X0202 4 2005-09-16 0 0001095330 SYMYX TECHNOLOGIES INC SMMX 0001201580 COLELLA SAMUEL D C/O SYMYX TECHNOLOGIES, INC. 3100 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 1 0 0 0 Common Stock 2005-09-16 5 G 0 E 500 0.00 D 67000 I Family Trust Common Stock 5528 I Family Partnership Bona fide gift, not for value. Held by Samuel D. and Nancy R. Colella as trustees of The Colella Family Trust. Held by Colella Family Partners, of which the reporting person is a general partner. The reporting person disclaims beneficial ownership of the shares held by such entity except to the extent of his individual partnership interest therein. Anne Marie Peters for Samuel D. Colella 2005-09-26