Entity Central Index Key Amount of lessee's undiscounted obligation for lease payments for operating lease, due after fourth fiscal year following latest fiscal year. Cover [Abstract] Entity Registrant Name Entity Registrant Name Entity Central Index Key Trading Symbol Trading Symbol Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well Known Seasoned Issuer Entity Voluntary Filers Entity Voluntary Filers Entity Interactive Data Current Entity Interactive Data Current Entity Current Reporting Status Entity Current Reporting Status Entity Filer Category Entity Filer Category Entity Public Float Entity Public Float Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Entity Shell Company Entity Shell Company Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company ICFR Auditor Attestation Flag Icfr Auditor Attestation Flag Title of 12(b) Security Security12b Title Security Exchange Name Security Exchange Name Entity File Number Entity File Number Entity Incorporation, State or Country Code Entity Incorporation State Country Code Entity Tax Identification Number Entity Tax Identification Number Entity Address, Address Line One Entity Address Address Line1 Entity Address, Address Line Two Entity Address Address Line2 Entity Address, City or Town Entity Address City Or Town Entity Address, State or Province Entity Address State Or Province Entity Address, Postal Zip Code Entity Address Postal Zip Code City Area Code City Area Code Local Phone Number Local Phone Number Document Annual Report Document Annual Report Document Transition Report Document Transition Report Auditor Firm ID Auditor Firm Id Auditor Name Auditor Name Auditor Location Auditor Location Documents Incorporated by Reference Documents Incorporated By Reference [Text Block] Statement Of Financial Position [Abstract] Assets Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Other current assets Other Assets Current Total current assets Assets Current Property and equipment, net Property Plant And Equipment Net Operating lease right-use-of assets Operating Lease Right Of Use Asset Goodwill Goodwill Intangible assets, net Other Intangible Assets Net Other assets Other Assets Noncurrent Total assets Assets Liabilities and Stockholders’ Equity Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable and accrued expenses Accounts Payable And Accrued Liabilities Current Operating lease liability Operating Lease Liability Current Term loan obligation, current Long Term Debt Current Total current liabilities Liabilities Current Noncurrent operating lease liability Operating Lease Liability Noncurrent Term loan obligation Long Term Debt Noncurrent Warrant liability Warrants And Rights Outstanding Total liabilities Liabilities Commitments and contingencies (Note 7) Commitments And Contingencies Stockholders’ equity: Stockholders Equity [Abstract] Preferred stock, $0.001 par value; 5,000,000 shares authorized; 1,952 and 1,954 shares issued and outstanding in 2021 and 2020, respectively Preferred Stock Value Common stock, $0.001 par value; 100,000,000 shares authorized; 15,510,025 and 6,749,028 shares issued and outstanding in 2021 and 2020, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders’ equity Stockholders Equity Total liabilities and stockholders’ equity Liabilities And Stockholders Equity Preferred stock, par value (in dollars per share) Preferred Stock Par Or Stated Value Per Share Preferred stock, shares authorized (in shares) Preferred Stock Shares Authorized Preferred stock, shares issued (in shares) Preferred Stock Shares Issued Preferred stock, shares outstanding (in shares) Preferred Stock Shares Outstanding Common stock, par value (in dollars per share) Common Stock Par Or Stated Value Per Share Common stock, shares authorized (in shares) Common Stock Shares Authorized Common stock, shares issued (in shares) Common Stock Shares Issued Common stock, shares outstanding (in shares) Common Stock Shares Outstanding Revenue earned during the period from non-product related activities and revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in government contract and other agreements. Aggregate revenue earned during the period from recognition of related party deferred revenue, non-product related activities and revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements. Development revenues abstract. Income Statement [Abstract] Development revenue: Development Revenues [Abstract] Government contracts and other Government Contracts And Other Total development revenues Development Revenues Operating expenses: Operating Expenses [Abstract] Research and development Research And Development Expense Excluding Acquired In Process Cost In process research and development acquired Research And Development In Process General and administrative General And Administrative Expense Loss on disposal of property and equipment Gain Loss On Disposition Of Assets Total operating expenses Operating Expenses Operating loss Operating Income Loss Other income (expense): Other Income And Expenses [Abstract] Interest income Investment Income Interest Interest expense Interest Expense Change in fair value of liability instruments Liabilities Fair Value Adjustment Total other expense Nonoperating Income Expense Net loss Net Income Loss Net loss per share, basic and diluted Earnings Per Share Basic And Diluted Basic and diluted weighted average shares used in calculating net loss per share attributable to common stockholders Weighted Average Number Of Share Outstanding Basic And Diluted Issuance of common stock, net of offering costs, shares. Stock issued during period shares warrants exercise. Stock issued during period shares warrants exercise(shares). Reclassification of warrants from derivative liabilities to additional paid in capital. Statement Of Stockholders Equity [Abstract] Statement [Table] Statement [Table] Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Convertible Preferred Stock [Member] Preferred