Note 4 - Distribution, Licensing and Collaboration Arrangements (Details Textual)					1 Months Ended			12 Months Ended
	Oct. 31, 2016 USD ($)	Oct. 28, 2016 USD ($)	May 05, 2016 USD ($) $ / item	Mar. 22, 2016 USD ($)	Dec. 31, 2016 USD ($)	Nov. 30, 2016 USD ($)	Jan. 31, 2015 USD ($)	Dec. 31, 2013 USD ($)
Repayments of Related Party Debt		$ 201,200
Debt Instrument, Number of Periodic Payments		3
Debt Instrument, Periodic Payment		$ 33,333
Distribution Agreement with Boyalife [Member] | Affiliated Entity [Member]
Due from Related Parties, Current			$ 500,000
Maximum Payment on Right Excercisable			$ 250,000
Distribution Agreement with Boyalife [Member] | Affiliated Entity [Member] | Aurix System [Member]
Distribution Fee per Unit Sold | $ / item			40
Restorix Distribution Agreement [Member]
Collaboration Agreement, Term				2 years
Restorix Distribution Agreement [Member] | Minimum [Member]
Collaboration Agreement, Available Extension of Term				1
Current Product Price				$ 700
Restorix Distribution Agreement [Member] | Maximum [Member]
Current Product Price				$ 750
Arthrex and Deerfield SS, LLC [Member]
Proceeds from License Fees Received	$ 33,333				$ 33,333	$ 33,333
Arthrex [Member]
Debt Instrument, Increase (Decrease), Net			$ 15,000,000
Rohto Pharmaceutical Co., Ltd [Member]
Proceeds from License Fees Received							$ 3,000,000
Millennia Holdings, Inc [Member]
Payments for Terminated Licenses							$ 1,500,000
Distributor and License Agreement with Arthrex [Member]
License Agreement, Original Term								5 years
License Agreement, Additional Term								3 years
License Agreement, Minimum Required Period from End of Original Term to Terminate Term Extension								1 year
Advance Royalties								$ 5,000,000