X0202 4 2004-05-27 0 0001095330 SYMYX TECHNOLOGIES INC SMMX 0001197808 ROSATI MARIO M 650 PAGE MILL RD PALO ALTO CA 94304 1 0 0 0 Common Stock 5185 I Spouse of reporting person Common Stock 9576 D Stock Option (right to buy) 25.05 2004-05-27 4 A 0 10000 A 2014-05-27 Common Stock 10000 10000 D Shares held by reporting person's spouse, Danelle Storm Rosati, acquired on July 20, 1996 and unintentionally omitted in prior Form 3 reports. The option vests over twelve months in 12 equal monthly installments beginning on May 27, 2004. No cash consideration was paid for the grant of the option. Christopher D. Mitchell, Attorney-in-Fact 2004-05-28