X0306 4 2018-08-14 0 0001159036 HALOZYME THERAPEUTICS INC HALO 0001091823 KIRK RANDAL J C/O THIRD SECURITY, LLC 1881 GROVE AVENUE RADFORD VA 24141 0 0 1 0 Common Stock 2018-08-14 4 S 0 123014 17.36 D 4719290 I by R.J. Kirk DOT Common Stock 2018-08-15 4 S 0 37144 17.15 D 4682146 I by R.J. Kirk DOT Common Stock 2018-08-16 4 S 0 38695 17.24 D 4643451 I by R.J. Kirk DOT Common Stock 2018-08-14 4 S 0 180154 17.36 D 3096119 I by Kapital Joe Common Stock 2018-08-15 4 S 0 54397 17.15 D 3041722 I by Kapital Joe Common Stock 2018-08-16 4 S 0 56668 17.24 D 2985054 I by Kapital Joe Common Stock 2327603 I by TSCP V Common Stock 290460 I by JPK 2012 Common Stock 46701 I by Kellie L. Banks LTT Common Stock 354654 I by JPK 2009 Common Stock 354653 I by MGK 2009 Common Stock 2235 I by ZSK 2009 Common Stock 302954 I by JPK 2008 Common Stock 302954 I by MGK 2008 Common Stock 302954 I by ZSK 2008 Common Stock 11317 I by Lotus Capital Common Stock 216795 I by Staff 2001 Common Stock 131144 I by Sr Staff 2006 Common Stock 65572 I by Staff 2006 Common Stock 21858 I by Incentive 2006 Common Stock 3562388 D Kapital Joe, LLC ("Kapital Joe") and the R.J. Kirk Declaration of Trust ("R.J. Kirk DOT") sold shares on a pro rata basis. Randal J. Kirk controls each of R.J. Kirk DOT, Kapital Joe, Third Security Capital Partners V, LLC ("TSCP V"), JPK 2012, LLC ("JPK 2012"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), JPK 2009, LLC ("JPK 2009"), MGK 2009, LLC ("MGK 2009"), ZSK 2009, LLC ("ZSK 2009"), JPK 2008, LLC ("JPK 2008"), MGK 2008, LLC ("MGK 2008"), ZSK 2008, LLC ("ZSK 2008"), Lotus Capital (2000) Company, Inc. ("Lotus Capital"), Third Security Staff 2001 LLC ("Staff 2001"), Third Security Senior Staff 2006 LLC ("Sr Staff 2006"), Third Security Staff 2006 LLC ("Staff 2006") and Third Security Incentive 2006 LLC ("Incentive 2006"). Shares held by these entities may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein. /s/ Randal J. Kirk 2018-08-16