Net of Valuation Allowance
Deferred Tax Liabilities
Deferred Tax Liabilities, Net
Deferred Tax Assets (Liabilities), Net
Deferred Tax Assets, Net
Valuation Allowance, Deferred Tax Asset, Change in Amount
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Income Tax Reconciliation, Tax Contingencies, Other
Effective Income Tax Rate Reconciliation, Tax Contingency, Other, Amount
Income Tax Reconciliation, Tax Contingencies, State and Local
Effective Income Tax Rate Reconciliation, Tax Contingency, State and Local, Amount
Net operating loss expirations
Net operating loss expirations
Net operating loss expirations
Income Tax Reconciliation, Nondeductible Expense, Other
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Income Tax Reconciliation, Other Adjustments
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Income Tax Expense (Benefit), Continuing Operations
Income Tax Expense (Benefit)
Document And Entity Information [Abstract]
Document and Entity Information [Abstract]
Entity Current Reporting Status
Entity Current Reporting Status
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Period Focus
Document Fiscal Period Focus
Document Fiscal Year Focus
Document Fiscal Year Focus
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Entity Public Float
Entity Public Float
Entity Voluntary Filers
Entity Voluntary Filers
Quarterly financial data (unaudited) [Abstract]
Quarterly financial data (unaudited) [Abstract]
Schedule of Quarterly Financial Information [Table Text Block]
Schedule of Quarterly Financial Information [Table Text Block]
Leases [Abstract]
Leases of Lessee Disclosure [Text Block]
Leases of Lessee Disclosure [Text Block]
Fair Value Disclosures [Abstract]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Income Statement Location [Axis]
Income Statement Location [Axis]
Income Statement Location [Domain]
Income Statement Location [Domain]
Liability Class [Axis]
Liability Class [Axis]
Fair Value by Liability Class [Domain]
Fair Value by Liability Class [Domain]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Accrued liabilitites [Abstract]
Accrued liabilitites [Abstract]
Professional fees
Accrued Professional Fees, Current
Payroll
Accrued Salaries, Current
Clinical trials
Clinical trials
Clinical trials
Accrued clinical trial expenses
Other
Other Accrued Liabilities, Current
Accrued liabilities
Accrued Liabilities, Current
Earnings Per Share [Abstract]
Schedule Of Anti-Dilutive Securities
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Accounting Policies [Abstract]
Schedule of Long-term Debt Instruments [Table]
Schedule of Long-term Debt Instruments [Table]
Debt Instrument [Axis]
Debt Instrument [Axis]
Debt Instrument, Name [Domain]
Debt Instrument, Name [Domain]
Notes 2006 [Member]
Notes 2006 [Member]
2006 Senior Convertible Notes [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Depreciation
Depreciation
Long-term Debt, Gross
Long-term Debt, Gross
Statement of Financial Position [Abstract]
Statement [Table]
Statement [Table]
Series A-1 Preferred Shares [Member]
Series A-1 Preferred Shares [Member]
Series A-1 Preferred Shares [Member]
Statement [Line Items]
Statement [Line Items]
Plant and equipment, accumulated amortization and depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Treasury stock, shares
Treasury Stock, Shares
Convertible preferred stock, shares designated
Convertible Preferred Stock, Shares Designated
Convertible Preferred Stock Shares Designated
Series A-1 convertible preferred stock, liquidation value
Auction Market Preferred Securities, Stock Series, Liquidation Value
Foreign Currency [Abstract]
Foreign Currency Transaction Gain (Loss), before Tax
Foreign Currency Transaction Gain (Loss), before Tax
Revenue [Abstract]
Revenue [Abstract]
Concentration Risk [Table]
Concentration Risk [Table]
Customer [Axis]
Customer [Axis]
Customer [Axis]
Customer [Domain]
Customer [Domain]
[Domain] for Customer [Axis]
One research partner [Member]
One research partner [Member]
One research partner [Member]
Percent of revenue earned from one research partner
One license partner [Member]
One license partner [Member]
One license partner [Member]
Percent of license revenue earned from one partner
One service partner [Member]
One service partner [Member] [Member]
One service partner [Member] [Member]
Statement, Business Segments [Axis]
Segments [Axis]
Segment [Domain]
Segments [Domain]
Concentration Risk by Benchmark [Axis]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark [Domain]
Concentration Risk Benchmark [Domain]
Concentration Risk by Type [Axis]
Concentration Risk Type [Axis]
Concentration Risk Type [Domain]
Concentration Risk Type [Domain]
Customer Concentration Risk [Member]
Customer Concentration Risk [Member]
Concentration Risk [Line Items]
Concentration Risk [Line Items]
Concentration Risk, Customer
Concentration Risk, Customer
Other Liabilities Disclosure [Abstract]
Schedule of Accrued Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Income Taxes [Abstract]
