Balance Sheet Components - Property and Equipment (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 1,681,581	$ 1,441,027
Less: Accumulated depreciation and impairment charges	(449,726)	(359,101)
Total property, plant and equipment, net	1,231,855	1,081,926
Depreciation	109,800	92,100	$ 80,100
Clinical and manufacturing equipment
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 583,776	452,876
Building
Property, Plant and Equipment [Line Items]
Estimated useful life	20 years
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 466,003	310,344
Leasehold improvements
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 64,238	61,289
Computer software and hardware
Property, Plant and Equipment [Line Items]
Estimated useful life	3 years
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 120,544	117,986
Land
Property, Plant and Equipment, Net [Abstract]
Property and equipment	58,885	58,869
Furniture, fixtures and other
Property, Plant and Equipment, Net [Abstract]
Property and equipment	102,933	71,977
Construction in progress
Property, Plant and Equipment, Net [Abstract]
Property and equipment	$ 285,202	$ 367,686
Maximum | Clinical and manufacturing equipment
Property, Plant and Equipment [Line Items]
Estimated useful life	10 years
Maximum | Furniture, fixtures and other
Property, Plant and Equipment [Line Items]
Estimated useful life	5 years
Minimum | Furniture, fixtures and other
Property, Plant and Equipment [Line Items]
Estimated useful life	2 years