Stock [Member] Common Stock [Member] Common Stock [Member] Additional Paid-in Capital [Member] Additional Paid In Capital [Member] Accumulated Deficit [Member] Retained Earnings [Member] Statement [Line Items] Statement [Line Items] Balance Balance (in shares) Shares Outstanding Share-based compensation Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Issuance of common stock, net of offering costs Stock Issued During Period Value New Issues Issuance of common stock, net of offering costs (share) Issuance Of Common Stock Net Of Offering Costs Shares Issuance of common stock, net of offering costs (share) Stock Issued During Period Shares New Issues Issuance of common stock for exercise of warrants Stock Issued During Period Shares Warrants Exercise Issuance of common stock for exercise of warrants (in shares) Stock Issued During Period Shares Warrants Exercise Shares Reclassification of warrant liabilities Reclassification Of Warrants From Derivative Liabilities To Additional Paid In Capital Issuance of common stock for in process research and development acquired from NanoTx Therapeutics Stock Issued During Period Value Acquisitions Issuance of common stock for in process research and development acquired (in share) Stock Issued During Period Shares Acquisitions Conversion of convertible preferred stock into common stock Stock Issued During Period Value Conversion Of Convertible Securities Conversion of convertible preferred stock into common stock (share) Stock Issued During Period Shares Conversion Of Convertible Securities Net loss Balance Balance (in shares) Amount of Issuance of net of offering cost. Offering costs,net Issuance Of Net Of Offering Cost Non cash lease expense. Payments to acquire property plant and equipment and intangible assets. Proceeds from warrant exercises. Unpaid Offering Costs. Common stock issued in payment for in process research and development. Reclassifications of warrants upon exercise from liability to equity. Statement Of Cash Flows [Abstract] Cash flows used in operating activities: Net Cash Provided By Used In Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation and amortization Depreciation Depletion And Amortization Amortization of deferred financing costs and debt discount Amortization Of Financing Costs And Discounts Change in fair value of liability instruments Fair Value Adjustment Of Warrants Share-based compensation expense Share Based Compensation Inventory write off Inventory Write Down Non-cash lease expense Non Cash Lease Expense Increases (decreases) in cash caused by changes in operating assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable Increase Decrease In Accounts Receivable Other current assets Increase Decrease In Other Current Assets Other assets Increase Decrease In Other Noncurrent Assets Accounts payable and accrued expenses Increase Decrease In Accounts Payable And Accrued Liabilities Other long-term liabilities Increase Decrease In Other Noncurrent Liabilities Net cash used in operating activities Net Cash Provided By Used In Operating Activities Cash flows from (used in) investing activities: Net Cash Provided By Used In Investing Activities [Abstract] Purchases of property and equipment and intangible assets Payments To Acquire Property Plant And Equipment And Intangible Assets Proceeds from sale of property and equipment Proceeds From Sale Of Property Plant And Equipment In process research and development acquired from NanoTx Therapeutics Payments To Acquire Intangible Assets Net cash used in investing activities Net Cash Provided By Used In Investing Activities Cash flows from financing activities: Net Cash Provided By Used In Financing Activities [Abstract] Principal payments of long-term obligations Repayments Of Long Term Debt Payment of financing lease liability Finance Lease Principal Payments Proceeds from exercise of warrants Proceeds From Warrant Exercises1 Proceeds from sale of common stock Proceeds From Issuance Of Common Stock Net cash provided by (used in) financing activities Net Cash Provided By Used In Financing Activities Net increase (decrease) in cash and cash equivalents Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect Cash and cash equivalents at beginning of period Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations Cash and cash equivalents at end of period Supplemental disclosure of cash flows information: Supplemental Cash Flow Information [Abstract] Cash paid during period for: Cash Paid During Period For [Abstract] Interest Interest Paid Net Supplemental schedule of non-cash investing and financing activities: Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract] Unpaid offering cost Unpaid Offering Costs Issuance costs paid in common stock Payments Of Stock Issuance Costs Common stock issued in payment for in process research and development Common Stock Issued In Payment For In Process Research And Development Reclassification of warrants liability to equity Reclassifications Of Warrants Upon Exercise From Liability To Equity Organization Consolidation And Presentation Of Financial Statements [Abstract] Organization and Operations Organization Consolidation And Presentation Of Financial Statements Disclosure [Text Block] Accounting Policies [Abstract] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Fair Value Disclosures [Abstract] Fair Value Measurements Fair Value Measurement Inputs Disclosure [Text Block] Earnings Per Share [Abstract] Loss per Share Earnings Per Share [Text Block] Composition of Certain Financial Statement Captions [Abstract] Composition Of Certain Financial Statement Captions [Abstract] Composition of Certain Financial Statement Captions Supplemental Balance Sheet Disclosures [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] Debt Disclosure [Abstract] Term Loan Obligations Debt Disclosure [Text Block] Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Compensation And Retirement Disclosure [Abstract] Employee Benefit Plan Compensation And Employee Benefit Plans [Text Block] Disclosure of accounting policy for license agreement. License agreement abstract. License Agreement [Abstract] License Agreement License Agreement Disclosure [Text Block] Stockholders Equity Note [Abstract] Stockholders' Equity Stockholders Equity Note Disclosure [Text Block] Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Stock-based Compensation Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Risks And Uncertainties [Abstract] COVID-19 Pandemic and CARES Act Unusual Or Infrequent Items Disclosure [Text Block] Subsequent Events [Abstract] Subsequent Events Subsequent Events [Text Block] Valuation And Qualifying Accounts [Abstract] Financial Statement Schedules Schedule Of Valuation And Qualifying Accounts Disclosure [Text Block] Use of Estimates Use Of Estimates Cash and cash equivalents Cash And Cash Equivalents Policy [Text Block] Financial Instruments Fair Value Of Financial Instruments Policy Property and Equipment Property Plant And Equipment Policy [Text Block] Impairment Property Plant And Equipment Impairment Goodwill Goodwill And Intangible Assets Policy [Text Block] Warrant Liability Standard Product Warranty Policy Revenue Recognition Revenue From Contract With Customer Policy [Text Block] Research and Development Research And Development Expense Policy Acquired In-Process Research and Development (IPR&D) In Process Research And Development Policy Deferred Financing Costs and Other Debt-Related Costs Debt Policy [Text Block] Income Taxes Income Tax Policy [Text Block] Share-Based Compensation Share Based Compensation Option And Incentive Plans Policy Segment Information Segment Reporting Policy Policy [Text Block] Loss Per Share Earnings Per Share Policy [Text Block] Concentration Risk Concentration Risk Credit Risk Recently Issued and Recently Adopted Accounting Pronouncements New Accounting Pronouncements Policy Policy [Text Block] Fair Value By Balance Sheet Grouping [Table] Fair Value By Balance Sheet Grouping [Table] Series U warrants member Series U Warrants [Member] Series U Warrants [Member] Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items] Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items] Schedule of Estimated Fair Value Determined Using Option Pricing Model Assumptions Fair Value Assets Measured On Nonrecurring Basis Valuation Techniques [Text Block] Summary of Change in Level 3 Warrant Liability Value Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Text Block] Schedule of Antidilutive Securities Excluded from Diluted Income (Loss) per Share Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Other Current Assets Schedule Of Other Current Assets Table [Text Block] Property and Equipment, net Property Plant And Equipment [Text Block] Accounts Payable and Accrued Expenses Schedule Of Accounts Payable And Accrued Liabilities Table [Text Block] Schedule of right of use assets and lease liabilities. Summary of Lease Liabilities and Right-of-Use Assets Schedule Of Right Of Use Assets And Lease Liabilities Table [Text Block] Summary of Lease Costs Lease Cost Table [Text Block] Schedule of operating and financing lease liability maturity. Summary of Future Minimum Annual Lease Payments under Operating and Financing Leases Schedule Of Operating And Financing Lease Liability Maturity Table [Text Block] Term Loan Outstanding Schedule Of Debt Instruments [Text Block] Future Payments under Obligation Contractual Obligation Fiscal Year Maturity Schedule Table [Text Block] Face Value to Book Value Reconciliation Schedule Of Debt Table [Text Block] Reconciliation of Total Income Tax Provision Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block] Deferred Tax Assets and Liabilities Schedule Of Deferred Tax Assets And Liabilities Table [Text Block] Unrecognized Tax Benefits Activity Schedule Of Unrecognized Tax Benefits Roll Forward Table [Text Block] Stock-based Compensation [Abstract] Stock Option Activity Schedule Of Share Based Compensation Activity Table [Text Block] Weighted-average Assumptions Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block] Summary of Share-Based Compensation Recognized Schedule Of Compensation Cost For Share Based Payment Arrangements Allocation Of Share Based Compensation Costs By Plan Table [Text Block] Common stock, sales, available for issuance. Refers to the period exercisable from the date of issuance. Reimbursement revenue recognized. Basis of presentation and new accounting standards line items. Basis of presentation and new accounting standards table. Basis Of Presentation And New Accounting Standards [Table] Basis Of Presentation And New Accounting Standards [Table] Subsequent Event Type Subsequent Event Type [Axis] Subsequent Event Type Subsequent Event Type [Domain] Subsequent Event [Member] Subsequent Event [Member] Sale of Stock Subsidiary Sale Of Stock [Axis] Sale of Stock Sale Of Stock Name Of Transaction [Domain] Underwriter. Underwriter [Member] Underwriter [Member] Legal Entity Legal Entity [Axis] Entity Entity [Domain] Canaccord Genuity LLC Member. Canaccord Genuity LLC [Member] Canaccord Genuity L L C [Member] Lincoln park capital fund, LLC. Lincoln Park Capital Fund, LLC [Member] Lincoln Park Capital Fund L L C [Member] Investment Type Investment Type [Axis] Investments Investment Type Categorization [Member] 2020 Repurchase Agreement. 