Income Taxes [Abstract]
Income Tax Disclosure [Text Block]
Income Tax Disclosure [Text Block]
Debt Disclosure [Abstract]
Debt Disclosure [Text Block]
Debt Disclosure [Text Block]
Quarterly Financial Information [Text Block]
Quarterly Financial Information [Text Block]
Share-based Compensation [Abstract]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs, by Report Line [Axis]
Research and Development Expense [Member]
Research and Development Expense [Member]
General and Administrative Expense [Member]
General and Administrative Expense [Member]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Allocated share-based compensation expense
Allocated Share-based Compensation Expense
Total share-based compensation expense
Share Based Compensation Expense
Share Based Compensation Expense
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Related Party Transactions [Abstract]
Related Party Transactions Disclosure [Text Block]
Related Party Transactions Disclosure [Text Block]
Statement of Comprehensive Income [Abstract]
Revenue:
Revenues [Abstract]
Service revenue
Sales Revenue, Services, Net
Research and development revenue
Research and Development Revenue
Research and Development Revenue
Total revenues
Revenues
Operating expenses:
Operating Expenses [Abstract]
Cost of revenues
Cost of Goods Sold
Research and development
Research and Development Expense
General and administrative
General and Administrative Expense
Operating loss
Operating Income (Loss)
Other income (expense):
Nonoperating Income (Expense) [Abstract]
Non-operating (loss) income
Nonoperating Income (Expense)
Interest expense
Interest Expense
Interest income
Investment Income, Interest
Net loss
Net Income (Loss) Attributable to Parent
Dividends on convertible preferred stock
Dividends, Preferred Stock
Net loss attributable to common stockholders
Net Income (Loss) Available to Common Stockholders, Basic
Per common share data, basic and diluted:
Earnings Per Share, Basic and Diluted [Abstract]
Basic and diluted net loss attributable to common stockholders
Earnings Per Share, Basic
Basic net income (loss) attributable to common stockholders
Earnings Per Share, Basic and Diluted
Weighted average number of common shares outstanding:
Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract]
Weighted average number of common shares outstanding, basic and diluted
Weighted Average Number of Shares Outstanding, Basic and Diluted 1
Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS)
Deferred tax table [Abstract]
Deferred tax table [Abstract]
Summary of Income Tax Contingencies [Table Text Block]
Summary of Income Tax Contingencies [Table Text Block]
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Investments [Abstract]
Cash, Cash Equivalents, and Short-term Investments [Text Block]
Cash, Cash Equivalents, and Short-term Investments [Text Block]
Property, Plant and Equipment [Abstract]
Schedule of Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Property, Plant and Equipment by Type [Axis]
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Domain]
Property, Plant and Equipment, Type [Domain]
Machinery and Equipment [Member]
Machinery and Equipment [Member]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment, Useful Life
Property, Plant and Equipment, Useful Life
Assets Disposed of by Method Other than Sale, in Period of Disposition, Gain (Loss) on Disposition
Assets Disposed of by Method Other than Sale, in Period of Disposition, Gain (Loss) on Disposition
Research and Development [Abstract]
Deferred Revenue Arrangement, by Type [Table]
Deferred Revenue Arrangement, by Type [Table]
Project [Axis]
Project [Axis]
Project [Axis]
Project [Domain]
Project [Domain]
[Domain] for Project [Axis]
Mount Sinai Agreement [Member]
Mount Sinai Agreement [Member]
Mount Sinai Agreement [Member]
Fordham Agreement [Member]
Fordham Agreement [Member]
Fordham Agreement [Member]
UConn Agreement [Member]
UConn Agreement [Member]
UConn Agreement [Member]
UConn Agreement, as amended [Member]
UConn Agreement, as amended [Member]
UConn Agreement, as amended [Member]
GSK Agreements [Member]
GSK Agreements [Member]
GSK Agreements [Member]
GSK Supply Agreement [Member]
GSK Supply Agreement [Member]
GSK Supply Agreement [Member]
GSK First Right to Negotiate Agreement [Member]
GSK First Right to Negotiate Agreement [Member]
GSK First Right to Negotiate Agreement [Member]
JANSSEN AI License Agreement [Member]
JANSSEN AI License Agreement [Member]
JANSSEN AI License Agreement [Member]
Other existing licensee [Member]
Other existing licensee [Member]
Other existing licensee [Member]
Range [Axis]
Range [Axis]
Range [Domain]
Range [Domain]
Minimum [Member]
Minimum [Member]
Maximum [Member]
Maximum [Member]
Deferred Revenue Arrangement [Line Items]
Deferred Revenue Arrangement [Line Items]
Equity interest
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners
Stock issued for license agreement (in shares)
