The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X Genomics Inc Class ACL A COM88025U109110,099608,282SH DFND1608,28200
10X Genomics Inc Class ACL A COM88025U10948,822269,735SH DFND2155,9340113,801
10X Genomics Inc Class ACL A COM88025U10982,391455,201SH DFND3353,3150101,886
10X Genomics Inc Class ACL A COM88025U10911,38662,908SH SOLE062,90800
1Life HealthcareCOM68269G10717445SH DFND344500
2UCOM90214J10110273SH DFND327300
8x8 IncCOM282914100862,657SH DFND32,65700
ACM ResearchCOM00108J10918220SH DFND322000
AJ Gallagher & CoCOM363576109136,4001,093,208SH DFND11,093,20800
AJ Gallagher & CoCOM363576109460,8243,693,384SH DFND23,455,7960237,588
AJ Gallagher & CoCOM36357610990,522725,509SH DFND3332,8700392,639
AJ Gallagher & CoCOM363576109300,3262,407,039SH SOLE02,033,5410373,498
Abcellera Biologics IncCOM00288U10619,403571,362SH DFND1571,36200
Abcellera Biologics IncCOM00288U1065,390158,715SH DFND245,1670113,548
Abcellera Biologics IncCOM00288U10612,344363,483SH DFND3263,3180100,165
Abcellera Biologics IncCOM00288U1062,09861,793SH SOLE061,79300
AbiomedCOM003654100334,9311,050,830SH DFND11,050,83000
AbiomedCOM003654100478,5861,501,541SH DFND21,379,4050122,136
AbiomedCOM003654100108,783341,302SH DFND3228,2320113,070
AbiomedCOM003654100174,873548,655SH SOLE0484,705063,950
Acadia Pharmaceuticals IncCOM00422510814544SH DFND354400
Accelerate DiagnosticsCOM00430H1023418SH DFND341800
Accenture 'A'COMG1151C1011348SH DFND34800
Acutus MedicalCOM0051111096424SH DFND342400
Adaptimmune Therapeutics ADRSPONDS ADR00653A10727,4365,166,864SH DFND15,166,86400
Adaptimmune Therapeutics ADRSPONDS ADR00653A10714,1352,662,011SH DFND2889,74201,772,269
Adaptimmune Therapeutics ADRSPONDS ADR00653A1076,3901,203,480SH DFND31,203,48000
Adaptimmune Therapeutics ADRSPONDS ADR00653A10712,9312,435,162SH SOLE02,435,16200
Adicet Bio IncCOM0070021081,22293,449SH DFND193,44900
Adicet Bio IncCOM0070021081,15388,177SH SOLE088,17700
Advanced Micro Devices IncCOM00790310743546SH DFND354600
AerovironmentCOM00807310840,681350,517SH DFND1350,51700
AerovironmentCOM00807310827,785239,403SH DFND279,6590159,744
AerovironmentCOM00807310812,548108,113SH DFND3108,11300
AerovironmentCOM00807310825,599220,567SH SOLE0220,56700
Affirm Holdings Inc Class ACOM CL A00827B10679,2341,120,389SH DFND11,120,38900
Affirm Holdings Inc Class ACOM CL A00827B10697,8641,383,820SH DFND21,323,450060,370
Affirm Holdings Inc Class ACOM CL A00827B1067,200101,811SH DFND383,853017,958
Affirm Holdings Inc Class ACOM CL A00827B10642,770604,774SH SOLE0604,77400
Affirm Holdings Inc Class A - converted at IPOCOM CL A00827B106175,7092,484,575SH SOLE02,484,57500
Affirm Holdings Inc Class B - converted at IPOCOM CL A00827B106175,7092,484,575SH SOLE02,484,57500
Agios Pharmaceuticals IncCOM00847X10410186SH DFND318600
Agora Inc ADRADS00851L10321,314423,988SH DFND1423,98800
Agora Inc ADRADS00851L1038,441167,912SH SOLE0167,91200
Albemarle CorpCOM012653101104,480715,079SH DFND1715,07900
Albemarle CorpCOM012653101297,8662,038,641SH DFND21,902,8560135,785
Albemarle CorpCOM01265310159,948410,296SH DFND3188,3290221,967
Albemarle CorpCOM012653101213,7981,463,267SH SOLE01,246,3840216,883
Alector IncCOM01444210782641,028SH DFND141,02800
Alector IncCOM0144421072,465122,375SH DFND2122,37500
Alector IncCOM0144421071,99098,810SH DFND398,81000
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102499,3332,202,325SH DFND12,202,32500
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W1023,125,72413,786,105SH DFND26,732,50007,053,605
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W102366,0621,614,528SH DFND31,120,8400493,688
Alibaba Group Holding Sponsored ADRSPONSORED ADS01609W1022,060,9839,090,034SH SOLE07,397,46701,692,567
Align Technology IncCOM01625510115,89229,346SH DFND229,34600
Alkermes PlcCOMG017671054192SH DFND319200
Allscripts Healthcare SolutionCOM01988P10811744SH DFND374400
Alnylam PharmaceuticalsCOM02043Q107375,0942,656,661SH DFND12,656,66100
Alnylam PharmaceuticalsCOM02043Q107564,5253,998,334SH DFND23,347,3090651,025
Alnylam PharmaceuticalsCOM02043Q107155,0701,098,306SH DFND3781,5920316,714
Alnylam PharmaceuticalsCOM02043Q107327,7952,321,662SH SOLE02,102,5310219,131
Alphabet Inc Class ACAP STK CL A02079K305112,87654,727SH DFND154,72700
Alphabet Inc Class ACAP STK CL A02079K30556,60827,446SH DFND218,34909,097
Alphabet Inc Class ACAP STK CL A02079K30571,63834,733SH DFND324,91209,821
Alphabet Inc Class ACAP STK CL A02079K30589,39443,342SH SOLE043,34200
Alphabet Inc Class CCAP STK CL C02079K107296,886143,518SH DFND1143,51800
Alphabet Inc Class CCAP STK CL C02079K1071,575,961761,838SH DFND2449,6070312,231
Alphabet Inc Class CCAP STK CL C02079K107236,051114,110SH DFND369,020045,090
Alphabet Inc Class CCAP STK CL C02079K107600,794290,431SH SOLE0191,336099,095