2020 Repurchase Agreement [Member] Twenty Twenty Repurchase Agreement [Member] Class of Stock Statement Class Of Stock [Axis] Class of Stock Class Of Stock [Domain] Commitment fee. Commitment Fee [Member] Commitment Fee [Member] Basis Of Presentation And New Accounting Standards [Line Items] Basis Of Presentation And New Accounting Standards [Line Items] Remaining availability under financing facility Common Stock Sales Available For Issuance Common stock issued (in shares) Remaining common stock issued and sold (in shares) Shares Issued Sale of common stock, net Period exercisable from the date of issuance Period Exercisable From The Date Of Issuance Reimbursement revenue recognized Reimbursement Revenue Recognized Net cash used in operating activities Substantial doubt about going concern, description Substantial Doubt About Going Concern Conditions Or Events Summary of significant accounting policies. Summary of significant accounting policies. Summary Of Significant Accounting Policies [Table] Summary Of Significant Accounting Policies [Table] Statistical Measurement Range [Axis] Statistical Measurement Range [Member] Minimum [Member] Minimum [Member] Maximum [Member] Maximum [Member] Research and Development Arrangement, Contract to Perform for Others, Type Research And Development Arrangement Contract To Perform For Others By Type [Axis] Research and Development Arrangement, Contract to Perform for Others, Type Research And Development Arrangement Contract To Perform For Others Type [Domain] Represents a contract to develop a new countermeasure for thermal burns with the U.S. Department of Health and Human Service's Biomedical Advanced Research and Development Authority (BARDA). BARDA Contract [Member] Barda Contract [Member] Product and Service Product Or Service [Axis] Product and Service Products And Services [Domain] Development. Development [Member] Development [Member] Accounting Standards Update Adjustments For New Accounting Pronouncements [Axis] Accounting Standards Update Type Of Adoption [Member] ASU 2019-12 [Member] Accounting Standards Update201912 [Member] Summary Of Significant Accounting Policies [Line Items] Summary Of Significant Accounting Policies [Line Items] Cash equivalents investments with original maturities Cash Equivalents At Carrying Value Useful lives of the assets Property Plant And Equipment Useful Life Impairment loss Impairment Of Long Lived Assets Held For Use Impairment charges Asset Impairment Charges Number of reporting units Number Of Reporting Units Revenue recognized Revenue From Contract With Customer Excluding Assessed Tax This represents contract with BARDA to develop a new countermeasure for thermal burns entitling the company to be reimbursed for qualifying expenditures. Qualifying expenditures related to research Qualifying Expenditures Related To Research And Development Expense Interest or penalties related to income tax matters Income Tax Examination Penalties And Interest Expense Number of operating segment Number Of Operating Segments Change in accounting principle, accounting standards update, adopted [true false] Change In Accounting Principle Accounting Standards Update Adopted Change in accounting principle, accounting standards update, adoption date Change In Accounting Principle Accounting Standards Update Adoption Date Change in accounting principle, accounting standards update, immaterial effect [true false] Change In Accounting Principle Accounting Standards Update Immaterial Effect Reclassification of number of warrants to equity from amendment of warrants. Warrants issued, registration offering, period. Related Party Related Party Transactions By Related Party [Axis] Related Party Related Party [Domain] Lincoln park. Lincoln Park [Member] Lincoln Park [Member] Twenty twenty purchase agreement. 2020 Purchase Agreement [Member] Twenty Twenty Purchase Agreement [Member] Warrants issued, registration offering, period Warrants Issued Registration Offering Period Reclassification of number of warrants to equity from amendment of warrants Reclassification Of Number Of Warrants To Equity From Amendment Of Warrants Fair Value Hierarchy and NAV Fair Value By Fair Value Hierarchy Level [Axis] Fair Value Hierarchy and NAV Fair Value Measurements Fair Value Hierarchy [Domain] Level 3 [Member] Fair Value Inputs Level3 [Member] Measurement Input Type Measurement Input Type [Axis] Measurement Input Type Measurement Input Type [Domain] Expected Term [Member] Measurement Input Expected Term [Member] Common Stock Market Price [Member] Measurement Input Share Price [Member] Risk-free Interest Rate [Member] Measurement Input Risk Free Interest Rate [Member] Expected Volatility [Member] Measurement Input Price Volatility [Member] Measurement input, resulting fair value per warrant. Resulting Fair Value (Per Warrant) [Member] Measurement Input Resulting Fair Value Per Warrant [Member] Warrants expected term Warrants And Rights Outstanding Term Warrants measurement input Warrants And Rights Outstanding Measurement Input Liability Class Fair Value By Liability Class [Axis] Fair Value by Liability Class Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation By Liability Class [Domain] Warrant liability. Warrant Liability [Member] Warrant Liability [Member] Warrant liability Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation Calculation Roll Forward Beginning balance Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Value Change in fair value of warrants Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Period Increase Decrease Reclassification to equity Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Purchases Sales Issuances Settlements Ending balance Change in fair value commitment shares. Commitment shares issued. Commitment shares issued as commitment fee Commitment Shares Issued Change in fair value of commitment shares Change In Fair Value Commitment Shares Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Options. Outstanding Stock Options [Member] Options [Member] Outstanding Warrants [Member] Warrant [Member] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Dilutive common shares excluded from the calculations of diluted loss per share (in shares) Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount Other. Other Current Assets [Abstract] Prepaid Expense And Other Assets Current [Abstract] Prepaid services Other Prepaid Expense Current Prepaid insurance Prepaid Insurance Other Other Total other current assets The gross