The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X Genomics Inc Class ACL A COM88025U109105,9182,340,730SH DFND12,340,73000
10X Genomics Inc Class ACL A COM88025U109106,4022,351,425SH DFND22,057,0700294,355
10X Genomics Inc Class ACL A COM88025U10961,8691,367,274SH DFND31,118,4360248,838
10X Genomics Inc Class ACL A COM88025U109104,9592,319,542SH SOLE02,160,4980159,044
1Life HealthcareCOM68269G1073445SH DFND344500
2UCOM90214J1013319SH DFND331900
2seventy bioCOM9013841074286SH DFND328600
8x8 IncCOM282914100112,045SH DFND32,04500
908 DevicesCOM65443P1025249SH DFND324900
A. O. SmithCOM83186520914263SH DFND326300
ACM ResearchCOM00108J10911660SH DFND366000
AJ Gallagher & CoCOM363576109178,3851,094,120SH DFND11,094,12000
AJ Gallagher & CoCOM363576109492,0263,017,823SH DFND22,754,8070263,016
AJ Gallagher & CoCOM36357610994,976582,532SH DFND3354,3300228,202
AJ Gallagher & CoCOM363576109426,6442,616,805SH SOLE01,720,3620896,443
Abcellera Biologics IncCOM00288U10648,2874,533,974SH DFND14,533,97400
Abcellera Biologics IncCOM00288U10632,5143,052,968SH DFND21,349,20901,703,759
Abcellera Biologics IncCOM00288U10642,5153,992,048SH DFND33,239,5560752,492
Abcellera Biologics IncCOM00288U10618,9111,775,725SH SOLE01,244,4240531,301
AbiomedCOM003654100270,5881,093,241SH DFND11,093,24100
AbiomedCOM003654100375,5661,517,376SH DFND21,376,6360140,740
AbiomedCOM003654100121,820492,184SH DFND3377,6200114,564
AbiomedCOM003654100150,244607,020SH SOLE0415,0050192,015
Acadia Pharmaceuticals IncCOM0042251088544SH DFND354400
Accelerate DiagnosticsCOM00430H1020418SH DFND341800
Accenture 'A'COMG1151C1011348SH DFND34800
Acutus MedicalCOM0051111090424SH DFND342400
Adaptimmune Therapeutics ADRSPONDS ADR00653A10710,2966,056,564SH DFND16,056,56400
Adaptimmune Therapeutics ADRSPONDS ADR00653A1075,8903,464,606SH DFND21,041,54602,423,060
Adaptimmune Therapeutics ADRSPONDS ADR00653A1072,5171,480,697SH DFND31,480,69700
Adaptimmune Therapeutics ADRSPONDS ADR00653A1077,3434,319,479SH SOLE04,319,47900
Adicet Bio IncCOM0070021081,36493,449SH DFND193,44900
Adicet Bio IncCOM0070021081,28788,177SH SOLE088,17700
Adobe SystemsCOM00724F10144,853122,530SH DFND1122,53000
Adobe SystemsCOM00724F101140,249383,130SH DFND2328,481054,649
Adobe SystemsCOM00724F10126,98573,717SH DFND342,764030,953
Adobe SystemsCOM00724F101124,607340,400SH SOLE0221,0580119,342
Advanced Micro Devices IncCOM0079031079118SH DFND311800
AerovironmentCOM00807310817,518213,117SH DFND1213,11700
AerovironmentCOM00807310818,904229,973SH DFND270,2290159,744
AerovironmentCOM0080731088,503103,447SH DFND3103,44700
AerovironmentCOM00807310818,131220,567SH SOLE0220,56700
Affirm Holdings Inc Class ACOM CL A00827B10661,5623,408,756SH DFND13,408,75600
Affirm Holdings Inc Class ACOM CL A00827B106153,6988,510,383SH DFND25,582,03102,928,352
Affirm Holdings Inc Class ACOM CL A00827B10616,627920,653SH DFND3758,2870162,366
Affirm Holdings Inc Class ACOM CL A00827B106105,5955,846,900SH SOLE05,015,7760831,124
Agios Pharmaceuticals IncCOM00847X1044186SH DFND318600
Agnico Eagle MinesCOM0084741081563,400SH DFND13,40000
Agora Inc ADRADS00851L1033,215489,288SH DFND1489,28800
Agora Inc ADRADS00851L1031,675255,012SH SOLE0255,01200
Albemarle CorpCOM012653101154,146737,613SH DFND1737,61300
Albemarle CorpCOM012653101332,1131,589,211SH DFND21,443,4530145,758
Albemarle CorpCOM01265310165,632314,057SH DFND3198,4290115,628
Albemarle CorpCOM012653101266,5511,275,488SH SOLE0891,6540383,834
Alector IncCOM01444210763562,503SH DFND162,50300
Alector IncCOM0144421071,336131,492SH DFND2131,49200
Alector IncCOM0144421071,631160,497SH DFND3160,49700
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102113SH DFND41300
Allbirds IncCOM CL A01675A1092,678681,466SH DFND2242,2310439,235
Allbirds IncCOM CL A01675A1092,698686,619SH SOLE0686,61900
Alnylam PharmaceuticalsCOM02043Q107377,9142,591,112SH DFND12,591,11200
Alnylam PharmaceuticalsCOM02043Q107562,7723,858,566SH DFND23,169,1790689,387
Alnylam PharmaceuticalsCOM02043Q107191,9921,316,368SH DFND31,036,7710279,597
Alnylam PharmaceuticalsCOM02043Q107321,2182,202,388SH SOLE01,583,6540618,734
Alphabet Inc Class ACAP STK CL A02079K3055,5112,529SH DFND12,52900
Alphabet Inc Class ACAP STK CL A02079K30526,50012,160SH DFND211,4430717
Alphabet Inc Class ACAP STK CL A02079K3052,6281,206SH DFND38710335
Alphabet Inc Class ACAP STK CL A02079K30587,79640,287SH SOLE040,28700
Alphabet Inc Class CCAP STK CL C02079K107176,51880,696SH DFND180,69600
Alphabet Inc Class CCAP STK CL C02079K107592,079270,671SH DFND2247,322023,349
Alphabet Inc Class CCAP STK CL C02079K107108,83249,753SH DFND329,179020,574
Alphabet Inc Class CCAP STK CL C02079K107414,861189,655SH SOLE0109,829079,826
Alteryx IncCOM02156B10316336SH DFND333600
Amazon.ComCOM023135106576,7165,429,963SH DFND15,429,96300
Amazon.ComCOM0231351061,979,93718,641,723SH DFND211,321,00107,320,722
Amazon.ComCOM023135106277,1032,609,010SH DFND31,975,8000633,210
Amazon.ComCOM0231351061,185,63811,163,148SH SOLE08,112,48103,050,667
AmbarellaSHSG037AX10118,335280,100SH DFND1280,10000
AmbarellaSHSG037AX10110,868166,027SH DFND249,9470116,080
AmbarellaSHSG037AX1015,05477,202SH DFND377,20200
AmbarellaSHSG037AX1016,38997,605SH SOLE097,60500
AmdocsCOMG0260210332386SH DFND338600
AmerenCOM0236081021,16812,931SH DFND112,93100
American Superconductor CorpCOM0301112073,747723,370SH DFND1723,37000
American Superconductor CorpCOM0301112073,978768,000SH SOLE0768,00000
American Tower Corp REITCOM03027X1009113,564SH DFND13,56400
American Well Corp Class ACOM03044L10541896,754SH DFND196,75400
American Well Corp Class ACOM03044L105853197,523SH DFND2197,52300
American Well Corp Class ACOM03044L1051,457337,239SH DFND3337,23900
Amicus Therapeutics IncCOM03152W1096538SH DFND353800
Amkor TechnologyCOM031652100331,976SH DFND31,97600
Analog DevicesCOM03265410595,879656,302SH DFND1656,30200
Analog DevicesCOM032654105176,8361,210,462SH DFND21,104,6620105,800
Analog DevicesCOM03265410537,880259,292SH DFND3169,330089,962
Analog DevicesCOM032654105165,8451,135,222SH SOLE0797,2130338,009
AnterixCOM03676C1007162SH DFND316200
Apellis PharmaceuticalsCOM03753U10613283SH DFND328300
AppFolioCOM03783C10019212SH DFND321200
Appian CorpCL A03782L10199,2822,096,333SH DFND12,096,33300
Appian CorpCL A03782L101128,8822,721,316SH DFND22,392,3550328,961
Appian CorpCL A03782L10112,426262,379SH DFND3262,37900
Appian CorpCL A03782L10130,775649,816SH SOLE0649,81600
AppleCOM03783310047,732349,123SH DFND1349,12300
AppleCOM0378331004503,289SH DFND2003,289
AppleCOM0378331007,08151,790SH DFND351,79000
AppleCOM03783310025,923189,606SH SOLE0189,60600
Archer-Daniels-Midland CoCOM03948310212,013154,806SH DFND2154,80600
Archer-Daniels-Midland CoCOM0394831023,26142,029SH SOLE042,02900
Ares Capital CorpCOM04010L10342,8922,392,200SH DFND12,392,20000
Ares Capital CorpCOM04010L1031055,875SH DFND25,87500
Ares Capital CorpCOM04010L1033,748209,040SH DFND3209,04000
Ascendis Pharma ADR 1:1SPON ADR04351P1011,41515,222SH DFND115,22200
Ascendis Pharma ADR 1:1SPON ADR04351P1012,95431,777SH DFND231,77700
Ascendis Pharma ADR 1:1SPON ADR04351P1013,60738,801SH DFND338,80100
Asensus Surgical IncCOM04367G10325,338SH DFND35,33800
AstraZeneca ADRCOM04635310826400SH DFND340000
Atlassian Corp PlcCL AG0624210494,736505,526SH DFND1505,52600
Atlassian Corp PlcCL AG06242104626,7223,344,303SH DFND21,272,03802,072,265
Atlassian Corp PlcCL AG0624210497,599520,808SH DFND3415,6520105,156
Atlassian Corp PlcCL AG06242104198,5411,059,452SH SOLE0459,3100600,142
Aurora Innovation Class A CommonCOM CL A05177410728,65015,000,000SH SOLE015,000,00000
AutoZoneCOM0533321024,7392,205SH SOLE02,20500
Avalara IncCOM05338G10612165SH DFND216500
Avalara IncCOM05338G1063244,588SH DFND34,58800
AvangridCOM05351W10397421,126SH DFND121,12600
Avery Dennison CorporationCOM05361110916100SH DFND310000
Axogen IncCOM05463X1064444SH DFND344400
Axon Enterprise IncCOM05464C10150,711544,284SH DFND1544,28400
Axon Enterprise IncCOM05464C10198,9541,062,076SH DFND2837,2960224,780
Axon Enterprise IncCOM05464C10124,333261,169SH DFND3191,951069,218
Axon Enterprise IncCOM05464C10183,024891,105SH SOLE0625,6860265,419
Axonics Modulation TechnologiesCOM05465P10111198SH DFND319800
Baidu.com Sponsored ADRSPON ADR REP A056752108458,6273,083,618SH DFND22,888,4080195,210
Banco Bradesco Pn ADRSP ADR PFD NEW05946030319,4015,951,140SH DFND15,951,14000
Banco Bradesco Pn ADRSP ADR PFD NEW059460303154,99847,545,516SH DFND226,404,185021,141,331
Banco Bradesco Pn ADRSP ADR PFD NEW0594603035,3651,645,743SH DFND31,645,74300
BandwidthCOM05988J1037398SH DFND239800
BandwidthCOM05988J10321611,463SH DFND311,46300
