-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 TxVtr99lO2LWuYVMrjgnDA==

<SEC-DOCUMENT>0000950103-03-001842.txt : 20030911
<SEC-HEADER>0000950103-03-001842.hdr.sgml : 20030911
<ACCEPTANCE-DATETIME>20030911154537
ACCESSION NUMBER:		0000950103-03-001842
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030910
FILED AS OF DATE:		20030911

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MEDICINES CO /DE
		CENTRAL INDEX KEY:			0001113481
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043324394
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8 CAMPUS DRIVE
		CITY:			PARSIPPANY
		STATE:			NJ
		ZIP:			07054
		BUSINESS PHONE:		973-656-1616

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MEDICINES CO/ MA
		DATE OF NAME CHANGE:	20000504

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			HUSAIN FAZLE M
		CENTRAL INDEX KEY:			0001091618

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-31191
		FILM NUMBER:		03891991

	BUSINESS ADDRESS:	
		STREET 1:		C/O DAVIS, POLK & WARDWELL
		STREET 2:		450 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
		BUSINESS PHONE:		2124504403

	MAIL ADDRESS:	
		STREET 1:		450 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>sep1103_form4-husainex.xml
<TEXT>
<XML>
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<!-- - EDGAR Ease Plus 1.0                                   07/25/03  TT    -->
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType>
   <periodOfReport>2003-09-10</periodOfReport>
   <notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0001113481</issuerCik>
        <issuerName>MEDICINES CO /DE</issuerName>
        <issuerTradingSymbol>MDCO</issuerTradingSymbol>
   </issuer>
   <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001091618</rptOwnerCik>
            <rptOwnerName>HUSAIN FAZLE M</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THE MEDICINES COMPANY</rptOwnerStreet1>
            <rptOwnerStreet2>ONE CAMBRIDGE CENTER</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02142</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
         <isDirector>1</isDirector>
         <isOfficer>0</isOfficer>
         <isTenPercentOwner>0</isTenPercentOwner>
         <isOther>0</isOther>
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   <nonDerivativeTransaction>
      <securityTitle>
         <value>Common Stock</value>
      </securityTitle>
      <transactionDate>
         <value>2003-09-10</value>
      </transactionDate>
      <transactionCoding>
         <transactionFormType>4</transactionFormType>
         <transactionCode>M</transactionCode>
         <equitySwapInvolved>0</equitySwapInvolved>
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      <transactionAmounts>
         <transactionShares>
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         <transactionPricePerShare>
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           <value>13.80</value>
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   <nonDerivativeTransaction>
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         <value>Common Stock</value>
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           <value>D</value>
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   </nonDerivativeTransaction>
 </nonDerivativeTable>
 <derivativeTable>
   <derivativeTransaction>
      <securityTitle>
         <value>Options (Right to Buy)</value>
      </securityTitle>
      <conversionOrExercisePrice>
         <value>13.80</value>
      </conversionOrExercisePrice>
      <transactionDate>
         <value>2003-09-10</value>
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           <value>4219</value>
         </transactionShares>
         <transactionPricePerShare>
           <value>0</value>
         </transactionPricePerShare>
         <transactionAcquiredDisposedCode>
           <value>D</value>
         </transactionAcquiredDisposedCode>
      </transactionAmounts>
      <exerciseDate>
            <footnoteId id="F1"/>
      </exerciseDate>
      <expirationDate>
         <value>2011-05-31</value>
      </expirationDate>
      <underlyingSecurity>
         <underlyingSecurityTitle>
           <value>Common Stock</value>
         </underlyingSecurityTitle>
         <underlyingSecurityShares>
           <value>3281</value>
         </underlyingSecurityShares>
      </underlyingSecurity>
      <postTransactionAmounts>
         <sharesOwnedFollowingTransaction>
           <value>3281</value>
         </sharesOwnedFollowingTransaction>
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      <securityTitle>
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      <conversionOrExercisePrice>
         <value>8.51</value>
      </conversionOrExercisePrice>
      <transactionDate>
         <value>2003-09-10</value>
      </transactionDate>
      <transactionCoding>
         <transactionFormType>4</transactionFormType>
         <transactionCode>M</transactionCode>
         <equitySwapInvolved>0</equitySwapInvolved>
      </transactionCoding>
      <transactionAmounts>
         <transactionShares>
           <value>2344</value>
         </transactionShares>
         <transactionPricePerShare>
           <value>0</value>
         </transactionPricePerShare>
         <transactionAcquiredDisposedCode>
           <value>D</value>
         </transactionAcquiredDisposedCode>
      </transactionAmounts>
      <exerciseDate>
            <footnoteId id="F2"/>
      </exerciseDate>
      <expirationDate>
         <value>2012-05-31</value>
      </expirationDate>
      <underlyingSecurity>
         <underlyingSecurityTitle>
           <value>Common Stock</value>
         </underlyingSecurityTitle>
         <underlyingSecurityShares>
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         </underlyingSecurityShares>
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           <value>D</value>
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   </derivativeTransaction>
   <derivativeTransaction>
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      </securityTitle>
      <conversionOrExercisePrice>
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      <transactionDate>
         <value>2003-09-10</value>
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      <transactionCoding>
         <transactionFormType>4</transactionFormType>
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      <transactionAmounts>
         <transactionShares>
           <value>781</value>
         </transactionShares>
         <transactionPricePerShare>
           <value>0</value>
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         <transactionAcquiredDisposedCode>
           <value>D</value>
         </transactionAcquiredDisposedCode>
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      <exerciseDate>
            <footnoteId id="F3"/>
      </exerciseDate>
      <expirationDate>
         <value>2013-05-29</value>
      </expirationDate>
      <underlyingSecurity>
         <underlyingSecurityTitle>
           <value>Common Stock</value>
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         <underlyingSecurityShares>
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           <value>11719</value>
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           <value>D</value>
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 </derivativeTable>
   <footnotes>
      <footnote id="F1"> The option vests in 48 equal monthly installments beginning on June 30, 2001.</footnote>

      <footnote id="F2"> The option vests in 48 equal monthly installments beginning on June 30, 2002.</footnote>

      <footnote id="F3"> The option vests in 48 equal monthly installments beginning on June 29, 2003.</footnote>
   </footnotes>
   <ownerSignature>
      <signatureName>/s/ Debra Abamovitz, Attorney-in-Fact for M. Fazle Husain</signatureName>
      <signatureDate>2003-09-11</signatureDate>
   </ownerSignature>
</ownershipDocument>

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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----