<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2007-03-27</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001097136</issuerCik>
        <issuerName>SENORX INC</issuerName>
        <issuerTradingSymbol>SENO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001036288</rptOwnerCik>
            <rptOwnerName>HILLMAN CO</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>330 GRANT ST</rptOwnerStreet1>
            <rptOwnerStreet2>1900 GRANT BUILDING</rptOwnerStreet2>
            <rptOwnerCity>PITTSBURGH</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>15219</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Series A Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1250000</value>
                    <footnoteId id="F1"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Medicus Venture Partners X, a California Limited Partnership</value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F4"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>640680</value>
                    <footnoteId id="F4"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F3"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Medicus Venture Partners X, a California Limited Partnership</value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The reported securities are convertible at any time at the option of the registered holder and each share of Preferred Stock will automatically convert into 0.28571429 shares of Common Stock immediately prior to the closing of the Issuer's initial public offering, estimated to be on or about April 3, 2007.</footnote>
        <footnote id="F2">Not applicable.</footnote>
        <footnote id="F3">Henry L. Hillman, Elsie Hilliard Hillman and C. G. Grefenstette, Trustees of the Henry L. Hillman Trust dated November 18, 1985 (the &quot;HLH Trustees&quot;) is a revocable trust of which Henry L. Hillman is settlor and beneficiary.  The HLH Trustees own a majority of the voting stock of The Hillman Company, a Pennsylvania corporation.  A wholly-owned, indirect subsidiary of The Hillman Company is the general partner of Hillman/Chesapeake Limited Partnership, a Delaware limited partnership which is a general partner of Medicus Venture Partners X, a California Limited Partnership.  The HLH Trustees disclaim beneficial ownership of these securities except to the extent of their pecuniary interest therein.</footnote>
        <footnote id="F4">The reported securities are convertible at any time at the option of the registered holder and each share of Preferred Stock will automatically convert into 0.32615787 shares of Common Stock immediately prior to the closing of the Issuer's initial public offering, estimated to be on or about April 3, 2007.</footnote>
    </footnotes>

    <remarks>The Date of Event is based upon the date of effectiveness of the Issuer's Registration Statement on Form S-1 filed in connection with the Issuer's initial public offering, estimated to be on or about March 28, 2007.</remarks>

    <ownerSignature>
        <signatureName>C. G. Grefenstette, Trustee</signatureName>
        <signatureDate>2007-03-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
