X0101 EFFECT 33 LIVE 2007-07-03 0000891092-07-002724 485APOS 0001097077 BLACKROCK LARGE CAP SERIES FUNDS, INC. 333-89389 S000018858 BlackRock Large Cap Growth Retirement Portfolio C000052206 Class K S000018859 BlackRock Large Cap Value Retirement Portfolio C000052207 Class K S000018860 BlackRock Large Cap Core Retirement Portfolio C000052208 Class K