Alteryx IncCOM02156B10328336SH DFND333600
Amazon.ComCOM0231351061,243,016401,740SH DFND1401,74000
Amazon.ComCOM0231351064,779,6701,544,779SH DFND2984,2790560,500
Amazon.ComCOM023135106491,575158,876SH DFND3109,670049,206
Amazon.ComCOM0231351062,605,714842,161SH SOLE0698,4200143,741
AmbarellaSHSG037AX10129,234291,200SH DFND1291,20000
AmbarellaSHSG037AX10113,098130,468SH DFND242,469087,999
AmbarellaSHSG037AX1015,72056,979SH DFND356,97900
AmbarellaSHSG037AX1019,79997,605SH SOLE097,60500
AmdocsCOMG0260210328400SH DFND340000
AmerenCOM02360810246,690573,868SH DFND1573,86800
AmerenCOM023608102941,150SH DFND21,15000
AmerenCOM0236081022,57631,666SH DFND331,66600
American Electric PowerCOM02553710152,607621,100SH DFND1621,10000
American Electric PowerCOM025537101971,148SH DFND21,14800
American Electric PowerCOM0255371012,87033,889SH DFND333,88900
American Superconductor CorpCOM0301112079,696511,400SH DFND1511,40000
American Superconductor CorpCOM03011120712,330650,300SH SOLE0650,30000
American Well Corp Class ACOM03044L1051,06861,505SH DFND161,50500
American Well Corp Class ACOM03044L1053,243186,680SH DFND2186,68000
American Well Corp Class ACOM03044L1052,624151,086SH DFND3151,08600
Amicus Therapeutics IncCOM03152W1095538SH DFND353800
Amkor TechnologyCOM031652100542,282SH DFND32,28200
Amneal Pharmaceuticals IncCOM03168L1053452SH DFND345200
Analog DevicesCOM03265410526,593171,478SH DFND1171,47800
Analog DevicesCOM0326541055993,863SH DFND2003,863
Analog DevicesCOM0326541051621,047SH DFND31,04700
Analog DevicesCOM03265410525,774166,197SH SOLE0166,19700
Anaplan Inc CommonCOM03272L10816306SH DFND330600
Annaly Capital Man.COM035710409647,446SH DFND17,44600
AnterixCOM03676C1008162SH DFND316200
Anthem IncCOM036752103181,687506,163SH DFND1506,16300
Anthem IncCOM036752103664,4511,851,095SH DFND21,728,2230122,872
Anthem IncCOM036752103134,976376,031SH DFND3172,4970203,534
Anthem IncCOM036752103427,4371,190,797SH SOLE0998,3250192,472
AppFolioCOM03783C10039277SH DFND327700
Appian CorpCL A03782L101293,1862,205,234SH DFND12,205,23400
Appian CorpCL A03782L101339,8142,555,954SH DFND22,152,6180403,336
Appian CorpCL A03782L10137,249280,173SH DFND3280,17300
Appian CorpCL A03782L101121,538914,163SH SOLE0914,16300
AppleCOM03783310025,989212,759SH DFND1212,75900
AppleCOM0378331005844,782SH DFND2004,782
AppleCOM0378331001591,299SH DFND31,29900
AppleCOM03783310024,935204,135SH SOLE0204,13500
Applied OptoelectronicsCOM03823U1022260SH DFND326000
AptivCOMG6095L10921149SH DFND314900
Ares Capital CorpCOM04010L10398,3025,254,000SH DFND15,254,00000
Ares Capital CorpCOM04010L10320010,700SH DFND210,70000
Ares Capital CorpCOM04010L1035,431290,270SH DFND3290,27000
ArganCOM04010E1095103SH DFND310300
Ascendis Pharma Adr 1:1SPON ADR04351P1012,06416,017SH DFND116,01700
Ascendis Pharma Adr 1:1SPON ADR04351P1016,07647,146SH DFND247,14600
Ascendis Pharma Adr 1:1SPON ADR04351P1015,04339,131SH DFND339,13100
Atlassian Corp PlcCL AG06242104109,944521,657SH DFND1521,65700
Atlassian Corp PlcCL AG06242104871,6484,135,738SH DFND21,294,85302,840,885
Atlassian Corp PlcCL AG0624210499,265470,984SH DFND3378,834092,150
Atlassian Corp PlcCL AG06242104238,0021,129,257SH SOLE0498,8450630,412
AtrionCOM04990410569SH DFND3900
Autohome Inc - ADRSP ADR RP CL A05278C10734,331368,082SH DFND1368,08200
Autohome Inc - ADRSP ADR RP CL A05278C107127,2271,364,070SH DFND21,271,665092,405
Autohome Inc - ADRSP ADR RP CL A05278C10725,588274,346SH DFND3125,7520148,594
Autohome Inc - ADRSP ADR RP CL A05278C10786,375926,073SH SOLE0776,2170149,856
AvangridCOM05351W10370,5851,417,085SH DFND11,417,08500
AvangridCOM05351W1031352,701SH DFND22,70100
AvangridCOM05351W1033,31266,501SH DFND366,50100
Avery Dennison CorporationCOM05361110922118SH DFND311800
Axogen IncCOM05463X1068,912439,900SH DFND1439,90000
Axogen IncCOM05463X1067,780383,987SH DFND2129,4120254,575
Axogen IncCOM05463X1063,611178,247SH DFND3178,24700
Axogen IncCOM05463X1063,436169,600SH SOLE0169,60000
Axon Enterprise IncCOM05464C101113,750798,695SH DFND1798,69500
Axon Enterprise IncCOM05464C101264,7831,859,167SH DFND21,599,0100260,157
Axon Enterprise IncCOM05464C10163,062442,787SH DFND3257,4100185,377
Axon Enterprise IncCOM05464C101176,4261,238,775SH SOLE01,060,5210178,254
Axonics Modulation TechnologiesCOM05465P10114230SH DFND323000
Baidu.com Sponsored ADRSPON ADR REP A05675210813,66362,805SH DFND162,80500
Baidu.com Sponsored ADRSPON ADR REP A056752108793,1063,645,628SH DFND23,336,4380309,190
Baidu.com Sponsored ADRSPON ADR REP A05675210841,435190,461SH DFND328,4810161,980
Baidu.com Sponsored ADRSPON ADR REP A0567521081,6597,628SH DFND47,62800
Baidu.com Sponsored ADRSPON ADR REP A0567521085092,340SH SOLE02,34000
Banco Bradesco Pn ADRSP ADR PFD NEW05946030323,9195,089,126SH DFND15,089,12600