Stock Issued for License Agreement, Shares
Stock Issued for License Agreement, Shares
Stock issued for license agreement, amount
Stock Issued for License Agreement, Amount
Stock Issued for License Agreement, Amount
License costs
License Costs
Period for which failure to pay royalties may result in contract termination
Period for Which Failure to Make Payments May Result in Contract Termination
Period for Which Failure to Make Payments May Result in Contract Termination
Period for which company may terminate the contract
Period for Which We May Terminate the Contract
Period for Which We May Terminate the Contract
Period the Company may continue to manufacture and sell products, after contract breach
Period We May Continue to Manufacture and Sell Products, After Contract Breach
Period We May Continue to Manufacture and Sell Products, After Contract Breach
Milestone payments for license costs
Milestone Payments for License Costs
Milestone Payments for License Costs
Estimate of total payments for clinical trials
Estimate of Total Payments for Clinical Trials
Estimate of Total Payments for Clinical Trials
Clinical trials expense
Clinical Trials Expense
Clinical Trials Expense
Cumulative payments for clinical trials
Cumulative Payments for Clinical Trials
Cumulative Payments for Clinical Trials to date
Negotiation right expiration period
Negotiation Right Expiration Period
Negotiation Right Expiration Period
Proceeds from negotiation right
Proceeds From Negotiation Right
Proceeds From Negotiation Right
Proceeds from negotiation right creditable against future royalty payments
Proceeds From Negotiation Right Creditable Against Future Royalty Payments
Proceeds From Negotiation Right Creditable Against Future Royalty Payments
Proceeds from license fees received
Proceeds from License Fees Received
Total potential proceeds from license
Total Potential Proceeds from License Fees Received
Total Potential Proceeds from License Fees Received
cumulated payment received to date
cumulated payment received to date
cumulated payment received to date
Period to receive license fees
Period to Receive License Fees
Period to Receive License Fees
Deferred revenue
Deferred Revenue
License and services revenue
License and Services Revenue
401K Plan [Abstract]
401K Plan [Abstract]
Schedule of Defined Benefit Plans Disclosures [Table]
Schedule of Defined Benefit Plans Disclosures [Table]
Defined Benefit Plans and Other Postretirement Benefit Plans Disclosures [Axis]
Defined Benefit Plans and Other Postretirement Benefit Plans [Axis]
Defined Benefit Plans and Other Postretirement Benefit Plans [Domain]
Defined Benefit Plan and Other Postretirement Benefit Plan [Domain]
Maximum contribution, Under 50 [Member]
Maximum Contribution, Under Fifty [Member]
Under 50 Retirement Plan [Member]
Maximum contribution, Over 50 [Member]
Maximum Contribution, Over Fifty [Member]
Maximum Contribution, Over Fifty [Member]
Defined Benefit Plan by Plan Asset Categories [Axis]
Defined Benefit Plan, Asset Categories [Axis]
Plan Asset Categories [Domain]
Plan Asset Categories [Domain]
Defined Benefit Plan, Fair Value of Plan Assets by Measurement [Axis]
Fair Value, Hierarchy [Axis]
Fair Value Plan Asset Measurement [Domain]
Fair Value Hierarchy [Domain]
Defined Benefit Plan Disclosure [Line Items]
Defined Benefit Plan Disclosure [Line Items]
Maximum annual contributions per employee
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Maximum annual contributions per employee, Amount
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Amount
Employer contribution amount
Defined Contribution Plan, Employer Discretionary Contribution Amount
Expensed plan contributions
Defined Contribution Plan, Cost Recognized
Statement of Stockholders' Equity [Abstract]
Deferred Compensation Arrangement with Individual, Share-based Payments, by Title of Individual [Axis]
Title of Individual [Axis]
Relationship to Entity [Domain]
Relationship to Entity [Domain]
Chief Executive Officer [Member]
Chief Executive Officer [Member]
Consultant [Member]
Consultant [Member]
Consultant [Member]
Director other [Member]
Director other [Member]
Director other [Member]
Director [Member]
Director [Member]
Series A-1 convertible preferred stock
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Treasury Stock [Member]
Treasury Stock [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Noncontrolling Interest [Member]
Noncontrolling Interest [Member]
Stockholders' Equity Attributable to Parent, Beginning Balance
Stockholders' Equity Attributable to Parent
Balance, shares
Shares, Issued
Net loss
2006 Note Amendment
Effect on Additional Paid-In Capital due to Note Amendment
Effect on Additional Paid-In Capital due to Note Amendment
Shares sold at the market, shares
Shares sold at the market, value
Common stock issued to preferred shareholder, shares
Stock Issued During Period, Shares, Conversion of Convertible Securities
Common stock issued to preferred shareholder
