Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024
Cash flows from operating activities:
Net loss	$ (56,382)	$ (118,251)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	6,371	6,737
Share-based compensation	7,067	8,185
Non-cash royalty revenue	(48,387)	(50,349)
Non-cash interest expense	25,681	61,263
Loss on disposal of assets, net	929	9
Gain on lease terminations	0	(5,475)
Other, net	255	1,056
Changes in operating assets and liabilities:
Accounts receivable	(232)	25,121
Prepaid expenses	980	5,890
Accounts payable	12,706	(8,718)
Deferred revenue	1	(9)
Accrued liabilities and other current liabilities	4,230	(386)
Other operating assets and liabilities	941	(1,444)
Net cash used in operating activities	(45,840)	(76,371)
Cash flows from investing activities:
Purchases of plant and equipment	(6)	(496)
Proceeds from sale of plant and equipment	282	0
Proceeds from sale of long-term investment	62	488
Net cash provided by investing activities	338	(8)
Cash flows from financing activities:
Net proceeds from sale of equity	18,560	19,161
Net proceeds from sale of subsidiary shares in private placement	0	5,800
Proceeds from Ligand Purchase Agreement, net of expenses	0	73,851
Proceeds from employee stock purchases and option exercises	44	207
Proceeds from the issuance of long-term debt, net	2,500	0
Purchase of treasury shares to satisfy tax withholdings	(87)	0
Payment of long-term debt	(2,500)	0
Payment of finance lease obligation	(3,981)	(5,106)
Net cash provided by financing activities	14,536	93,913
Effect of exchange rate changes on cash	63	44
Net decrease in cash, cash equivalents and restricted cash	(30,903)	17,578
Cash, cash equivalents and restricted cash, beginning of period	44,071	79,779
Cash, cash equivalents and restricted cash, end of period	13,168	97,357
Supplemental cash flow information:
Cash paid for interest	645	1,193
Supplemental disclosures - non-cash activities:
Insurance financing agreement	552	612
Issuance of stock options for payment of certain employee bonuses	0	4,966
Lease right-of-use assets obtained in exchange for new operating lease liabilities	107	105
Lease right-of-use assets obtained in exchange for new finance lease liabilities	0	122
Employee Bonus [Member]
Supplemental disclosures - non-cash activities:
Issuance of subsidiary stock options for payment of certain employee bonuses	$ 0	$ 540