X0306 4 2022-03-01 0 0001095981 PLUS THERAPEUTICS, INC. PSTV 0001802687 Sims Andrew John Hugh MacIntyre C/O PLUS THERAPEUTICS INC. 4200 MARATHON BOULEVARD, SUITE 200 AUSTIN TX 78756 0 1 0 0 Chief Financial Officer Common Stock 2022-03-01 4 P 0 2000 1.0999 A 9230 D The price reported in column 4 is a weighted average price. These shares were purchased in multiple transactions at prices of $1.0998 or $1.00 per share. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. Andrew Sims 2022-03-03