Stock Issued During Period, Value, Conversion of Convertible Securities
Extinguishment of debt, shares
Stock Issued During Period for Extinguishment of Debt, shares
Stock Issued During Period for Extinguishment of Debt, shares
Extinguishment of debt
Stock Issued During Period for Extinguishment of Debt
Stock Issued During Period for Extinguishment of Debt
Reclassification of liability classified option grants
Reclassification of liability classified option grants
Reclassification of liability classified option grants
Vesting of nonvested shares, shares
Vesting of nonvested shares, shares
Vesting of nonvested shares, shares
Vesting of nonvested shares, value
Vesting of nonvested shares, value
Vesting of nonvested shares, value
Shares issued for compensation, value
Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures
Shares issued for compensation, shares
Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures
Exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Employee share purchases, shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Employee share purchases, value
Stock Issued During Period, Value, Employee Stock Purchase Plan
Dividends on series A convertible preferred stock
Dividends, Preferred Stock, Cash
Stockholders' Equity Attributable to Parent, Ending Balance
Balance, shares
Significant Accounting Policies [Text Block]
Significant Accounting Policies [Text Block]
ASSETS
Assets [Abstract]
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Inventories
Inventory, Net
Accounts receivable
Accounts Receivable, Net, Current
Prepaid expenses
Prepaid Expense, Current
Other current assets
Other Assets, Current
Total current assets
Assets, Current
Plant and equipment, net of accumulated amortization and depreciation of $27,637,443 and $27,404,751 at December 31, 2013 and 2012, respectively
Property, Plant and Equipment, Net
Goodwill
Goodwill
Other long-term assets
Other Assets, Noncurrent
Total assets
Assets
LIABILITIES AND STOCKHOLDERS’ DEFICIT
Liabilities and Equity [Abstract]
Current portion, long-term debt
Long-term Debt, Current Maturities
Current portion, deferred revenue
Deferred Revenue, Current
Accounts payable
Accounts Payable, Current
Accrued liabilities
Other current liabilities
Other Liabilities, Current
Total current liabilities
Liabilities, Current
Convertible notes
Senior Notes, Noncurrent
Other long-term debt
Other L T D
Carrying value as of the balance sheet date of debt not otherwise defined (with maturities initially due after one year or beyond the operating cycle if longer), excluding current portion.
Deferred revenue
Deferred Revenue, Noncurrent
Contingent Royalty
Contingent Royalty
Contingent royalty.
Other long-term liabilities
Other Liabilities, Noncurrent
Commitments and contingencies (Notes 11 and 14)
Commitments and Contingencies
STOCKHOLDERS’ DEFICIT
Stockholders' Equity Attributable to Parent [Abstract]
Preferred stock, par value $0.01 per share; 5,000,000 and 25,000,000 shares authorized at December 31, 2012 and December 31, 2011, respectively
Preferred Stock, Value, Issued
Common stock, par value $0.01 per share; 70,000,000 shares authorized December 31, 2013 and 2012; 36,391,191 and 24,645,112 shares issued at December 31, 2013 and 2012, respectively
Common Stock, Value, Issued
Additional paid-in capital
Additional Paid in Capital
Treasury stock, at cost; 43,490 shares of common stock at December 31, 2013 and 2012
Treasury Stock, Value
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Noncontrolling interest
Noncontrolling Interest
This element represents that portion of equity (net assets) in a subsidiary not attributable, directly or indirectly, to the parent. A noncontrolling interest is sometimes called a minority interest.
Total stockholders’ deficit
Total liabilities and stockholders’ deficit
Liabilities and Equity
Plant and Equipment [Abstract]
Plant and Equipment [Abstract]
Property, Plant and Equipment Disclosure [Text Block]
Property, Plant and Equipment Disclosure [Text Block]
Description of Business [Abstract]
Business Liquidity And Basis Of Presentation [Abstract]
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
Underwritten offering [Member]
Underwritten offering [Member]
Underwritten offering [Member]
Revenue Interests Assignment Agreement [Member]
Revenue Interests Assignment Agreement [Member]
Revenue Interests Assignment Agreement [Member]
SVB Note [Member]
SVB Note [Member]
SVB Note [Member]
Subordinated Notes [Member]
Subordinated Notes [Member]
Subordinated Notes [Member]
8% Senior Secured Convertible Notes [Member]
Eight Percent Senior Secured Convertible Notes [Member]
8% Percent Senior Secured Convertible Notes [Member]
Debt outstanding
Debt Instrument, Periodic Payment, Principal
Debt Instrument, Periodic Payment, Principal
Repayments of Long-term Debt
Repayments of Long-term Debt
Noncontrolling Interest, Period Increase (Decrease)
Noncontrolling Interest, Period Increase (Decrease)