amount of office and computer equipment cost as of the balance sheet date. Property and Equipment, net [Abstract] Property Plant And Equipment Net [Abstract] Office and computer equipment Office And Computer Equipment Gross Leasehold improvements Leasehold Improvements Gross Property and equipment, gross Property Plant And Equipment Gross Less accumulated depreciation Accumulated Depreciation Depletion And Amortization Property Plant And Equipment Property and equipment, net Depreciation expense Depreciation Accrued vacation and compensation, current. Carrying value as of the balance sheet date of obligations incurred through that date and payable for research and development studies. Accounts Payable and Accrued Expenses [Abstract] Accounts Payable And Accrued Liabilities Current And Noncurrent [Abstract] Accounts payable Accounts Payable Current Accrued payroll and bonus Accrued Bonuses Current Accrued professional fees Accrued Professional Fees Current Accrued vacation and compensation Accrued Vacation And Compensation Current Finance lease obligation -- current Finance Lease Liability Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration] Finance Lease Liability Current Statement Of Financial Position Extensible List Other current liabilities Other Liabilities Current Accrued R&D studies Accrued Research And Development Studies Accounts payable and accrued expenses, Total Annual increase in lease rate Lease commencement date. Operating leases, expiry year. Recorded Unconditional Purchase Obligation [Table] Recorded Unconditional Purchase Obligation [Table] Geographical Statement Geographical [Axis] Geographical Segment Geographical [Domain] San Antonio, Texas [Member] TEXAS Charlottesville Charlottesville [Member] Charlottesville [Member] Long-Lived Tangible Asset Property Plant And Equipment By Type [Axis] Long-Lived Tangible Asset Property Plant And Equipment Type [Domain] Office, laboratory and storage space. Office Laboratory and Storage Space [Member] Office Laboratory And Storage Space [Member] Piramal pharma solutions inc. Piramal Pharma Solutions, Inc. [Member] Piramal Pharma Solutions Inc [Member] Recorded Unconditional Purchase Obligation by Category of Item Purchased Recorded Unconditional Purchase Obligation By Category Of Item Purchased [Axis] Unconditional Purchase Obligation, Category of Goods or Services Acquired Unconditional Purchase Obligation Category Of Goods Or Services Acquired [Domain] Contractual obligation to provide funding of research and development costs over periods that initially exceed one year or the normal operating cycle, if longer. Pre-clinical Research Study Obligations [Member] Pre Clinical Research Study Obligations [Member] Litigation Case Litigation Case [Axis] Litigation Case Litigation Case Type [Domain] Lorem Vascular, Pte. Ltd. Lorem Vascular Pte Ltd [Member] Lorem Vascular Pte Ltd [Member] Recorded Unconditional Purchase Obligation [Line Items] Recorded Unconditional Purchase Obligation [Line Items] Operating leases expiry year Operating Leases Expiry Year Lessee, operating lease, option to extend Lessee Operating Lease Option To Extend Lessee, operating lease, term of contract Lessee Operating Lease Term Of Contract Lessee, operating lease, existence of option to extend [true false] Lessee Operating Lease Existence Of Option To Extend Lessee, operating lease, renewal term Lessee Operating Lease Renewal Term Minimum lease payment Lessee Operating Lease Liability Payments Due Annual increase in lease rate Annual Increase In Lease Rate Lease commencement date Lease Commencement Date Lease assets. Lease liabilities. Operating Financing Finance Lease Right Of Use Asset Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Finance Lease Right Of Use Asset Statement Of Financial Position Extensible List Total leased assets Lease Assets Liabilities Liabilities [Abstract] Operating lease liabilities, current Financing lease liabilities, current Finance Lease Liability Current Operating lease liabilities. noncurrent Total lease liabilities Lease Liabilities Weighted-average remaining lease term (years) - operating leases Operating Lease Weighted Average Remaining Lease Term1 Weighted-average remaining lease term (years) - finance leases Finance Lease Weighted Average Remaining Lease Term1 Weighted-average discount rate - operating leases Operating Lease Weighted Average Discount Rate Percent Weighted-average discount rate - finance leases Finance Lease Weighted Average Discount Rate Percent Cash paid for amounts included in the measurement of lease liabilities. Finance lease expense. Cash payment information. Lease expense: Lease Cost [Abstract] Operating lease expense Operating Lease Cost Finance lease expense: Finance Lease Expense [Abstract] Depreciation of right-of-use assets Finance Lease Right Of Use Asset Amortization Interest expense on lease liabilities Finance Lease Interest Expense Total lease expense Lease Cost Cash payment information: Cash Payment Information [Abstract] Operating cash used for operating leases Operating Lease Payments Financing cash used for financing leases Total cash paid for amounts included in the measurement of lease liabilities Cash Paid For Amounts Included In Measurement Of Lease Liabilities Rent expense Operating Lease Expense Operating Leases Operating Lease Liabilities Payments Due [Abstract] 2022 Lessee Operating Lease Liability Payments Due Next Twelve Months 2023 Lessee Operating Lease Liability Payments Due Year Two 2024 Lessee Operating Lease Liability Payments Due Year Three 2025 Lessee Operating Lease Liability Payments Due Year Four Thereafter Lessee Operating Lease Liability Payments Due After Year Four Total minimum lease payments Less: amount representing interest Lessee Operating Lease Liability Undiscounted Excess Amount Present value of obligations under leases Operating Lease Liability Less: current portion Master services agreement date. Master service