X0508 4 2025-11-17 0 0001094038 Marker Therapeutics, Inc. MRKR 0001270905 Eansor Norman David C/O MARKER THERAPEUTICS, INC. 2450 HOLCOMBE BLVD, TMC PARTNERS OFFICE HOUSTON TX 77021 1 0 0 0 0 Stock Option (Right to Buy) 0.9548 2025-11-17 4 A 0 84411 0 A 2035-11-17 Common Stock 84411 84411 D Stock Option (Right to Buy) 0.9548 2025-11-17 4 A 0 137330 0 A 2035-11-17 Common Stock 137330 137330 D Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for the remaining options due as service as a director for the year 2024. 30,000 shares were previously granted on February 12, 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025. Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for service as a director for the year 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025. /s/ Julio C. Esquivel as Attorney-In-Fact for Norman David Eansor 2025-11-19