Gains (Losses) on Extinguishment of Debt
Gains (Losses) on Extinguishment of Debt
Debt interest rate
Debt Instrument, Interest Rate, Stated Percentage
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]
Share-Based Compensation
Disclosure of Compensation Related Costs, Share-based Payments [Text Block]
Fair Value Measurements [Abstract]
Fair Value Measurements [Abstract]
Fair Value, by Balance Sheet Grouping [Table]
Fair Value, by Balance Sheet Grouping [Table]
Fair Value, Hierarchy [Axis]
Fair Value, Measurements, Fair Value Hierarchy [Domain]
Level 2 [Member]
Fair Value, Inputs, Level 2 [Member]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Contingent Royalty
Contingent Royalty Consideration
Contingent Royalty Consideration
Contingent Royalty Consideration
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease)
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease)
Contingent Royalty
Fair Value Inputs, Discount Rate
Fair Value Inputs, Discount Rate
Convertible notes
Convertible Debt, Fair Value Disclosures
Pension and Other Postretirement Plans, Policy [Policy Text Block]
Pension and Other Postretirement Plans, Policy [Policy Text Block]
Schedule of Related Party Transactions, by Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Related Party Transactions, by Related Party [Axis]
Related Party [Axis]
Related Party [Domain]
Related Party [Domain]
Shares sold to CEO [Member]
Shares sold to CEO [Member]
Shares issued to CEO [Member]
Shares sold to Armen Partners [Member]
Shares sold to Armen Partners [Member]
Shares sold to Armen Partners [Member]
Options awarded to director for services [Member]
Options awarded to director for services [Member]
Options awarded to director for services [Member]
Class of Warrant or Right [Axis]
Vesting [Axis]
Vesting [Axis]
Vesting [Domain]
Vesting [Domain]
Monthly Installment [Member]
Monthly Installment [Member]
Monthly Equal Installment [Member]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Award Type [Axis]
Award Type [Axis]
Equity Award [Domain]
Equity Award [Domain]
Restricted Stock [Member]
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Nonvested shares outstanding, beginning balance
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Nonvested shares granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Nonvested shares vested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Nonvested shares forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Nonvested shares outstanding, ending balance
Nonvested shares outstanding, weighted average grant date fair value, beginning balance
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Nonvested shares granted, weighted average grant date fair value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Nonvested shares vested, weighted average grant date fair value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Nonvested shares outstanding, weighted average grant date fair value, ending balance
Nonvested shares forfeited in Period, Weighted Average Grant Date Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Equity
Stockholders' Equity Note Disclosure [Text Block]
Business, Liquidity And Basis Of Presentation
Business Liquidity And Basis Of Presentation [Text Block]
Business Liquidity And Basis Of Presentation [Text Block]
Unrecognized tax benefits [Abstract]
Unrecognized tax benefits [Abstract]
Reconciliation of Unrecognized Tax Benefits [Roll Forward]
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Unrecognized Tax Benefits
Unrecognized Tax Benefits
Unrecognized Tax Benefits, Increases Resulting from Current Period Tax Positions
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Unrecognized Tax Benefits, Increases Resulting from Prior Period Tax Positions
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Unrecognized Tax Benefits
License, Research, and Other Agreements
Long-term Contracts or Programs Disclosure [Text Block]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule Of Stock Option Activity
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
Schedule Of Nonvested Shares
Schedule of Nonvested Share Activity [Table Text Block]
Accrued Liabilities Disclosure [Text Block]
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Other Current Liabilities
Dividends on series A convertible preferred stock, per share
Subsequent Events [Abstract]
Subsequent Events
Subsequent Events [Text Block]
Statement of Cash Flows [Abstract]
Cash flows from operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Depreciation and amortization
Depreciation, Depletion and Amortization, Nonproduction
Share-based compensation
Share-based Compensation
Non-cash interest expense
Other Noncash Expense
Loss on extinguishment of debt
Gain on Sale of Investments
Gain on Sale of Investments
Change in fair value of derivative liability
Change in fair value of derivative liability
This is the P&L impact of recording our derivative liability at fair value on the balance sheet date.
