<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2017-02-21</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0000730708</issuerCik>
        <issuerName>SEACOAST BANKING CORP OF FLORIDA</issuerName>
        <issuerTradingSymbol>SBCF</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001228649</rptOwnerCik>
            <rptOwnerName>GOLDSTEIN ROBERT</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAPGEN CAPITAL GROUP III LP</rptOwnerStreet1>
            <rptOwnerStreet2>120 WEST 45TH STREET, SUITE 1010</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001453863</rptOwnerCik>
            <rptOwnerName>Ludwig Eugene</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAPGEN CAPITAL GROUP III LP</rptOwnerStreet1>
            <rptOwnerStreet2>120 WEST 45TH STREET, SUITE 1010</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001503574</rptOwnerCik>
            <rptOwnerName>Sullivan John P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAPGEN CAPITAL GROUP III LP</rptOwnerStreet1>
            <rptOwnerStreet2>120 WEST 45TH STREET, SUITE 1010</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001091449</rptOwnerCik>
            <rptOwnerName>ROSE JOHN W</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAPGEN CAPITAL GROUP III LP</rptOwnerStreet1>
            <rptOwnerStreet2>120 WEST 45TH STREET, SUITE 1010</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001488107</rptOwnerCik>
            <rptOwnerName>CapGen Capital Group III LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>120 WEST 45TH STREET, SUITE 1010</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001488108</rptOwnerCik>
            <rptOwnerName>CapGen Capital Group III LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CAPGEN CAPITAL GROUP III LP</rptOwnerStreet1>
            <rptOwnerStreet2>120 WEST 45TH STREET, SUITE 1010</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.10 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2017-02-21</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>6210000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>22.25</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1253141</value>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                    <footnoteId id="F3"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.10 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>52985</value>
                    <footnoteId id="F6"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.10 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>12437</value>
                    <footnoteId id="F7"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote.</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.10 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>9950</value>
                    <footnoteId id="F8"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.10 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>49373</value>
                    <footnoteId id="F9"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">CapGen Capital Group III LP (&quot;CapGen III&quot;) sold 6,210,000 shares of common stock, par value $0.10 per share (&quot;Common Stock&quot;), of Seacoast Banking Corporation of Florida (the &quot;Issuer&quot;) in an underwritten public offering by Issuer and CapGen III, which closed on February 21, 2017.</footnote>
        <footnote id="F2">The sale price reflects the public offering price. The price received by the reporting person will be $21.02625 per share, which is net of an underwriting discount of $1.22375 per share.</footnote>
        <footnote id="F3">CapGen Capital Group III LLC (&quot;CapGen LLC&quot;), as the sole general partner of CapGen III, may be deemed to be an indirect beneficial owner of the shares in this row under Rule 16a-1(a)(2) promulgated under the Securities Exchange Act of 1934, as amended (the &quot;Exchange Act&quot;). Pursuant to Rule 16a-1(a)(4) promulgated under the Exchange Act, CapGen LLC disclaims that it is the beneficial owner of such shares, except to the extent of its pecuniary interest.</footnote>
        <footnote id="F4">Each of Mr. Ludwig, as the managing member of CapGen LLC, Mr. Sullivan, as a member of the investment committee of CapGen LLC, and Mr. Goldstein and Mr. Rose, as principal members and members of the investment committee of CapGen LLC, may be deemed to be an indirect beneficial owner of the shares in this row pursuant to Rule 16a-1(a)(2) promulgated under the Exchange Act.</footnote>
        <footnote id="F5">Pursuant to Rule 16a-1(a)(4) promulgated under the Exchange Act, each of Mr. Ludwig, Mr. Sullivan, Mr. Rose and Mr. Goldstein disclaims that he is the beneficial owner of the shares in this row, except to the extent of his pecuniary interest.</footnote>
        <footnote id="F6">Mr. Goldstein directly owns the shares reported in this row.</footnote>
        <footnote id="F7">The shares reported in this row are held in a retirement account over which Mr. Goldstein holds discretionary authority.</footnote>
        <footnote id="F8">Mr. Sullivan directly owns the shares reported in this row.</footnote>
        <footnote id="F9">Mr. Rose directly owns the shares reported in this row.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Robert B. Goldstein</signatureName>
        <signatureDate>2017-02-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Eugene A. Ludwig</signatureName>
        <signatureDate>2017-02-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ CapGen Capital Group III LP, by CapGen Capital Group III LLC, its general partner, by Eugene A. Ludwig, its Managing Member</signatureName>
        <signatureDate>2017-02-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John P. Sullivan</signatureName>
        <signatureDate>2017-02-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ John W. Rose</signatureName>
        <signatureDate>2017-02-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ CapGen Capital Group III LLC, by Eugene A. Ludwig, its Managing Member</signatureName>
        <signatureDate>2017-02-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