Banco Bradesco Pn ADRSP ADR PFD NEW059460303160,92734,239,687SH DFND218,367,296015,872,391
Banco Bradesco Pn ADRSP ADR PFD NEW0594603037,0001,489,412SH DFND31,489,41200
BandwidthCOM05988J10320161SH DFND316100
Baozun Spn Adr 1:1SPONSORED ADR06684L10322,594592,408SH DFND1592,40800
Baozun Spn Adr 1:1SPONSORED ADR06684L10316,578434,663SH DFND2144,4680290,195
Baozun Spn Adr 1:1SPONSORED ADR06684L1037,421194,584SH DFND3194,58400
Baozun Spn Adr 1:1SPONSORED ADR06684L10311,217294,100SH SOLE0294,10000
Beam TherapeuticsCOM07373V10542519SH DFND351900
BeiGene LtdSPONSORED ADR07725L102142,161408,415SH DFND1408,41500
BeiGene LtdSPONSORED ADR07725L1021,065,1443,060,054SH DFND21,153,03601,907,018
BeiGene LtdSPONSORED ADR07725L10298,264282,302SH DFND3226,812055,490
BeiGene LtdSPONSORED ADR07725L102235,979677,944SH SOLE0300,4910377,453
Benefitfocus IncCOM08180D1064,232306,448SH DFND1306,44800
Benefitfocus IncCOM08180D1063,999289,591SH DFND281,9100207,681
Benefitfocus IncCOM08180D1061,686122,107SH DFND3122,10700
Benefitfocus IncCOM08180D1063,126226,368SH SOLE0226,36800
Berkeley Lights IncCOM08431010125,859514,820SH DFND1514,82000
Berkeley Lights IncCOM0843101019,421187,557SH DFND2135,336052,221
Berkeley Lights IncCOM08431010112,925257,312SH DFND3210,851046,461
Berkeley Lights IncCOM0843101018,019159,654SH SOLE0159,65400
Beyond Meat IncCOM08862E109127,704981,430SH DFND1981,43000
Beyond Meat IncCOM08862E109515,4453,961,308SH DFND21,234,16502,727,143
Beyond Meat IncCOM08862E10997,463749,025SH DFND3574,2000174,825
Beyond Meat IncCOM08862E109141,8531,090,169SH SOLE0507,8760582,293
Bilibili Inc ADRSPONSORED ADR09004010692,091860,182SH DFND1860,18200
Bilibili Inc ADRSPONSORED ADR090040106413,8523,865,608SH DFND21,207,48702,658,121
Bilibili Inc ADRSPONSORED ADR09004010646,694436,152SH DFND3345,661090,491
Bilibili Inc ADRSPONSORED ADR090040106116,1711,085,100SH SOLE0485,3300599,770
BioNTech ADRSPONS ADS09075V10262,023568,031SH DFND1568,03100
BioNTech ADRSPONS ADS09075V102485,8904,449,952SH DFND21,428,44703,021,505
BioNTech ADRSPONS ADS09075V10253,970494,276SH DFND3393,4670100,809
BioNTech ADRSPONS ADS09075V102133,8401,225,753SH SOLE0546,6860679,067
Biomarin Pharmaceutical IncCOM09061G101682SH DFND38200
BlackRock Floating Rate IncomeCOM0919411049,811784,230SH DFND1784,23000
BlacklineCOM09239B10965,793606,942SH DFND1606,94200
BlacklineCOM09239B10936,162333,596SH DFND2111,0220222,574
BlacklineCOM09239B10916,257149,972SH DFND3149,97200
BlacklineCOM09239B10930,414280,576SH SOLE0280,57600
Blackrock IncCOM09247X1011621SH DFND32100
Blue Apron Holdings IncCL A09523Q101937148,506SH DFND1148,50600
Bluebird Bio IncCOM09609G10028913SH DFND391300
Blueprint Medicines CorpCOM09627Y10941426SH DFND342600
Booking Holdings IncCOM09857L108120,76351,833SH DFND151,83300
Booking Holdings IncCOM09857L108352,908151,473SH DFND2141,211010,262
Booking Holdings IncCOM09857L10875,21732,284SH DFND315,215017,069
Booking Holdings IncCOM09857L108233,632100,278SH SOLE084,002016,276
Box IncCOM10316T10422979SH DFND397900
Brady CorpCOM10467410613245SH DFND324500
BridgeBio Pharma IncCOM10806X1023,00348,748SH DFND148,74800
BridgeBio Pharma IncCOM10806X1028,914144,703SH DFND2144,70300
BridgeBio Pharma IncCOM10806X1027,342119,194SH DFND3119,19400
Bristol Myers SquibbCOM11012210838607SH DFND360700
British Amer.Tobacco - ADRSPONSORED ADR1104481073,85099,377SH DFND199,37700
British Amer.Tobacco - ADRSPONSORED ADR1104481071002,586SH DFND2002,586
British Amer.Tobacco - ADRSPONSORED ADR11044810731813SH DFND381300
British Amer.Tobacco - ADRSPONSORED ADR1104481074,495116,021SH SOLE0116,02100
Broadridge Finl.Sltn.COM11133T10375,933495,968SH DFND1495,96800
Broadridge Finl.Sltn.COM11133T103299,5351,956,469SH DFND21,834,5020121,967
Broadridge Finl.Sltn.COM11133T10357,277374,113SH DFND3171,7960202,317
Broadridge Finl.Sltn.COM11133T103184,7511,206,734SH SOLE01,012,2610194,473
Brookfield RenewableCOM11284V10548,2901,031,831SH DFND11,031,83100
Brookfield RenewableCOM11284V1051453,106SH DFND23,10600
Brookfield RenewableCOM11284V1053,53375,499SH DFND375,49900
Bumble IncCOM CL A12047B10524,952400,000SH SOLE0400,00000
Burning Rock Biotech Ltd ADRSPON ADS12233L10752,4451,948,186SH DFND11,948,18600
Burning Rock Biotech Ltd ADRSPON ADS12233L107115,8534,303,621SH DFND22,919,69901,383,922
Burning Rock Biotech Ltd ADRSPON ADS12233L1075,345198,549SH DFND320,8370177,712
Burning Rock Biotech Ltd ADRSPON ADS12233L1073,547131,772SH SOLE0131,77200
Butterfly Network IncCOM CL A1241551021,08664,528SH DFND164,52800
Butterfly Network IncCOM CL A1241551023,286195,222SH DFND2195,22200
Butterfly Network IncCOM CL A1241551022,677159,049SH DFND3159,04900
Butterfly Network IncCOM CL A12415510214,582866,410SH SOLE0866,41000
C3.aiCL A12468P1048117SH DFND311700
CEVA IncCOM15721010510,033178,680SH DFND1178,68000