Loss on disposal of assets
Gain (Loss) on Disposition of Property Plant Equipment
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Inventories
Increase (Decrease) in Inventories
Prepaid expenses
Increase (Decrease) in Prepaid Expense
Accounts payable
Increase (Decrease) in Accounts Payable
Deferred revenue
Increase (Decrease) in Deferred Revenue
Accrued liabilities and other current liabilities
Increase (Decrease) in Other Accounts Payable and Accrued Liabilities
Other operating assets and liabilities
Increase (Decrease) in Other Operating Assets and Liabilities, Net
Net cash (used in) provided by operating activities
Net Cash Provided by (Used in) Operating Activities
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Proceeds from maturities of available-for-sale securities
Proceeds from Maturities, Prepayments and Calls of Available-for-sale Securities
Purchases of available-for-sale securities
Payments to Acquire Available-for-sale Securities
Proceeds from sale of equipment
Proceeds from Sale of Property, Plant, and Equipment
Proceeds from Sale of Other Investments
Proceeds from Sale of Other Investments
Purchases of plant and equipment
Payments to Acquire Property, Plant, and Equipment
Net cash used in investing activities
Net Cash Provided by (Used in) Investing Activities
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Net proceeds from sales of equity
Proceeds from Issuance or Sale of Equity
Proceeds from employee stock purchases
Proceeds from Issuance of Shares under Incentive and Share-based Compensation Plans, Including Stock Options
Financing of property and equipment
Financing of property and equipment
Financing of property and equipment
Payments of series A convertible preferred stock dividends
Payments of Ordinary Dividends, Preferred Stock and Preference Stock
Payments of long-term debt
Proceeds from (Repayments of) Notes Payable
Debt Issuance Cost
Debt Issuance Cost
Proceeds from Issuance of Debt
Proceeds from Issuance of Debt
Repayments of Convertible Debt
Repayments of Convertible Debt
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Net increase (decrease) in cash and cash equivalents
Cash and Cash Equivalents, Period Increase (Decrease)
Cash and cash equivalents, beginning of year
Cash and cash equivalents, end of year
Supplemental cash flow information:
Supplemental Cash Flow Information [Abstract]
Cash paid for interest
Interest Paid
Non-cash investing and financing activities:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Issuance of senior secured convertible notes as payment in-kind for interest
Issuance of senior secured convertible notes as payment in-kind for interest
Issuance of senior secured convertible notes as payment in-kind for interest
Convertible note adjustment to equity for conversion option
Convertible Note Adjustment To Equity For Conversion Option
Convertible Note Adjustment To Equity For Conversion Option
Reclassification of derivative liability into equity
Reclassification Of Derivative Liability Into Equity
Reclassification Of Derivative Liability Into Equity
Long-term debt—equipment financing
Notes Assumed
Issuance of common stock, $0.01 par value, as payment of long-term debt including accrued and unpaid interest
Stock Issued During Period, Value, Other
Stock Issued During Period, Value, Stock Dividend
Stock Issued During Period, Value, Stock Dividend
Conversion Of Notes Payable To Future Royalties
Conversion Of Notes Payable To Future Royalties
Conversion of notes payable to future royalties.
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Antidilutive Securities Excluded from Computation of Earnings Per Share, by Antidilutive Securities [Axis]
Antidilutive Securities [Axis]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name [Domain]
Warrants [Member]
Warrant [Member]
Stock Options [Member]
Employee Stock Option [Member]
Nonvested shares [Member]
Convertible Preferred Stock [Member]
Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Schedule of Operating Leased Assets [Table]
Schedule of Operating Leased Assets [Table]
Parties to Contractual Arrangement [Axis]
Parties to Contractual Arrangement [Axis]
Parties to Contractual Arrangement [Domain]
Parties to Contractual Arrangement [Domain]
Operating Leased Assets [Line Items]
Operating Leased Assets [Line Items]
Rental Income, Nonoperating
Rental Income, Nonoperating
Operating Leases, Future Minimum Payments Due, Current
Operating Leases, Future Minimum Payments Due, Next Twelve Months
Operating Leases, Future Minimum Payments, Due in Two Years
Operating Leases, Future Minimum Payments, Due in Two Years
Operating Leases, Future Minimum Payments, Due in Three Years
Operating Leases, Future Minimum Payments, Due in Three Years
Operating Leases, Future Minimum Payments, Due in Four Years
Operating Leases, Future Minimum Payments, Due in Four Years
Operating Leases, Future Minimum Payments, Due in Five Years
Operating Leases, Future Minimum Payments, Due in Five Years
Operating Leases, Future Minimum Payments, Due Thereafter
Operating Leases, Future Minimum Payments, Due Thereafter
Operating Leases, Future Minimum Payments Due
Operating Leases, Future Minimum Payments Due
QS-21 Stimulon revenue [Member]
QS-21 Stimulon revenue [Member]
QS-21 Stimulon revenue [Member]
HerpV revenue [Member]
HerpV revenue [Member]
HerpV revenu [Member]
Debt Instrument, Redemption, Period [Axis]
Debt Instrument, Redemption, Period [Axis]
Debt Instrument, Redemption, Period [Domain]
Debt Instrument, Redemption, Period [Domain]
Retained Earnings [Member]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Axis]
Long-term Debt, Type [Domain]
Long-term Debt, Type [Domain]
Notes [Member]
Notes [Member]
Notes [Member]
Senior Convertible Notes [Member]
Senior Convertible Notes [Member]
Senior Convertible Notes [Member]
Amendment [Member]
Amendment [Member]
Ninth Amendment of Rights Agreement to the 2006 Notes [Member]
Aquila Debentures [Member]
Aquila Debentures [Member]
Aquila Debentures [Member]
Equipment Purchase Financing Agreement 2011 [Member]
Equipment Purchase Financing Agreement 2011 [Member]
Equipment Purchase Financing Agreement 2011 [Member]
Stock Issued During Period, Value, Other
Percent of revenue due under Revenue Interest Agreement
Percent of revenue due under Revenue Interest Agreement
Percent of revenue due under Revenue Interest Agreement
Debt Instrument, Debt Default, Cross Default Threshold Amount
Debt Instrument, Debt Default, Cross Default Threshold Amount
Debt Instrument, Debt Default, Cross Default Threshold Amount
Debt Instrument, Debt Default, Additional Increase in Percentage Rate
Debt Instrument, Debt Default, Additional Increase in Percentage Rate
Debt Instrument, Debt Default, Additional Increase in Percentage Rate
Debt Instrument, Prepayment Premium
Debt Instrument, Prepayment Premium
Debt Instrument, Prepayment Premium
Debt Instrument, Face Amount
Debt Instrument, Face Amount
Debt Instrument, Waiver of Right to Prepay, Trading Threshold, Stock Price Trigger
Debt Instrument, Waiver of Right to Prepay, Trading Threshold, Stock Price Trigger
Debt Instrument, Waiver of Right to Prepay, Trading Threshold, Stock Price Trigger
Debt Instrument, Redemtpion, Threshold Trading Days
Debt Instrument, Redemtpion, Threshold Trading Days
Period of which shares trade at a weighted average price over a certain threshold that would trigger a waiver to the right of repaying notes.
