X0202 4 2006-05-01 0 0001095330 SYMYX TECHNOLOGIES INC SMMX 0001216631 WEINBERG W HENRY C/O SYMYX TECHNOLOGIES, INC. 3100 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 0 1 0 0 Exec. Vice President and CTO Common Stock 2006-05-01 4 S 0 98 29.11 D 107790 D Common Stock 2006-05-01 4 S 0 645 29.17 D 107145 D Common Stock 2006-05-01 4 S 0 3775 29.20 D 103370 D Common Stock 2006-05-01 4 S 0 700 29.23 D 102670 D Common Stock 2006-05-01 4 S 0 130 29.24 D 102540 D Common Stock 2006-05-01 4 S 0 4165 29.25 D 98375 D Common Stock 2006-05-01 4 S 0 300 29.26 D 98075 D Common Stock 2006-05-01 4 S 0 285 29.27 D 97790 D Common Stock 2006-05-01 4 S 0 200 29.28 D 97590 D Common Stock 2006-05-01 4 S 0 160 29.30 D 97430 D Common Stock 2006-05-01 4 S 0 690 29.31 D 96740 D Common Stock 2006-05-01 4 S 0 70 29.32 D 96670 D Common Stock 2006-05-01 4 S 0 50 29.36 D 96620 D Common Stock 2006-05-01 4 S 0 50 29.37 D 96570 D Common Stock 2006-05-01 4 S 0 99 29.38 D 96471 D Common Stock 2006-05-02 4 S 0 117 29.16 D 96354 D Common Stock 2006-05-02 4 S 0 6600 29.21 D 89754 D Common Stock 2006-05-02 4 S 0 5 29.22 D 89749 D Common Stock 2006-05-02 4 S 0 500 29.24 D 89249 D Common Stock 2006-05-02 4 S 0 100 29.25 D 89149 D Common Stock 2006-05-02 4 S 0 500 29.26 D 88649 D Common Stock 2006-05-02 4 S 0 2600 29.28 D 86049 D Common Stock 2006-05-02 4 S 0 1400 29.30 D 84649 D Common Stock 2006-05-02 4 S 0 471 29.31 D 84178 D Common Stock 2006-05-02 4 S 0 290 29.33 D 83888 D The sale reported by this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 25, 2005. Includes 33,000 restricted stock units payable solely in common stock. Each restricted stock unit represents a contingent right to receive one share of common stock. W. Henry Weinberg by Andrew Powell, Attorney-In-Fact 2006-05-03