CEVA IncCOM1572101058,768156,153SH DFND250,6320105,521
CEVA IncCOM1572101053,95370,396SH DFND370,39600
CEVA IncCOM1572101054,63282,500SH SOLE082,50000
CH Robinson WorldwideCOM NEW12541W20928,982303,694SH DFND1303,69400
CH Robinson WorldwideCOM NEW12541W2096596,905SH DFND2006,905
CH Robinson WorldwideCOM NEW12541W2091771,856SH DFND31,85600
CH Robinson WorldwideCOM NEW12541W20927,508288,257SH SOLE0288,25700
Calavo Growers IncCOM1282461059113SH DFND311300
Cardlytics IncCOM14161W10517,815162,400SH DFND1162,40000
Cardlytics IncCOM14161W10513,712125,000SH DFND241,700083,300
Cardlytics IncCOM14161W1056,15256,077SH DFND356,07700
Cardlytics IncCOM14161W10511,211102,200SH SOLE0102,20000
Cargurus IncCOM1417881098345SH DFND334500
CarvanaCOM146869102288,3131,098,753SH DFND11,098,75300
CarvanaCOM146869102834,4723,180,153SH DFND21,712,42101,467,732
CarvanaCOM14686910272,542276,455SH DFND3230,376046,079
CarvanaCOM146869102441,1481,681,205SH SOLE01,365,5440315,661
Cbre Group IncCL A12504L109131,6521,664,158SH DFND11,664,15800
Cbre Group IncCL A12504L109403,8125,104,439SH DFND24,782,2380322,201
Cbre Group IncCL A12504L10979,3021,002,430SH DFND3470,4890531,941
Cbre Group IncCL A12504L109249,6633,155,895SH SOLE02,639,5130516,382
Cemex ADRSPON ADR NEW15129088934,8314,997,287SH DFND14,997,28700
Cemex ADRSPON ADR NEW151290889173,44624,884,702SH DFND210,176,754014,707,948
Cemex ADRSPON ADR NEW15129088960,2598,645,527SH DFND31,226,13407,419,393
Cemex ADRSPON ADR NEW1512908892,648379,900SH DFND4379,90000
CertaraCOM15687V10921,498787,464SH SOLE0787,46400
CerusCOM15708510171,143SH DFND31,14300
ChargePoint Holdings IncCOM CL A15961R105106,8004,000,000SH SOLE04,000,00000
CheggCOM163092109487,5575,691,764SH DFND15,691,76400
CheggCOM163092109680,6887,946,398SH DFND27,056,7260889,672
CheggCOM163092109101,2971,182,548SH DFND3862,6470319,901
CheggCOM163092109266,3583,109,485SH SOLE02,838,5800270,905
Chewy IncCL A16679L109243,5532,875,143SH DFND12,875,14300
Chewy IncCL A16679L109326,8053,857,931SH DFND23,687,1310170,800
Chewy IncCL A16679L10912,364145,958SH DFND3145,95800
Chewy IncCL A16679L10956,752669,960SH SOLE0669,96000
Chinook TherapeuticsCOM16961L1066,157396,187SH DFND1396,18700
Chinook TherapeuticsCOM16961L1063,507225,682SH DFND279,6190146,063
Chinook TherapeuticsCOM16961L1061,656106,558SH DFND3106,55800
Chinook TherapeuticsCOM16961L1061,819117,058SH SOLE0117,05800
Church & Dwight Co IncCOM17134010216179SH DFND317900
CimpressCOMg2143t103884SH DFND38400
Cisco SystemsCOM17275R10217,369335,890SH DFND1335,89000
Cisco SystemsCOM17275R1023947,627SH DFND2007,627
Cisco SystemsCOM17275R1021042,008SH DFND32,00800
Cisco SystemsCOM17275R10216,433317,784SH SOLE0317,78400
Cloudera IncCOM18914U10039,8113,271,228SH DFND13,271,22800
Cloudera IncCOM18914U10019,3341,588,696SH DFND2527,37501,061,321
Cloudera IncCOM18914U1008,687713,766SH DFND3713,76600
Cloudera IncCOM18914U10021,5041,766,990SH SOLE01,766,99000
Cloudflare IncCL A COM18915M107344,6694,905,617SH DFND14,905,61700
Cloudflare IncCL A COM18915M1071,199,38717,070,696SH DFND29,688,70307,381,993
Cloudflare IncCL A COM18915M107146,4062,083,770SH DFND31,425,7960657,974
Cloudflare IncCL A COM18915M107417,0035,935,135SH SOLE03,969,20401,965,931
Clover Health Investments CorpCOM CL A18914F10338,8755,142,177SH SOLE05,142,17700
Clovis OncologyCOM189464100192SH DFND39200
CoStar GroupCOM22160N109274,527334,019SH DFND1334,01900
CoStar GroupCOM22160N109468,565570,107SH DFND2541,569028,538
CoStar GroupCOM22160N10943,34252,734SH DFND332,128020,606
CoStar GroupCOM22160N109156,632190,575SH SOLE0170,663019,912
Coca ColaCOM19121610024,632467,320SH DFND1467,32000
Coca ColaCOM19121610058911,165SH DFND20011,165
Coca ColaCOM1912161001603,028SH DFND33,02800
Coca ColaCOM19121610024,593466,580SH SOLE0466,58000
CodexisCOM19200510646,1932,018,055SH DFND12,018,05500
CodexisCOM19200510642,3001,847,959SH DFND2606,76501,241,194
CodexisCOM19200510618,666815,470SH DFND3815,47000
CodexisCOM19200510628,5911,249,067SH SOLE01,249,06700
Cognyte SoftwareORD SHSM251331058303SH DFND330300
Cohen & Steers IncCOM19247A10023356SH DFND335600
Coherus BioSciencesCOM19249H103261,807SH DFND31,80700
Columbia Sportswear CoCOM1985161061095SH DFND39500
Commscope Holding Co IncCOM20337X109241,543SH DFND31,54300
Consolidated EdisonCOM20911510454,712731,438SH DFND1731,43800
Consolidated EdisonCOM209115104951,275SH DFND21,27500
Consolidated EdisonCOM2091151042,45532,815SH DFND332,81500
Cooper Cos Inc/TheCOM21664840213,71235,700SH DFND235,70000
Copa Holdings S ACL AP3107610531,502389,924SH DFND1389,92400
Copa Holdings S ACL AP31076105273,7493,388,401SH DFND22,208,69301,179,708
Copa Holdings S ACL AP3107610561,098756,255SH DFND396,0570660,198
Copa Holdings S ACL AP310761052,42129,964SH DFND429,96400