New Accounting Pronouncement or Change in Accounting Principle, Cumulative Effect of Change on Equity or Net Assets
New Accounting Pronouncement or Change in Accounting Principle, Cumulative Effect of Change on Equity or Net Assets
New Accounting Pronouncement or Change in Accounting Principle, Cumulative Effect of Change on Debt Discount
New Accounting Pronouncement or Change in Accounting Principle, Cumulative Effect of Change on Debt Discount
New Accounting Pronouncement or Change in Accounting Principle, Cumulative Effect of Change on Debt Discount
New Accounting Pronouncement or Change in Accounting Principle, Cumulative Effect of Change on Derivative Liability
New Accounting Pronouncement or Change in Accounting Principle, Cumulative Effect of Change on Derivative Liability
New Accounting Pronouncement or Change in Accounting Principle, Cumulative Effect of Change on Derivative Liability
Debt Instrument, Unamortized Discount
Debt Instrument, Unamortized Discount
Effect on Additional Paid-In Capital due to Note Amendment
Long-term Debt, Fair Value
Long-term Debt, Fair Value
Debt Instrument, Convertible, Beneficial Conversion Feature
Debt Instrument, Convertible, Beneficial Conversion Feature
Debt Instrument, Interest Rate, Stated Percentage
Debt Instrument, Debt Default, Other Indebtness Default Threshold Amount
Debt Instrument, Debt Default, Other Indebtness Default Threshold Amount
Debt Instrument, Debt Default, Other Indebtness Default Threshold Amount
Debt Instrument, Debt Default, Legal Judgement Not Covered By Insurance Threshold Amount
Debt Instrument, Debt Default, Legal Judgement Not Covered By Insurance Threshold Amount
Debt Instrument, Debt Default, Legal Judgement Not Covered By Insurance Threshold Amount
Debt Instrument, Convertible, Remaining Discount Amortization Period
Debt Instrument, Convertible, Remaining Discount Amortization Period
Debt Instrument, Interest Rate, Effective Percentage
Debt Instrument, Interest Rate, Effective Percentage
Income Statement [Abstract]
Name of Property [Axis]
Name of Property [Axis]
Information by name of property.
Name of Property [Domain]
Name of Property [Domain]
[Domain] for Information by name of property.
