X0202 4 2006-04-03 0 0001095330 SYMYX TECHNOLOGIES INC SMMX 0001216630 SCHULTZ PETER G C/O SYMYX TECHNOLOGIES, INC. 3100 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 1 0 0 0 Common Stock 2006-04-03 4 S 0 1000 27.68 D 476953 D Common Stock 2006-04-03 4 S 0 190 27.71 D 476763 D Common Stock 2006-04-03 4 S 0 272 27.72 D 476491 D Common Stock 2006-04-03 4 S 0 9 27.73 D 476482 D Common Stock 2006-04-03 4 S 0 24 27.75 D 476458 D Common Stock 2006-04-03 4 S 0 150 27.81 D 476308 D Common Stock 2006-04-03 4 S 0 650 27.82 D 475658 D Common Stock 2006-04-03 4 S 0 838 27.83 D 474820 D Common Stock 2006-04-03 4 S 0 659 27.84 D 474161 D Common Stock 2006-04-03 4 S 0 800 27.85 D 473361 D Common Stock 2006-04-03 4 S 0 751 27.86 D 472610 D Common Stock 2006-04-03 4 S 0 132 27.87 D 472478 D Common Stock 2006-04-03 4 S 0 637 27.88 D 471841 D Common Stock 2006-04-03 4 S 0 138 27.90 D 471703 D Common Stock 2006-04-04 4 S 0 1000 27.70 D 470703 D Common Stock 2006-04-04 4 S 0 150 27.74 D 470553 D Common Stock 2006-04-04 4 S 0 700 27.75 D 469853 D Common Stock 2006-04-04 4 S 0 405 27.76 D 469448 D Common Stock 2006-04-04 4 S 0 346 27.79 D 469102 D Common Stock 2006-04-04 4 S 0 399 27.83 D 468703 D Common Stock 2006-04-04 4 S 0 408 27.89 D 468295 D Common Stock 2006-04-04 4 S 0 803 27.90 D 467492 D Common Stock 2006-04-04 4 S 0 592 27.92 D 466900 D Common Stock 2006-04-04 4 S 0 350 27.93 D 466550 D Common Stock 2006-04-04 4 S 0 297 27.94 D 466253 D Common Stock 2006-04-04 4 S 0 100 27.95 D 466153 D Common Stock 2006-04-04 4 S 0 100 27.96 D 466053 D Common Stock 2006-04-04 4 S 0 600 27.98 D 465453 D The sale reported by this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 25, 2005. Peter G. Schultz by Jeryl L. Hilleman, Attorney-In-Fact 2006-04-05