Exhibit 1

Agreement of Joint Filing

Pursuant to 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, the undersigned persons hereby agree to file with the Securities and Exchange Commission the Statement on Schedule 13D/A (the “Statement”) to which this Agreement is attached as an exhibit, and agree that such Statement, as so filed, is filed on behalf of each of them.

IN WITNESS WHEREOF, the undersigned have executed this Agreement.

QVT FINANCIAL LP
By QVT Financial GP LLC,
its General Partner
By:	/s/ Daniel Gold
Name:	Daniel Gold
Title:	Managing Member
By:	/s/ Nicholas Brumm
Name:	Nicholas Brumm
Title:	Managing Member
QVT FINANCIAL GP LLC
By:	/s/ Daniel Gold
Name:	Daniel Gold
Title:	Managing Member
By:	/s/ Nicholas Brumm
Name:	Nicholas Brumm
Title:	Managing Member

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Appendix A

Covered Persons

Name of Covered Person	Principal Business Address	Principal Occupation
Daniel Gold	QVT Financial LP 527 Madison Avenue, 8th Floor New York, New York 10022	Investment Management
Lars Bader	QVT Financial LP 527 Madison Avenue, 8th Floor New York, New York 10022	Investment Management
Nicholas Brumm	QVT Financial LP 527 Madison Avenue, 8th Floor New York, New York 10022	Investment Management
Tracy Fu	QVT Financial LP 527 Madison Avenue, 8th Floor New York, New York 10022	Investment Management

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