agreement date Master Services Agreement Date Master services agreement initial term. Master services agreement Terms description. Master services agreement initial term Master Services Agreement Initial Term Master services agreement terms, Description Master Services Agreement Terms Description Contractual obligation Contractual Obligation Compensatory damages and operational. Compensatory damages and operational Compensatory Damages And Operational Floating interest rate for funds borrowed, under the debt agreement. The date that the warrant or right expires. Debt Instrument [Table] Debt Instrument [Table] Debt Instrument Debt Instrument [Axis] Debt Instrument, Name Debt Instrument Name [Domain] Second amendment to the amended and restated loan and security agreement. Term Loan [Member] Term Loan [Member] Variable Rate Variable Rate [Axis] Variable Rate Variable Rate [Domain] LIBOR [Member] London Interbank Offered Rate L I B O R [Member] Derivative Instrument Derivative Instrument Risk [Axis] Derivative Contract Derivative Contract Type [Domain] Interest Rate Floor [Member] Interest Rate Floor [Member] Financial Instrument Financial Instrument [Axis] Financial Instruments Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain] Loan and security agreement. Loan and Security Agreement [Member] Loan And Security Agreement [Member] Disposal Group Classification Disposal Group Classification [Axis] Disposal Group Classification Disposal Group Classification [Domain] Sale of the japanese subsidiary and certain assets. Sale of the Japanese Subsidiary and Certain Assets [Member] Sale Of Japanese Subsidiary And Certain Assets [Member] Debt Instrument [Line Items] Debt Instrument [Line Items] Origination Date Debt Instrument Offering Date1 Original Loan Amount Debt Instrument Face Amount Interest rate Debt Instrument Floating Interest Rate Percentage Basis variable rate Debt Instrument Basis Spread On Variable Rate1 Maturity date Debt Instrument Maturity Date Fees amount associated with loan Debt Instrument Fee Amount Number of shares callable by warrants (in shares) Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights Warrant exercise price (in dollars per share) Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1 Date from which warrants are exercisable Class Of Warrant Or Righst Date From Which Warrants Or Rights Exercisable Warrant expiration date Class Of Warrant Or Right Expiration Date Minimum liquidity covenant amount. Payments for principal, interest and fees Payments For Loans Minimum liquidity covenant Minimum Liquidity Covenant Amount Debt principal repayment start date. Prepayments of long term debt. Related final payment Long term debt remaining amount. Debt instrument amendment fee. Debt principal repayment start date Debt Principal Repayment Start Date Prepayments of term loan Prepayments Of Long Term Debt Related final payment Related Final Payment Term loan, remaining amount Long Term Debt Remaining Amount Amendment fee Debt Instrument Amendment Fee Long term debt outstanding threshold amount. Long Term Debt Outstanding Threshold Amount Long Term Debt Outstanding Threshold Amount Debt Instrument, Covenant Compliance Debt Instrument Covenant Compliance Interest expense Non-cash amortization Amortization Of Debt Discount Premium Debt instrument amended expiration date. Additional details relating term loan that is outstanding [Abstract] Additional details relating term loan that is outstanding [Abstract] Additional Details Relating Term Loan That Is Outstanding [Abstract] Interest Rate Debt Instrument Interest Rate Stated Percentage Current Monthly Payment Debt Instrument Periodic Payment Amended expiration date Debt Instrument Amended Expiration Date Remaining Principal (Face Value) Debt Instrument Carrying Amount Future contractual principal and final fee payments on all debt [Abstract] Contractual Obligation Fiscal Year Maturity [Abstract] 2022 Contractual Obligation Due In Next Twelve Months 2023 Contractual Obligation Due In Second Year 2024 Contractual Obligation Due In Third Year Total Reconciliation of Face Value to Book Value [Abstract] Reconciliation of Face Value to Book Value [Abstract] Debt Instrument Reconciliation Of Face Value To Book Value [Abstract] Total debt obligations, including final payment fee (Face Value) Less: Debt discount Debt Instrument Unamortized Discount Total obligation Long Term Debt And Capital Lease Obligations Including Current Maturities Income taxes. Income taxes. Income Taxes [Table] Income Taxes [Table] Income Tax Authority Income Tax Authority [Axis] Income Tax Authority Income Tax Authority [Domain] Federal [Member] Domestic Country [Member] State [Member] State And Local Jurisdiction [Member] Income Taxes [Line Items] Income Taxes [Line Items] Provision or benefit for income taxes Income Tax Expense Benefit Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to net operating loss expiration. Effective income tax rate reconciliation tax return to provision. Effective income tax rate reconciliation mark to market adjustment. Reconciliation of the total income tax provision tax rate [Abstract] Effective Income Tax Rate Continuing Operations Tax Rate Reconciliation [Abstract] Income tax expense (benefit) at federal statutory rate Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate Change in valuation allowance Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance Income tax expense (benefit) at state statutory rate Effective Income Tax Rate Reconciliation State And Local Income Taxes Stock compensation Effective Income Tax Rate Reconciliation Nondeductible Expense Share Based Compensation Cost NOLs expiring and adjustments to NOL Effective Income Tax Rate Reconciliation Net Operating Loss Expiration Research credit Effective Income Tax Rate Reconciliation Tax Credits Research Return to provision Effective Income Tax Rate Reconciliation Tax Return To Provision Change in state rate Effective Income