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Leasehold Improvements and Equipment (Tables)
3 Months Ended
Mar. 31, 2019
Schedule of Leasehold Improvements and Equipment [Table Text Block]
                  March 31,     December 31,  
                  2019     2018  
            Accumulated     Net Carrying     Net Carrying  
      Cost     Depreciation     Amount     Amount  
                           
  Manufacturing equipment $  4,203   $  653   $  3,550   $  3,512  
  Laboratory and office equipment   1,313     755     558     562  
  Computer equipment   109     72     37     39  
  Leasehold improvements   3,134     1,000     2,134     2,135  
                           
    $  8,759   $  2,480   $  6,279   $  6,248