Non-cash Investing and Financing transactions for years ended December 31 include:

	2014		2013
Conversion of convertible debt to common stock	$	3,067,423	$	523,927
Reclassification of the unamortized balance of debt discount and derivative liability, related to the extinguishment and conversion of the subordinated convertible debt, to additional paid-in capital		2,860,627		—
Derivative liability created from conversion option embedded in Deerfield convertible credit facility		8,825,935		—
Effect of modification of convertible debt		—		151,032
Common Stock issued for committed equity financing facility		—		204,015
Warrants issued for term loan modification		—		151,758
Warrants issued for term loan		—		568,324
Common stock and warrants issued for release of security interest in patents		—		325,693
Warrants issued in connection with convertible debt and equity facility		29,137,682		1,353,842
Derivative liability for embedded conversion option		—		965,484
Common stock issued for professional services		—		17,850
Common stock issued for settlement of contingency		39,150		39,150
Reclassification of warrant derivative liability to additional paid-in capital as a result of the expiration of non-standard anti-dilution clause contained in warrants		1,331,776		—
Issuance of common stock in connection with convertible debt facility		1,050,000		—
Common stock issued to satisfy contingent consideration		127		—
Accrued property and equipment		64,108		—