X0306 4 2022-05-18 0 0001097149 ALIGN TECHNOLOGY INC ALGN 0001188901 SANTORA GREG J C/O ALIGN TECHNOLOGY INC. 410 NO. SCOTTSDALE RD., SUITE 1300 TEMPE AZ 85281 1 0 0 0 Common Stock 2022-05-18 4 M 0 524 0.00 A 10873 I See Footnote Restricted Stock Units 0.0001 2022-05-18 4 M 0 524 0.00 D Common Stock 524 0 D Restricted Stock Units 0.0001 2022-05-18 4 A 0 1114 0.00 A Common Stock 1114 1114 D The shares are held directly by a family trust for which the reporting person is a co-trustee. Represents par value of ALGN common stock. 100% of the restricted stock unit granted on May 19, 2021 became vested on May 18, 2022 and shares were delivered to reporting person. 100% of the restricted stock unit granted on May 18, 2022 will become vested on the earlier of (i) May 18, 2023 or (i) the date of the 2023 annual meeting of stockholders. Shares will be delivered to reporting person on the vest date. /s/ Julie Ann Coletti Attorney-in-Fact for Greg J Santora 2022-05-19