<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-03-15</periodOfReport>

    <issuer>
        <issuerCik>0001430723</issuerCik>
        <issuerName>ServisFirst Bancshares, Inc.</issuerName>
        <issuerTradingSymbol>[N/A]</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001097672</rptOwnerCik>
            <rptOwnerName>FILLER JAMES J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2964 SHOOKHILL PKWY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BIRMINGHAM</rptOwnerCity>
            <rptOwnerState>AL</rptOwnerState>
            <rptOwnerZipCode>35223</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>ServisFirst Cap. Trust II Convertible Preferred Securities</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>25.00</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2010-03-15</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>600</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1000</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2013-03-15</value>
                <footnoteId id="F3"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>24000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>600</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The ServisFirst Cap. Trust II Convertible Preferred Securities were issued by ServisFirst Capital Trust II, all of the common securities of which are owned by ServisFirst Bancshares, Inc. (&quot;ServisFirst&quot;).</footnote>
        <footnote id="F2">The ServisFirst Cap. Trust II Convertible Preferred Securities are convertible, in whole or in part, at any time prior to the earliest to occur of maturity, issuer redemption or mandatory conversion, at the option of the holder, into ServisFirst Common Stock at a conversion price of $25 per share.</footnote>
        <footnote id="F3">The ServisFirst Cap. Trust II Convertible Preferred Securities not previously redeemed or converted into Common Stock of ServisFirst will automatically and mandatorily convert into ServisFirst Common Stock on March 15, 2013 at a conversion price of $25 per share.</footnote>
        <footnote id="F4">The ServisFirst Cap. Trust II Convertible Preferred Securities are held jointly with spouse.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Matthew T. Franklin, Attorney-in-Fact</signatureName>
        <signatureDate>2010-03-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