Baozun Spn Adr 1:1SPONSORED ADR06684L1036,481592,408SH DFND1592,40800
Baozun Spn Adr 1:1SPONSORED ADR06684L1034,564417,226SH DFND2127,0310290,195
Baozun Spn Adr 1:1SPONSORED ADR06684L1031,822166,530SH DFND3166,53000
Baozun Spn Adr 1:1SPONSORED ADR06684L1033,217294,100SH SOLE0294,10000
Beam TherapeuticsCOM07373V10515398SH DFND339800
Beam TherapeuticsCOM07373V10539810,275SH SOLE010,27500
BeiGene LtdSPONSORED ADR07725L10248,993302,706SH DFND1302,70600
BeiGene LtdSPONSORED ADR07725L102321,2161,984,650SH DFND2731,86401,252,786
BeiGene LtdSPONSORED ADR07725L10250,717313,360SH DFND3250,642062,718
BeiGene LtdSPONSORED ADR07725L102102,648634,215SH SOLE0276,0570358,158
Benefitfocus IncCOM08180D1062,384306,448SH DFND1306,44800
Benefitfocus IncCOM08180D1062,258290,178SH DFND282,4970207,681
Benefitfocus IncCOM08180D1061,352173,791SH DFND3173,79100
Benefitfocus IncCOM08180D1061,761226,368SH SOLE0226,36800
Berkeley Lights IncCOM0843101016,5391,315,767SH DFND11,315,76700
Berkeley Lights IncCOM0843101013,632730,704SH DFND2509,0410221,663
Berkeley Lights IncCOM0843101015,8691,180,823SH DFND31,004,8140176,009
Berkeley Lights IncCOM0843101012,245451,690SH SOLE0326,6900125,000
Beyond Meat IncCOM08862E10930,3831,269,122SH DFND11,269,12200
Beyond Meat IncCOM08862E109106,2164,436,740SH DFND21,737,01402,699,726
Beyond Meat IncCOM08862E10930,6371,279,751SH DFND31,011,4100268,341
Beyond Meat IncCOM08862E10934,5431,442,896SH SOLE0616,0810826,815
Bilibili Inc ADRSPONSORED ADR0900401061,43355,974SH DFND342,949013,025
BioCryst PharmaceuticalsCOM09058V103181,687SH DFND31,68700
BioNTech ADRSPONS ADS09075V10292,349619,379SH DFND1619,37900
BioNTech ADRSPONS ADS09075V102703,7604,720,057SH DFND22,028,48002,691,577
BioNTech ADRSPONS ADS09075V10291,346612,647SH DFND3511,8200100,827
BioNTech ADRSPONS ADS09075V10214SH DFND4400
BioNTech ADRSPONS ADS09075V102195,4541,310,893SH SOLE0570,0780740,815
Biomarin Pharmaceutical IncCOM09061G101782SH DFND38200
BlacklineCOM09239B10930,113452,142SH DFND1452,14200
BlacklineCOM09239B10924,704370,934SH DFND2110,7520260,182
BlacklineCOM09239B10910,659160,044SH DFND3160,04400
BlacklineCOM09239B10918,686280,576SH SOLE0280,57600
Blackrock IncCOM09247X1011219SH DFND31900
Blink ChargingCOM09354A1005327SH DFND332700
Blue Apron Holdings IncCL A09523Q200541148,506SH DFND1148,50600
Bluebird Bio IncCOM09609G1004860SH DFND386000
Blueprint Medicines CorpCOM09627Y10916315SH DFND331500
Booking Holdings IncCOM09857L10869,21539,574SH DFND139,57400
Booking Holdings IncCOM09857L108215,682123,318SH DFND2111,731011,587
Booking Holdings IncCOM09857L10842,75624,446SH DFND314,247010,199
Booking Holdings IncCOM09857L108197,428112,881SH SOLE073,651039,230
Boston OmahaCOM10104410511529SH DFND352900
Box IncCOM10316T10425979SH DFND397900
Brady CorpCOM1046741069200SH DFND320000
BridgeBio Pharma IncCOM10806X10278085,887SH DFND185,88700
BridgeBio Pharma IncCOM10806X1021,682185,242SH DFND2185,24200
BridgeBio Pharma IncCOM10806X1021,937213,348SH DFND3213,34800
Bristol Myers SquibbCOM11012210838488SH DFND348800
Broadridge Finl.Sltn.COM11133T10367,544473,824SH DFND1473,82400
Broadridge Finl.Sltn.COM11133T103226,1731,586,622SH DFND21,449,6380136,984
Broadridge Finl.Sltn.COM11133T10342,026294,818SH DFND3173,1690121,649
Broadridge Finl.Sltn.COM11133T103187,1961,313,193SH SOLE0850,9700462,223
Brookfield RenewableCOM11284V10565,4521,838,010SH DFND11,838,01000
Brookfield RenewableCOM11284V1051052,953SH DFND22,95300
Brookfield RenewableCOM11284V1054,169117,065SH DFND3117,06500
Brunswick CorpCOM11704310913200SH DFND320000
Bumble IncCOM CL A12047B10511,260400,000SH SOLE0400,00000
Burford CapitalORD SHSG179771105,761589,318SH DFND2501,535087,783
Burford CapitalORD SHSG1797711010,6091,085,189SH DFND11,085,18900
Burning Rock Biotech Ltd ADRSPON ADS12233L107466160,181SH DFND1160,18100
Burning Rock Biotech Ltd ADRSPON ADS12233L107517177,712SH DFND300177,712
Butterfly Network IncCOM CL A124155102735239,457SH DFND1239,45700
Butterfly Network IncCOM CL A1241551021,153375,532SH DFND2375,53200
Butterfly Network IncCOM CL A1241551021,884613,830SH DFND3613,83000
Butterfly Network IncCOM CL A1241551022,493812,150SH SOLE0812,15000
C3.aiCL A12468P1042117SH DFND311700
CEVA IncCOM1572101055,997178,680SH DFND1178,68000
CEVA IncCOM1572101054,987148,594SH DFND243,0730105,521
CEVA IncCOM1572101052,33969,698SH DFND369,69800
CEVA IncCOM1572101052,76982,500SH SOLE082,50000
CH Robinson WorldwideCOM NEW12541W20936,251357,611SH DFND1357,61100
CH Robinson WorldwideCOM NEW12541W2093453,408SH DFND2003,408
CH Robinson WorldwideCOM NEW12541W2095,31852,464SH DFND352,46400
CH Robinson WorldwideCOM NEW12541W20920,009197,381SH SOLE0197,38100
CRH Plc ADRADR12626K203260SH DFND46000
CS Disco IncCOM12632710513700SH DFND270000
CS Disco IncCOM12632710535219,527SH DFND319,52700
Calavo Growers IncCOM1282461055113SH DFND311300
Calix IncCOM13100M50912353SH DFND235300
Calix IncCOM13100M5093349,794SH DFND39,79400
Cardlytics IncCOM14161W1058,788393,924SH DFND1393,92400
Cardlytics IncCOM14161W1057,468334,732SH DFND2100,5040234,228
Cardlytics IncCOM14161W1053,296147,731SH DFND3147,73100
Cardlytics IncCOM14161W1055,902264,524SH SOLE0264,52400
Cargurus IncCOM141788109231,066SH DFND21,06600
Cargurus IncCOM14178810964129,842SH DFND329,84200
Carmax IncCOM1431301024,03544,597SH SOLE044,59700
CarvanaCOM14686910236,2671,606,170SH DFND11,606,17000
CarvanaCOM146869102126,6975,611,044SH DFND23,273,64702,337,397
CarvanaCOM14686910216,646737,182SH DFND3572,0100165,172
CarvanaCOM14686910266,5492,947,233SH SOLE02,087,8860859,347
Castle BiosciencesCOM14843C1055225SH DFND322500
Cbre Group IncCL A12504L10958,973801,152SH DFND1801,15200
Cbre Group IncCL A12504L109206,8802,810,484SH DFND22,578,7450231,739
Cbre Group IncCL A12504L10935,595483,561SH DFND3281,6960201,865
Cbre Group IncCL A12504L109163,5162,221,382SH SOLE01,463,0500758,332
Cellectis ADRSPONS ADS15117K1031,366482,819SH DFND1482,81900
Cellectis ADRSPONS ADS15117K103616217,613SH DFND2174,990042,623
Cellectis ADRSPONS ADS15117K103511180,500SH SOLE0180,50000
Celsius HoldingsCOM15118V20715230SH DFND323000
Cemex ADRSPON ADR NEW15129088951,23013,068,778SH DFND113,068,77800
Cemex ADRSPON ADR NEW151290889173,98344,383,405SH DFND211,510,562032,872,843
Cemex ADRSPON ADR NEW15129088962,06015,831,670SH DFND31,561,634014,270,036
Cemex ADRSPON ADR NEW1512908892,520642,732SH DFND4642,73200
Cemex ADRSPON ADR NEW1512908894,0531,033,870SH SOLE01,033,87000
CertaraCOM15687V10931,9711,489,790SH DFND11,489,79000
CertaraCOM15687V10997,4574,541,325SH DFND24,118,0030423,322
CertaraCOM15687V10919,427905,286SH DFND3532,3380372,948
CertaraCOM15687V10991,3014,254,488SH SOLE02,805,27401,449,214
CerusCOM15708510181,459SH DFND31,45900
ChargePoint Holdings IncCOM CL A15961R105966,985SH DFND16,98500
ChargePoint Holdings IncCOM CL A15961R10562,6314,574,933SH SOLE04,574,93300
Charles River Laboratories InternationalCOM1598641073,38015,796SH SOLE015,79600
Charles SchwabCOM80851310573,6021,164,956SH DFND11,164,95600
Charles SchwabCOM808513105237,5493,759,871SH DFND23,423,2650336,606
Charles SchwabCOM80851310544,768708,585SH DFND3413,8500294,735
Charles SchwabCOM808513105204,8443,242,226SH SOLE02,123,64001,118,586
CheggCOM163092109106,7325,683,270SH DFND15,683,27000
CheggCOM163092109150,4328,010,231SH DFND27,021,8660988,365
CheggCOM16309210922,5511,200,813SH DFND3969,6170231,196
CheggCOM16309210964,5373,436,474SH SOLE02,793,3890643,085
Chewy IncCL A16679L109136,4633,930,372SH DFND13,930,37200
Chewy IncCL A16679L109272,1367,838,014SH DFND27,450,9960387,018
Chewy IncCL A16679L10931,087895,349SH DFND3592,2810303,068
Chewy IncCL A16679L109134,3493,869,495SH SOLE02,725,56001,143,935
Chinook TherapeuticsCOM16961L1061,61492,275SH DFND192,27500
Chinook TherapeuticsCOM16961L1063,689210,918SH DFND264,8550146,063
Chinook TherapeuticsCOM16961L1061,47984,574SH DFND384,57400
Chinook TherapeuticsCOM16961L1062,047117,058SH SOLE0117,05800
Church & Dwight Co IncCOM17134010217179SH DFND317900
Cisco SystemsCOM17275R10223,666555,019SH DFND1555,01900
Cisco SystemsCOM17275R1022225,198SH DFND2005,198
Cisco SystemsCOM17275R1023,49782,008SH DFND382,00800
Cisco SystemsCOM17275R10212,809300,399SH SOLE0300,39900
Clear Secure IncCOM18467V10920,0001,000,000SH SOLE01,000,00000
Cloudflare IncCL A COM18915M107181,0024,137,196SH DFND14,137,19600
Cloudflare IncCL A COM18915M107588,77013,457,602SH DFND28,192,18205,265,420
Cloudflare IncCL A COM18915M10776,5791,750,376SH DFND31,371,8550378,521
Cloudflare IncCL A COM18915M107208,6634,769,434SH SOLE02,734,73902,034,695
Clover Health Investments CorpCOM CL A18914F1035,6612,645,503SH SOLE02,645,50300
