X0304 4 2011-08-31 0 0000109657 OXIS INTERNATIONAL INC OXIS.OB 0001375530 Saloff David 1 1 0 0 Chief Executive Officer Common Stock Option 0.0535 2011-08-31 4 A 0 538713 0.0535 A 2021-08-31 Common Stock 538713 1316491 D David Saloff received a non-qualified stock option to purchase 538,713 shares of Common Stock under the Issuer's 2010 Equity Incentive Plan, in connection with his appointment as Chief Executive Officer of the Company. The options vest and become exercisable in equal quarterly installments during the one-year period following the date of grant. The options have a term of 10 years from the date of grant. /s/ David Saloff 2011-09-01