Copa Holdings S ACL AP3107610522,446277,829SH SOLE0277,82900
Cornerstone Ondemand IncCOM21925Y103451,043SH DFND31,04300
Coupa Software IncCOM22266L10698387SH DFND338700
CoupangCL A22266T109105,7522,142,895SH DFND12,142,89500
CoupangCL A22266T109693,57114,054,118SH DFND26,754,37207,299,746
CoupangCL A22266T10994,2411,909,645SH DFND31,230,0220679,623
CoupangCL A22266T10991518,547SH DFND418,54700
CoupangCL A22266T109193,8873,928,818SH SOLE01,776,46402,152,354
Coursera IncCOM22266M10459,8361,329,689SH DFND11,329,68900
Coursera IncCOM22266M10465,9751,466,109SH DFND21,355,3870110,722
Coursera IncCOM22266M1049,571212,688SH DFND3167,050045,638
Coursera IncCOM22266M10412,629280,646SH SOLE0280,64600
CredicorpCOMG2519Y1087,57955,496SH DFND155,49600
CredicorpCOMG2519Y108129,359947,201SH DFND2629,3640317,837
CredicorpCOMG2519Y10827,896204,259SH DFND327,1140177,145
CredicorpCOMG2519Y1081,2469,127SH DFND49,12700
CredicorpCOMG2519Y10815,282111,900SH SOLE0111,90000
CrowdStrike HoldingsCOM22788C10525138SH DFND313800
Cullen/Frost BankersCOM22989910912,893118,545SH DFND1118,54500
Cullen/Frost BankersCOM2298991092892,654SH DFND2002,654
Cullen/Frost BankersCOM22989910977707SH DFND370700
Cullen/Frost BankersCOM22989910913,207121,435SH SOLE0121,43500
CureVac N.V. - Converted at IPOCOMN2451R105171,0311,870,009SH DFND21,870,00900
CureVac N.V. - Converted at IPOCOMN2451R105142,5261,558,341SH SOLE01,558,34100
Curevac N.V.COMN2451R105200,2032,188,967SH DFND21,716,6900472,277
Curevac N.V.COMN2451R10519,461212,784SH SOLE0212,78400
CyberArk Software LtdSHSM2682V10832,862254,077SH DFND1254,07700
CyberArk Software LtdSHSM2682V10827,477212,439SH DFND270,5440141,895
CyberArk Software LtdSHSM2682V10812,33295,348SH DFND395,34800
CyberArk Software LtdSHSM2682V10814,889115,118SH SOLE0115,11800
DTE Energy CoCOM23333110760,432453,900SH DFND1453,90000
DTE Energy CoCOM233331107112838SH DFND283800
DTE Energy CoCOM2333311073,21124,117SH DFND324,11700
Dada Nexus Ltd ADRADS23344D10880,4662,964,859SH DFND12,964,85900
Dada Nexus Ltd ADRADS23344D10894,8753,495,753SH DFND22,289,10001,206,653
Dada Nexus Ltd ADRADS23344D10887132,079SH DFND332,07900
Dada Nexus Ltd ADRADS23344D10819,121704,517SH SOLE0704,51700
Darden RestaurantsCOM2371941051282SH DFND38200
DatadogCOM23804L103131,7141,580,443SH DFND11,580,44300
DatadogCOM23804L103261,9173,142,747SH DFND22,969,7420173,005
DatadogCOM23804L10332,049384,557SH DFND3208,7000175,857
DatadogCOM23804L103111,8621,342,237SH SOLE01,169,5730172,664
Deere & CoCOM24419910593,958251,131SH DFND1251,13100
Deere & CoCOM24419910526,10969,785SH DFND219,696050,089
Deere & CoCOM24419910561,281163,792SH DFND3118,305045,487
Deere & CoCOM24419910510,54828,192SH SOLE028,19200
Denali TherapeuticsCOM24823R105138,4842,425,289SH DFND12,425,28900
Denali TherapeuticsCOM24823R105177,6003,110,329SH DFND22,976,8540133,475
Denali TherapeuticsCOM24823R10514,520254,283SH DFND3225,199029,084
Denali TherapeuticsCOM24823R105411,4227,205,296SH SOLE07,205,29600
Dexcom IncCOM252131107253,022704,032SH DFND1704,03200
Dexcom IncCOM2521311071,142,4573,178,878SH DFND21,000,17302,178,705
Dexcom IncCOM252131107204,840569,966SH DFND3443,9630126,003
Dexcom IncCOM252131107315,315877,362SH SOLE0407,3330470,029
DigimarcCOM25381B1017,784262,445SH DFND1262,44500
DigimarcCOM25381B1018,607290,200SH DFND295,3270194,873
DigimarcCOM25381B1013,774127,253SH DFND3127,25300
DigimarcCOM25381B1014,589154,711SH SOLE0154,71100
DoceboCOM25609L1051,28529,900SH DFND229,90000
DoceboCOM25609L10513300SH DFND330000
Dolby Laboratories 'A'COM25659T10714,825150,174SH DFND1150,17400
Dolby Laboratories 'A'COM25659T1073443,481SH DFND2003,481
Dolby Laboratories 'A'COM25659T10791918SH DFND391800
Dolby Laboratories 'A'COM25659T10714,379145,651SH SOLE0145,65100
Doordash IncCOM25809K105111,467850,047SH DFND1850,04700
Doordash IncCOM25809K105253,8461,935,835SH DFND21,819,5410116,294
Doordash IncCOM25809K10538,059290,237SH DFND3147,2020143,035
Doordash IncCOM25809K105248,2831,893,408SH SOLE01,755,0570138,351
DropboxCL A26210C10423881SH DFND388100
Duck Creek TechnologiesSHS26412010616355SH DFND335500
Duke Realty Corporation REITCOM26441150554,8341,307,740SH DFND11,307,74000
Duke Realty Corporation REITCOM2644115051172,800SH DFND22,80000
Duke Realty Corporation REITCOM2644115052,46758,840SH DFND358,84000
EOG ResourcesCOM26875P10169,372956,464SH DFND1956,46400
EOG ResourcesCOM26875P101241,9003,335,176SH DFND23,112,0330223,143
EOG ResourcesCOM26875P10135,441488,646SH DFND3252,6460236,000
EOG ResourcesCOM26875P101159,4252,198,057SH SOLE01,832,1310365,926
EcolabCOM27886510063,146294,977SH DFND1294,97700
EcolabCOM27886510029,639138,454SH DFND279,620058,834
EcolabCOM27886510041,461193,680SH DFND3139,964053,716
EcolabCOM2788651005,76526,932SH SOLE026,93200