CoStar GroupCOM22160N109204,8223,390,539SH DFND13,390,53900
CoStar GroupCOM22160N109383,8776,354,529SH DFND26,103,7100250,819
CoStar GroupCOM22160N10938,028629,501SH DFND3436,6170192,884
CoStar GroupCOM22160N109168,1392,783,303SH SOLE02,040,0880743,215
Coca ColaCOM19121610025,803410,154SH DFND1410,15400
Coca ColaCOM1912161004817,652SH DFND2007,652
Coca ColaCOM1912161001,00315,944SH DFND315,94400
Coca ColaCOM19121610027,745441,022SH SOLE0441,02200
CodexisCOM19200510628,1042,686,842SH DFND12,686,84200
CodexisCOM19200510621,4562,051,206SH DFND2640,60301,410,603
CodexisCOM19200510610,6941,022,397SH DFND3944,592077,805
CodexisCOM19200510617,1501,639,622SH SOLE01,639,62200
Cognizant Technology Solutions CorpCL A1924461024,52967,105SH DFND367,10500
Cognyte SoftwareORD SHSM251331052369SH DFND336900
Cohen & Steers IncCOM19247A10019301SH DFND330100
Coherus BioSciencesCOM19249H103101,431SH DFND31,43100
CohuCOM19257610619700SH DFND370000
Coinbase Global IncCOM CL A19260Q1073507,447SH SOLE07,44700
Columbia Sportswear CoCOM198516106795SH DFND39500
Commscope Holding Co IncCOM20337X10991,442SH DFND31,44200
Consensus Cloud SolutionsCOM20848V105124SH DFND32400
Consolidated EdisonCOM20911510485,781902,006SH DFND1902,00600
Consolidated EdisonCOM2091151041281,341SH DFND21,34100
Consolidated EdisonCOM2091151045,04453,036SH DFND353,03600
Cooper Cos Inc/TheCOM2166484029,82431,373SH DFND231,37300
Copa Holdings S ACL AP3107610526,143412,541SH DFND1412,54100
Copa Holdings S ACL AP31076105227,6293,592,065SH DFND22,331,67601,260,389
Copa Holdings S ACL AP3107610547,126743,659SH DFND383,4610660,198
Copa Holdings S ACL AP310761052,14533,847SH DFND433,84700
CorningCOM21935010521679SH DFND367900
Costco Wholesale CorporationCOM22160K1053063SH DFND36300
CoupangCL A22266T109112,9848,861,490SH DFND18,861,49000
CoupangCL A22266T109997,24978,215,607SH DFND251,139,522027,076,085
CoupangCL A22266T10987,4966,862,398SH DFND34,365,95502,496,443
CoupangCL A22266T10927921,849SH DFND421,84900
CoupangCL A22266T109183,51214,393,090SH SOLE07,503,30706,889,783
Coursera IncCOM22266M10490,7146,397,309SH DFND16,397,30900
Coursera IncCOM22266M104100,6027,094,614SH DFND26,439,9360654,678
Coursera IncCOM22266M10437,8842,671,657SH DFND32,150,0830521,574
Coursera IncCOM22266M10424,7491,745,339SH SOLE01,378,1760367,163
CredicorpCOMG2519Y10819,395161,745SH DFND1161,74500
CredicorpCOMG2519Y108100,659839,454SH DFND2329,3330510,121
CredicorpCOMG2519Y10833,714281,159SH DFND335,4400245,719
CredicorpCOMG2519Y1081,68214,031SH DFND414,03100
CrowdStrike HoldingsCOM22788C10519114SH DFND311400
Cullen/Frost BankersCOM22989910923,556202,284SH DFND1202,28400
Cullen/Frost BankersCOM2298991092181,874SH DFND2001,874
Cullen/Frost BankersCOM2298991093,47929,878SH DFND329,87800
Cullen/Frost BankersCOM22989910912,649108,625SH SOLE0108,62500
Curevac N.V.COMN2451R1053,909287,249SH DFND2287,24900
CyberArk Software LtdSHSM2682V10811,57090,416SH DFND190,41600
CyberArk Software LtdSHSM2682V10820,211157,949SH DFND247,5420110,407
CyberArk Software LtdSHSM2682V1089,19571,857SH DFND371,85700
CyberArk Software LtdSHSM2682V10814,730115,118SH SOLE0115,11800
Cytokinetics IncCOM NEW23282W60513340SH DFND334000
Dada Nexus Ltd ADRADS23344D10821,5892,661,997SH DFND12,661,99700
Dada Nexus Ltd ADRADS23344D1089,4831,169,302SH DFND21,169,30200
Dada Nexus Ltd ADRADS23344D10832940,516SH DFND340,51600
Dada Nexus Ltd ADRADS23344D1086,348782,705SH SOLE0782,70500
Darden RestaurantsCOM237194105982SH DFND38200
DatadogCOM23804L103141,9241,490,172SH DFND11,490,17200
DatadogCOM23804L103276,7712,906,035SH DFND22,773,3850132,650
DatadogCOM23804L10330,365318,829SH DFND3213,2870105,542
DatadogCOM23804L103128,9371,353,814SH SOLE0954,4760399,338
Deere & CoCOM244199105138,491462,453SH DFND1462,45300
Deere & CoCOM24419910583,516278,880SH DFND2166,8570112,023
Deere & CoCOM244199105141,645472,985SH DFND3371,3450101,640
Deere & CoCOM24419910536,200120,880SH SOLE051,286069,594
Denali TherapeuticsCOM24823R10585,2712,897,408SH DFND12,897,40800
Denali TherapeuticsCOM24823R105124,3564,225,497SH DFND24,107,1060118,391
Denali TherapeuticsCOM24823R10513,089444,740SH DFND3406,120038,620
Denali TherapeuticsCOM24823R105214,8907,301,729SH SOLE07,301,72900
DermTechCOM24984K1052286SH DFND328600
Dexcom IncCOM252131107218,3352,929,495SH DFND12,929,49500
Dexcom IncCOM252131107677,5729,091,261SH DFND23,633,29705,457,964
Dexcom IncCOM252131107227,5563,053,212SH DFND32,424,2010629,011
Dexcom IncCOM252131107225,4853,025,431SH SOLE01,310,65801,714,773
DigimarcCOM25381B1013,711262,445SH DFND1262,44500
DigimarcCOM25381B1013,967280,535SH DFND285,6620194,873
DigimarcCOM25381B1011,839130,075SH DFND3130,07500
DigimarcCOM25381B1012,188154,711SH SOLE0154,71100
Digital Realty Trust REITCOM2538681034753,656SH DFND13,65600
DoceboCOM25609L1054,615161,041SH DFND2137,496023,545
DoceboCOM25609L1058267SH DFND326700
Dolby Laboratories 'A'COM25659T10718,703261,366SH DFND1261,36600
Dolby Laboratories 'A'COM25659T1071772,480SH DFND2002,480
Dolby Laboratories 'A'COM25659T1072,76438,623SH DFND338,62300
Dolby Laboratories 'A'COM25659T10714,360200,666SH SOLE0200,66600
Dollar General CorpCOM2566771051769SH DFND36900
DomoCOM2575541059321SH DFND332100
DonaldsonCOM25765110921436SH DFND343600
Doordash IncCOM25809K10595,1021,482,034SH DFND11,482,03400
Doordash IncCOM25809K105195,9913,054,245SH DFND22,891,6980162,547
Doordash IncCOM25809K10524,202377,150SH DFND3246,4620130,688
Doordash IncCOM25809K105167,8502,615,713SH SOLE02,122,6640493,049
DropboxCL A26210C10418881SH DFND388100
Duck Creek TechnologiesSHS2641201065355SH DFND335500
Duke Realty Corporation REITCOM26441150596,7181,760,103SH DFND11,760,10300
Duke Realty Corporation REITCOM2644115052063,740SH DFND23,74000
Duke Realty Corporation REITCOM2644115058,795160,051SH DFND3160,05100
Duolingo IncCL A COM26603R10686,326986,019SH DFND1986,01900
Duolingo IncCL A COM26603R10693,0781,063,143SH DFND2971,368091,775
Duolingo IncCL A COM26603R10632,768374,273SH DFND3301,233073,040
Duolingo IncCL A COM26603R10620,136229,989SH SOLE0179,822050,167
EHang Holdings Ltd ADRADS26853E102293,105SH DFND13,10500
EargoCOM2700871090263SH DFND326300
EcolabCOM27886510061,205398,054SH DFND1398,05400
EcolabCOM27886510039,306255,630SH DFND2159,110096,520
EcolabCOM27886510062,876408,920SH DFND3321,066087,854
EcolabCOM27886510014,02591,211SH SOLE032,065059,146
Edwards Lifesciences CorpCOM28176E1083,98241,875SH DFND141,87500
Edwards Lifesciences CorpCOM28176E10821,970231,040SH DFND2231,04000
Edwards Lifesciences CorpCOM28176E10810,157106,815SH DFND3106,81500
Edwards Lifesciences CorpCOM28176E1083,85140,495SH SOLE040,49500
Electronic Arts, Inc.COM28551210921170SH DFND317000
Electronic Arts, Inc.COM2855121094,29135,276SH SOLE035,27600
Elevance Health IncCOM036752103256,532531,585SH DFND1531,58500
Elevance Health IncCOM036752103828,7171,717,263SH DFND21,564,8370152,426
Elevance Health IncCOM036752103156,790324,900SH DFND3191,1600133,740
Elevance Health IncCOM036752103720,0781,492,142SH SOLE0975,2170516,925
Emergent Biosolutions IncCOM29089Q10512385SH DFND338500
Enanta PharmaceuticalsCOM29251M10615318SH DFND331800
Enphase Energy IncCOM29355A1072011,029SH DFND11,02900
Enphase Energy IncCOM29355A1071892SH DFND39200
Estee Lauder 'A'COM51843910487,879345,069SH DFND1345,06900
Estee Lauder 'A'COM518439104307,3631,206,908SH DFND21,106,7230100,185
Estee Lauder 'A'COM51843910454,115212,491SH DFND3124,432088,059
Estee Lauder 'A'COM518439104253,891996,941SH SOLE0654,8970342,044
EverQuote IncCOM CL A30041R1086,356718,967SH DFND1718,96700
EverQuote IncCOM CL A30041R1082,327263,204SH DFND278,0820185,122
EverQuote IncCOM CL A30041R1081,446163,605SH DFND3163,60500
EverQuote IncCOM CL A30041R1082,047231,550SH SOLE0231,55000
Everbridge IncCOM29978A1049,226330,786SH DFND1330,78600
Everbridge IncCOM29978A1045,638202,169SH DFND261,2930140,876
Everbridge IncCOM29978A1042,63194,337SH DFND394,33700
Everbridge IncCOM29978A1044,140148,446SH SOLE0148,44600
Eversource EnergyCOM30040W10870,790838,049SH DFND1838,04900
Eversource EnergyCOM30040W1081091,293SH DFND21,29300
Eversource EnergyCOM30040W1084,32551,207SH DFND351,20700
Exact SciencesCOM30063P10544,0481,118,241SH DFND11,118,24100
Exact SciencesCOM30063P10562,7441,592,886SH DFND21,148,3150444,571
Exact SciencesCOM30063P10520,059509,233SH DFND3404,4950104,738
Exact SciencesCOM30063P10547,0371,194,147SH SOLE0872,9700321,177
ExelixisCOM30161Q104261,230SH DFND31,23000
Exelon CorporationCOM30161N1011,28928,452SH DFND128,45200
Expedia Group IncCOM30212P30317176SH DFND317600
Expeditors IntlCOM30213010910107SH DFND310700
Expensify IncCOM CL A30219Q10612,402697,160SH DFND1697,16000
Expensify IncCOM CL A30219Q106181,020SH DFND21,02000
Expensify IncCOM CL A30219Q10650228,200SH DFND328,20000
Expensify IncCOM CL A30219Q1066,389359,144SH SOLE0359,14400
ExponentCOM30214U10222242SH DFND324200
Exscientia Ltd ADRADS30223G10211,6481,069,649SH DFND11,069,64900
Exscientia Ltd ADRADS30223G10220,2631,860,659SH DFND2213,83801,646,821
Exscientia Ltd ADRADS30223G1021,986182,326SH DFND3182,32600
Exscientia Ltd ADRADS30223G10219,1601,759,407SH SOLE0975,3740784,033
FTI ConsultingCOM3029411095,31929,413SH SOLE029,41300
Factset Research SystemsCOM3030751052361SH DFND36100
FarfetchORD SHS CL A30744W10734,7334,850,961SH DFND14,850,96100
FarfetchORD SHS CL A30744W107116,57016,280,796SH DFND213,343,43802,937,358
FarfetchORD SHS CL A30744W10712,9971,815,198SH DFND31,184,2630630,935
FarfetchORD SHS CL A30744W10785,06911,881,112SH SOLE07,271,10904,610,003
FastenalCOM31190010477,2761,547,989SH DFND11,547,98900
FastenalCOM31190010415,542311,345SH DFND2239,961071,384
FastenalCOM31190010414,630293,068SH DFND3264,792028,276
FastenalCOM31190010441,508831,486SH SOLE0831,48600
FastlyCL A31188V1002205SH DFND320500
Fate TherapeuticsCOM31189P1029372SH DFND337200
Ferrari NVCOMN3167Y1031,566,1538,550,606SH DFND26,777,80401,772,802
Ferrari NVCOMN3167Y103249,0871,359,921SH SOLE01,359,92100
Fibrogen IncCOM31572Q8085467SH DFND346700
First Industrial REITCOM32054K10373,0791,539,153SH DFND11,539,15300
First Industrial REITCOM32054K1031282,703SH DFND22,70300
First Industrial REITCOM32054K1036,045127,313SH DFND3127,31300
First Republic BankCOM33616C100136,435946,152SH DFND1946,15200
First Republic BankCOM33616C100213,0951,477,776SH DFND21,435,569042,207
First Republic BankCOM33616C10014,22498,643SH DFND384,536014,107
First Republic BankCOM33616C10030,458211,222SH SOLE0211,22200
Fiverr IntlORD SHSM4R82T1066,847199,100SH DFND1199,10000
Fiverr IntlORD SHSM4R82T1065,929172,400SH DFND251,2000121,200
Fiverr IntlORD SHSM4R82T1062,30567,019SH DFND367,01900
Fiverr IntlORD SHSM4R82T1066,489188,700SH SOLE0188,70000
FortisCOM3495531071,59933,889SH DFND133,88900
Fortive CorpCOM34959J1085,31997,814SH DFND297,81400
FoxCOM35137L10510310SH DFND331000
Freshpet IncCOM35803910514276SH DFND227600
Freshpet IncCOM3580391053977,643SH DFND37,64300
Full Truck Alliance Co Ltd ADRSPONS ADS35969L108143,93215,886,582SH DFND215,436,9480449,634
Futu Hdgs ADRSPON ADR CL A36118L10657,8631,108,279SH DFND2863,8970244,382
Futu Hdgs ADRSPON ADR CL A36118L10608SH DFND4800
GANCOMG3728V1092572SH DFND357200
Gentex CorpCOM37190110914516SH DFND351600
Ginkgo Bioworks Holdings IncCL A COM37611X10051,56321,664,932SH DFND121,664,93200
Ginkgo Bioworks Holdings IncCL A COM37611X100157,42966,146,772SH DFND237,682,067028,464,705
Ginkgo Bioworks Holdings IncCL A COM37611X10018,2857,682,791SH DFND36,298,56201,384,229
Ginkgo Bioworks Holdings IncCL A COM37611X100261,403109,833,291SH SOLE0101,771,58908,061,702
GitLabCLASS A37637K1084,48084,315SH SOLE084,31500
Glaukos CorpCOM37732210212269SH DFND326900
Global Blood Therapeutics IncCOM37890U10827835SH DFND383500
Globus MedicalCL A3795772083,59764,077SH SOLE064,07700
Golub Capital BDC IncCOM38173M1021,582122,100SH DFND1122,10000
Goodyear Tire & Rubber Co/TheCOM382550101151,400SH DFND31,40000
GracoCOM38410910422363SH DFND336300
Grainger, WWCOM3848021042760SH DFND36000
HDFC Bank ADRADR REPS 3 SHS40415F10157,2671,041,984SH DFND2896,7600145,224
HDFC Bank ADRADR REPS 3 SHS40415F10110,792196,355SH DFND3132,986063,369
HDFC Bank ADRADR REPS 3 SHS40415F10186,8951,581,058SH SOLE01,147,1390433,919
HUYA ADRADS REP SHS A44852D1084,4411,144,570SH DFND11,144,57000
HUYA ADRADS REP SHS A44852D1082,410621,141SH SOLE0621,14100
Halozyme TherapeuticsCOM40637H10936815SH DFND381500
Harris CorpCOM5024311091561SH DFND36100
Hashicorp IncCOM CL A41810010350,2581,707,134SH DFND11,707,13400
Hashicorp IncCOM CL A41810010367,7802,302,317SH DFND22,131,3990170,918
Hashicorp IncCOM CL A4181001035,308180,295SH DFND3180,29500
Hashicorp IncCOM CL A41810010312,037408,859SH SOLE0408,85900
Health Catalyst IncCOM42225T10797567,271SH DFND167,27100
Health Catalyst IncCOM42225T1072,192151,258SH DFND2151,25800
Health Catalyst IncCOM42225T1072,521173,988SH DFND3173,98800
Healthcare Services Group IncCOM4219061083157SH DFND315700
Heron Therapeutics IncCOM4277461021308SH DFND330800
Hershey Foods CorporationCOM42786610815,96474,198SH DFND274,19800
Hershey Foods CorporationCOM4278661084,47120,779SH SOLE020,77900
HillenbrandCOM4315711087170SH DFND317000
Homology MedicinesCOM4380831071481SH DFND348100
Howard HughesCOM44267D10727,595405,518SH DFND1405,51800
Howard HughesCOM44267D10781,6121,199,301SH DFND21,087,4260111,875
Howard HughesCOM44267D10716,409241,132SH DFND3141,576099,556
Howard HughesCOM44267D10774,9841,101,896SH SOLE0717,3710384,525
HubbellCOM4435106071687SH DFND38700
Hubspot IncCOM44357310039131SH DFND313100
HumanaCOM4448591022860SH DFND36000
Hutchison China MeditechSPONSORED ADR44842L1031,520120,243SH DFND1120,24300
Hutchison China MeditechSPONSORED ADR44842L10377261,045SH DFND2365060,680
Hutchison China MeditechSPONSORED ADR44842L1032,322183,691SH DFND31020183,589
ICICI Bank ADRADR45104G10471,0864,007,099SH DFND14,007,09900
ICICI Bank ADRADR45104G10460,7023,421,778SH DFND23,421,77800
ICICI Bank ADRADR45104G10411,904671,046SH DFND3671,04600
ICICI Bank ADRADR45104G1044,265240,440SH DFND4240,44000
IPG Photonics CorpCOM44980X10911,366120,747SH DFND1120,74700
IPG Photonics CorpCOM44980X10910,312109,549SH DFND233,281076,268
IPG Photonics CorpCOM44980X1094,65249,416SH DFND349,41600
IPG Photonics CorpCOM44980X1098,50390,336SH SOLE090,33600
Iac/InteractivecorpCOM44891N20816,632218,935SH DFND1218,93500
Iac/InteractivecorpCOM44891N20849,174647,278SH DFND2587,612059,666
Iac/InteractivecorpCOM44891N20810,235134,727SH DFND380,028054,699
Iac/InteractivecorpCOM44891N20843,854577,251SH SOLE0370,3230206,928
Ii-Vi IncCOM90210410824477SH DFND347700
IlluminaCOM452327109380,3342,062,997SH DFND12,062,99700
IlluminaCOM4523271091,980,78710,744,127SH DFND27,840,32902,903,798
IlluminaCOM452327109241,3201,308,959SH DFND31,019,7480289,211
IlluminaCOM4523271091,074,0025,825,570SH SOLE04,833,8290991,741
InModeSHSM5425M10313596SH DFND359600
Incyte CorpCOM45337C10213165SH DFND316500
InfineraCOM45667G103162,941SH DFND32,94100
Infosys Ltd ADRSPONSORED ADR45678810821,5791,165,809SH DFND11,165,80900
Infosys Ltd ADRSPONSORED ADR45678810819,0211,027,594SH DFND2111,4630916,131
Infosys Ltd ADRSPONSORED ADR45678810825,3141,367,593SH DFND3529,2570838,336
Infosys Ltd ADRSPONSORED ADR4567881083,232174,620SH DFND4174,62000
Inogen IncCOM45780L1043141SH DFND314100
Insmed IncCOM45766930714707SH DFND370700
Inspire Medical SystemsCOM45773010932173SH DFND317300
Intercept Pharmaceuticals IncCOM45845P1081101SH DFND310100
International Game TechnologySHSG4863A108191,024SH DFND31,02400
IntuitCOM46120210320,07052,071SH DFND152,07100
IntuitCOM461202103200518SH DFND200518
IntuitCOM4612021032,7767,201SH DFND37,20100
IntuitCOM46120210311,36629,489SH SOLE029,48900
Intuitive SurgicalCOM NEW46120E60277,817387,707SH DFND1387,70700
Intuitive SurgicalCOM NEW46120E602519,2912,587,271SH DFND2982,16501,605,106
Intuitive SurgicalCOM NEW46120E60280,222399,693SH DFND3318,285081,408
Intuitive SurgicalCOM NEW46120E602164,089817,545SH SOLE0354,7080462,837
InvitaeCOM46185L1032800SH DFND380000
Ionis PharmaceuticalsCOM4622221002,03454,949SH DFND154,94900
Ionis PharmaceuticalsCOM4622221004,340117,222SH DFND2117,22200
Ionis PharmaceuticalsCOM4622221005,140138,844SH DFND3138,84400
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210610,3192,410,946SH DFND12,410,94600
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210629,9126,988,859SH DFND2485,58206,503,277
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210638,1128,904,694SH DFND3827,94108,076,753
Itau Unibanco Holding SA-ADRSPON ADR REP PFD4655621061,649385,212SH DFND4385,21200
Ivanhoe MinesCOM CL A46579R10481,400SH DFND21,40000
J&J Snack Foods CorpCOM4660321091283SH DFND38300
JD.Com Inc - ADRSPON ADR CL A47215P10601SH DFND4100
JDS Uniphase CorporationCOM925550105151,142SH DFND31,14200
JFrog LtdORD SHSM6191J10012,746604,939SH DFND1604,93900
JFrog LtdORD SHSM6191J1008,972425,802SH DFND2128,8700296,932
JFrog LtdORD SHSM6191J1004,223200,422SH DFND3200,42200
JFrog LtdORD SHSM6191J1008,725414,081SH SOLE0414,08100
Jack Henry & AssociatesCOM4262811011162SH DFND36200
Jazz PharmaceuticalsSHSG5087110526168SH DFND316800
Joby Aviation IncCOMG6516310037,6957,677,200SH SOLE07,677,20000
Johnson & JohnsonCOM4781601041899SH DFND39900
Jumia Technologies Ag ADRSPONSORED ADS48138M10557,2559,447,992SH DFND28,765,4970682,495
Jumia Technologies Ag ADRSPONSORED ADS48138M1052,631434,078SH DFND33740433,704
KE Holdings ADRADR4824971048,934497,723SH DFND1497,72300
KE Holdings ADRADR48249710419,9461,111,204SH DFND2579,6880531,516
KE Holdings ADRADR48249710419510,854SH DFND310,85400
KE Holdings ADRADR48249710486948,406SH SOLE048,40600
KFORCE INC.COM49373210118295SH DFND329500
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K1013,531793,536SH DFND2793,53600
Knowles CorpCOM49926D109211,200SH DFND31,20000
Kulicke & Soffa Industries IncCOM50124210121491SH DFND349100
Lemonade IncCOM52567D10729,0651,591,709SH DFND11,591,70900
Lemonade IncCOM52567D10743,4682,380,478SH DFND22,357,419023,059
Lemonade IncCOM52567D1071,70593,391SH DFND393,39100
Lemonade IncCOM52567D10718,5901,018,079SH SOLE01,018,07900
LendingTreeCOM52603B1079,933226,675SH DFND1226,67500
LendingTreeCOM52603B1079,320212,691SH DFND266,1890146,502
LendingTreeCOM52603B1074,447101,492SH DFND395,65905,833
LendingTreeCOM52603B1075,249119,788SH SOLE0119,78800
Li Auto ADRSPONS ADS50202M10266,4701,735,052SH DFND11,735,05200
Li Auto ADRSPONS ADS50202M102203,0845,301,066SH DFND24,809,9650491,101
Li Auto ADRSPONS ADS50202M10240,4691,056,369SH DFND3617,1760439,193
Li Auto ADRSPONS ADS50202M102182,5854,766,001SH SOLE03,135,60701,630,394
Liberty Broadband CorpCOM530307305870SH DFND37000
Lightspeed POSCOM53229C1077310SH DFND331000
Lilium N.V.CL A COMN52586109229,151SH DFND19,15100
Lilium N.V.CL A COMN525861092,6411,118,923SH DFND21,118,92300
Lilium N.V.CL A COMN5258610941,77117,699,615SH SOLE017,699,61500
Lincoln Electric Holdings IncCOM5339001061191SH DFND39100
LivePerson IncCOM5381461016,067429,091SH DFND1429,09100
LivePerson IncCOM5381461015,123362,307SH DFND2109,6470252,660
LivePerson IncCOM5381461012,013142,393SH DFND3142,39300
LivePerson IncCOM5381461013,505247,880SH SOLE0247,88000
Liveramp Holdings IncCOM53815P10815,883615,401SH DFND1615,40100
Liveramp Holdings IncCOM53815P1088,097313,729SH DFND296,4830217,246
Liveramp Holdings IncCOM53815P1084,125159,816SH DFND3159,81600
Liveramp Holdings IncCOM53815P1087,616295,075SH SOLE0295,07500
Logitech International SASHSH5043023213235SH DFND323500
Lufax Holding LtdCOM54975P10243,4707,245,015SH DFND17,245,01500
Lufax Holding LtdCOM54975P102105,47117,578,530SH DFND29,992,99507,585,535
Lufax Holding LtdCOM54975P1021,033172,168SH DFND3172,16800
Lyell Immunopharma IncCOM55083R104793121,571SH DFND1121,57100
Lyell Immunopharma IncCOM55083R1041,814278,187SH DFND2278,18700
Lyell Immunopharma IncCOM55083R1042,008307,907SH DFND3307,90700
Lyft Inc Class A CommonCL A COM55087P104161,228SH DFND31,22800
M&T Bank CorpCOM55261F1043,93824,709SH SOLE024,70900
MELI Kaszek PioneerCL A COMG5S74L10619,8002,000,000SH DFND22,000,00000
MP MaterialsCOM CL A55336810160,7791,894,600SH DFND11,894,60000
MP MaterialsCOM CL A553368101782,430SH DFND22,43000
MP MaterialsCOM CL A5533681013,420106,600SH DFND3106,60000
MakeMyTripSHSV5633W10967,2362,618,235SH DFND21,955,2240663,011
Marathon Digital HoldingsCOM5657881062343SH DFND334300
Markel CorpCOM57053510463,39849,022SH DFND149,02200
Markel CorpCOM570535104203,364157,250SH DFND2143,139014,111
Markel CorpCOM57053510437,87829,289SH DFND317,228012,061
Markel CorpCOM570535104183,166141,632SH SOLE095,006046,626
MarketAxess HoldingsCOM57060D108124,037484,501SH DFND1484,50100
MarketAxess HoldingsCOM57060D108174,848682,973SH DFND2545,5000137,473
MarketAxess HoldingsCOM57060D10827,890108,943SH DFND399,83609,107
MarketAxess HoldingsCOM57060D10849,027191,506SH SOLE0191,50600
Martin Marietta MaterialsCOM573284106153,730513,735SH DFND1513,73500
Martin Marietta MaterialsCOM573284106510,6141,706,370SH DFND21,553,9960152,374
Martin Marietta MaterialsCOM57328410682,740276,502SH DFND3159,3830117,119
Martin Marietta MaterialsCOM573284106329,1041,099,799SH SOLE0758,9220340,877
Masimo CorpCOM5747951002,04415,646SH DFND115,64600
Masimo CorpCOM5747951004,41433,780SH DFND233,78000
Masimo CorpCOM5747951005,23340,046SH DFND340,04600
Mastercard Inc-Class ACL A57636Q104120,316381,375SH DFND1381,37500
Mastercard Inc-Class ACL A57636Q104389,3431,234,128SH DFND21,125,4460108,682
Mastercard Inc-Class ACL A57636Q10472,402229,498SH DFND3136,056093,442
Mastercard Inc-Class ACL A57636Q104320,1161,014,696SH SOLE0656,2410358,455
Materialise Nv ADRSPONSORED ADS57667T1003,650268,000SH DFND2268,00000
Maxlinear IncCOM57776J10014405SH DFND340500
McDonald'sCOM58013510118,76075,990SH DFND175,99000
McDonald'sCOM5801351013501,416SH DFND2001,416
McDonald'sCOM5801351017423,007SH DFND33,00700
McDonald'sCOM58013510120,39582,612SH SOLE082,61200
Medifast IncCOM58470H10124133SH DFND313300
MedtronicCOMG5960L10322,002245,150SH DFND1245,15000
MedtronicCOMG5960L1032242,494SH DFND2002,494
MedtronicCOMG5960L1033,00033,422SH DFND333,42200
MedtronicCOMG5960L10312,572140,079SH SOLE0140,07900
MercadoLibreCOM58733R102228,251358,395SH DFND1358,39500
MercadoLibreCOM58733R1022,734,4124,293,516SH DFND23,411,9840881,532
MercadoLibreCOM58733R102142,079223,089SH DFND3182,780040,309
MercadoLibreCOM58733R1025,7058,958SH DFND48,95800
MercadoLibreCOM58733R102345,164541,969SH SOLE0514,119027,850
Meta Platforms IncCL A30303M102121,888755,894SH DFND1755,89400
Meta Platforms IncCL A30303M102630,2323,908,416SH DFND22,056,41301,852,003
Meta Platforms IncCL A30303M102103,014638,848SH DFND3466,0000172,848
Meta Platforms IncCL A30303M102298,3631,850,316SH SOLE01,016,1200834,196
Mettler-ToledoCOM59268810586,76175,525SH DFND175,52500
Mettler-ToledoCOM592688105340,276296,209SH DFND2221,330074,879
Mettler-ToledoCOM5926881053,6043,137SH DFND33,13700
Mettler-ToledoCOM59268810529,52625,702SH SOLE025,70200
MicrosoftCOM594918104262,4871,022,026SH DFND11,022,02600
MicrosoftCOM594918104656,0602,554,451SH DFND22,339,2430215,208
MicrosoftCOM594918104127,309495,695SH DFND3307,4120188,283
MicrosoftCOM594918104569,9222,219,063SH SOLE01,491,1490727,914
Mirati TherapeuticsCOM60468T10513196SH DFND319600
Mobile Telesystems ADRSPONSORED ADR607409109042,174SH DFND142,17400
Moderna IncCOM60770K107689,5204,826,880SH DFND14,826,88000
Moderna IncCOM60770K1073,524,63124,673,648SH DFND219,439,56505,234,083
Moderna IncCOM60770K107372,1582,605,239SH DFND32,045,4980559,741
Moderna IncCOM60770K1071,921,90713,454,024SH SOLE011,687,44801,766,576
Momentive Global IncCOM60878Y108101,095SH DFND31,09500
MongoDB IncCOM60937P10655213SH DFND321300
MongoDB IncCOM60937P1068803,393SH SOLE03,39300
Monolithic Power Systems IncCOM6098391052463SH DFND36300
Moody's CorpCOM615369105172,322633,605SH DFND1633,60500
Moody's CorpCOM615369105557,4212,049,567SH DFND21,867,1850182,382
Moody's CorpCOM615369105105,351387,361SH DFND3227,1370160,224
Moody's CorpCOM615369105470,7331,730,827SH SOLE01,109,2410621,586
NIO Inc ADRSPON ADS62914V10663,3462,916,485SH DFND12,916,48500
NIO Inc ADRSPON ADS62914V1061,351,29162,214,136SH DFND246,897,006015,317,130
NIO Inc ADRSPON ADS62914V10664,9842,991,884SH DFND32,380,6930611,191
NIO Inc ADRSPON ADS62914V106621,38028,608,634SH SOLE025,144,37403,464,260
NV5 GlobalCOM62945V10918155SH DFND315500
NVIDIACOM67066G104309,0142,038,483SH DFND12,038,48300
NVIDIACOM67066G1041,246,3848,222,075SH DFND24,185,54104,036,534
NVIDIACOM67066G104162,2531,070,344SH DFND3860,7630209,581
NVIDIACOM67066G104602,3223,973,360SH SOLE02,877,41101,095,949
Nano Dimension ADRSPONS ADS63008G20351,600SH DFND31,60000
Nanobiotix ADRCOM63009J1073,276850,841SH DFND1850,84100
Nanobiotix ADRCOM63009J1072,114549,159SH SOLE0549,15900
National Instruments CorpCOM63651810226,357843,961SH DFND1843,96100
National Instruments CorpCOM6365181022518,049SH DFND2008,049
National Instruments CorpCOM6365181023,855123,427SH DFND3123,42700
National Instruments CorpCOM63651810214,374460,267SH SOLE0460,26700
Nektar TherapeuticsCOM64026810851,376SH DFND31,37600
NetEase.com ADRSPONSORED ADR64110W1029,648103,340SH DFND200103,340
Netflix IncCOM64110L106207,7971,188,294SH DFND11,188,29400
Netflix IncCOM64110L106645,3783,690,617SH DFND22,229,66501,460,952
Netflix IncCOM64110L10684,061480,708SH DFND3375,5850105,123
Netflix IncCOM64110L106369,6592,113,909SH SOLE01,603,7020510,207
Nevro CorpCOM64157F1037154SH DFND315400
New RelicCOM64829B10037733SH DFND373300
Newmont MiningCOM6516391061,20420,172SH DFND120,17200
Newmont MiningCOM6516391061562,615SH DFND22,61500
NextEra EnergyCOM65339F10140,585523,943SH DFND1523,94300
NextEra EnergyCOM65339F10172927SH DFND292700
NextEra EnergyCOM65339F1012,83236,559SH DFND336,55900
NikeCOM654106103990SH DFND39000
Novanta IncCOM67000B10432264SH DFND226400
Novanta IncCOM67000B1048887,322SH DFND37,32200
Novavax IncCOM NEW6700024017130SH DFND313000
Novocure LtdORD SHSG6674U108174,0972,504,992SH DFND12,504,99200
Novocure LtdORD SHSG6674U108281,7024,053,266SH DFND23,574,2830478,983
Novocure LtdORD SHSG6674U10844,396638,789SH DFND3527,8470110,942
Novocure LtdORD SHSG6674U108133,3831,919,183SH SOLE01,498,3500420,833
Nu Holdings Ltd.ORD SHS CL AG6683N10323,1466,188,749SH DFND16,188,74900
Nu Holdings Ltd.ORD SHS CL AG6683N10358,44315,626,543SH DFND213,407,28102,219,262
Nu Holdings Ltd.ORD SHS CL AG6683N10323,4776,277,327SH DFND34,937,94601,339,381
Nu Holdings Ltd.ORD SHS CL AG6683N1035,6461,509,738SH SOLE0575,4230934,315
Nucana Plc ADRSPONSORED ADR67022C1061,7552,420,041SH DFND12,420,04100
Nucana Plc ADRSPONSORED ADR67022C1068981,238,989SH SOLE01,238,98900
Nutanix IncCOM67059N1088563SH DFND356300
Oatly Inc.SPONS ADS67421J108127,15436,749,580SH DFND230,647,47206,102,108
Oatly Inc.SPONS ADS67421J1083,6741,061,969SH SOLE01,061,96900
On Semiconductor CorpCOM68218910529575SH DFND357500
Opko Health IncCOM68375N103176,635SH DFND36,63500
Oscar Health IncCOM68779310912,0542,836,131SH DFND12,836,13100
Oscar Health IncCOM68779310934,6578,154,518SH DFND27,413,6480740,870
Oscar Health IncCOM6877931097,6191,792,770SH DFND31,099,1260693,644
Oscar Health IncCOM68779310934,0098,002,211SH SOLE05,534,77402,467,437
Outset MedicalCOM6901451075306SH DFND330600
Oxford Industries IncCOM691497309555SH DFND35500
Ozon Holdings ADRCOM69269L1040333,970SH DFND1333,97000
Ozon Holdings ADRCOM69269L10402,478,153SH DFND21,319,30801,158,845
Ozon Holdings ADRCOM69269L104019,278SH DFND319,27800
PROCEPT BioRoboticsCOM74276L10512376SH DFND337600
PaccarCOM6937181083,51342,668SH SOLE042,66800
Pacira BioSciencesCOM69512710040,484694,400SH DFND1694,40000
Pacira BioSciencesCOM69512710033,178569,090SH DFND2188,0490381,041
Pacira BioSciencesCOM69512710019,310331,223SH DFND3287,036044,187
Pacira BioSciencesCOM69512710019,824340,039SH SOLE0340,03900
PagerDutyCOM69553P10014565SH DFND356500
Pagseguro Digital LtdCOM CL AG687071012148SH DFND214800
Pagseguro Digital LtdCOM CL AG6870710198596,176SH DFND396,17600
PaychexCOM70432610713116SH DFND311600
Peloton Interactive IncCL A COM70614W10043,9844,791,320SH DFND14,791,32000
Peloton Interactive IncCL A COM70614W100144,40315,730,207SH DFND28,058,47407,671,733
Peloton Interactive IncCL A COM70614W10024,9682,719,794SH DFND32,180,8990538,895
Peloton Interactive IncCL A COM70614W10039,6844,322,897SH SOLE02,067,37602,255,521
Penumbra IncCOM70975L10758,782472,071SH DFND1472,07100
Penumbra IncCOM70975L10783,437670,071SH DFND2663,53206,539
Penumbra IncCOM70975L1073,61329,016SH DFND329,01600
Penumbra IncCOM70975L10712,715102,116SH SOLE0102,11600
PepsicoCOM71344810861,373368,252SH DFND1368,25200
PepsicoCOM7134481085783,468SH DFND2003,468
PepsicoCOM7134481088,94153,646SH DFND353,64600
PepsicoCOM71344810833,518201,118SH SOLE0201,11800
Petrobras Common ADRSPONSORED ADR71654V408166,86914,286,702SH DFND114,286,70200
Petrobras Common ADRSPONSORED ADR71654V408536,27845,914,243SH DFND223,372,010022,542,233
Petrobras Common ADRSPONSORED ADR71654V40821,4431,835,913SH DFND31,835,91300
Petrobras Common ADRSPONSORED ADR71654V4088,423721,118SH DFND4721,11800
Petrobras Common ADRSPONSORED ADR71654V4088,641739,803SH SOLE0739,80300
Petrobras Pref ADRSP ADR NON VTG71654V10115,0361,414,518SH DFND11,414,51800
Petrobras Pref ADRSP ADR NON VTG71654V10190,6428,527,009SH DFND26,304,50102,222,508
Petrobras Pref ADRSP ADR NON VTG71654V10179474,696SH DFND374,69600
PfizerCOM71708110326500SH DFND350000
Piedmont Lithium IncCOM72016P1058212SH DFND321200
Pinduoduo Inc ADRSPONSORED ADS722304102115,9811,876,715SH DFND11,876,71500
Pinduoduo Inc ADRSPONSORED ADS722304102985,40215,945,018SH DFND28,252,68707,692,331
Pinduoduo Inc ADRSPONSORED ADS722304102114,9351,859,788SH DFND31,484,6570375,131
Pinduoduo Inc ADRSPONSORED ADS722304102520,2688,418,583SH SOLE06,294,60402,123,979
PinterestCOM72352L10640,7172,242,117SH DFND12,242,11700
PinterestCOM72352L10662,3963,435,914SH DFND23,403,508032,406
PinterestCOM72352L1062,446134,692SH DFND3134,69200
PinterestCOM72352L1069,444520,071SH SOLE0520,07100
Precision BioSciences IncCOM74019P10832,133SH DFND22,13300
Precision BioSciences IncCOM74019P1089156,678SH DFND356,67800
Procter & GambleCOM74271810968,416475,804SH DFND1475,80400
Procter & GambleCOM7427181096394,447SH DFND2004,447
Procter & GambleCOM7427181099,99169,480SH DFND369,48000
Procter & GambleCOM74271810938,025264,451SH SOLE0264,45100
ProgressiveCOM7433151033,92433,746SH SOLE033,74600
ProgynyCOM74340E10317,125589,485SH DFND1589,48500
ProgynyCOM74340E10315,678539,689SH DFND2173,6040366,085
ProgynyCOM74340E1038,243283,761SH DFND3254,097029,664
ProgynyCOM74340E1036,720231,309SH SOLE0231,30900
Prologis Inc REITCOM74340W10373,086621,218SH DFND1621,21800
Prologis Inc REITCOM74340W1031221,034SH DFND21,03400
Prologis Inc REITCOM74340W1035,84249,659SH DFND349,65900
Proterra IncCOM74374T1095411,566SH DFND111,56600
Ptc Therapeutics IncCOM69366J20010246SH DFND324600
Pure Storage IncCOM74624M102341,335SH DFND31,33500
Q2 Holdings IncCOM74736L10912,279318,346SH DFND1318,34600
Q2 Holdings IncCOM74736L1097,065183,184SH DFND256,2370126,947
Q2 Holdings IncCOM74736L1093,47490,058SH DFND390,05800
Q2 Holdings IncCOM74736L1094,715122,235SH SOLE0122,23500
QualcommCOM74752510323183SH DFND318300
Quanterix CorpCOM74766Q1016,332391,135SH DFND1391,13500
Quanterix CorpCOM74766Q101171,045SH DFND21,04500
Quanterix CorpCOM74766Q10147029,013SH DFND329,01300
Quanterix CorpCOM74766Q1013,395209,677SH SOLE0209,67700
QuantumScape CorpCOM CL A74767V109263,002SH DFND13,00200
QuantumScape CorpCOM CL A74767V1097,845913,279SH SOLE0913,27900
Quest DiagnosticsCOM74834L10019145SH DFND314500
Quidel CorpCOM21979810512128SH DFND312800
REGENXBIOCOM75901B10719752SH DFND375200
Rambus IncCOM75091710614630SH DFND363000
Recursion Pharmaceuticals IncCL A75629V10421,6732,662,543SH DFND12,662,54300
Recursion Pharmaceuticals IncCL A75629V10431,5213,872,304SH DFND23,836,239036,065
Recursion Pharmaceuticals IncCL A75629V1044,110504,853SH DFND3504,85300
Recursion Pharmaceuticals IncCL A75629V104118,56714,565,985SH SOLE014,565,98500
RedfinCOM75737F10830,6053,714,187SH DFND13,714,18700
RedfinCOM75737F10842,4495,151,612SH DFND25,014,5080137,104
RedfinCOM75737F1083,129379,784SH DFND3338,187041,597
RedfinCOM75737F1086,180750,021SH SOLE0750,02100
Regeneron PharmaceuticalsCOM75886F1073050SH DFND35000
Relay Therapeutics IncCOM75943R10263537,930SH DFND137,93000
Relay Therapeutics IncCOM75943R1021,38582,714SH DFND282,71400
Relay Therapeutics IncCOM75943R1021,65898,978SH DFND398,97800
ResMedCOM7611521072,66912,734SH DFND112,73400
ResMedCOM7611521075,77727,556SH DFND227,55600
ResMedCOM7611521076,76532,269SH DFND332,26900
Research in MotionCOM09228F103132,434SH DFND32,43400
Rexford Industrial Realty REITCOM76169C10091,9301,596,281SH DFND11,596,28100
Rexford Industrial Realty REITCOM76169C1001652,866SH DFND22,86600
Rexford Industrial Realty REITCOM76169C1007,864136,543SH DFND3136,54300
Rio Tinto Spn.Adr 1:1SPONSORED ADR767204100238SH DFND43800
Ritchie Bros Auctioneers (USA)COM767744105104,8311,611,301SH DFND21,474,2430137,058
Ritchie Bros Auctioneers (USA)COM767744105121SH DFND42100
Ritchie Bros. AuctioneersCOM76774410573,8911,138,092SH DFND2673,7860464,306
Rivian Automotive IncCOM CL A76954A10331,2231,213,033SH DFND11,213,03300
Rivian Automotive IncCOM CL A76954A10346,6241,811,360SH DFND21,793,741017,619
Rivian Automotive IncCOM CL A76954A1031,92974,942SH DFND374,94200
Rivian Automotive IncCOM CL A76954A1037,721299,948SH SOLE0299,94800
Robert Half International IncCOM77032310310131SH DFND313100
RobloxCL A77104910366,0442,009,867SH DFND12,009,86700
RobloxCL A771049103290,5508,842,051SH DFND24,100,16304,741,888
RobloxCL A77104910340,7281,239,439SH DFND31,000,8910238,548
RobloxCL A77104910388,4482,691,659SH SOLE01,326,72801,364,931
RokuCOM CL A77543R102102,3501,246,038SH DFND11,246,03800
RokuCOM CL A77543R102151,4361,843,632SH DFND21,825,639017,993
RokuCOM CL A77543R1026,23075,849SH DFND375,84900
RokuCOM CL A77543R10222,729276,707SH SOLE0276,70700
Rollins IncCOM77571110420562SH DFND356200
Royalty PharmaSHS CLASS AG7709Q104100,1322,381,823SH DFND12,381,82300
Royalty PharmaSHS CLASS AG7709Q104319,4567,598,867SH DFND26,899,8660699,001
Royalty PharmaSHS CLASS AG7709Q10461,2831,457,742SH DFND3849,1180608,624
Royalty PharmaSHS CLASS AG7709Q104275,6356,556,486SH SOLE04,266,27002,290,216
Rubius Therapeutics IncCOM78116T103755887,000SH DFND1887,00000
Rubius Therapeutics IncCOM78116T103239280,797SH DFND279,1710201,626
Rubius Therapeutics IncCOM78116T103130152,722SH DFND3152,72200
Rubius Therapeutics IncCOM78116T1033,0503,585,559SH SOLE03,585,55900
Ryanair ADRSPONSORED ADR NE78351320317,549260,957SH DFND1260,95700
Ryanair ADRSPONSORED ADR NE783513203619,7319,215,330SH DFND28,038,65101,176,679
Ryanair ADRSPONSORED ADR NE7835132035,85387,037SH DFND387,03700
Ryanair ADRSPONSORED ADR NE783513203340SH DFND44000
Ryanair ADRSPONSORED ADR NE7835132038,217122,188SH SOLE0115,04507,143
S&P Global IncCOM78409V10474,536221,135SH DFND1221,13500
S&P Global IncCOM78409V104242,550719,606SH DFND2656,937062,669
S&P Global IncCOM78409V10445,477134,924SH DFND379,496055,428
S&P Global IncCOM78409V104207,419615,377SH SOLE0401,9180213,459
SCP Pool CorporationCOM73278L1052570SH DFND37000
SEA Ltd ADRADR81141R100168,5872,521,492SH DFND12,521,49200
SEA Ltd ADRADR81141R100713,44110,670,668SH DFND28,023,20102,647,467
SEA Ltd ADRADR81141R10053,419798,973SH DFND3554,2280244,745
SEA Ltd ADRADR81141R10097314,559SH DFND414,55900
SEA Ltd ADRADR81141R100194,8362,914,085SH SOLE01,842,07701,072,008
SKYWORKS SOLUTIONS, INC.COM83088M10213136SH DFND313600
Sage Therapeutics IncCOM78667J10850015,465SH DFND115,46500
Sage Therapeutics IncCOM78667J1081,09533,912SH DFND233,91200
Sage Therapeutics IncCOM78667J1081,26239,069SH DFND339,06900
Sailpoint Technologies HoldingCOM78781P10523363SH DFND336300
Salesforce.comCOM79466L30250,695307,167SH DFND1307,16700
Salesforce.comCOM79466L302345,9282,096,027SH DFND2842,69501,253,332
Salesforce.comCOM79466L30252,012315,150SH DFND3252,101063,049
Salesforce.comCOM79466L302105,381638,516SH SOLE0277,8690360,647
Sana Biotechnology IncCOM79956610411,7021,819,974SH DFND11,819,97400
Sana Biotechnology IncCOM79956610417,8862,781,677SH DFND22,781,67700
Sana Biotechnology IncCOM7995661041,187184,538SH DFND3184,53800
Sana Biotechnology IncCOM79956610440,0296,225,273SH SOLE06,225,27300
Sangamo BiosciencesCOM800677106102,510SH DFND32,51000
Sarepta Therapeutics IncCOM80360710015199SH DFND319900
SchrodingerCOM80810D1038,783332,569SH DFND1332,56900
SchrodingerCOM80810D10311,097420,169SH DFND2126,6020293,567
SchrodingerCOM80810D1034,776180,858SH DFND3180,85800
SchrodingerCOM80810D1038,473320,840SH SOLE0320,84000
Schweitzer-Maudit Int.COM8085411067265SH DFND326500
Seagen IncCOM81181C10423128SH DFND312800
SeerCOM CL A81578P1062223SH DFND322300
Sei Investments CoCOM78411710322409SH DFND340900
Service Corp.Intl.COM817565104160,4022,320,636SH DFND12,320,63600
Service Corp.Intl.COM817565104535,5017,747,414SH DFND27,067,6090679,805
Service Corp.Intl.COM81756510497,7951,414,852SH DFND3825,1670589,685
Service Corp.Intl.COM817565104442,7326,405,261SH SOLE04,196,87902,208,382
Sherwin-Williams CoCOM8243481069,95344,453SH DFND244,45300
ShockWave Medical IncCOM82489T10423,396122,381SH DFND1122,38100
ShockWave Medical IncCOM82489T10438,616201,997SH DFND2118,693083,304
ShockWave Medical IncCOM82489T10429,166152,568SH DFND3152,56800
ShockWave Medical IncCOM82489T10416,42085,892SH SOLE085,89200
Shopify 'A'CL A82509L107332,37310,639,340SH DFND110,639,34000
Shopify 'A'CL A82509L1071,001,12232,046,154SH DFND222,699,52409,346,630
Shopify 'A'CL A82509L107113,7373,640,760SH DFND32,805,3000835,460
Shopify 'A'CL A82509L107130SH DFND43000
Shopify 'A'CL A82509L107331,77210,620,109SH SOLE07,735,48902,884,620
Shopify IncCOM82509L1073,02597,020SH DFND297,02000
Shopify IncCOM82509L107591,890SH DFND31,89000
Signature BankCOM82669G1041,79210,002SH SOLE010,00200
Silicon Motion Technology ADRCOM82706C10833,649402,015SH DFND1402,01500
Silicon Motion Technology ADRCOM82706C1082923,484SH DFND2003,484
Silicon Motion Technology ADRCOM82706C1084,71456,318SH DFND356,31800
Silicon Motion Technology ADRCOM82706C10818,634222,630SH SOLE0222,63000
Silk Road MedicalCOM82710M1009235SH DFND323500
SiteOne Landscape SupplyCOM82982L10342,771359,814SH DFND1359,81400
SiteOne Landscape SupplyCOM82982L103133,0491,119,285SH DFND21,015,6270103,658
SiteOne Landscape SupplyCOM82982L10326,284221,112SH DFND3130,617090,495
SiteOne Landscape SupplyCOM82982L103118,269994,947SH SOLE0646,6650348,282
Sixth Street Specialty LendingCOM83012A1091,47179,500SH DFND179,50000
SmartsheetCOM83200N10310311SH DFND331100
Snap IncCL A83304A10653,3494,063,120SH DFND14,063,12000
Snap IncCL A83304A10677,9775,938,837SH DFND25,880,960057,877
Snap IncCL A83304A1063,276249,520SH DFND3249,52000
Snap IncCL A83304A10614,4031,096,937SH SOLE01,096,93700
Snap OnCOM8330341011786SH DFND38600
Snowflake IncCOM833445109124,955898,569SH DFND1898,56900
Snowflake IncCOM833445109235,6601,694,664SH DFND21,628,651066,013
Snowflake IncCOM83344510922,469161,576SH DFND3111,323050,253
Snowflake IncCOM833445109231,6911,666,125SH SOLE01,475,2590190,866
Solaredge Technologies IncCOM83417M1043701,353SH DFND11,35300
Solaredge Technologies IncCOM83417M10446167SH DFND316700
Sorrento TherapeuticsCOM83587F20294,314SH DFND34,31400
Spire Global IncCOM CL A8485601081,005866,045SH SOLE0866,04500
Splunk IncCOM8486371046,59474,540SH DFND174,54000
Splunk IncCOM84863710411,884134,348SH DFND240,185094,163
Splunk IncCOM8486371044,63652,411SH DFND352,41100
Splunk IncCOM8486371046,53673,884SH SOLE073,88400
Spotify Technology SASHSL8681T102109,8321,170,538SH DFND11,170,53800
Spotify Technology SASHSL8681T1022,002,39321,340,644SH DFND216,485,10204,855,542
Spotify Technology SASHSL8681T10252,394558,391SH DFND3431,3740127,017
Spotify Technology SASHSL8681T10219SH DFND4900
Spotify Technology SASHSL8681T102293,6933,130,055SH SOLE02,517,3830612,672
Sprout SocialCOM85209W10918,645321,078SH DFND1321,07800
Sprout SocialCOM85209W10917,680304,466SH DFND291,1270213,339
Sprout SocialCOM85209W1098,151140,364SH DFND3140,36400
Sprout SocialCOM85209W10914,278245,870SH SOLE0245,87000
Staar SurgicalCOM PAR $0.01852312305102,3971,443,638SH DFND11,443,63800
Staar SurgicalCOM PAR $0.01852312305128,2521,808,153SH DFND21,197,5450610,608
Staar SurgicalCOM PAR $0.0185231230540,479570,693SH DFND3453,9180116,775
Staar SurgicalCOM PAR $0.01852312305103,7621,462,874SH SOLE01,140,4010322,473
Starbucks CorpCOM85524410919,158250,796SH DFND1250,79600
Starbucks CorpCOM85524410913,239173,303SH DFND2171,16002,143
Starbucks CorpCOM8552441092,94438,536SH DFND338,53600
Starbucks CorpCOM85524410914,501189,833SH SOLE0189,83300
Stitch FixCOM CL A86089710761,147SH DFND21,14700
Stitch FixCOM CL A86089710716032,301SH DFND332,30100
StoneCoCOM CL AG851581061,235160,397SH DFND1160,39700
StoneCoCOM CL AG851581069,5371,238,614SH DFND2674,8130563,801
StoneCoCOM CL AG85158106709,131SH DFND39,13100
StratasysSHSM855481014,241226,300SH DFND1226,30000
StratasysSHSM855481016,485346,075SH DFND299,0250247,050
StratasysSHSM855481012,876153,480SH DFND3153,48000
StratasysSHSM855481012,710144,600SH SOLE0144,60000
StrykerCOM863667101947SH DFND34700
Sumo LogicCOM86646P1035726SH DFND372600
Sunpower CorpCOM867652406191,210SH DFND31,21000
Sutro BiopharmaCOM8693671025,4311,042,428SH DFND11,042,42800
Sutro BiopharmaCOM869367102132,494SH DFND22,49400
Sutro BiopharmaCOM86936710236269,532SH DFND369,53200
Sutro BiopharmaCOM8693671023,911750,726SH SOLE0750,72600
T. Rowe PriceCOM74144T10818,284160,937SH DFND1160,93700
T. Rowe PriceCOM74144T1081721,513SH DFND2001,513
T. Rowe PriceCOM74144T1082,63923,228SH DFND323,22800
T. Rowe PriceCOM74144T10810,23490,076SH SOLE090,07600
TJX CompaniesCOM8725401096,000107,431SH DFND2107,43100
TJX CompaniesCOM8725401094,12573,855SH SOLE073,85500
TSMC ADRSPONSORED ADR874039100574,4257,026,601SH DFND25,397,94701,628,654
TSMC ADRSPONSORED ADR8740391001,15014,066SH DFND314,06600
TSMC ADRSPONSORED ADR874039100452SH DFND45200
TSMC ADRSPONSORED ADR87403910073,705901,587SH SOLE0729,5130172,074
Tabula Rasa HealthCare IncCOM8733791011,442561,175SH DFND1561,17500
Tabula Rasa HealthCare IncCOM87337910131,076SH DFND21,07600
Tabula Rasa HealthCare IncCOM8733791017629,449SH DFND329,44900
Tabula Rasa HealthCare IncCOM873379101613238,574SH SOLE0238,57400
Tandem Diabetes CareCOM NEW8753722038,683146,692SH DFND1146,69200
Tandem Diabetes CareCOM NEW87537220323382SH DFND238200
Tandem Diabetes CareCOM NEW87537220363810,772SH DFND310,77200
Tandem Diabetes CareCOM NEW8753722038,782148,377SH SOLE0148,37700
Target CorpCOM87612E1061497SH DFND39700
Tata Motors Ltd ADRCOM87656850259,1612,286,839SH DFND12,286,83900
Tata Motors Ltd ADRCOM87656850228,8431,114,917SH DFND21,114,91700
Tata Motors Ltd ADRCOM87656850291835,474SH DFND335,47400
Tata Motors Ltd ADRCOM87656850214,598564,300SH SOLE0564,30000
TeladocCOM87918A10592,8452,795,681SH DFND12,795,68100
TeladocCOM87918A10592,2722,778,440SH DFND22,222,4860555,954
TeladocCOM87918A10544,9471,353,416SH DFND31,139,1420214,274
TeladocCOM87918A10526,969812,086SH SOLE0666,0630146,023
Telus CorpCOM87971M1039397SH DFND339700
Tenable HoldingsCOM88025T10214315SH DFND331500
Tencent ADRSPON ADR88032Q109366SH DFND46600
Tencent Music Entertainment ADRSPONSORED ADS88034P1098,2721,647,810SH DFND11,647,81000
Tencent Music Entertainment ADRSPONSORED ADS88034P109147,55029,392,337SH DFND220,677,69008,714,647
Tencent Music Entertainment ADRSPONSORED ADS88034P10926652,900SH DFND352,90000
Tencent Music Entertainment ADRSPONSORED ADS88034P1091171SH DFND417100
TeradyneCOM88077010270,113782,948SH DFND1782,94800
TeradyneCOM880770102217,7012,431,052SH DFND22,209,8380221,214
TeradyneCOM88077010242,702476,851SH DFND3283,9010192,950
TeradyneCOM880770102190,2352,124,343SH SOLE01,367,2170757,126
Tesla IncCOM88160R101774,8221,150,577SH DFND11,150,57700
Tesla IncCOM88160R1013,507,5785,208,604SH DFND23,819,06601,389,538
Tesla IncCOM88160R101380,581565,147SH DFND3442,0110123,136
Tesla IncCOM88160R1011,670,0652,479,976SH SOLE02,001,2850478,691
Texas InstrumentsCOM8825081043,69724,059SH SOLE024,05900
Texas Roadhouse IncCOM88268110910131SH DFND313100
The Trade DeskCOM CL A88339J105439,28310,486,594SH DFND110,486,59400
The Trade DeskCOM CL A88339J1051,053,62125,152,095SH DFND218,189,64806,962,447
The Trade DeskCOM CL A88339J105123,7162,953,345SH DFND32,264,1220689,223
The Trade DeskCOM CL A88339J105355,0908,476,715SH SOLE05,392,64103,084,074
Thermo Fisher ScientificCOM88355610295,820176,373SH DFND1176,37300
Thermo Fisher ScientificCOM883556102316,584582,728SH DFND2533,783048,945
Thermo Fisher ScientificCOM88355610257,514105,864SH DFND362,042043,822
Thermo Fisher ScientificCOM883556102272,297501,210SH SOLE0334,5900166,620
Thor Industries IncCOM88516010111151SH DFND315100
Toro CoCOM89109210819245SH DFND324500
Tractor Supply CoCOM89235610630155SH DFND315500
TransMedics GroupCOM89377M109361,155SH DFND21,15500
TransMedics GroupCOM89377M1091,02432,572SH DFND332,57200
Trip.com Group Sponsored ADRAMERICAN DEP SHS89677Q10721,927798,804SH DFND2384,8850413,919
TrupanionCOM89820210611,907197,600SH DFND1197,60000
TrupanionCOM89820210620,084333,282SH DFND299,1610234,121
TrupanionCOM8982021068,700144,372SH DFND3144,37200
TrupanionCOM89820210622,967381,138SH SOLE0381,13800
TuSimple HdgsCL A90089L1083349SH DFND334900
Twilio IncCL A90138F102135,4901,616,627SH DFND11,616,62700
Twilio IncCL A90138F102242,7892,896,894SH DFND22,760,8380136,056
Twilio IncCL A90138F10226,580317,143SH DFND3221,726095,417
Twilio IncCL A90138F102100,4151,198,121SH SOLE0877,5300320,591
UltragenyxCOM90400D1087115SH DFND311500
United Parcel ServiceCL B91131210675,117411,511SH DFND1411,51100
United Parcel ServiceCL B9113121067404,052SH DFND2004,052
United Parcel ServiceCL B91131210610,58858,006SH DFND358,00600
United Parcel ServiceCL B91131210646,966257,293SH SOLE0257,29300
UnitedHealthCOM91324P1023467SH DFND36700
Unity Biotechnology IncCOM91381U101140248,000SH DFND1248,00000
Unity Biotechnology IncCOM91381U101192341,111SH SOLE0341,11100
Upwork IncCOM91688F10453,4012,582,263SH DFND12,582,26300
Upwork IncCOM91688F10440,8161,973,704SH DFND2622,31501,351,389
Upwork IncCOM91688F10420,537993,097SH DFND3909,038084,059
Upwork IncCOM91688F10427,7511,341,907SH SOLE01,341,90700
Vale SA ADRADR91912E10511,659796,951SH DFND1796,95100
Vale SA ADRADR91912E10570,9214,847,672SH DFND23,553,41401,294,258
Vale SA ADRADR91912E10561642,102SH DFND342,10200
Varonis Systems IncCOM92228010222735SH DFND273500
Varonis Systems IncCOM92228010261420,943SH DFND320,94300
Veeco InstrumentsCOM9224171004,504232,154SH DFND1232,15400
Veeco InstrumentsCOM9224171009,676498,785SH DFND2153,2050345,580
Veeco InstrumentsCOM9224171004,443229,031SH DFND3229,03100
Veeva Systems Inc Class ACOM9224751081,3706,920SH DFND16,92000
Veeva Systems Inc Class ACOM9224751083,02715,287SH DFND215,28700
Veeva Systems Inc Class ACOM9224751083,54517,899SH DFND317,89900
Verint Systems IncCOM92343X10017395SH DFND339500
VeritoneCOM92347M1004649SH DFND364900
ViewRayCOM92672L1072911SH DFND391100
Vimeo Inc.COM92719V1001,026170,422SH DFND1170,42200
Vimeo Inc.COM92719V1003,032503,582SH DFND2454,776048,806
Vimeo Inc.COM92719V100623103,417SH DFND360,413043,004
Vimeo Inc.COM92719V1002,696447,822SH SOLE0284,4650163,357
Vir Biotechnology IncCOM92764N10275529,649SH DFND129,64900
Vir Biotechnology IncCOM92764N1021,61463,371SH DFND263,37100
Vir Biotechnology IncCOM92764N1021,96076,947SH DFND376,94700
Vir Biotechnology IncCOM92764N10295,7903,760,885SH SOLE03,760,88500
Visa Inc-Class A SharesCOM CL A92826C83910,31552,389SH DFND252,38900
Visa Inc-Class A SharesCOM CL A92826C83922110SH DFND311000
Visteon CorpCOM92839U20624230SH DFND323000
VuzixCOM92921W3007924SH DFND392400
WD-40 CoCOM9292361071258SH DFND35800
WEC Energy GroupCOM92939U1061,91218,996SH DFND118,99600
Wal-Mart StoresCOM93114210312101SH DFND310100
Warby Parker IncCL A COM93403J1061,927171,156SH DFND1171,15600
Warby Parker IncCL A COM93403J1066,179548,795SH DFND2215,6890333,106
Warby Parker IncCL A COM93403J10691381,120SH DFND357,451023,669
Warby Parker IncCL A COM93403J10661,6615,476,151SH SOLE05,476,15100
WatersCOM9418481038,90126,893SH DFND126,89300
WatersCOM94184810311,61335,086SH DFND227,41907,667
WatersCOM9418481034,15112,542SH DFND38,93303,609
WatersCOM9418481035191,567SH SOLE01,56700
Watsco IncCOM942622200205,881862,075SH DFND1862,07500
Watsco IncCOM942622200226,884950,020SH DFND2926,607023,413
Watsco IncCOM94262220021,45789,847SH DFND383,78906,058
Watsco IncCOM94262220064,474269,971SH SOLE0269,97100
Wayfair Inc Class ACL A94419L101116,1392,666,186SH SOLE02,385,3310280,855
Wayfair Inc Class ACL A94419L10116,422377,008SH DFND3292,277084,731
Wayfair Inc Class ACL A94419L10199,8232,291,632SH DFND12,291,63200
Wayfair Inc Class ACL A94419L101161,4913,707,319SH DFND23,489,6310217,688
West Pharmaceutical ServicesCOM9553061051240SH DFND34000
Wheaton Precious MetalsCOM96287910273620,416SH DFND120,41600
Williams-Sonoma IncCOM969904101763SH DFND36300
Wix ComSHSM98068105530,3998,091,511SH DFND26,099,52201,991,989
Wix ComSHSM9806810527406SH DFND340600
Workday IncCL A98138H101163,1831,169,101SH SOLE0616,2860552,815
Workday IncCL A98138H10178,878565,109SH DFND3456,4350108,674
Workday IncCL A98138H101187,6321,344,264SH DFND11,344,26400
Workday IncCL A98138H101598,0694,284,773SH DFND22,332,75001,952,023
XPCL AG982391091608,893SH DFND48,89300
XPCL AG982391091,22868,387SH DFND168,38700
XPCL AG982391093,087171,904SH DFND212,1290159,775
XPCL AG982391093,749208,760SH DFND322,2860186,474
XPELCOM98379L10015326SH DFND332600
Xencor IncCOM98401F105291,054SH DFND21,05400
Xencor IncCOM98401F10581029,603SH DFND329,60300
Xperi Holding CorpCOM98390M103211,448SH DFND31,44800
XylemCOM98419M10084,0501,075,082SH DFND3839,7200235,362
XylemCOM98419M10019,571250,337SH SOLE092,6730157,664
XylemCOM98419M10082,1011,050,152SH DFND11,050,15200
XylemCOM98419M10042,591544,783SH DFND2290,2730254,510
Zai Lab ADRADR98887Q10419,604567,403SH DFND218,8400548,563
Zai Lab ADRADR98887Q1045,865169,749SH DFND313,9630155,786
Ziff Davis IncCOM48123V102453SH DFND35300
Zillow Group Inc Class ACL A98954M1011,99662,733SH DFND362,73300
Zillow Group Inc Class ACL A98954M1015,087159,914SH DFND248,3170111,597
Zillow Group Inc Class ACL A98954M10198630,990SH DFND130,99000
Zillow Group Inc Class ACL A98954M1012,89090,840SH SOLE090,84000
Zillow Group Inc Class CCL C CAP STK98954M20018,528583,573SH SOLE0583,57300
Zillow Group Inc Class CCL C CAP STK98954M2008,407264,788SH DFND3264,78800
Zillow Group Inc Class CCL C CAP STK98954M20030,977975,649SH DFND1975,64900
Zillow Group Inc Class CCL C CAP STK98954M20022,023693,637SH DFND2205,5550488,082
Zoom Video Communications IncCL A98980L101210,0321,945,280SH SOLE01,567,7700377,510
Zoom Video Communications IncCL A98980L10145,459421,038SH DFND3347,731073,307
Zoom Video Communications IncCL A98980L101404,2983,744,539SH DFND22,407,47601,337,063
Zoom Video Communications IncCL A98980L101153,9921,426,245SH DFND11,426,24500
Zuora Inc Class ACOM CL A98983V1066,994781,436SH SOLE0781,43600
Zuora Inc Class ACOM CL A98983V10617,9922,010,224SH DFND12,010,22400
Zuora Inc Class ACOM CL A98983V10611,5371,289,086SH DFND2388,1080900,978
Zuora Inc Class ACOM CL A98983V1065,431606,825SH DFND3606,82500
Zymergen IncCOM98985X1003,4712,821,956SH SOLE02,821,95600
ZynexCOM98986M1034481SH DFND348100
dLocalCL AG290181016,465246,272SH DFND300246,272
dLocalCL AG2901810114,535553,728SH DFND1553,72800
dLocalCL AG290181014142SH DFND214200
iRobotCOM4627261007,860213,872SH DFND1213,87200
iRobotCOM4627261008,857241,019SH DFND276,7700164,249
iRobotCOM4627261004,898133,267SH SOLE0133,26700
iRobotCOM4627261004,822131,214SH DFND3120,426010,788
nLIGHTCOM65487K1005468SH DFND346800