CONSOLIDATED STATEMENTS OF OPERATIONS (USD $)	12 Months Ended
	Dec. 31, 2012		Dec. 31, 2011		Dec. 31, 2010
Income Statement [Abstract]
Product and service revenue	$ 24,407,127		$ 23,223,265		$ 15,738,841
Research and development contract revenue	1,701,330		3,886,114		3,597,870
Licensed technology revenue			516,563		135,938
Total revenue	26,108,457		27,625,942		19,472,649
Cost of product and service revenue	37,657,699		30,669,602		23,111,151
Cost of research and development contract revenue	2,804,817		6,232,210		6,370,797
Research and development expense	5,434,235		5,655,748		12,901,170
Selling, general and administrative expenses	14,576,998		14,545,965		25,572,364
Gain on sale of assets			(673,358)		(3,217,594)
Amortization of intangible assets	2,306,489		2,322,876		2,263,627
Operating loss	(36,671,781)		(31,127,101)		(47,528,866)
Interest and other income and net realized losses from available-for-sale securities	226,120		248,430		1,056,932
Change in fair value of common stock warrant liability	4,845,165		3,447,153
Change in fair value of auction rate securities repurchase agreement					(5,977,822)
Net trading gain					5,977,822
Interest and other expense and foreign currency gain (loss)	(261,958)		(22,436)		(486,987)
Net loss	$ (31,862,454)		$ (27,453,954)		$ (46,958,921)
Loss per share:
Basic and diluted (in dollars per share)	$ (0.93)	[1]	$ (1.46)	[1]	$ (3.58)	[1]
Weighted average number of common shares outstanding (in shares)	34,376,427	[1]	18,778,066	[1]	13,123,162	[1]

[1] Share and per share information for the prior periods has been retroactively adjusted to reflect the May 19, 2011 one-for-ten reverse stock split of the Company's common stock.