Edwards Lifesciences CorpCOM28176E1083,33739,897SH DFND139,89700
Edwards Lifesciences CorpCOM28176E10822,374267,504SH DFND2267,50400
Edwards Lifesciences CorpCOM28176E1088,16097,556SH DFND397,55600
Emergent Biosolutions IncCOM29089Q10539423SH DFND342300
EquifaxCOM294429105952SH DFND35200
Estee Lauder 'A'COM518439104107,369369,155SH DFND1369,15500
Estee Lauder 'A'COM518439104432,2231,486,067SH DFND21,398,149087,918
Estee Lauder 'A'COM51843910479,266272,532SH DFND3125,5100147,022
Estee Lauder 'A'COM518439104255,752879,325SH SOLE0736,8800142,445
Eventbrite Inc Class ACOM CL A29975E10935,6011,606,535SH DFND11,606,53500
Eventbrite Inc Class ACOM CL A29975E10944,4492,005,823SH DFND21,909,026096,797
Eventbrite Inc Class ACOM CL A29975E1091,80881,575SH DFND381,57500
Eventbrite Inc Class ACOM CL A29975E1094,760214,801SH SOLE0214,80100
EverQuote IncCOM CL A30041R10826,091718,967SH DFND1718,96700
EverQuote IncCOM CL A30041R10810,008275,780SH DFND290,6580185,122
EverQuote IncCOM CL A30041R1084,600126,745SH DFND3126,74500
EverQuote IncCOM CL A30041R1088,403231,550SH SOLE0231,55000
Everbridge IncCOM29978A10440,085330,786SH DFND1330,78600
Everbridge IncCOM29978A10425,589211,165SH DFND270,2890140,876
Everbridge IncCOM29978A10411,52195,072SH DFND395,07200
Everbridge IncCOM29978A10417,989148,446SH SOLE0148,44600
Eversource EnergyCOM30040W10846,412536,000SH DFND1536,00000
Eversource EnergyCOM30040W108931,077SH DFND21,07700
Eversource EnergyCOM30040W1082,43828,161SH DFND328,16100
Exact SciencesCOM30063P105140,6941,067,643SH DFND11,067,64300
Exact SciencesCOM30063P105222,0981,685,371SH DFND21,361,4100323,961
Exact SciencesCOM30063P10566,502504,642SH DFND3352,0430152,599
Exact SciencesCOM30063P105143,5571,089,370SH SOLE0958,8490130,521
Exelon CorporationCOM30161N10197422,268SH DFND122,26800
Expeditors IntlCOM30213010914126SH DFND312600
ExponentCOM30214U10224242SH DFND324200
Extreme NetworksCOM30226D1066687SH DFND368700
Facebook Cl.ACL A30303M102238,209808,775SH DFND1808,77500
Facebook Cl.ACL A30303M1021,431,1424,859,071SH DFND22,346,21202,512,859
Facebook Cl.ACL A30303M102198,125672,683SH DFND3450,8390221,844
Facebook Cl.ACL A30303M102538,6171,828,735SH SOLE01,151,3930677,342
FarfetchORD SHS CL A30744W10794,6221,784,653SH DFND11,784,65300
FarfetchORD SHS CL A30744W107304,3365,740,024SH DFND25,349,5690390,455
FarfetchORD SHS CL A30744W10770,0261,320,754SH DFND3683,5050637,249
FarfetchORD SHS CL A30744W107262,5634,952,156SH SOLE03,940,31401,011,842
FastenalCOM31190010449,692988,303SH DFND1988,30300
FastenalCOM31190010421,198421,604SH DFND2403,267018,337
FastenalCOM3119001044,29385,391SH DFND358,191027,200
FastenalCOM31190010439,973795,014SH SOLE0795,01400
Ferrari NVCOMN3167Y1032,120,22910,114,885SH DFND28,208,94601,905,939
Ferrari NVCOMN3167Y103419,8582,003,000SH SOLE02,003,00000
Fibrogen IncCOM31572Q80813377SH DFND337700
First Industrial REITCOM32054K10345,8101,000,438SH DFND11,000,43800
First Industrial REITCOM32054K103962,100SH DFND22,10000
First Industrial REITCOM32054K1032,05944,974SH DFND344,97400
First Republic BankCOM33616C100292,8531,756,237SH DFND11,756,23700
First Republic BankCOM33616C100415,3312,490,739SH DFND22,394,399096,340
First Republic BankCOM33616C10022,513135,012SH DFND3117,098017,914
First Republic BankCOM33616C10067,819406,708SH SOLE0406,70800
FirstCashCOM33767D10520,097306,030SH DFND1306,03000
FirstCashCOM33767D1051,07116,313SH DFND316,31300
Fiverr IntlORD SHSM4R82T10622100SH DFND310000
FortisCOM3495531071,32130,457SH DFND130,45700
Fortive CorpCOM34959J1087,704109,062SH DFND2109,06200
FoxCOM35137L10513359SH DFND335900
GANCOMG3728V10910572SH DFND357200
Gentex CorpCOM37190110918516SH DFND351600
Glaukos CorpCOM377322102209,9102,501,011SH DFND12,501,01100
Glaukos CorpCOM377322102201,6092,402,109SH DFND22,163,8930238,216
Glaukos CorpCOM37732210251,765616,760SH DFND3479,4360137,324
Glaukos CorpCOM37732210238,414457,696SH SOLE0457,69600
Global Blood Therapeutics IncCOM37890U108411,007SH DFND31,00700
Glu MobileCOM379890106685,417SH DFND35,41700
Grifols ADRSP ADR REP B NVT39843840849,5482,865,701SH DFND22,215,5580650,143
Grifols ADRSP ADR REP B NVT3984384086,682386,447SH SOLE0386,44700
HDFC Bank ADRADR REPS 3 SHS40415F10167,105863,755SH DFND2801,733062,022
HDFC Bank ADRADR REPS 3 SHS40415F10114,796190,449SH DFND399,294091,155
HDFC Bank ADRADR REPS 3 SHS40415F10181,6281,050,686SH SOLE0947,3940103,292
HEICOCOM42280610913,705108,944SH DFND1108,94400
HEICOCOM4228061097,06756,177SH SOLE056,17700
HEICO 'A'CL A42280620859,858526,920SH DFND1526,92000
HEICO 'A'CL A422806208107,038942,233SH DFND2905,162037,071
HEICO 'A'CL A4228062083,77933,263SH DFND333,26300
HEICO 'A'CL A4228062089,31081,956SH SOLE081,95600
HUYA ADRADS REP SHS A44852D10852,9042,715,802SH DFND12,715,80200
HUYA ADRADS REP SHS A44852D10864,2083,296,114SH DFND21,949,14601,346,968
HUYA ADRADS REP SHS A44852D1087,564388,295SH DFND320,2660368,029
HUYA ADRADS REP SHS A44852D10812,885661,423SH SOLE0661,42300
Halozyme TherapeuticsCOM40637H109421,006SH DFND31,00600
Harris CorpCOM5024311091261SH DFND36100
Health Catalyst IncCOM42225T1071,92741,208SH DFND141,20800
Health Catalyst IncCOM42225T1075,698121,823SH DFND2121,82300
Health Catalyst IncCOM42225T1074,66899,799SH DFND399,79900
Healthcare Services Group IncCOM4219061084157SH DFND315700
Heron Therapeutics IncCOM4277461025308SH DFND330800
HillenbrandCOM4315711088170SH DFND317000
Home DepotCOM4370761021961SH DFND36100
Homology MedicinesCOM4380831075481SH DFND348100
Hormel Foods CorpCOM44045210013264SH DFND326400
Howard HughesCOM44267D10764,001672,774SH DFND1672,77400
Howard HughesCOM44267D107139,4481,465,873SH DFND21,368,093097,780
Howard HughesCOM44267D10729,649311,672SH DFND3150,4340161,238
Howard HughesCOM44267D10793,825986,284SH SOLE0828,0380158,246
HubbellCOM4435106071896SH DFND39600
Hubspot IncCOM44357310073160SH DFND316000
Hutchison China MeditechSPONSORED ADR44842L1033,943139,564SH DFND1139,56400
Hutchison China MeditechSPONSORED ADR44842L1035,186183,589SH DFND300183,589
ICICI Bank ADRADR45104G104129,9918,109,230SH DFND18,109,23000
ICICI Bank ADRADR45104G104149,3079,314,196SH DFND28,669,9410644,255
ICICI Bank ADRADR45104G10472,6414,531,550SH DFND32,711,08301,820,467
ICICI Bank ADRADR45104G1047,381460,474SH DFND4460,47400
ICICI Bank ADRADR45104G104133,8228,348,251SH SOLE07,170,27201,177,979
IPG Photonics CorpCOM44980X10925,470120,747SH DFND1120,74700
IPG Photonics CorpCOM44980X10924,121114,351SH DFND238,083076,268
IPG Photonics CorpCOM44980X10910,88151,583SH DFND351,58300
IPG Photonics CorpCOM44980X10919,05590,336SH SOLE090,33600
Iac/InteractivecorpCOM44891N10948,088222,312SH DFND1222,31200
Iac/InteractivecorpCOM44891N109159,710738,338SH DFND2684,425053,913
Iac/InteractivecorpCOM44891N10936,288167,760SH DFND377,993089,767
Iac/InteractivecorpCOM44891N109115,024531,755SH SOLE0445,111086,644
Iclick Interactive Asia GSPON ADR45113Y10436,5533,105,623SH DFND13,105,62300
Iclick Interactive Asia GSPON ADR45113Y1049,845836,416SH DFND2836,41600
Iclick Interactive Asia GSPON ADR45113Y10435129,830SH DFND329,83000
Iclick Interactive Asia GSPON ADR45113Y1048,139691,490SH SOLE0691,49000
Ii-Vi IncCOM90210410845664SH DFND366400
IlluminaCOM452327109771,3532,008,417SH DFND12,008,41700
IlluminaCOM4523271094,873,19512,688,629SH DFND28,973,80603,714,823
IlluminaCOM452327109379,698988,643SH DFND3744,5020244,141
IlluminaCOM4523271092,207,4415,747,646SH SOLE04,963,2250784,421
InModeSHSM5425M10327369SH DFND336900
Incyte CorpCOM45337C10213165SH DFND316500
InfineraCOM45667G103282,941SH DFND32,94100
Infosys Ltd ADRSPONSORED ADR45678810818,7431,001,245SH DFND11,001,24500
Infosys Ltd ADRSPONSORED ADR45678810814,444771,582SH DFND289,6580681,924
Infosys Ltd ADRSPONSORED ADR45678810812,907689,499SH DFND3567,0820122,417
Infosys Ltd ADRSPONSORED ADR4567881083,069163,946SH DFND4163,94600
Inogen IncCOM45780L1047141SH DFND314100
Inphi CorpCOM45772F107100560SH DFND356000
Insmed IncCOM45766930727787SH DFND378700
Inspire Medical SystemsCOM45773010943208SH DFND320800
Interactive Brokers GroupCOM45841N10738,874532,232SH DFND1532,23200
Interactive Brokers GroupCOM45841N107146,8142,010,045SH DFND21,891,1570118,888
Interactive Brokers GroupCOM45841N10728,501390,212SH DFND3182,2220207,990
Interactive Brokers GroupCOM45841N10786,2291,180,579SH SOLE0984,9190195,660
Intercept Pharmaceuticals IncCOM45845P1082101SH DFND310100
Intersect ENTCOM46071F1038361SH DFND336100
Intuitive SurgicalCOM NEW46120E60298,663133,520SH DFND1133,52000
Intuitive SurgicalCOM NEW46120E602780,4861,056,224SH DFND2331,2680724,956
Intuitive SurgicalCOM NEW46120E60289,005120,449SH DFND396,726023,723
Intuitive SurgicalCOM NEW46120E602213,421288,820SH SOLE0127,6440161,176
Invesco Senior Income TrustCOM46131H10710,7392,556,949SH DFND12,556,94900
Invesco Senior Income TrustCOM46131H1072,683638,746SH DFND3638,74600
Ionis PharmaceuticalsCOM4622221001,66336,982SH DFND136,98200
Ionis PharmaceuticalsCOM4622221004,948110,048SH DFND2110,04800
Ionis PharmaceuticalsCOM4622221004,08890,929SH DFND390,92900
Ironwood Pharmaceuticals IncCOM46333X10810935SH DFND393500
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210612,4762,515,293SH DFND12,515,29300
Itau Unibanco Holding SA-ADRSPON ADR REP PFD465562106108,66321,907,790SH DFND212,006,31509,901,475
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210646,2369,321,827SH DFND31,245,07408,076,753
Itau Unibanco Holding SA-ADRSPON ADR REP PFD4655621062,046412,444SH DFND4412,44400
Itau Unibanco Holding SA-ADRSPON ADR REP PFD46556210610,4092,098,498SH SOLE02,098,49800
Itron IncCOM46574110618204SH DFND320400
