<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0407</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2022-12-30</periodOfReport>

    <dateOfOriginalSubmission>2023-01-04</dateOfOriginalSubmission>

    <issuer>
        <issuerCik>0001089907</issuerCik>
        <issuerName>SWK Holdings Corp</issuerName>
        <issuerTradingSymbol>SWKH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001911405</rptOwnerCik>
            <rptOwnerName>Hatcher Robert K.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>14755 PRESTON ROAD, SUITE 105</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>DALLAS</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>75254</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-12-30</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>779</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>17.64</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5511</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Consists of restricted shares of common stock granted to the Reporting Person as compensation in advance for his services as a director, based on the $17.64 closing price of the common stock on December 30, 2022. The restricted shares vest on December 30, 2023, subject to the Reporting Person's continued service through such vesting date.</footnote>
        <footnote id="F2">Reflects securities beneficially owned following the reported transaction as of the applicable transaction date.</footnote>
    </footnotes>

    <remarks>On January 4, 2023, the Reporting Person filed a Form 4 (the &quot;Original Form 4&quot;), which mistakenly reported the acquisition of 1,120 shares of common stock by the Reporting Person in lieu of cash compensation for his services as a director. The Reporting Person elected to receive such compensation in cash, and did not acquire such shares. Accordingly, this amendment is being filed to amend and restate the Original Form 4 in its entirety.</remarks>

    <ownerSignature>
        <signatureName>/s/ Yvette Heinrichson, as attorney-in-fact</signatureName>
        <signatureDate>2023-07-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