Tax Rate Reconciliation Tax Settlements State And Local Mark to market adjustment Effective Income Tax Rate Reconciliation Mark To Market Adjustments Other, net Effective Income Tax Rate Reconciliation Other Adjustments Total income tax provision Effective Income Tax Rate Continuing Operations Portions of the deferred tax assets and deferred tax liabilities [Abstract] Components Of Deferred Tax Assets And Liabilities [Abstract] Deferred tax assets [Abstract] Components Of Deferred Tax Assets [Abstract] Accrued expenses Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Accrued Liabilities Stock based compensation Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost Net operating loss carryforwards Deferred Tax Assets Operating Loss Carryforwards Income tax credit carryforwards Deferred Tax Assets Tax Credit Carryforwards Property and equipment, principally due to differences in depreciation Deferred Tax Assets Property Plant And Equipment Intangible assets Deferred Tax Assets Goodwill And Intangible Assets Other, net Deferred Tax Assets Other Deferred tax assets (Total) Deferred Tax Assets Gross Valuation allowance Deferred Tax Assets Valuation Allowance Total deferred tax assets, net of allowance Deferred Tax Assets Net Deferred tax liabilities [Abstract] Components Of Deferred Tax Liabilities [Abstract] Other Deferred Tax Liabilities Other Total deferred tax liability Deferred Income Tax Liabilities Net deferred tax assets (liability) Deferred Tax Liabilities Deferred tax assets valuation allowances. Income tax contingency. Income Tax Contingency [Abstract] Income Tax Contingency [Abstract] Valuation allowance Deferred Tax Assets Valuation Allowances Increase (decrease) in valuation allowance Valuation Allowance Deferred Tax Asset Change In Amount The expiration date of each operating loss carryforward included in total operating loss carryforwards, or the applicable range of such expiration dates. Expiration date of the tax credit carryforward. Net operating loss carryforward. Percentage of net operating loss carryforwards available for offsetting against future taxable income. Tax loss carryforwards Operating Loss Carryforwards Net operating loss carryforwards, Expire date Operating Loss Carryforwards Expiration Dates1 Federal tax carry forward Deferred Tax Assets Operating Loss Carryforwards Domestic State tax credit carryforwards Deferred Tax Assets Operating Loss Carryforwards State And Local Federal tax credit carryforward, Expiration date Tax Credit Carryforward Expiration Date1 Net operating losses Net Operating Loss Carryforward Percentage of federal net operating losses used to offset of future taxable income Percentage Of Net Operating Loss Carryforwards Available For Offsetting Against Future Taxable Income Refers to cumulative change in ownership in percentage. Refers to the period of net operating loss and R&D tax credit carry forwards to offset future taxable income. Cumulative change in ownership Cumulative Change In Ownership Period of net operating loss and R&D tax credit carry forwards to offset future taxable income Net Operating Loss And Research And Development Tax Credit Carry Forwards To Offset Future Taxable Income Period Liability for uncertain tax positions Liability For Uncertain Tax Positions Current Schedule of reconciliation of unrecognized tax benefits activity [Roll Forward] Reconciliation Of Unrecognized Tax Benefits Excluding Amounts Pertaining To Examined Tax Returns Roll Forward Unrecognized Tax Benefits – Beginning Unrecognized Tax Benefits Gross decreases – tax positions in prior period Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions Gross increase – current-period tax positions Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions Unrecognized Tax Benefits – Ending Refers to period for material changes of liability for uncertain tax benefits. Period for material changes of liability for uncertain tax benefits Period For Material Changes Of Liability For Uncertain Tax Benefits Interest related to unrecognized tax benefits in interest expense and penalties Unrecognized Tax Benefits Income Tax Penalties And Interest Expense Defined Contribution Plan [Table] Defined Contribution Plan [Table] Defined Contribution Plan Disclosure [Line Items] Defined Contribution Plan Disclosure [Line Items] Percentage of matching contribution for employee contributions Defined Contribution Plan Employer Matching Contribution Percent Of Match Discretionary or matching contributions Defined Contribution Plan Employer Discretionary Contribution Amount Milestone Payments. License agreement maintenance fee. UTHSA License Agreement. UTHSA License Agreement [Member] U T H S A License Agreement [Member] Income Statement Location Income Statement Location [Axis] Income Statement Location Income Statement Location [Domain] Development and sales milestone. Development And Sales Milestone [Member] Development And Sales Milestone [Member] Nano Tx license agreement Member Nano Tx Licenses Agreement [Member] Nano Tx Licenses Agreement [Member] License fee payment in cash Payments For Royalties Milestone payments Milestone Payments License agreement maintenance fee License Agreement Maintenance Fee Preferred stock dividend rate percentage eliminated date. Schedule Of Stock By Class [Table] Schedule Of Stock By Class [Table] Series A convertible preferred stock. Series A Convertible Preferred Stock [Member] Series A Convertible Preferred Stock [Member] Series B convertible preferred stock. Series B Convertible Preferred Stock [Member] Series B Convertible Preferred Stock [Member] Series C convertible preferred stock. Series C Convertible Preferred Stock [Member] Series C Convertible Preferred Stock [Member] Class of Warrant or Right Class Of Warrant Or Right [Axis] Class of Warrant or Right Class Of Warrant Or Right [Domain] Two thousand eighteen rights offering. 