Lexington, MA [Member]
Lexington, MA [Member]
Lexington, MA [Member]
New York, NY [Member]
New York, NY [Member]
New York, NY [Member]
Operating Leases, Rent Expense
Operating Leases, Rent Expense
Letters of Credit Outstanding, Amount
Letters of Credit Outstanding, Amount
Security Deposit
Security Deposit
Square Footage of Real Estate Property
Area of Real Estate Property
Title of Individual [Axis]
Employees and directors [Member]
Employees and directors [Member]
Employees and directors [Member]
Outside Advisors [Member]
Outside Advisors [Member]
Outside Advisors [Member]
Plan Name [Axis]
Plan Name [Axis]
Plan Name [Domain]
Plan Name [Domain]
2009 EIP [Member]
2009 EIP [Member]
2009 EIP [Member]
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized
Deferred Compensation Arrangement with Individual, Maximum Contractual Term
Deferred Compensation Arrangement with Individual, Maximum Contractual Term
Options outstanding, beginning balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Options granted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures
Options exercised
Options forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Options expired
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period
Options outstanding, ending balance
Options vested or expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Options exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number
Options outstanding, weighted average exercise price, beginning balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Options granted, weighted average exercise price
Options exercised, weighted average exercise price
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Options forfeited, weighted average exercise price
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Options expired, weighted average exercise price
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Options outstanding, weighted average exercise price, ending balance
Options vested or expected to vest, weighted average exercise price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Options exercisable, weighted average exercise price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price
Options outstanding, weighted average remaining contractual term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Options vested or expected to vest, weighted average remaining contractual term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term
Options exercisable, weighted average remaining contractual term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Options outstanding, aggregate intrinsic value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Options vested or expected to vest, aggregate intrinsic value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Options exercisable, aggregate intrinsic value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Total Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Schedule of Deferred Compensation Arrangement with Individual, Share-based Payments [Table]
Schedule of Deferred Compensation Arrangement with Individual, Share-based Payments [Table]
1999 EIP [Member]
1999 EIP [Member]
1999 EIP [Member]
2009 ESPP [Member]
2009 ESPP [Member]
2009 ESPP [Member]
Director deferred compensation plan [Member]
Director deferred compensation plan [Member]
Director deferred compensation plan [Member]
Performance awards [Member]
Performance awards [Member]
Performance awards [Member]
Share-based Goods and Nonemployee Services Transaction, by Supplier [Axis]
Supplier [Axis]
Share-based Goods and Nonemployee Services Transaction, Supplier [Domain]
Share-based Goods and Nonemployee Services Transaction, Supplier [Domain]
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Share-Based compensation award by Share-based payment award, purchase price as percent of fair value
Share-Based compensation award by Share-based payment award, purchase price as percent of fair value
Share-Based compensation award by Share-based payment award, purchase price as percent of fair value
Maximum number of shares allowed to be purchased by employees
Maximum number of shares allowed to be purchased by employees
Maximum number of shares allowed to be purchased by employees in any offereing period of teh 2009 ESPP.
Employee stock purchase threshold as a percentage of the total combined voting power of the Company
Employee stock purchase threshold as a percentage of the total combined voting power of the Company
Employee stock purchase threshold as a percentage of the total combined voting power of the Company
Vesting period, minimum
Weighted average grant-date fair value of options granted
Unrecognized compensation cost
Unrecognized compensation cost, weighted average period
Instrinsic value of shares vested
Share-based Compensation Arrangement By Share-based Payment Award Options Vested During Period Intrinsic Value
Share-based Compensation Arrangement By Share-based Payment Award Options Vested During Period Intrinsic Value
Proceeds from Stock Plans
Proceeds from Stock Plans
Shares issued under ESPP
Shares issued under Director Deferred Compensation Plan
Deferred Compensation Arrangement with Individual, Shares Issued
Shares credited under Director Deferred Compensation Plan
Deferred compensation arrangement, shares credited
Deferred compensation arrangement, shares credited to directors accounts.
Weighted average stock price of shares credited under Director Deferred Compensation Plan
Weighted average stock price of shares credited under Director Deferred Compensation Plan
Weighted average stock price of shares credited under Director Deferred Compensation Plan
Shares issued from exercise of options
Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures
Furniture, fixtures and other [Member]
Furniture and Fixtures [Member]
Laboratory and manufacturing equipment [Member]
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Software and computer equipment [Member]
Computer Equipment [Member]
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Useful Life, Minimum
Plant and equipment, accumulated amortization and depreciation
Property, Plant and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Property, Plant and Equipment [Table Text Block]
Subsequent Event [Table]
Subsequent Event [Table]
Subsequent Event [Member]
Subsequent Event [Member]
4-antibody acquisition [Member]
4-antibody acquisition [Member]
4-antibody acquisition [Member]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Stock Issued During Period, Value, Acquisitions
Stock Issued During Period, Value, Acquisitions
Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High
Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Long-term Debt
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Noncurrent Liabilities, Long-term Debt
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Noncurrent Liabilities, Long-term Debt
Proceeds from Issuance of Common Stock
Treasury Stock, Shares, Retired
Treasury Stock, Shares, Retired
Fair Value Measurements
Fair Value Disclosures [Text Block]
Basis of Presentation and Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Segment Information
Segment Reporting, Policy [Policy Text Block]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Investments
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Concentration Risk Disclosure [Text Block]
Concentration Risk Disclosure [Text Block]
Inventories
Inventory, Policy [Policy Text Block]
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Revenue Recognition
Revenue Recognition, Policy [Policy Text Block]
Foreign Currency Transactions
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Research and Development
Research and Development Expense, Policy [Policy Text Block]
Share-based Compensation
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]
Income Taxes
Income Tax, Policy [Policy Text Block]
Earnings Per Share [Text Block]
Earnings Per Share [Text Block]
Goodwill
Goodwill and Intangible Assets, Goodwill, Policy [Policy Text Block]
Accounting for Asset Retirement Obligations
Asset Retirement Obligations, Policy [Policy Text Block]
Long-lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Description of New Accounting Pronouncements Not yet Adopted [Text Block]
Description of New Accounting Pronouncements Not yet Adopted [Text Block]
Contingencies Disclosure [Abstract]
Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies Disclosure [Text Block]