Share-Based Compensation (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended	9 Months Ended
Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Share-based compensation expense in condensed consolidated statements of operations
Total share-based compensation expense	$ 1,236	$ 614	$ 3,154	$ 1,843
Research and development [Member]
Share-based compensation expense in condensed consolidated statements of operations
Total share-based compensation expense	495	269	1,277	820
General and administrative [Member]
Share-based compensation expense in condensed consolidated statements of operations
Total share-based compensation expense	$ 741	$ 345	$ 1,877	$ 1,023

The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Statement of Financial Accounting Standard (FAS)

-Number 95

-Paragraph 28

-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 230

-SubTopic 10

-Section 45

-Paragraph 28

-Subparagraph (a)

-URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3602-108585

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Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration