The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X Genomics Inc Class ACL A COM88025U109154,6422,032,893SH DFND12,032,89300
10X Genomics Inc Class ACL A COM88025U109164,1402,157,753SH DFND21,996,8260160,927
10X Genomics Inc Class ACL A COM88025U10980,5401,058,765SH DFND3899,2930159,472
10X Genomics Inc Class ACL A COM88025U109160,2302,106,353SH SOLE02,106,35300
1Life HealthcareCOM68269G1075445SH DFND344500
2UCOM90214J1014319SH DFND331900
2seventy bioCOM9013841075286SH DFND328600
8x8 IncCOM282914100262,045SH DFND32,04500
908 DevicesCOM65443P1025249SH DFND324900
ACM ResearchCOM00108J10914660SH DFND366000
AJ Gallagher & CoCOM363576109189,5901,085,855SH DFND11,085,85500
AJ Gallagher & CoCOM363576109539,2553,088,518SH DFND22,805,4350283,083
AJ Gallagher & CoCOM363576109105,097601,931SH DFND3363,8170238,114
AJ Gallagher & CoCOM363576109461,3432,642,285SH SOLE01,722,4840919,801
Abcellera Biologics IncCOM00288U10637,8263,879,638SH DFND13,879,63800
Abcellera Biologics IncCOM00288U10624,6282,525,958SH DFND21,149,55601,376,402
Abcellera Biologics IncCOM00288U10633,6013,446,224SH DFND32,871,5460574,678
Abcellera Biologics IncCOM00288U10611,6701,196,945SH SOLE01,196,94500
AbiomedCOM003654100365,2381,102,640SH DFND11,102,64000
AbiomedCOM003654100508,6761,535,673SH DFND21,407,4790128,194
AbiomedCOM003654100161,839488,585SH DFND3380,7290107,856
AbiomedCOM003654100192,898582,352SH SOLE0427,4800154,872
Acadia Pharmaceuticals IncCOM00422510813544SH DFND354400
Accelerate DiagnosticsCOM00430H1021418SH DFND341800
Accenture 'A'COMG1151C1011648SH DFND34800
Acutus MedicalCOM0051111091424SH DFND342400
Adaptimmune Therapeutics ADRSPONDS ADR00653A10712,4776,056,564SH DFND16,056,56400
Adaptimmune Therapeutics ADRSPONDS ADR00653A1077,0033,399,534SH DFND2976,47402,423,060
Adaptimmune Therapeutics ADRSPONDS ADR00653A1073,3061,604,961SH DFND31,604,96100
Adaptimmune Therapeutics ADRSPONDS ADR00653A1078,8984,319,479SH SOLE04,319,47900
Adicet Bio IncCOM0070021081,86693,449SH DFND193,44900
Adicet Bio IncCOM0070021081,76188,177SH SOLE088,17700
Adobe SystemsCOM00724F10133,56073,658SH DFND173,65800
Adobe SystemsCOM00724F101103,800227,821SH DFND2194,873032,948
Adobe SystemsCOM00724F10120,27244,493SH DFND326,053018,440
Adobe SystemsCOM00724F10197,167213,264SH SOLE0141,795071,469
Advanced Micro Devices IncCOM00790310713118SH DFND311800
AerovironmentCOM00807310825,062266,217SH DFND1266,21700
AerovironmentCOM00807310821,255225,784SH DFND266,0400159,744
AerovironmentCOM00807310810,637112,990SH DFND3112,99000
AerovironmentCOM00807310820,764220,567SH SOLE0220,56700
Affirm Holdings Inc Class ACOM CL A00827B106158,4663,424,074SH DFND13,424,07400
Affirm Holdings Inc Class ACOM CL A00827B106417,5709,022,692SH DFND25,540,54903,482,143
Affirm Holdings Inc Class ACOM CL A00827B10640,765880,826SH DFND3754,0280126,798
Affirm Holdings Inc Class ACOM CL A00827B106216,1594,670,688SH SOLE03,903,8910766,797
Affirm Holdings Inc Class B - converted at IPOCOM CL A00827B106114,9862,484,575SH SOLE02,484,57500
Agios Pharmaceuticals IncCOM00847X1045186SH DFND318600
Agnico Eagle MinesCOM0084741082083,400SH DFND13,40000
Agora Inc ADRADS00851L1034,864489,288SH DFND1489,28800
Agora Inc ADRADS00851L1032,535255,012SH SOLE0255,01200
Albemarle CorpCOM012653101159,509721,269SH DFND1721,26900
Albemarle CorpCOM012653101389,7971,762,592SH DFND21,594,7800167,812
Albemarle CorpCOM01265310164,840293,196SH DFND3182,7710110,425
Albemarle CorpCOM012653101287,2111,298,714SH SOLE01,014,2700284,444
Alector IncCOM01444210797568,420SH DFND168,42000
Alector IncCOM0144421071,874131,492SH DFND2131,49200
Alector IncCOM0144421072,742192,439SH DFND3192,43900
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102187,6681,724,888SH DFND21,338,4870386,401
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W1022,53323,282SH DFND30023,282
Align Technology IncCOM01625510110,73924,631SH DFND224,63100
Allbirds IncCOM CL A01675A1094,096681,466SH DFND2242,2310439,235
Allbirds IncCOM CL A01675A1094,127686,619SH SOLE0686,61900
Allscripts Healthcare SolutionCOM01988P10817744SH DFND374400
Alnylam PharmaceuticalsCOM02043Q107453,7092,778,549SH DFND12,778,54900
Alnylam PharmaceuticalsCOM02043Q107634,9913,888,734SH DFND23,225,0210663,713
Alnylam PharmaceuticalsCOM02043Q107220,5201,350,482SH DFND31,082,1760268,306
Alnylam PharmaceuticalsCOM02043Q107346,4962,121,964SH SOLE01,574,9830546,981
Alphabet Inc Class ACAP STK CL A02079K3056,7502,427SH DFND12,42700
Alphabet Inc Class ACAP STK CL A02079K30533,76812,141SH DFND211,4620679
Alphabet Inc Class ACAP STK CL A02079K3053,0261,088SH DFND37530335
Alphabet Inc Class ACAP STK CL A02079K305103,15737,089SH SOLE037,08900
Alphabet Inc Class CCAP STK CL C02079K107235,87684,453SH DFND184,45300
Alphabet Inc Class CCAP STK CL C02079K107780,132279,318SH DFND2253,877025,441
Alphabet Inc Class CCAP STK CL C02079K107144,25251,648SH DFND330,210021,438
Alphabet Inc Class CCAP STK CL C02079K107539,159193,040SH SOLE0110,625082,415
Alteryx IncCOM02156B10324336SH DFND333600
Amazon.ComCOM023135106901,503276,539SH DFND1276,53900
Amazon.ComCOM0231351063,398,9641,042,643SH DFND2588,3150454,328
Amazon.ComCOM023135106423,203129,819SH DFND3101,531028,288
Amazon.ComCOM0231351061,838,335563,915SH SOLE0412,2110151,704
AmbarellaSHSG037AX10129,388280,100SH DFND1280,10000
AmbarellaSHSG037AX10112,890122,858SH DFND234,859087,999
AmbarellaSHSG037AX1016,75864,411SH DFND364,41100
AmbarellaSHSG037AX10110,24197,605SH SOLE097,60500
AmdocsCOMG0260210330365SH DFND336500
AmerenCOM0236081021,21212,931SH DFND112,93100
American Superconductor CorpCOM0301112075,505723,370SH DFND1723,37000
American Superconductor CorpCOM0301112075,844768,000SH SOLE0768,00000
American Tower Corp REITCOM03027X1007723,072SH DFND13,07200
American Well Corp Class ACOM03044L10541197,542SH DFND197,54200
American Well Corp Class ACOM03044L105851202,062SH DFND2202,06200
American Well Corp Class ACOM03044L1051,684399,957SH DFND3399,95700
Amicus Therapeutics IncCOM03152W1095538SH DFND353800
Amkor TechnologyCOM031652100381,765SH DFND31,76500
Amneal Pharmaceuticals IncCOM03168L1054853SH DFND385300
Analog DevicesCOM03265410578,523475,380SH DFND1475,38000
Analog DevicesCOM032654105126,466765,628SH DFND2691,041074,587
Analog DevicesCOM03265410531,113188,360SH DFND3126,353062,007
Analog DevicesCOM032654105138,386837,788SH SOLE0599,0860238,702
Anaplan Inc CommonCOM03272L10820306SH DFND330600
AnterixCOM03676C1009162SH DFND316200
Anthem IncCOM036752103270,117549,890SH DFND1549,89000
Anthem IncCOM036752103869,9631,771,026SH DFND21,606,4620164,564
Anthem IncCOM036752103165,292336,492SH DFND3196,8250139,667
Anthem IncCOM036752103744,1901,514,984SH SOLE0975,3720539,612
AppFolioCOM03783C10024212SH DFND321200
Appian CorpCL A03782L101131,7762,166,655SH DFND12,166,65500
Appian CorpCL A03782L101169,2852,783,371SH DFND22,439,1630344,208
Appian CorpCL A03782L10117,042280,199SH DFND3280,19900
Appian CorpCL A03782L10139,052642,084SH SOLE0642,08400
AppleCOM03783310048,410277,248SH DFND1277,24800
AppleCOM0378331006683,827SH DFND2003,827
AppleCOM0378331007,88145,133SH DFND345,13300
AppleCOM03783310033,222190,262SH SOLE0190,26200
Ares Capital CorpCOM04010L10365,8633,143,800SH DFND13,143,80000
Ares Capital CorpCOM04010L10322410,700SH DFND210,70000
Ares Capital CorpCOM04010L1036,081290,270SH DFND3290,27000
ArganCOM04010E1094103SH DFND310300
Ascendis Pharma ADR 1:1SPON ADR04351P1011,95316,638SH DFND116,63800
Ascendis Pharma ADR 1:1SPON ADR04351P1013,72931,777SH DFND231,77700
Ascendis Pharma ADR 1:1SPON ADR04351P1015,42646,236SH DFND346,23600
Asensus Surgical IncCOM04367G10335,338SH DFND35,33800
AstraZeneca ADRCOM04635310827400SH DFND340000
Atlassian Corp PlcCL AG06242104139,327474,176SH DFND1474,17600
Atlassian Corp PlcCL AG062421041,089,5623,708,138SH DFND21,253,44902,454,689
Atlassian Corp PlcCL AG06242104141,347481,050SH DFND3403,409077,641
Atlassian Corp PlcCL AG06242104303,4331,032,681SH SOLE0476,6010556,080
Aurora Innovation Class A CommonCOM CL A05177410783,85015,000,000SH SOLE015,000,00000
Avalara IncCOM05338G10638381SH DFND238100
Avalara IncCOM05338G1064574,588SH DFND34,58800
AvangridCOM05351W103109,7962,349,072SH DFND12,349,07200
AvangridCOM05351W1032966,328SH DFND26,32800
AvangridCOM05351W1036,901147,645SH DFND3147,64500
Avery Dennison CorporationCOM05361110917100SH DFND310000
Axogen IncCOM05463X1064444SH DFND344400
Axon Enterprise IncCOM05464C101102,236742,294SH DFND1742,29400
Axon Enterprise IncCOM05464C101223,2481,620,910SH DFND21,338,2720282,638
Axon Enterprise IncCOM05464C10152,039377,837SH DFND3265,0760112,761
Axon Enterprise IncCOM05464C101189,2651,374,172SH SOLE0925,7500448,422
Axonics Modulation TechnologiesCOM05465P10112198SH DFND319800
Baidu.com Sponsored ADRSPON ADR REP A0567521086,54349,456SH DFND149,45600
Baidu.com Sponsored ADRSPON ADR REP A056752108464,0483,507,540SH DFND23,114,0850393,455
Baidu.com Sponsored ADRSPON ADR REP A05675210824,102182,176SH DFND320,1960161,980
Baidu.com Sponsored ADRSPON ADR REP A0567521081,0267,754SH DFND47,75400
Banco Bradesco Pn ADRSP ADR PFD NEW05946030325,7705,553,831SH DFND15,553,83100
Banco Bradesco Pn ADRSP ADR PFD NEW059460303200,15043,135,790SH DFND223,855,429019,280,361
Banco Bradesco Pn ADRSP ADR PFD NEW0594603037,2781,568,558SH DFND31,568,55800
BandwidthCOM05988J10331971SH DFND297100
BandwidthCOM05988J10337111,463SH DFND311,46300
Baozun Spn Adr 1:1SPONSORED ADR06684L1035,083592,408SH DFND1592,40800
Baozun Spn Adr 1:1SPONSORED ADR06684L1033,502408,111SH DFND2117,9160290,195
Baozun Spn Adr 1:1SPONSORED ADR06684L1031,583184,540SH DFND3184,54000
Baozun Spn Adr 1:1SPONSORED ADR06684L1032,523294,100SH SOLE0294,10000
Beam TherapeuticsCOM07373V10523398SH DFND339800
Beam TherapeuticsCOM07373V10558910,275SH SOLE010,27500
BeiGene LtdSPONSORED ADR07725L10270,967376,282SH DFND1376,28200
BeiGene LtdSPONSORED ADR07725L102531,5952,818,638SH DFND21,149,77501,668,863
BeiGene LtdSPONSORED ADR07725L10254,777290,442SH DFND3243,798046,644
BeiGene LtdSPONSORED ADR07725L102116,480617,606SH SOLE0285,2710332,335
Benefitfocus IncCOM08180D1063,867306,448SH DFND1306,44800
Benefitfocus IncCOM08180D1063,615286,429SH DFND278,7480207,681
Benefitfocus IncCOM08180D1062,193173,762SH DFND3173,76200
Benefitfocus IncCOM08180D1062,857226,368SH SOLE0226,36800
Berkeley Lights IncCOM0843101019,4391,327,518SH DFND11,327,51800
Berkeley Lights IncCOM0843101014,640652,600SH DFND2504,3340148,266
Berkeley Lights IncCOM0843101018,7671,233,098SH DFND31,072,2280160,870
Berkeley Lights IncCOM0843101012,323326,690SH SOLE0326,69000
Beyond Meat IncCOM08862E10959,1501,224,383SH DFND11,224,38300
Beyond Meat IncCOM08862E109231,6164,794,379SH DFND21,700,16003,094,219
Beyond Meat IncCOM08862E10959,5581,232,838SH DFND31,011,4100221,428
Beyond Meat IncCOM08862E10963,4211,312,794SH SOLE0636,5000676,294
Bilibili Inc ADRSPONSORED ADR0900401063,579139,895SH DFND200139,895
Bilibili Inc ADRSPONSORED ADR09004010666626,051SH DFND30026,051
BioCryst PharmaceuticalsCOM09058V103271,687SH DFND31,68700
BioNTech ADRSPONS ADS09075V10287,865515,155SH DFND1515,15500
BioNTech ADRSPONS ADS09075V102786,1144,609,017SH DFND21,820,17202,788,845
BioNTech ADRSPONS ADS09075V10285,076498,803SH DFND3434,650064,153
BioNTech ADRSPONS ADS09075V102191,3211,121,722SH SOLE0518,3330603,389
Biomarin Pharmaceutical IncCOM09061G101682SH DFND38200
BlacklineCOM09239B10941,995573,542SH DFND1573,54200
BlacklineCOM09239B10922,969313,694SH DFND291,1200222,574
BlacklineCOM09239B10911,289154,176SH DFND3154,17600
BlacklineCOM09239B10920,544280,576SH SOLE0280,57600
Blackrock IncCOM09247X1011519SH DFND31900
Blink ChargingCOM09354A10011400SH DFND340000
Blue Apron Holdings IncCL A09523Q101601148,506SH DFND1148,50600
Bluebird Bio IncCOM09609G1004860SH DFND386000
Blueprint Medicines CorpCOM09627Y10920315SH DFND331500
Booking Holdings IncCOM09857L108111,31947,401SH DFND147,40100
Booking Holdings IncCOM09857L108300,421127,923SH DFND2115,463012,460
Booking Holdings IncCOM09857L10861,61626,237SH DFND315,638010,599
Booking Holdings IncCOM09857L108263,271112,104SH SOLE071,888040,216
Boston OmahaCOM10104410513529SH DFND352900
Box IncCOM10316T10428979SH DFND397900
Brady CorpCOM1046741069200SH DFND320000
BridgeBio Pharma IncCOM10806X10293191,704SH DFND191,70400
BridgeBio Pharma IncCOM10806X1021,880185,242SH DFND2185,24200
BridgeBio Pharma IncCOM10806X1022,689264,945SH DFND3264,94500
Bristol Myers SquibbCOM11012210834463SH DFND346300
Broadridge Finl.Sltn.COM11133T10377,431497,279SH DFND1497,27900
Broadridge Finl.Sltn.COM11133T103255,1151,638,397SH DFND21,491,9940146,403
Broadridge Finl.Sltn.COM11133T10346,955301,556SH DFND3174,4580127,098
Broadridge Finl.Sltn.COM11133T103206,6061,326,866SH SOLE0845,6250481,241
Brookfield RenewableCOM11284V10577,8351,777,047SH DFND11,777,04700
Brookfield RenewableCOM11284V1051864,252SH DFND24,25200
Brookfield RenewableCOM11284V1054,33999,073SH DFND399,07300
Bumble IncCOM CL A12047B10511,592400,000SH SOLE0400,00000
Burford CapitalORD SHSG179771104,578501,035SH DFND2501,03500
Burford CapitalORD SHSG1797711010,2241,118,922SH DFND11,118,92200
Burning Rock Biotech Ltd ADRSPON ADS12233L10720,0762,161,037SH DFND12,161,03700
Burning Rock Biotech Ltd ADRSPON ADS12233L10759,4696,401,378SH DFND24,175,72902,225,649
Burning Rock Biotech Ltd ADRSPON ADS12233L1072,017217,063SH DFND339,3510177,712
Burning Rock Biotech Ltd ADRSPON ADS12233L1071,224131,772SH SOLE0131,77200
Butterfly Network IncCOM CL A1241551021,258264,363SH DFND1264,36300
Butterfly Network IncCOM CL A1241551021,788375,532SH DFND2375,53200
Butterfly Network IncCOM CL A1241551023,635763,585SH DFND3763,58500
Butterfly Network IncCOM CL A1241551023,866812,150SH SOLE0812,15000
C3.aiCL A12468P1043117SH DFND311700
CEVA IncCOM1572101057,263178,680SH DFND1178,68000
CEVA IncCOM1572101055,939146,102SH DFND240,5810105,521
CEVA IncCOM1572101053,08075,778SH DFND375,77800
CEVA IncCOM1572101053,35482,500SH SOLE082,50000
CH Robinson WorldwideCOM NEW12541W20930,185280,242SH DFND1280,24200
CH Robinson WorldwideCOM NEW12541W2094303,994SH DFND2003,994
CH Robinson WorldwideCOM NEW12541W2094,91045,582SH DFND345,58200
CH Robinson WorldwideCOM NEW12541W20921,260197,381SH SOLE0197,38100
CS Disco IncCOM126327105551,628SH DFND21,62800
CS Disco IncCOM12632710566319,527SH DFND319,52700
Calavo Growers IncCOM1282461054113SH DFND311300
Calix IncCOM13100M50936836SH DFND283600
Calix IncCOM13100M5094209,794SH DFND39,79400
Cardlytics IncCOM14161W10521,658393,924SH DFND1393,92400
Cardlytics IncCOM14161W10514,593265,427SH DFND276,5030188,924
Cardlytics IncCOM14161W1057,276132,333SH DFND3132,33300
Cardlytics IncCOM14161W10514,544264,524SH SOLE0264,52400
Cargurus IncCOM1417881091042,460SH DFND22,46000
Cargurus IncCOM1417881091,26929,876SH DFND329,87600
CarvanaCOM146869102167,8301,406,906SH DFND11,406,90600
CarvanaCOM146869102598,1195,013,995SH DFND22,829,81302,184,182
CarvanaCOM14686910268,627575,294SH DFND3460,1260115,168
CarvanaCOM146869102296,6372,486,688SH SOLE01,829,8420656,846
Castle BiosciencesCOM14843C10510225SH DFND322500
Cbre Group IncCL A12504L109134,6271,471,013SH DFND11,471,01300
Cbre Group IncCL A12504L109394,9914,315,903SH DFND23,927,6160388,287
Cbre Group IncCL A12504L10975,402823,882SH DFND3489,3430334,539
Cbre Group IncCL A12504L109325,2173,553,505SH SOLE02,286,23601,267,269
Cellectis ADRSPONS ADS15117K1033,299726,605SH DFND1726,60500
Cellectis ADRSPONS ADS15117K103794174,990SH DFND2174,99000
Cellectis ADRSPONS ADS15117K103819180,500SH SOLE0180,50000
Celsius HoldingsCOM15118V20714260SH DFND326000
Cemex ADRSPON ADR NEW15129088933,5856,348,848SH DFND16,348,84800
Cemex ADRSPON ADR NEW151290889209,59639,621,123SH DFND211,412,651028,208,472
Cemex ADRSPON ADR NEW15129088983,65615,813,921SH DFND31,543,885014,270,036
Cemex ADRSPON ADR NEW1512908892,915551,029SH DFND4551,02900
CertaraCOM15687V10932,1561,497,040SH DFND11,497,04000
CertaraCOM15687V109101,3214,716,971SH DFND24,256,8040460,167
CertaraCOM15687V10919,882925,612SH DFND3534,0310391,581
CertaraCOM15687V10992,0994,287,660SH SOLE02,798,91501,488,745
CerusCOM15708510161,143SH DFND31,14300
ChargePoint Holdings IncCOM CL A15961R1051306,540SH DFND16,54000
ChargePoint Holdings IncCOM CL A15961R10590,9504,574,933SH SOLE04,574,93300
Charles SchwabCOM80851310577,867923,575SH DFND1923,57500
Charles SchwabCOM808513105248,1822,943,679SH DFND22,668,6760275,003
Charles SchwabCOM80851310547,040557,938SH DFND3330,0880227,850
Charles SchwabCOM808513105214,7942,547,671SH SOLE01,654,9670892,704
CheggCOM163092109211,2705,823,308SH DFND15,823,30800
CheggCOM163092109295,7028,150,548SH DFND27,121,37301,029,175
CheggCOM16309210944,4851,226,151SH DFND3989,3500236,801
CheggCOM163092109125,4323,457,330SH SOLE02,814,7460642,584
Chewy IncCL A16679L109140,2083,438,153SH DFND13,438,15300
Chewy IncCL A16679L109255,2816,259,960SH DFND25,998,6820261,278
Chewy IncCL A16679L10923,849584,813SH DFND3412,9910171,822
Chewy IncCL A16679L10997,2792,385,470SH SOLE01,737,3350648,135
Chinook TherapeuticsCOM16961L1066,482396,187SH DFND1396,18700
Chinook TherapeuticsCOM16961L1063,396207,590SH DFND261,5270146,063
Chinook TherapeuticsCOM16961L1061,47390,044SH DFND390,04400
Chinook TherapeuticsCOM16961L1061,915117,058SH SOLE0117,05800
Church & Dwight Co IncCOM17134010218179SH DFND317900
Cisco SystemsCOM17275R10224,311435,997SH DFND1435,99700
Cisco SystemsCOM17275R1023396,084SH DFND2006,084
Cisco SystemsCOM17275R1024,02772,223SH DFND372,22300
Cisco SystemsCOM17275R10216,750300,399SH SOLE0300,39900
Clear Secure IncCOM18467V10926,8801,000,000SH SOLE01,000,00000
Cloudflare IncCL A COM18915M107527,8034,409,378SH DFND14,409,37800
Cloudflare IncCL A COM18915M1071,856,69815,511,261SH DFND29,177,77706,333,484
Cloudflare IncCL A COM18915M107213,2211,781,293SH DFND31,411,5650369,728
Cloudflare IncCL A COM18915M107650,1985,431,896SH SOLE03,194,14302,237,753
Clover Health Investments CorpCOM CL A18914F10327,6467,787,680SH SOLE07,787,68000
CoStar GroupCOM22160N109233,4963,505,413SH DFND13,505,41300
CoStar GroupCOM22160N109436,5086,553,189SH DFND26,262,2670290,922
CoStar GroupCOM22160N10942,041631,144SH DFND3430,8900200,254
CoStar GroupCOM22160N109181,3922,723,201SH SOLE01,965,5030757,698
Coca ColaCOM19121610027,295440,250SH DFND1440,25000
Coca ColaCOM1912161005508,874SH DFND2008,874
Coca ColaCOM1912161001,01716,408SH DFND316,40800
Coca ColaCOM19121610027,343441,022SH SOLE0441,02200
CodexisCOM19200510654,9872,666,691SH DFND12,666,69100
CodexisCOM19200510641,5882,016,891SH DFND2614,60001,402,291
CodexisCOM19200510622,1541,074,383SH DFND3996,578077,805
CodexisCOM19200510633,5831,628,663SH SOLE01,628,66300
Cognyte SoftwareORD SHSM251331054369SH DFND336900
Cohen & Steers IncCOM19247A10026301SH DFND330100
Coherus BioSciencesCOM19249H103181,431SH DFND31,43100
CohuCOM19257610621700SH DFND370000
Columbia Sportswear CoCOM198516106995SH DFND39500
Commscope Holding Co IncCOM20337X109111,442SH DFND31,44200
Consensus Cloud SolutionsCOM20848V105124SH DFND32400
Consolidated EdisonCOM209115104142,3691,503,689SH DFND11,503,68900
Consolidated EdisonCOM2091151043924,135SH DFND24,13500
Consolidated EdisonCOM2091151049,03995,470SH DFND395,47000
Cooper Cos Inc/TheCOM21664840213,10131,373SH DFND231,37300
Copa Holdings S ACL AP3107610534,611413,810SH DFND1413,81000
Copa Holdings S ACL AP31076105297,7593,560,004SH DFND22,304,91501,255,089
Copa Holdings S ACL AP3107610562,647749,002SH DFND388,8040660,198
Copa Holdings S ACL AP310761052,61231,229SH DFND431,22900
CorningCOM21935010524653SH DFND365300
Costco Wholesale CorporationCOM22160K1053663SH DFND36300
Coupa Software IncCOM22266L10633325SH DFND332500
CoupangCL A22266T109154,3028,727,502SH DFND18,727,50200
CoupangCL A22266T1091,431,80980,984,664SH DFND250,588,632030,396,032
CoupangCL A22266T109114,9046,499,112SH DFND34,229,40902,269,703
CoupangCL A22266T10932818,547SH DFND418,54700
CoupangCL A22266T109249,94514,137,177SH SOLE07,625,32506,511,852
Coursera IncCOM22266M104150,3686,526,389SH DFND16,526,38900
Coursera IncCOM22266M104163,1687,081,929SH DFND26,554,6450527,284
Coursera IncCOM22266M10460,9932,647,262SH DFND32,177,4910469,771
Coursera IncCOM22266M10426,8601,165,800SH SOLE01,165,80000
CredicorpCOMG2519Y10828,366165,041SH DFND1165,04100
CredicorpCOMG2519Y108141,232821,736SH DFND2328,4840493,252
CredicorpCOMG2519Y10848,852284,239SH DFND338,5200245,719
CredicorpCOMG2519Y1082,25313,108SH DFND413,10800
CrowdStrike HoldingsCOM22788C10526114SH DFND311400
Cullen/Frost BankersCOM22989910921,567155,820SH DFND1155,82000
Cullen/Frost BankersCOM2298991093042,195SH DFND2002,195
Cullen/Frost BankersCOM2298991093,62426,180SH DFND326,18000
Cullen/Frost BankersCOM22989910915,035108,625SH SOLE0108,62500
Curevac N.V.COMN2451R10576,7023,911,347SH DFND23,424,9250486,422
CyberArk Software LtdSHSM2682V10816,81099,616SH DFND199,61600
CyberArk Software LtdSHSM2682V10833,726199,858SH DFND257,9630141,895
CyberArk Software LtdSHSM2682V10816,63998,600SH DFND398,60000
CyberArk Software LtdSHSM2682V10819,426115,118SH SOLE0115,11800
Dada Nexus Ltd ADRADS23344D10828,9843,174,568SH DFND13,174,56800
Dada Nexus Ltd ADRADS23344D10834,7223,803,066SH DFND22,598,22901,204,837
Dada Nexus Ltd ADRADS23344D10851155,932SH DFND355,93200
Dada Nexus Ltd ADRADS23344D1087,146782,705SH SOLE0782,70500
Darden RestaurantsCOM2371941051182SH DFND38200
DatadogCOM23804L103234,0111,544,933SH DFND11,544,93300
DatadogCOM23804L103455,2243,005,373SH DFND22,852,8180152,555
DatadogCOM23804L10349,337325,719SH DFND3216,1380109,581
DatadogCOM23804L103200,9561,326,706SH SOLE0909,7100416,996
Deere & CoCOM244199105188,227453,058SH DFND1453,05800
Deere & CoCOM24419910585,219205,120SH DFND2124,109081,011
Deere & CoCOM244199105192,397463,095SH DFND3373,193089,902
Deere & CoCOM24419910517,02140,968SH SOLE040,96800
Denali TherapeuticsCOM24823R10593,7992,915,723SH DFND12,915,72300
Denali TherapeuticsCOM24823R105140,0294,352,772SH DFND24,207,4460145,326
Denali TherapeuticsCOM24823R10514,896463,042SH DFND3424,422038,620
Denali TherapeuticsCOM24823R105233,1977,248,895SH SOLE07,248,89500
DermTechCOM24984K1054286SH DFND328600
Dexcom IncCOM252131107360,884705,402SH DFND1705,40200
Dexcom IncCOM2521311071,251,7252,446,687SH DFND2891,98401,554,703
Dexcom IncCOM252131107375,915734,784SH DFND3605,3520129,432
Dexcom IncCOM252131107341,452667,420SH SOLE0328,3710339,049
DigimarcCOM25381B1016,921262,445SH DFND1262,44500
DigimarcCOM25381B1017,246274,790SH DFND279,9170194,873
DigimarcCOM25381B1013,678139,458SH DFND3139,45800
DigimarcCOM25381B1014,080154,711SH SOLE0154,71100
Digital Realty Trust REITCOM2538681034563,215SH DFND13,21500
DoceboCOM25609L1057,217139,497SH DFND2139,49700
DoceboCOM25609L10514267SH DFND326700
Dolby Laboratories 'A'COM25659T10715,861202,778SH DFND1202,77800
Dolby Laboratories 'A'COM25659T1072242,867SH DFND2002,867
Dolby Laboratories 'A'COM25659T1072,61433,422SH DFND333,42200
Dolby Laboratories 'A'COM25659T10711,119142,145SH SOLE0142,14500
DomoCOM25755410516321SH DFND332100
DonaldsonCOM25765110923436SH DFND343600
Doordash IncCOM25809K105182,7101,559,089SH DFND11,559,08900
Doordash IncCOM25809K105369,1343,149,879SH DFND22,970,5100179,369
Doordash IncCOM25809K10545,146385,237SH DFND3249,5300135,707
Doordash IncCOM25809K105304,5692,598,931SH SOLE02,085,5020513,429
DropboxCL A26210C10420881SH DFND388100
Duck Creek TechnologiesSHS2641201068355SH DFND335500
Duke Realty Corporation REITCOM264411505131,5322,265,450SH DFND12,265,45000
Duke Realty Corporation REITCOM2644115053946,782SH DFND26,78200
Duke Realty Corporation REITCOM2644115058,620148,468SH DFND3148,46800
Duolingo IncCL A COM26603R10673,963777,655SH DFND1777,65500
Duolingo IncCL A COM26603R10674,449782,771SH DFND2713,172069,599
Duolingo IncCL A COM26603R10633,787355,238SH DFND3290,190065,048
Duolingo IncCL A COM26603R10612,786134,437SH SOLE0134,43700
EHang Holdings Ltd ADRADS26853E102352,950SH DFND12,95000
EargoCOM2700871091263SH DFND326300
EcolabCOM27886510068,824389,806SH DFND1389,80600
EcolabCOM27886510039,531223,894SH DFND2154,637069,257
EcolabCOM27886510069,669394,590SH DFND3316,963077,627
EcolabCOM2788651005,66132,065SH SOLE032,06500
Edwards Lifesciences CorpCOM28176E1085,87549,904SH DFND149,90400
Edwards Lifesciences CorpCOM28176E10827,649234,867SH DFND2234,86700
Edwards Lifesciences CorpCOM28176E10816,534140,454SH DFND3140,45400
Electronic Arts, Inc.COM28551210921164SH DFND316400
Emergent Biosolutions IncCOM29089Q10516385SH DFND338500
Enanta PharmaceuticalsCOM29251M10623318SH DFND331800
Enphase Energy IncCOM29355A107195964SH DFND196400
Estee Lauder 'A'COM51843910497,796359,122SH DFND1359,12200
Estee Lauder 'A'COM518439104338,6741,243,662SH DFND21,136,2230107,439
Estee Lauder 'A'COM51843910460,591222,500SH DFND3130,359092,141
Estee Lauder 'A'COM518439104268,849987,254SH SOLE0638,0560349,198
EverQuote IncCOM CL A30041R10811,633718,967SH DFND1718,96700
EverQuote IncCOM CL A30041R1084,216260,555SH DFND275,4330185,122
EverQuote IncCOM CL A30041R1082,605161,032SH DFND3161,03200
EverQuote IncCOM CL A30041R1083,746231,550SH SOLE0231,55000
Everbridge IncCOM29978A10414,436330,786SH DFND1330,78600
Everbridge IncCOM29978A1048,657198,371SH DFND257,4950140,876
Everbridge IncCOM29978A1044,424101,381SH DFND3101,38100
Everbridge IncCOM29978A1046,478148,446SH SOLE0148,44600
Eversource EnergyCOM30040W108124,4521,411,182SH DFND11,411,18200
Eversource EnergyCOM30040W1083023,428SH DFND23,42800
Eversource EnergyCOM30040W1087,02579,654SH DFND379,65400
Exact SciencesCOM30063P10578,8941,128,346SH DFND11,128,34600
Exact SciencesCOM30063P105106,5071,523,265SH DFND21,145,7230377,542
Exact SciencesCOM30063P10535,039501,125SH DFND3393,1770107,948
Exact SciencesCOM30063P10584,3221,205,984SH SOLE0862,0950343,889
ExelixisCOM30161Q104271,200SH DFND31,20000
Exelon CorporationCOM30161N1011,35528,452SH DFND128,45200
Expedia Group IncCOM30212P30332165SH DFND316500
Expeditors IntlCOM30213010913126SH DFND312600
Expensify IncCOM CL A30219Q10612,242697,160SH DFND1697,16000
Expensify IncCOM CL A30219Q106422,371SH DFND22,37100
Expensify IncCOM CL A30219Q10649528,200SH DFND328,20000
Expensify IncCOM CL A30219Q1066,307359,144SH SOLE0359,14400
ExponentCOM30214U10226242SH DFND324200
Exscientia Ltd ADRADS30223G10213,128911,680SH DFND1911,68000
Exscientia Ltd ADRADS30223G10222,5421,565,418SH DFND2201,32301,364,095
Exscientia Ltd ADRADS30223G1023,163219,626SH DFND3219,62600
Exscientia Ltd ADRADS30223G10218,9881,318,611SH SOLE0761,3050557,306
Factset Research SystemsCOM3030751052661SH DFND36100
FarfetchORD SHS CL A30744W10761,0454,037,339SH DFND14,037,33900
FarfetchORD SHS CL A30744W107218,66014,461,618SH DFND211,958,57602,503,042
FarfetchORD SHS CL A30744W10728,2721,869,874SH DFND31,213,9100655,964
FarfetchORD SHS CL A30744W107154,55210,221,700SH SOLE06,478,60203,743,098
FastenalCOM31190010474,8491,260,090SH DFND11,260,09000
FastenalCOM31190010418,645313,885SH DFND2241,917071,968
FastenalCOM31190010415,453260,146SH DFND3231,870028,276
FastenalCOM31190010444,545749,922SH SOLE0749,92200
FastlyCL A31188V1004205SH DFND320500
Ferrari NVCOMN3167Y1031,906,9408,625,424SH DFND26,870,49701,754,927
Ferrari NVCOMN3167Y103300,6561,359,921SH SOLE01,359,92100
Fibrogen IncCOM31572Q8086467SH DFND346700
First Industrial REITCOM32054K103103,1551,666,203SH DFND11,666,20300
First Industrial REITCOM32054K1033004,853SH DFND24,85300
First Industrial REITCOM32054K1036,585106,362SH DFND3106,36200
First Majestic SilverCOM32076V1031078,100SH DFND28,10000
First Republic BankCOM33616C100157,581972,121SH DFND1972,12100
First Republic BankCOM33616C100245,4971,514,476SH DFND21,465,763048,713
First Republic BankCOM33616C10015,44195,259SH DFND381,395013,864
First Republic BankCOM33616C10029,477181,846SH SOLE0181,84600
FirstCash Holdings IncCOM33768G10711,986170,398SH DFND1170,39800
FirstCash Holdings IncCOM33768G1071,29418,391SH DFND318,39100
Fiverr IntlORD SHSM4R82T106561SH DFND36100
FortisCOM3495531071,67833,889SH DFND133,88900
Fortive CorpCOM34959J1085,96097,814SH DFND297,81400
FoxCOM35137L10514359SH DFND335900
Freshpet IncCOM35803910566641SH DFND264100
Freshpet IncCOM3580391057847,643SH DFND37,64300
Full Truck Alliance Co Ltd ADRSPONS ADS35969L108107,58316,129,360SH DFND215,675,4670453,893
Full Truck Alliance Co Ltd ADRSPONS ADS35969L10841,7486,259,050SH SOLE06,259,05000
Futu Hdgs ADRSPON ADR CL A36118L10634,5141,060,019SH DFND2822,1900237,829
GANCOMG3728V1093572SH DFND357200
Gentex CorpCOM37190110915516SH DFND351600
Ginkgo Bioworks Holdings IncCL A COM37611X10074,06818,379,088SH DFND118,379,08800
Ginkgo Bioworks Holdings IncCL A COM37611X100177,79344,117,424SH DFND228,497,743015,619,681
Ginkgo Bioworks Holdings IncCL A COM37611X10015,3353,805,213SH DFND33,329,7310475,482
Ginkgo Bioworks Holdings IncCL A COM37611X100408,847101,450,955SH SOLE098,047,50903,403,446
Glaukos CorpCOM37732210214234SH DFND323400
Global Blood Therapeutics IncCOM37890U10829835SH DFND383500
Golub Capital BDC IncCOM38173M10241,8642,752,375SH DFND12,752,37500
Golub Capital BDC IncCOM38173M1021308,560SH DFND28,56000
Golub Capital BDC IncCOM38173M1023,305217,300SH DFND3217,30000
Goodyear Tire & Rubber Co/TheCOM382550101201,400SH DFND31,40000
GracoCOM38410910425363SH DFND336300
Grainger, WWCOM3848021043059SH DFND35900
HDFC Bank ADRADR REPS 3 SHS40415F1014,98881,323SH DFND181,32300
HDFC Bank ADRADR REPS 3 SHS40415F10166,5651,085,356SH DFND2940,9910144,365
HDFC Bank ADRADR REPS 3 SHS40415F10112,413202,394SH DFND3139,025063,369
HDFC Bank ADRADR REPS 3 SHS40415F101101,8601,660,853SH SOLE01,218,1810442,672
HUYA ADRADS REP SHS A44852D1085,1161,144,570SH DFND11,144,57000
HUYA ADRADS REP SHS A44852D1081,645368,029SH DFND300368,029
HUYA ADRADS REP SHS A44852D1082,777621,141SH SOLE0621,14100
Halozyme TherapeuticsCOM40637H10931779SH DFND377900
Harris CorpCOM5024311091561SH DFND36100
Hashicorp IncCOM CL A41810010370,3871,303,468SH DFND11,303,46800
Hashicorp IncCOM CL A41810010393,1341,724,711SH DFND21,695,504029,207
Hashicorp IncCOM CL A4181001034,17377,269SH DFND377,26900
Hashicorp IncCOM CL A41810010314,123261,535SH SOLE0261,53500
Health Catalyst IncCOM42225T1071,97275,476SH DFND175,47600
Health Catalyst IncCOM42225T1073,952151,258SH DFND2151,25800
Health Catalyst IncCOM42225T1075,577213,433SH DFND3213,43300
Healthcare Services Group IncCOM4219061083157SH DFND315700
Hecla Mining CoCOM42270410611016,700SH DFND216,70000
Heron Therapeutics IncCOM4277461022308SH DFND330800
HillenbrandCOM4315711088170SH DFND317000
Home DepotCOM4370761021756SH DFND35600
Homology MedicinesCOM4380831071481SH DFND348100
Howard HughesCOM44267D10758,109560,843SH DFND1560,84300
Howard HughesCOM44267D107128,5721,240,927SH DFND21,122,6430118,284
Howard HughesCOM44267D10728,016270,396SH DFND3166,6850103,711
Howard HughesCOM44267D107114,3501,103,661SH SOLE0710,4950393,166
HubbellCOM4435106071687SH DFND38700
Hubspot IncCOM44357310063132SH DFND313200
HumanaCOM4448591022456SH DFND35600
Hutchison China MeditechSPONSORED ADR44842L1032,292121,150SH DFND1121,15000
Hutchison China MeditechSPONSORED ADR44842L1031,15460,971SH DFND2291060,680
Hutchison China MeditechSPONSORED ADR44842L1033,475183,671SH DFND3820183,589
ICICI Bank ADRADR45104G10477,3384,083,324SH DFND14,083,32400
ICICI Bank ADRADR45104G10464,7863,420,589SH DFND23,420,58900
ICICI Bank ADRADR45104G10414,182748,772SH DFND3748,77200
ICICI Bank ADRADR45104G1044,160219,620SH DFND4219,62000
IPG Photonics CorpCOM44980X10913,253120,747SH DFND1120,74700
IPG Photonics CorpCOM44980X10911,802107,525SH DFND231,257076,268
IPG Photonics CorpCOM44980X1095,87453,521SH DFND353,52100
IPG Photonics CorpCOM44980X1099,91590,336SH SOLE090,33600
Iac/InteractivecorpCOM44891N20821,955218,935SH DFND1218,93500
Iac/InteractivecorpCOM44891N20867,348671,595SH DFND2608,613062,982
Iac/InteractivecorpCOM44891N20813,719136,804SH DFND380,234056,570
Iac/InteractivecorpCOM44891N20860,509603,400SH SOLE0382,2200221,180
Ii-Vi IncCOM90210410834475SH DFND347500
IlluminaCOM452327109742,2482,124,350SH DFND12,124,35000
IlluminaCOM4523271093,953,50611,315,130SH DFND27,978,72303,336,407
IlluminaCOM452327109450,2621,288,671SH DFND31,040,2290248,442
IlluminaCOM4523271092,158,9106,178,907SH SOLE05,300,1770878,730
InModeSHSM5425M10319526SH DFND352600
Incyte CorpCOM45337C10213165SH DFND316500
InfineraCOM45667G103252,941SH DFND32,94100
Infosys Ltd ADRSPONSORED ADR45678810829,0171,165,809SH DFND11,165,80900
Infosys Ltd ADRSPONSORED ADR45678810824,9051,000,585SH DFND2100,1420900,443
Infosys Ltd ADRSPONSORED ADR45678810834,7721,397,031SH DFND3558,6950838,336
Infosys Ltd ADRSPONSORED ADR4567881084,070163,530SH DFND4163,53000
Inogen IncCOM45780L1045141SH DFND314100
Insmed IncCOM45766930717707SH DFND370700
Inspire Medical SystemsCOM45773010940154SH DFND315400
Intercept Pharmaceuticals IncCOM45845P1082101SH DFND310100
International Game TechnologySHSG4863A108251,024SH DFND31,02400
Intersect ENTCOM46071F10312440SH DFND344000
IntuitCOM4612021032347SH DFND34700
Intuitive SurgicalCOM NEW46120E602110,786367,229SH DFND1367,22900
Intuitive SurgicalCOM NEW46120E602863,2332,861,420SH DFND2968,25301,893,167
Intuitive SurgicalCOM NEW46120E602110,240365,421SH DFND3305,430059,991
Intuitive SurgicalCOM NEW46120E602240,520797,270SH SOLE0368,0140429,256
InvitaeCOM46185L1036800SH DFND380000
Ionis PharmaceuticalsCOM4622221002,22860,157SH DFND160,15700
Ionis PharmaceuticalsCOM4622221004,342117,222SH DFND2117,22200
Ionis PharmaceuticalsCOM4622221006,352171,484SH DFND3171,48400
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210613,7672,410,946SH DFND12,410,94600
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210639,1486,856,003SH DFND2485,58206,370,421
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210651,1608,959,743SH DFND3882,99008,076,753
Itau Unibanco Holding SA-ADRSPON ADR REP PFD4655621062,200385,212SH DFND4385,21200
Itron IncCOM4657411069173SH DFND317300
Ivanhoe MinesCOM CL A46579R104131,400SH DFND21,40000
J&J Snack Foods CorpCOM4660321091383SH DFND38300
JD.Com Inc - ADRSPON ADR CL A47215P1063,95768,377SH DFND268,37700
JDS Uniphase CorporationCOM925550105181,142SH DFND31,14200
JFrog LtdORD SHSM6191J10016,303604,939SH DFND1604,93900
JFrog LtdORD SHSM6191J10011,267418,087SH DFND2121,1550296,932
JFrog LtdORD SHSM6191J1005,810215,575SH DFND3215,57500
JFrog LtdORD SHSM6191J10011,159414,081SH SOLE0414,08100
Jack Henry & AssociatesCOM4262811011471SH DFND37100
Jazz PharmaceuticalsSHSG5087110526165SH DFND316500
Joby Aviation IncCOMG6516310050,8237,677,200SH SOLE07,677,20000
Johnson & JohnsonCOM4781601041689SH DFND38900
Jumia Technologies Ag ADRSPONSORED ADS48138M10591,5419,555,480SH DFND28,914,9070640,573
Jumia Technologies Ag ADRSPONSORED ADS48138M1054,158434,078SH DFND33740433,704
KE Holdings ADRADR48249710427,1562,195,349SH DFND12,195,34900
KE Holdings ADRADR482497104124,76010,085,661SH DFND24,443,95205,641,709
KE Holdings ADRADR48249710414,0331,134,436SH DFND3879,2720255,164
KE Holdings ADRADR48249710459,7044,826,543SH SOLE03,519,15201,307,391
KFORCE INC.COM49373210122295SH DFND329500
Kaleido Biosciences IncCOM483347100608368,288SH DFND1368,28800
Kaleido Biosciences IncCOM483347100106,004SH DFND26,00400
Kaleido Biosciences IncCOM48334710011670,130SH DFND370,13000
Kaleido Biosciences IncCOM483347100477289,103SH SOLE0289,10300
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K10110,8001,779,200SH DFND11,779,20000
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K1015,340879,750SH DFND2879,75000
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K1011,866307,429SH DFND323,5600283,869
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K1012,386393,153SH SOLE0393,15300
Knowles CorpCOM49926D109261,200SH DFND31,20000
Kulicke & Soffa Industries IncCOM50124210128491SH DFND349100
Lemonade IncCOM52567D10742,9321,628,048SH DFND11,628,04800
Lemonade IncCOM52567D10764,5772,448,867SH DFND22,410,191038,676
Lemonade IncCOM52567D1072,46393,391SH DFND393,39100
Lemonade IncCOM52567D10725,468965,782SH SOLE0965,78200
LendingTreeCOM52603B10727,126226,675SH DFND1226,67500
LendingTreeCOM52603B10724,917208,212SH DFND262,7720145,440
LendingTreeCOM52603B10712,894107,750SH DFND3101,91705,833
LendingTreeCOM52603B10714,237118,966SH SOLE0118,96600
Li Auto ADRSPONS ADS50202M10245,3161,755,764SH DFND11,755,76400
Li Auto ADRSPONS ADS50202M102141,0895,466,444SH DFND24,936,3280530,116
Li Auto ADRSPONS ADS50202M10227,8081,077,418SH DFND3617,5440459,874
Li Auto ADRSPONS ADS50202M102127,1954,928,144SH SOLE03,193,50501,734,639
Liberty Broadband CorpCOM530307305970SH DFND37000
Lightspeed POSCOM53227R1069310SH DFND331000
Lilium N.V.CL A COMN52586109358,720SH DFND18,72000
Lilium N.V.CL A COMN525861092,181547,944SH DFND2547,94400
Lilium N.V.CL A COMN5258610970,44417,699,615SH SOLE017,699,61500
LivePerson IncCOM53814610112,022492,291SH DFND1492,29100
LivePerson IncCOM5381461018,652354,293SH DFND2101,6330252,660
LivePerson IncCOM5381461013,847157,554SH DFND3157,55400
LivePerson IncCOM5381461016,053247,880SH SOLE0247,88000
Liveramp Holdings IncCOM53815P10823,010615,401SH DFND1615,40100
Liveramp Holdings IncCOM53815P10811,545308,781SH DFND291,5350217,246
Liveramp Holdings IncCOM53815P1086,426171,857SH DFND3171,85700
Liveramp Holdings IncCOM53815P10811,033295,075SH SOLE0295,07500
Logitech International SASHSH5043023217235SH DFND323500
Lowes CosCOM5486611071469SH DFND36900
Lufax Holding LtdCOM54975P10242,9597,712,615SH DFND17,712,61500
Lufax Holding LtdCOM54975P10297,87517,571,896SH DFND29,972,18907,599,707
Lufax Holding LtdCOM54975P102919164,971SH DFND3164,97100
Lumentum HdgsCOM55024U10914141SH DFND314100
Lyell Immunopharma IncCOM55083R104658130,375SH DFND1130,37500
Lyell Immunopharma IncCOM55083R1041,405278,187SH DFND2278,18700
Lyell Immunopharma IncCOM55083R1041,900376,179SH DFND3376,17900
Lyft Inc Class A CommonCL A COM55087P1044,161108,361SH DFND1108,36100
Lyft Inc Class A CommonCL A COM55087P10447512,360SH DFND312,36000
MELI Kaszek PioneerCL A COMG5S74L10620,5602,000,000SH DFND22,000,00000
MP MaterialsCOM CL A553368101109,5191,910,000SH DFND11,910,00000
MP MaterialsCOM CL A5533681012474,300SH DFND24,30000
MP MaterialsCOM CL A5533681016,112106,600SH DFND3106,60000
MakeMyTripSHSV5633W10967,2012,504,679SH DFND21,856,7140647,965
Marathon Digital HoldingsCOM56578810610343SH DFND334300
Markel CorpCOM57053510475,30251,044SH DFND151,04400
Markel CorpCOM570535104236,000159,974SH DFND2144,769015,205
Markel CorpCOM57053510445,39030,768SH DFND318,152012,616
Markel CorpCOM570535104212,345143,939SH SOLE093,900050,039
MarketAxess HoldingsCOM57060D108167,292491,745SH DFND1491,74500
MarketAxess HoldingsCOM57060D108236,197694,290SH DFND2554,6790139,611
MarketAxess HoldingsCOM57060D10838,416112,923SH DFND3103,81609,107
MarketAxess HoldingsCOM57060D10860,337177,358SH SOLE0177,35800
Martin Marietta MaterialsCOM573284106218,898568,728SH DFND1568,72800
Martin Marietta MaterialsCOM573284106674,0761,751,347SH DFND21,586,0940165,253
Martin Marietta MaterialsCOM573284106110,707287,633SH DFND3168,6320119,001
Martin Marietta MaterialsCOM573284106495,0801,286,290SH SOLE0922,3010363,989
Masimo CorpCOM5747951002,50917,236SH DFND117,23600
Masimo CorpCOM5747951004,91633,780SH DFND233,78000
Masimo CorpCOM5747951007,15449,158SH DFND349,15800
Mastercard Inc-Class ACL A57636Q104143,228400,772SH DFND1400,77200
Mastercard Inc-Class ACL A57636Q104458,8731,283,991SH DFND21,163,8030120,188
Mastercard Inc-Class ACL A57636Q10486,051240,783SH DFND3141,903098,880
Mastercard Inc-Class ACL A57636Q104366,6081,025,822SH SOLE0657,7130368,109
Materialise Nv ADRSPONSORED ADS57667T1005,186268,000SH DFND2268,00000
Maxlinear IncCOM57776J10023400SH DFND340000
McDonald'sCOM58013510121,32686,242SH DFND186,24200
McDonald'sCOM5801351014351,759SH DFND2001,759
McDonald'sCOM5801351018203,318SH DFND33,31800
McDonald'sCOM58013510121,18785,680SH SOLE085,68000
Medifast IncCOM58470H10120120SH DFND312000
MedtronicCOMG5960L10321,789196,385SH DFND1196,38500
MedtronicCOMG5960L1033242,920SH DFND2002,920
MedtronicCOMG5960L1033,34330,129SH DFND330,12900
MedtronicCOMG5960L10315,527139,946SH SOLE0139,94600
MercadoLibreCOM58733R102360,146302,776SH DFND1302,77600
MercadoLibreCOM58733R1024,913,9524,131,177SH DFND23,333,9790797,198
MercadoLibreCOM58733R102212,405178,570SH DFND3149,839028,731
MercadoLibreCOM58733R1028,6127,240SH DFND47,24000
MercadoLibreCOM58733R102494,300415,560SH SOLE0415,56000
Meta Platforms IncCL A30303M102166,906750,612SH DFND1750,61200
Meta Platforms IncCL A30303M102943,8784,244,819SH DFND22,063,07702,181,742
Meta Platforms IncCL A30303M102136,638614,492SH DFND3461,4040153,088
Meta Platforms IncCL A30303M102408,5771,837,456SH SOLE01,029,7110807,745
Mettler-ToledoCOM592688105118,99486,655SH DFND186,65500
Mettler-ToledoCOM592688105533,429388,460SH DFND2285,5950102,865
Mettler-ToledoCOM5926881054,9783,625SH DFND33,62500
Mettler-ToledoCOM59268810533,75724,583SH SOLE024,58300
MicrosoftCOM594918104304,588987,929SH DFND1987,92900
MicrosoftCOM594918104815,2232,644,168SH DFND22,409,9450234,223
MicrosoftCOM594918104156,483507,552SH DFND3311,2640196,288
MicrosoftCOM594918104681,6172,210,818SH SOLE01,461,2880749,530
Mobile Telesystems ADRSPONSORED ADR607409109042,174SH DFND142,17400
Moderna IncCOM60770K107835,2474,848,756SH DFND14,848,75600
Moderna IncCOM60770K1074,312,29725,033,655SH DFND219,226,72505,806,930
Moderna IncCOM60770K107438,3842,544,897SH DFND32,056,3470488,550
Moderna IncCOM60770K1072,274,16213,201,918SH SOLE011,655,71601,546,202
Momentive Global IncCOM78489X103181,095SH DFND31,09500
MongoDB IncCOM60937P10696216SH DFND321600
Monolithic Power Systems IncCOM6098391053163SH DFND36300
Moody's CorpCOM615369105222,475659,361SH DFND1659,36100
Moody's CorpCOM615369105713,0852,113,409SH DFND21,915,1160198,293
Moody's CorpCOM615369105135,066400,302SH DFND3233,1880167,114
Moody's CorpCOM615369105592,9871,757,468SH SOLE01,113,6030643,865
NIO Inc ADRSPON ADS62914V10640,4671,922,423SH DFND11,922,42300
NIO Inc ADRSPON ADS62914V1061,223,98058,146,319SH DFND244,791,584013,354,735
NIO Inc ADRSPON ADS62914V10641,6981,980,898SH DFND31,660,3080320,590
NIO Inc ADRSPON ADS62914V106562,05626,700,981SH SOLE024,410,83402,290,147
NV5 GlobalCOM62945V10918138SH DFND313800
NVIDIACOM67066G104547,9222,008,069SH DFND12,008,06900
NVIDIACOM67066G1042,437,8988,934,611SH DFND24,187,16904,747,442
NVIDIACOM67066G104274,5481,006,187SH DFND3846,8070159,380
NVIDIACOM67066G1041,342,8394,921,348SH SOLE03,904,32501,017,023
Nano Dimension ADRSPONS ADS63008G20361,600SH DFND31,60000
Nanobiotix ADRCOM63009J1076,381850,841SH DFND1850,84100
Nanobiotix ADRCOM63009J1074,119549,159SH SOLE0549,15900
National Instruments CorpCOM63651810226,994665,036SH DFND1665,03600
National Instruments CorpCOM6365181023839,442SH DFND2009,442
National Instruments CorpCOM6365181024,455109,766SH DFND3109,76600
National Instruments CorpCOM63651810218,682460,267SH SOLE0460,26700
Nektar TherapeuticsCOM64026810871,376SH DFND31,37600
NetEase.com ADRSPONSORED ADR64110W10214,293159,358SH DFND1159,35800
NetEase.com ADRSPONSORED ADR64110W1029,313103,840SH DFND25000103,340
NetEase.com ADRSPONSORED ADR64110W10214154SH DFND315400
Netflix IncCOM64110L106445,5551,189,448SH DFND11,189,44800
Netflix IncCOM64110L1061,491,3193,981,203SH DFND22,254,63601,726,567
Netflix IncCOM64110L106169,449452,359SH DFND3365,093087,266
Netflix IncCOM64110L106780,0042,082,288SH SOLE01,597,7450484,543
Nevro CorpCOM64157F10311154SH DFND315400
New RelicCOM64829B10049733SH DFND373300
Newmont MiningCOM6516391061,60320,172SH DFND120,17200
Newmont MiningCOM6516391062703,400SH DFND23,40000
NextEra EnergyCOM65339F10153,647633,299SH DFND1633,29900
NextEra EnergyCOM65339F1011802,130SH DFND22,13000
NextEra EnergyCOM65339F1014,20049,579SH DFND349,57900
NikeCOM6541061031290SH DFND39000
Novanta IncCOM67000B10487614SH DFND261400
Novanta IncCOM67000B1041,0427,322SH DFND37,32200
Novavax IncCOM NEW67000240110130SH DFND313000
Novocure LtdORD SHSG6674U108214,5432,589,535SH DFND12,589,53500
Novocure LtdORD SHSG6674U108344,0484,152,657SH DFND23,654,4650498,192
Novocure LtdORD SHSG6674U10856,620683,400SH DFND3568,0300115,370
Novocure LtdORD SHSG6674U108158,6791,915,253SH SOLE01,479,3060435,947
Nu Holdings Ltd.ORD SHS CL AG6683N10346,7076,050,078SH DFND16,050,07800
Nu Holdings Ltd.ORD SHS CL AG6683N103118,05215,291,660SH DFND213,488,93801,802,722
Nu Holdings Ltd.ORD SHS CL AG6683N10347,3666,135,526SH DFND34,937,94601,197,580
Nu Holdings Ltd.ORD SHS CL AG6683N1034,442575,423SH SOLE0575,42300
Nucana Plc ADRSPONSORED ADR67022C1062,4182,420,041SH DFND12,420,04100
Nucana Plc ADRSPONSORED ADR67022C1061,2381,238,989SH SOLE01,238,98900
Nutanix IncCOM67059N10815563SH DFND356300
Oatly Inc.SPONS ADS67421J108115,75123,103,983SH DFND219,026,87804,077,105
Oatly Inc.SPONS ADS67421J1085,3201,061,969SH SOLE01,061,96900
On Semiconductor CorpCOM68218910531500SH DFND350000
OneConnect Financial Technology ADRCOM68248T105931659,993SH DFND1659,99300
Opko Health IncCOM68375N103236,635SH DFND36,63500
Oscar Health IncCOM68779310928,2762,836,131SH DFND12,836,13100
Oscar Health IncCOM68779310984,0528,430,442SH DFND27,635,0770795,365
Oscar Health IncCOM68779310918,6471,870,333SH DFND31,151,0070719,326
Oscar Health IncCOM68779310982,2038,244,998SH SOLE05,656,83502,588,163
Outset MedicalCOM69014510716346SH DFND334600
Oxford Industries IncCOM691497309773SH DFND37300
Ozon HoldingsCOM69269L1040333,970SH DFND1333,97000
Ozon HoldingsCOM69269L10402,478,153SH DFND21,319,30801,158,845
Ozon HoldingsCOM69269L104019,278SH DFND319,27800
PROCEPT BioRoboticsCOM74276L10513376SH DFND337600
Pacific Biosciences of CaliforniaCOM69404D1085561SH DFND356100
Pacira BioSciencesCOM69512710067,743887,616SH DFND1887,61600
Pacira BioSciencesCOM69512710042,826561,143SH DFND2185,1940375,949
Pacira BioSciencesCOM69512710025,707336,836SH DFND3292,649044,187
Pacira BioSciencesCOM69512710025,491334,005SH SOLE0334,00500
PagerDutyCOM69553P10019565SH DFND356500
Pagseguro Digital LtdCOM CL AG687071013148SH DFND214800
Pan American Silver CorpCOM6979001081234,500SH DFND24,50000
PaychexCOM70432610716116SH DFND311600
Peloton Interactive IncCL A COM70614W100143,8145,443,379SH DFND15,443,37900
Peloton Interactive IncCL A COM70614W100499,82318,918,339SH DFND29,779,33709,139,002
Peloton Interactive IncCL A COM70614W10079,1102,994,324SH DFND32,397,5620596,762
Peloton Interactive IncCL A COM70614W100154,1775,835,629SH SOLE03,239,41802,596,211
Penumbra IncCOM70975L107106,226478,215SH DFND1478,21500
Penumbra IncCOM70975L107153,387690,529SH DFND2679,496011,033
Penumbra IncCOM70975L1076,37728,708SH DFND328,70800
Penumbra IncCOM70975L10722,547101,505SH SOLE0101,50500
PepsicoCOM71344810848,552290,071SH DFND1290,07100
PepsicoCOM7134481086734,018SH DFND2004,018
PepsicoCOM7134481087,83146,785SH DFND346,78500
PepsicoCOM71344810833,663201,118SH SOLE0201,11800
Petrobras Common ADRSPONSORED ADR71654V408253,15517,105,088SH DFND117,105,08800
Petrobras Common ADRSPONSORED ADR71654V408749,09050,614,174SH DFND225,671,925024,942,249
Petrobras Common ADRSPONSORED ADR71654V40833,6722,275,157SH DFND32,275,15700
Petrobras Common ADRSPONSORED ADR71654V40811,453773,864SH DFND4773,86400
Petrobras Common ADRSPONSORED ADR71654V40815,2871,032,931SH SOLE01,032,93100
Petrobras Pref ADRSP ADR NON VTG71654V10122,4811,608,059SH DFND11,608,05900
Petrobras Pref ADRSP ADR NON VTG71654V101130,6569,345,934SH DFND26,907,27102,438,663
Petrobras Pref ADRSP ADR NON VTG71654V1011,13581,219SH DFND381,21900
PfizerCOM71708110326500SH DFND350000
Piedmont Lithium IncCOM72016P10515212SH DFND321200
Pinduoduo Inc ADRSPONSORED ADS72230410271,7541,788,927SH DFND11,788,92700
Pinduoduo Inc ADRSPONSORED ADS722304102693,22417,283,075SH DFND28,237,06609,046,009
Pinduoduo Inc ADRSPONSORED ADS72230410267,8401,691,337SH DFND31,416,7290274,608
Pinduoduo Inc ADRSPONSORED ADS722304102333,8828,324,153SH SOLE06,352,42801,971,725
PinterestCOM72352L10656,0472,277,401SH DFND12,277,40100
PinterestCOM72352L10687,0893,538,772SH DFND23,484,277054,495
PinterestCOM72352L1063,315134,692SH DFND3134,69200
PinterestCOM72352L10612,761518,530SH SOLE0518,53000
Plantronics IncCOM72749310810254SH DFND325400
Precision BioSciences IncCOM74019P108154,887SH DFND24,88700
Precision BioSciences IncCOM74019P10817556,678SH DFND356,67800
Procter & GambleCOM74271810957,801378,278SH DFND1378,27800
Procter & GambleCOM7427181097995,230SH DFND2005,230
Procter & GambleCOM7427181099,31560,961SH DFND360,96100
Procter & GambleCOM74271810940,408264,451SH SOLE0264,45100
ProgynyCOM74340E10327,753539,946SH DFND1539,94600
ProgynyCOM74340E10318,688363,573SH DFND2116,6030246,970
ProgynyCOM74340E10310,712208,408SH DFND3185,015023,393
ProgynyCOM74340E10311,579225,281SH SOLE0225,28100
Prologis Inc REITCOM74340W103106,111657,115SH DFND1657,11500
Prologis Inc REITCOM74340W1033141,947SH DFND21,94700
Prologis Inc REITCOM74340W1036,89042,665SH DFND342,66500
Proterra IncCOM74374T1098210,898SH DFND110,89800
Ptc Therapeutics IncCOM69366J2009246SH DFND324600
Pure Storage IncCOM74624M102471,335SH DFND31,33500
Q2 Holdings IncCOM74736L10919,626318,346SH DFND1318,34600
Q2 Holdings IncCOM74736L10911,093179,932SH DFND252,9850126,947
Q2 Holdings IncCOM74736L1095,94296,375SH DFND396,37500
Q2 Holdings IncCOM74736L1097,536122,235SH SOLE0122,23500
Quaker Chemical CorpCOM7473161071586SH DFND38600
QualcommCOM74752510328181SH DFND318100
Quanterix CorpCOM74766Q10111,417391,135SH DFND1391,13500
Quanterix CorpCOM74766Q101712,423SH DFND22,42300
Quanterix CorpCOM74766Q10184729,013SH DFND329,01300
Quanterix CorpCOM74766Q1016,120209,677SH SOLE0209,67700
QuantumScape CorpCOM CL A74767V109603,002SH DFND13,00200
QuantumScape CorpCOM CL A74767V10918,256913,279SH SOLE0913,27900
Quest DiagnosticsCOM74834L10020145SH DFND314500
Quidel CorpCOM74838J10114128SH DFND312800
REGENXBIOCOM75901B10725752SH DFND375200
Rambus IncCOM75091710620630SH DFND363000
Recursion Pharmaceuticals IncCL A75629V10420,3812,846,499SH DFND12,846,49900
Recursion Pharmaceuticals IncCL A75629V10428,4883,978,800SH DFND23,916,615062,185
Recursion Pharmaceuticals IncCL A75629V1044,227590,320SH DFND3590,32000
Recursion Pharmaceuticals IncCL A75629V104104,29214,565,985SH SOLE014,565,98500
RedfinCOM75737F10871,4313,959,592SH DFND13,959,59200
RedfinCOM75737F10895,6245,300,639SH DFND25,136,1880164,451
RedfinCOM75737F1086,544362,762SH DFND3321,165041,597
RedfinCOM75737F10813,297737,083SH SOLE0737,08300
Regeneron PharmaceuticalsCOM75886F1073246SH DFND34600
Relay Therapeutics IncCOM75943R1021,28042,777SH DFND142,77700
Relay Therapeutics IncCOM75943R1022,47682,714SH DFND282,71400
Relay Therapeutics IncCOM75943R1023,555118,786SH DFND3118,78600
ResMedCOM7611521073,37713,927SH DFND113,92700
ResMedCOM7611521076,68327,556SH DFND227,55600
ResMedCOM7611521079,50539,196SH DFND339,19600
Research in MotionCOM09228F103202,731SH DFND32,73100
Rexford Industrial Realty REITCOM76169C100129,8121,740,339SH DFND11,740,33900
Rexford Industrial Realty REITCOM76169C1003845,146SH DFND25,14600
Rexford Industrial Realty REITCOM76169C1008,416112,824SH DFND3112,82400
Ringcentral IncCOM76680R20642356SH DFND335600
Ritchie Bros Auctioneers (USA)COM76774410596,6811,637,820SH DFND21,494,1090143,711
Ritchie Bros. AuctioneersCOM76774410565,3831,105,995SH DFND2650,2940455,701
Rivian Automotive IncCOM CL A76954A10365,1781,297,331SH DFND11,297,33100
Rivian Automotive IncCOM CL A76954A10393,6961,864,964SH DFND21,835,200029,764
Rivian Automotive IncCOM CL A76954A1033,94978,608SH DFND378,60800
Rivian Automotive IncCOM CL A76954A10314,928297,127SH SOLE0297,12700
Robert Half International IncCOM77032310315131SH DFND313100
RobloxCL A77104910330,373656,849SH DFND1656,84900
RobloxCL A771049103235,6705,096,679SH DFND21,727,40903,369,270
RobloxCL A77104910330,707664,088SH DFND3557,2410106,847
RobloxCL A77104910365,8481,424,053SH SOLE0658,6280765,425
RokuCOM CL A77543R102159,2941,271,608SH DFND11,271,60800
RokuCOM CL A77543R102242,7781,938,041SH DFND21,907,596030,445
RokuCOM CL A77543R1029,50775,889SH DFND375,88900
RokuCOM CL A77543R10234,106272,260SH SOLE0272,26000
Rollins IncCOM77571110420562SH DFND356200
Royal Caribbean CruisesCOMV7780T10312,920154,209SH DFND1154,20900
Royal Caribbean CruisesCOMV7780T1031,42116,960SH DFND316,96000
Royalty PharmaSHS CLASS AG7709Q1045,962153,037SH DFND1153,03700
Royalty PharmaSHS CLASS AG7709Q10418,431473,067SH DFND2404,652068,415
Royalty PharmaSHS CLASS AG7709Q1043,64893,636SH DFND355,142038,494
Royalty PharmaSHS CLASS AG7709Q10415,868407,291SH SOLE0258,4390148,852
Rubius Therapeutics IncCOM78116T1034,887887,000SH DFND1887,00000
Rubius Therapeutics IncCOM78116T1031,555282,190SH DFND280,5640201,626
Rubius Therapeutics IncCOM78116T103841152,722SH DFND3152,72200
Rubius Therapeutics IncCOM78116T10319,7563,585,559SH SOLE03,585,55900
Ryanair ADRSPONSORED ADR NE78351320333,358382,894SH DFND1382,89400
Ryanair ADRSPONSORED ADR NE783513203756,2398,680,427SH DFND27,561,37801,119,049
Ryanair ADRSPONSORED ADR NE7835132034,31549,528SH DFND349,52800
Ryanair ADRSPONSORED ADR NE78351320313,541155,430SH SOLE0149,13206,298
S&P Global IncCOM78409V10493,146227,085SH DFND1227,08500
S&P Global IncCOM78409V104304,276741,811SH DFND2674,293067,518
S&P Global IncCOM78409V10457,197139,444SH DFND381,812057,632
S&P Global IncCOM78409V104251,888614,092SH SOLE0394,4990219,593
SCP Pool CorporationCOM73278L1053070SH DFND37000
SEA Ltd ADRADR81141R100313,1092,613,814SH DFND12,613,81400
SEA Ltd ADRADR81141R1001,306,62910,907,667SH DFND28,026,25602,881,411
SEA Ltd ADRADR81141R10096,722807,432SH DFND3569,3330238,099
SEA Ltd ADRADR81141R1001,74314,549SH DFND414,54900
SEA Ltd ADRADR81141R100353,3262,949,542SH SOLE01,884,98901,064,553
SKYWORKS SOLUTIONS, INC.COM83088M10218136SH DFND313600
Sage Therapeutics IncCOM78667J10853916,276SH DFND116,27600
Sage Therapeutics IncCOM78667J1081,12233,912SH DFND233,91200
Sage Therapeutics IncCOM78667J1081,60848,578SH DFND348,57800
Sailpoint Technologies HoldingCOM78781P10520388SH DFND338800
Salesforce.comCOM79466L30261,058287,577SH DFND1287,57700
Salesforce.comCOM79466L302489,0162,303,205SH DFND2828,35501,474,850
Salesforce.comCOM79466L30260,757286,160SH DFND3239,286046,874
Salesforce.comCOM79466L302132,227622,773SH SOLE0288,2220334,551
Sana Biotechnology IncCOM79956610416,5842,007,781SH DFND12,007,78100
Sana Biotechnology IncCOM79956610423,4762,842,131SH DFND22,842,13100
Sana Biotechnology IncCOM7995661041,766213,787SH DFND3213,78700
Sana Biotechnology IncCOM79956610449,7436,022,162SH SOLE06,022,16200
Sarepta Therapeutics IncCOM80360710014177SH DFND317700
SchrodingerCOM80810D10311,347332,569SH DFND1332,56900
SchrodingerCOM80810D10314,049411,756SH DFND2118,1890293,567
SchrodingerCOM80810D1036,745197,686SH DFND3197,68600
SchrodingerCOM80810D10310,947320,840SH SOLE0320,84000
Schweitzer-Maudit Int.COM8085411067265SH DFND326500
Seagen IncCOM81181C10418128SH DFND312800
SeerCOM CL A81578P1063223SH DFND322300
Sei Investments CoCOM78411710326438SH DFND343800
Service Corp.Intl.COM817565104144,7102,198,572SH DFND12,198,57200
Service Corp.Intl.COM817565104465,4147,071,009SH DFND26,420,3750650,634
Service Corp.Intl.COM81756510488,8391,349,725SH DFND3788,1910561,534
Service Corp.Intl.COM817565104397,3256,036,540SH SOLE03,914,61102,121,929
Sherwin-Williams CoCOM82434810611,09644,453SH DFND244,45300
ShockWave Medical IncCOM82489T10427,734133,748SH DFND1133,74800
ShockWave Medical IncCOM82489T10441,334199,336SH DFND2116,032083,304
ShockWave Medical IncCOM82489T10436,847177,698SH DFND3177,69800
ShockWave Medical IncCOM82489T10417,81185,892SH SOLE085,89200
Shopify 'A'CL A82509L107725,4961,073,283SH DFND11,073,28300
Shopify 'A'CL A82509L1071,968,2702,911,814SH DFND21,993,1880918,626
Shopify 'A'CL A82509L107236,022349,166SH DFND3275,026074,140
Shopify 'A'CL A82509L107695,4351,028,811SH SOLE0763,0830265,728
Shopify IncCOM82509L1076,5679,702SH DFND29,70200
Shopify IncCOM82509L107126186SH DFND318600
Silicon Motion Technology ADRCOM82706C10828,128420,954SH DFND1420,95400
Silicon Motion Technology ADRCOM82706C1083234,839SH DFND2004,839
Silicon Motion Technology ADRCOM82706C1084,49867,320SH DFND367,32000
Silicon Motion Technology ADRCOM82706C10819,764295,784SH SOLE0295,78400
Silk Road MedicalCOM82710M10010235SH DFND323500
SiteOne Landscape SupplyCOM82982L10370,616436,739SH DFND1436,73900
SiteOne Landscape SupplyCOM82982L103219,0481,354,738SH DFND21,226,6330128,105
SiteOne Landscape SupplyCOM82982L10342,574263,305SH DFND3154,1040109,201
SiteOne Landscape SupplyCOM82982L103188,8841,168,184SH SOLE0748,1260420,058
Six Flags Entertainment CorpCOM83001A10213,751316,104SH DFND1316,10400
Six Flags Entertainment CorpCOM83001A1021,50934,700SH DFND334,70000
Sixth Street Specialty LendingCOM83012A10922,240954,900SH DFND1954,90000
Sixth Street Specialty LendingCOM83012A1091406,000SH DFND26,00000
Sixth Street Specialty LendingCOM83012A1093,582153,800SH DFND3153,80000
SmartsheetCOM83200N10317311SH DFND331100
Snap IncCL A83304A106150,2564,174,931SH DFND14,174,93100
Snap IncCL A83304A106220,3086,121,354SH DFND26,023,314098,040
Snap IncCL A83304A1068,956248,850SH DFND3248,85000
Snap IncCL A83304A10634,428956,596SH SOLE0956,59600
Snap OnCOM8330341011886SH DFND38600
Snowflake IncCOM833445109215,628941,074SH DFND1941,07400
Snowflake IncCOM833445109392,6891,713,827SH DFND21,637,671076,156
Snowflake IncCOM83344510938,259166,975SH DFND3114,760052,215
Snowflake IncCOM833445109377,2441,646,417SH SOLE01,448,3700198,047
Sohu.comCOM83410S1083,366200,140SH DFND300200,140
Solaredge Technologies IncCOM83417M1044361,353SH DFND11,35300
Solaredge Technologies IncCOM83417M10454167SH DFND316700
Sorrento TherapeuticsCOM83587F202104,314SH DFND34,31400
Spire Global IncCOM CL A8485601081,819866,045SH SOLE0866,04500
Splunk IncCOM84863710411,07774,540SH DFND174,54000
Splunk IncCOM84863710419,560131,619SH DFND237,456094,163
Splunk IncCOM8486371048,57157,674SH DFND357,67400
Splunk IncCOM84863710410,98073,884SH SOLE073,88400
Spotify Technology SASHSL8681T102188,7211,249,642SH DFND11,249,64200
Spotify Technology SASHSL8681T1022,768,88318,334,543SH DFND213,706,52004,628,023
Spotify Technology SASHSL8681T10279,450526,088SH DFND3418,9280107,160
Spotify Technology SASHSL8681T102470,9263,118,301SH SOLE02,529,6510588,650
Sprout SocialCOM85209W10925,725321,078SH DFND1321,07800
Sprout SocialCOM85209W10913,759171,732SH DFND249,6040122,128
Sprout SocialCOM85209W1097,69896,076SH DFND396,07600
Sprout SocialCOM85209W10919,699245,870SH SOLE0245,87000
Staar SurgicalCOM PAR $0.01852312305118,5331,483,337SH DFND11,483,33700
Staar SurgicalCOM PAR $0.01852312305138,2041,729,492SH DFND21,191,7180537,774
Staar SurgicalCOM PAR $0.0185231230544,271554,006SH DFND3433,7850120,221
Staar SurgicalCOM PAR $0.01852312305118,2541,479,839SH SOLE01,139,7440340,095
Starbucks CorpCOM85524410916,697183,549SH DFND1183,54900
Starbucks CorpCOM8552441092272,499SH DFND2002,499
Starbucks CorpCOM8552441093,07633,810SH DFND333,81000
Starbucks CorpCOM85524410912,600138,502SH SOLE0138,50200
Stitch FixCOM CL A860897107272,668SH DFND22,66800
Stitch FixCOM CL A86089710732532,301SH DFND332,30100
StoneCoCOM CL AG851581061,877160,397SH DFND1160,39700
StoneCoCOM CL AG8515810615,5091,325,566SH DFND2761,7650563,801
StoneCoCOM CL AG851581061079,131SH DFND39,13100
StratasysSHSM855481015,746226,300SH DFND1226,30000
StratasysSHSM855481018,637340,181SH DFND293,1310247,050
StratasysSHSM855481014,176164,468SH DFND3164,46800
StratasysSHSM855481013,671144,600SH SOLE0144,60000
StrykerCOM8636671011454SH DFND35400
Summit Therapeutics New ListingCOM86627T108526214,617SH DFND1214,61700
Summit Therapeutics New ListingCOM86627T108544221,895SH SOLE0221,89500
Sumo LogicCOM86646P1038726SH DFND372600
Sunpower CorpCOM867652406251,171SH DFND31,17100
Sutro BiopharmaCOM8693671028,5691,042,428SH DFND11,042,42800
Sutro BiopharmaCOM869367102485,815SH DFND25,81500
Sutro BiopharmaCOM86936710257269,532SH DFND369,53200
Sutro BiopharmaCOM8693671026,171750,726SH SOLE0750,72600
T. Rowe PriceCOM74144T10818,473122,185SH DFND1122,18500
T. Rowe PriceCOM74144T1082671,765SH DFND2001,765
T. Rowe PriceCOM74144T1083,09020,438SH DFND320,43800
T. Rowe PriceCOM74144T10813,61990,076SH SOLE090,07600
TJX CompaniesCOM8725401096,508107,431SH DFND2107,43100
TSMC ADRSPONSORED ADR874039100727,6166,978,858SH DFND25,315,12901,663,729
TSMC ADRSPONSORED ADR8740391001,67816,093SH DFND316,09300
TSMC ADRSPONSORED ADR87403910094,524906,617SH SOLE0734,5430172,074
Tabula Rasa HealthCare IncCOM8733791013,232561,175SH DFND1561,17500
Tabula Rasa HealthCare IncCOM873379101142,492SH DFND22,49200
Tabula Rasa HealthCare IncCOM87337910117029,449SH DFND329,44900
Tabula Rasa HealthCare IncCOM8733791011,374238,574SH SOLE0238,57400
Tandem Diabetes CareCOM NEW87537220320,210173,792SH DFND1173,79200
Tandem Diabetes CareCOM NEW875372203103882SH DFND288200
Tandem Diabetes CareCOM NEW8753722031,25010,750SH DFND310,75000
Tandem Diabetes CareCOM NEW87537220317,255148,377SH SOLE0148,37700
Target CorpCOM87612E10622105SH DFND310500
Tata Motors Ltd ADRCOM87656850268,3292,444,687SH DFND12,444,68700
Tata Motors Ltd ADRCOM87656850230,8721,104,545SH DFND21,104,54500
Tata Motors Ltd ADRCOM87656850290132,237SH DFND332,23700
Tata Motors Ltd ADRCOM87656850215,772564,300SH SOLE0564,30000
TeladocCOM87918A105233,1553,232,425SH DFND13,232,42500
TeladocCOM87918A105293,5954,070,354SH DFND23,448,3020622,052
TeladocCOM87918A105118,3121,640,256SH DFND31,335,0110305,245
TeladocCOM87918A105128,7571,785,064SH SOLE01,367,2880417,776
Telus CorpCOM87971M10310397SH DFND339700
Tenable HoldingsCOM88025T10218315SH DFND331500
Tencent Music Entertainment ADRSPONSORED ADS88034P10921,1794,348,812SH DFND14,348,81200
Tencent Music Entertainment ADRSPONSORED ADS88034P109180,48237,059,992SH DFND227,196,89909,863,093
Tencent Music Entertainment ADRSPONSORED ADS88034P1098,2691,698,049SH DFND31,047,6000650,449
Tencent Music Entertainment ADRSPONSORED ADS88034P10934,0116,983,725SH SOLE04,401,47702,582,248
TeradyneCOM88077010295,618808,749SH DFND1808,74900
TeradyneCOM880770102293,4602,482,113SH DFND22,243,4950238,618
TeradyneCOM88077010257,864489,423SH DFND3288,7230200,700
TeradyneCOM880770102252,5222,135,853SH SOLE01,363,6720772,181
Tesla IncCOM88160R1011,332,9141,236,928SH DFND11,236,92800
Tesla IncCOM88160R1015,917,0585,490,960SH DFND23,850,07501,640,885
Tesla IncCOM88160R101669,206621,015SH DFND3503,2080117,807
Tesla IncCOM88160R1012,654,5062,463,350SH SOLE02,025,6010437,749
Texas Roadhouse IncCOM88268110911131SH DFND313100
The Trade DeskCOM CL A88339J105783,13211,308,762SH DFND111,308,76200
The Trade DeskCOM CL A88339J1051,956,77128,256,615SH DFND219,973,91708,282,698
The Trade DeskCOM CL A88339J105211,3053,051,339SH DFND32,367,5510683,788
The Trade DeskCOM CL A88339J105631,2909,116,098SH SOLE05,860,44303,255,655
Thermo Fisher ScientificCOM883556102107,771182,462SH DFND1182,46200
Thermo Fisher ScientificCOM883556102352,133596,179SH DFND2543,531052,648
Thermo Fisher ScientificCOM88355610264,599109,369SH DFND363,514045,855
Thermo Fisher ScientificCOM883556102290,192491,310SH SOLE0320,9140170,396
Thor Industries IncCOM88516010110133SH DFND313300
Toro CoCOM89109210821245SH DFND324500
Tractor Supply CoCOM89235610632136SH DFND313600
TransMedics GroupCOM89377M109722,677SH DFND22,67700
TransMedics GroupCOM89377M10987632,502SH DFND332,50200
Trip.com Group Sponsored ADRAMERICAN DEP SHS89677Q10776,5403,310,561SH DFND22,453,3780857,183
TrupanionCOM89820210617,610197,600SH DFND1197,60000
TrupanionCOM89820210629,177327,385SH DFND293,2640234,121
TrupanionCOM89820210614,127158,513SH DFND3158,51300
TrupanionCOM89820210633,967381,138SH SOLE0381,13800
TuSimple HdgsCL A90089L1084349SH DFND334900
Twilio IncCL A90138F102275,3601,670,775SH DFND11,670,77500
Twilio IncCL A90138F102493,9032,996,801SH DFND22,842,2670154,534
Twilio IncCL A90138F10252,511318,616SH DFND3220,720097,896
Twilio IncCL A90138F102198,2531,202,918SH SOLE0868,4800334,438
UltragenyxCOM90400D1088115SH DFND311500
United Parcel ServiceCL B91131210670,733329,817SH DFND1329,81700
United Parcel ServiceCL B9113121061,0014,666SH DFND2004,666
United Parcel ServiceCL B91131210610,99251,256SH DFND351,25600
United Parcel ServiceCL B91131210650,749236,637SH SOLE0236,63700
UnitedHealthCOM91324P1023467SH DFND36700
Unity Biotechnology IncCOM91381U101278248,000SH DFND1248,00000
Unity Biotechnology IncCOM91381U101382341,111SH SOLE0341,11100
Upwork IncCOM91688F10459,5762,563,524SH DFND12,563,52400
Upwork IncCOM91688F10438,0851,638,750SH DFND2513,57101,125,179
Upwork IncCOM91688F10420,922900,271SH DFND3820,107080,164
Upwork IncCOM91688F10430,9331,331,003SH SOLE01,331,00300
Uxin ADRADS91818X108753738,636SH DFND1738,63600
Uxin ADRADS91818X108351344,229SH SOLE0344,22900
Vale SA ADRADR91912E10531,5251,577,061SH DFND11,577,06100
Vale SA ADRADR91912E105181,0159,055,283SH DFND26,623,03802,432,245
Vale SA ADRADR91912E1051,56878,455SH DFND378,45500
Varonis Systems IncCOM922280102811,708SH DFND21,70800
Varonis Systems IncCOM92228010299620,943SH DFND320,94300
Veeco InstrumentsCOM9224171008,082297,254SH DFND1297,25400
Veeco InstrumentsCOM92241710013,292488,864SH DFND2143,2840345,580
Veeco InstrumentsCOM9224171006,671245,365SH DFND3245,36500
Veeva Systems Inc Class ACOM9224751081,6407,718SH DFND17,71800
Veeva Systems Inc Class ACOM9224751083,24815,287SH DFND215,28700
Veeva Systems Inc Class ACOM9224751084,60021,650SH DFND321,65000
Veoneer IncCOM92336X10926700SH DFND370000
Verint Systems IncCOM92343X10020395SH DFND339500
Verisk AnalyticsCOM92345Y10610,83850,495SH DFND250,49500
VeritoneCOM92347M10012649SH DFND364900
ViewRayCOM92672L1074911SH DFND391100
Vimeo Inc.COM92719V10011,818994,740SH DFND1994,74000
Vimeo Inc.COM92719V10036,0783,036,844SH DFND22,741,9010294,943
Vimeo Inc.COM92719V1007,171603,633SH DFND3352,6200251,013
Vimeo Inc.COM92719V10031,6722,665,979SH SOLE01,712,4580953,521
Vir Biotechnology IncCOM92764N10282732,165SH DFND132,16500
Vir Biotechnology IncCOM92764N1021,63063,371SH DFND263,37100
Vir Biotechnology IncCOM92764N1022,43094,468SH DFND394,46800
Vir Biotechnology IncCOM92764N10296,6343,757,156SH SOLE03,757,15600
Visa Inc-Class A SharesCOM CL A92826C83911,61852,389SH DFND252,38900
Visa Inc-Class A SharesCOM CL A92826C83924110SH DFND311000
Visteon CorpCOM92839U20625230SH DFND323000
VuzixCOM92921W3006924SH DFND392400
Vyne Therapeutics IncCOM92941V2093248,706SH DFND148,70600
Vyne Therapeutics IncCOM92941V2093350,056SH SOLE050,05600
WD-40 CoCOM9292361071158SH DFND35800
WEC Energy GroupCOM92939U1061,89618,996SH DFND118,99600
Wal-Mart StoresCOM93114210315101SH DFND310100
Warby Parker IncCL A COM93403J1065,787171,156SH DFND1171,15600
Warby Parker IncCL A COM93403J10618,441545,421SH DFND2215,8810329,540
Warby Parker IncCL A COM93403J1062,49873,869SH DFND350,200023,669
Warby Parker IncCL A COM93403J106185,0335,472,724SH SOLE05,472,72400
WatersCOM9418481038,07126,003SH DFND126,00300
WatersCOM94184810310,84334,934SH DFND227,72307,211
WatersCOM9418481033,52611,359SH DFND37,82003,539
WatersCOM9418481033401,094SH SOLE01,09400
Watsco IncCOM942622200240,667790,003SH DFND1790,00300
Watsco IncCOM942622200297,151975,416SH DFND2947,179028,237
Watsco IncCOM94262220023,70077,796SH DFND371,84005,956
Watsco IncCOM94262220068,921226,238SH SOLE0226,23800
Wayfair Inc Class ACL A94419L101261,3862,359,503SH DFND12,359,50300
Wayfair Inc Class ACL A94419L101422,9933,818,313SH DFND23,576,5030241,810
Wayfair Inc Class ACL A94419L10142,548384,075SH DFND3296,203087,872
Wayfair Inc Class ACL A94419L101292,8702,643,706SH SOLE02,351,1600292,546
Wheaton Precious MetalsCOM96287910297120,416SH DFND120,41600
Williams-Sonoma IncCOM969904101963SH DFND36300
Wix ComSHSM98068105395,3323,784,531SH DFND22,427,06601,357,465
Wix ComSHSM9806810541395SH DFND339500
Workday IncCL A98138H101320,8141,339,741SH DFND11,339,74100
Workday IncCL A98138H1011,139,3164,757,856SH DFND22,454,73302,303,123
Workday IncCL A98138H101122,805512,840SH DFND3429,835083,005
Workday IncCL A98138H101273,2981,141,310SH SOLE0628,9680512,342
XPCL AG982391092,05868,387SH DFND168,38700
XPCL AG982391094,944164,256SH DFND212,1290152,127
XPCL AG982391096,284208,760SH DFND322,2860186,474
XPCL AG982391092688,893SH DFND48,89300
XPELCOM98379L10016295SH DFND329500
Xencor IncCOM98401F105652,434SH DFND22,43400
Xencor IncCOM98401F10579029,603SH DFND329,60300
Xperi Holding CorpCOM98390M103271,549SH DFND31,54900
XylemCOM98419M10087,6361,027,868SH DFND11,027,86800
XylemCOM98419M10039,379461,869SH DFND2278,0430183,826
XylemCOM98419M10089,2431,046,711SH DFND3839,0130207,698
XylemCOM98419M1007,90192,673SH SOLE092,67300
Yatsen Holding Ltd ADRCOM985194109551802,289SH DFND1802,28900
Yatsen Holding Ltd ADRCOM9851941095,1077,439,172SH DFND26,943,6090495,563
Yatsen Holding Ltd ADRCOM9851941090626SH DFND362600
YelpCOM9858171059262SH DFND326200
Zai Lab ADRADR98887Q10432,822746,286SH DFND1746,28600
Zai Lab ADRADR98887Q10467,7721,540,982SH DFND2622,8780918,104
Zai Lab ADRADR98887Q10414,931339,500SH DFND327,9270311,573
Zai Lab ADRADR98887Q1042896,577SH DFND46,57700
Zai Lab ADRADR98887Q1044,12893,865SH SOLE093,86500
Ziff Davis IncCOM48123V102553SH DFND35300
Zillow Group Inc Class ACL A98954M1011,49530,990SH DFND130,99000
Zillow Group Inc Class ACL A98954M1017,545156,432SH DFND244,8350111,597
Zillow Group Inc Class ACL A98954M1013,33369,099SH DFND369,09900
Zillow Group Inc Class ACL A98954M1014,38190,840SH SOLE090,84000
Zillow Group Inc Class CCL C CAP STK98954M20049,7061,008,449SH DFND11,008,44900
Zillow Group Inc Class CCL C CAP STK98954M20033,543680,533SH DFND2192,4510488,082
Zillow Group Inc Class CCL C CAP STK98954M20014,559295,366SH DFND3295,36600
Zillow Group Inc Class CCL C CAP STK98954M20028,764583,573SH SOLE0583,57300
Zoom Video Communications IncCL A98980L101171,6251,464,005SH DFND11,464,00500
Zoom Video Communications IncCL A98980L101471,3384,020,630SH DFND22,433,87001,586,760
Zoom Video Communications IncCL A98980L10146,275394,736SH DFND3337,761056,975
Zoom Video Communications IncCL A98980L101225,5461,923,965SH SOLE01,573,1090350,856
Zuora Inc Class ACOM CL A98983V10630,1132,010,224SH DFND12,010,22400
Zuora Inc Class ACOM CL A98983V10616,3461,091,187SH DFND2314,1010777,086
Zuora Inc Class ACOM CL A98983V1068,515568,414SH DFND3568,41400
Zuora Inc Class ACOM CL A98983V10611,706781,436SH SOLE0781,43600
Zymergen IncCOM98985X1008,1552,821,956SH SOLE02,821,95600
ZynexCOM98986M1033481SH DFND348100
Zynga IncCOM98986T108303,223SH DFND33,22300
dLocalCL AG290181017,698246,272SH DFND300246,272
dLocalCL AG290181014142SH DFND214200
dLocalCL AG2901810117,310553,728SH DFND1553,72800
iRobotCOM4627261008,349131,693SH SOLE0131,69300
iRobotCOM4627261008,564135,084SH DFND3124,296010,788
iRobotCOM46272610015,128238,615SH DFND274,3660164,249
iRobotCOM46272610013,559213,872SH DFND1213,87200
iShares Physical Silver ETC (c)COM46428Q1093,023126,100SH DFND3126,10000
iShares Physical Silver ETC (c)COM46428Q10918,190758,716SH DFND1758,71600
nLIGHTCOM65487K1008468SH DFND346800