2018 Rights Offering [Member] Two Thousand Eighteen Rights Offering [Member] Class of Stock [Line Items] Class Of Stock [Line Items] Convertible preferred stock Preferred Stock Dividend Rate Percentage Series A 3.6% Convertible preferred stock eliminated date Preferred Stock Dividend Rate Percentage Eliminated Date Number Of Preferred Stock Shares Exercised. Number of preferred stock, shares converted Number Of Preferred Stock Shares Exercised Common Class A [Member] Common Class A [Member] Common Class B [Member] Common Class B [Member] Representative Series U Warrant. Representative Warrants [Member] Representative Series U Warrant [Member] Number of securities called by warrant or right Sale of Stock, Price Per Share Sale Of Stock Price Per Share Warrant exercise price decrease Warrant Exercise Price Decrease Change in fair value of warrants Number of warrants exercised Number of warrant equity. Class of warrant outstanding Class Of Warrant Or Right Outstanding Number of warrant classified as equity Number Of Warrant Equity Number of warrants exercised Number Of Warrants Exercised Single Regular Purchase [Member] Single Stock Future [Member] At the market offering program. At The Market Offering Program [Member] At The Market Offering Program [Member] Canaccord Genuity LLC [Member] Sales agreement. Sales Agreement [Member] Sales Agreement [Member] Two thousand twenty two distribution agreement. 2022 Distribution Agreement [Member] Two Thousand Twenty Two Distribution Agreement [Member] Distribution agreement member. 2020 Distribution Agreement [Member] Distribution Agreement [Member] Closing price per share Share Price Percentage issuance of common stock. Percentage issuance of common stock Percentage Issuance Of Common Stock Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Plan Name Plan Name [Axis] Plan Name Plan Name [Domain] Stock based compensation 2015 equity incentive plan 1 member. 2015 Plan [Member] Stock Based Compensation2015 Equity Incentive Plan1 [Member] Stock based compensation 2020 equity incentive plan. 2020 Plan [Member] Stock Based Compensation2020 Equity Incentive Plan [Member] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Increased in the total number of shares of common stock reserved for issuance Common Stock Capital Shares Reserved For Future Issuance Securities remaining and available for future issuances (in shares) Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Common stock shares to be issued (in shares) Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross Stock option activity. Stock Option Activity [Abstract] Stock Option Activity [Abstract] Stock option vesting period Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1 Stock option vesting percentage Sharebased Compensation Arrangement By Sharebased Payment Award Award Vesting Rights Percentage Stock option contractual term Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period Options [Roll Forward] Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward Balance as of December 31, 2020 (in shares) Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number Granted (in shares) Cancelled/forfeited (in shares) Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period Balance as of December 31, 2021 (in shares) Vested and expected to vest at December 31, 2021 (in shares) Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number Exercisable at December 31, 2021 Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number Weighted Average Exercise Price [Roll Forward] Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward Balance as of December 31, 2020 (in dollars per share) Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Granted (in dollars per share) Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price Cancelled/forfeited (in dollars per share) Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price Balance as of December 31, 2021 (in dollars per share) Vested and expected to vest at December 31, 2021 (in dollars per share) Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Weighted Average Exercise Price Exercisable at December 31, 2021 (in dollars per share) Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price Weighted Average Remaining Contractual Life (years) [Roll Forward] Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract] Balance as of December 31, 2021 Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2 Vested and expected to vest at December 31, 2021 Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1 Exercisable at December 31, 2021 Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1 Weighted Average Remaining Contractual Terms [Abstract] Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Additional Disclosures [Abstract] Stock options exercised Stock Issued During Period Value Stock Options Exercised Black-Scholes-Merton option valuation model based on weighted-average assumptions [Abstract] Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions And Methodology [Abstract] Expected term Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1 Risk-free interest rate Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Expected volatility Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted Average Volatility Rate Dividends Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate Resulting fair value Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value Dividend yield assumed Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted Average Expected Dividend Research and Development [Member] Research And Development Expense [Member] General and Administrative [Member] General And Administrative Expense [Member] Total unamortized compensation cost related to outstanding unvested stock options and restricted stock awards Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Weighted average period for recognition of cost Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1 Subsequent Event [Table] Subsequent Event [Table] Subsequent Event [Line Items] Subsequent Event [Line Items]