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Income Taxes - Reconciliation to the Federal Statutory Rate (Details)
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Income Tax Disclosure [Abstract]      
Tax Benefit at Federal statutory rate 34.00% 34.00% 34.00%
State, net of Federal benefit 0.90% (0.10%) 3.60%
Stock compensation 0.00% 0.30% (3.50%)
Research and development credit 0.00% 6.50% 6.90%
Return to Provision and True-ups 0.00% (2.80%) 3.80%
Change in valuation allowance (35.90%) (12.70%) (44.60%)
Other 1.30% (0.40%) (2.50%)
Benefit (Provision) for taxes 0.30% 24.80% (2.30%)