J&J Snack Foods CorpCOM4660321091383SH DFND38300
JD.Com Inc - ADRSPON ADR CL A47215P106121,4471,440,140SH DFND11,440,14000
JD.Com Inc - ADRSPON ADR CL A47215P1068,09095,934SH DFND295,93400
JD.Com Inc - ADRSPON ADR CL A47215P1061972,331SH DFND32,33100
JD.Com Inc - ADRSPON ADR CL A47215P10624,619291,937SH SOLE0291,93700
JDS Uniphase CorporationCOM925550105181,142SH DFND31,14200
JFROG LtdORD SHSM6191J10023,183522,500SH DFND1522,50000
JFROG LtdORD SHSM6191J10010,718241,566SH DFND280,2660161,300
JFROG LtdORD SHSM6191J1004,825108,736SH DFND3108,73600
JFROG LtdORD SHSM6191J10012,259276,300SH SOLE0276,30000
Jack Henry & AssociatesCOM4262811011171SH DFND37100
Jaguar Health - US indemnity sharesCOM47010C40902,033,592SH SOLE02,033,59200
John Wiley & Sons IncCOM9682232068153SH DFND315300
Johnson & JohnsonCOM4781601041589SH DFND38900
Jumia Technologies Ag ADRSPONSORED ADS48138M105325,2179,171,365SH DFND29,051,6530119,712
KE Holdings ADRADR482497104123,8242,173,106SH DFND12,173,10600
KE Holdings ADRADR482497104679,38411,923,195SH DFND25,506,58606,416,609
KE Holdings ADRADR48249710458,8291,032,447SH DFND3740,1030292,344
KE Holdings ADRADR482497104287,0905,038,427SH SOLE03,757,38501,281,042
Kaleido Biosciences IncCOM4833471002,983368,288SH DFND1368,28800
Kaleido Biosciences IncCOM4833471002,342289,103SH SOLE0289,10300
Keysight TechnologiesCOM49338L10324169SH DFND316900
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K10176,2801,939,975SH DFND11,939,97500
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K101182,5314,642,183SH DFND22,810,01801,832,165
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K10112,272312,103SH DFND328,2340283,869
Kingsoft Cloud Holdings Ltd ADRSPON ADR49639K10115,459393,153SH SOLE0393,15300
Korea Electric Power ADRSPONSORED ADR500631106191,900SH DFND21,90000
Korea Electric Power ADRSPONSORED ADR5006311061,624158,319SH DFND3158,31900
LUFAX Holdings LTDCOM54975P10289,1296,138,374SH DFND16,138,37400
LUFAX Holdings LTDCOM54975P102163,68111,272,762SH DFND26,800,04704,472,715
LUFAX Holdings LTDCOM54975P1021,06373,205SH DFND373,20500
LUFAX Holdings LTDCOM54975P10211,656802,735SH SOLE0802,73500
Lci IndustriesCOM50189K1031186SH DFND38600
Lemonade IncCOM52567D107113,5101,218,829SH DFND11,218,82900
Lemonade IncCOM52567D107150,3001,613,875SH DFND21,540,735073,140
Lemonade IncCOM52567D1075,82762,572SH DFND362,57200
Lemonade IncCOM52567D10769,416745,370SH SOLE0745,37000
LendingTreeCOM52603B10767,579317,272SH DFND1317,27200
LendingTreeCOM52603B107121,559570,699SH DFND2413,3030157,396
LendingTreeCOM52603B10737,590176,477SH DFND3132,015044,462
LendingTreeCOM52603B10775,360353,803SH SOLE0316,227037,576
Li Auto ADRSPONS ADS50202M10230,0131,200,501SH DFND11,200,50100
Li Auto ADRSPONS ADS50202M102106,5524,262,093SH DFND23,822,2340439,859
Li Auto ADRSPONS ADS50202M10222,206888,249SH DFND3408,5790479,670
Li Auto ADRSPONS ADS50202M10270,6332,825,325SH SOLE02,375,8470449,478
Liberty Broadband CorpCOM5303073051170SH DFND37000
Lightspeed POSCOM53227R10621335SH DFND333500
LivePerson IncCOM53814610125,963492,291SH DFND1492,29100
LivePerson IncCOM53814610119,985378,927SH DFND2126,2670252,660
LivePerson IncCOM5381461019,005170,744SH DFND3170,74400
LivePerson IncCOM53814610113,073247,880SH SOLE0247,88000
Liveramp Holdings IncCOM53815P10831,927615,401SH DFND1615,40100
Liveramp Holdings IncCOM53815P10816,932326,365SH DFND2109,1190217,246
Liveramp Holdings IncCOM53815P1087,708148,578SH DFND3148,57800
Liveramp Holdings IncCOM53815P10815,308295,075SH SOLE0295,07500
Lowes CosCOM5486611071369SH DFND36900
Lumentum HdgsCOM55024U10915168SH DFND316800
Lyft Inc Class A CommonCL A COM55087P104131,6422,083,603SH DFND12,083,60300
Lyft Inc Class A CommonCL A COM55087P104282,0784,464,666SH DFND24,199,8110264,855
Lyft Inc Class A CommonCL A COM55087P10447,811756,736SH DFND3381,2070375,529
Lyft Inc Class A CommonCL A COM55087P104246,8483,907,067SH SOLE03,547,0840359,983
MakeMyTripSHSV5633W10983,4382,642,107SH DFND21,977,9400664,167
Markel CorpCOM57053510462,63154,958SH DFND154,95800
Markel CorpCOM570535104228,438200,451SH DFND2187,674012,777
Markel CorpCOM57053510446,22040,557SH DFND318,990021,567
Markel CorpCOM570535104144,319126,638SH SOLE0106,111020,527
MarketAxess HoldingsCOM57060D108297,403597,291SH DFND1597,29100
MarketAxess HoldingsCOM57060D108409,820823,064SH DFND2684,0950138,969
MarketAxess HoldingsCOM57060D10860,491121,487SH DFND3112,20309,284
MarketAxess HoldingsCOM57060D108101,595204,039SH SOLE0204,03900
Martin Marietta MaterialsCOM573284106184,158548,382SH DFND1548,38200
Martin Marietta MaterialsCOM573284106582,7191,735,213SH DFND21,621,3350113,878
Martin Marietta MaterialsCOM573284106118,625353,241SH DFND3165,1300188,111
Martin Marietta MaterialsCOM573284106386,1801,149,960SH SOLE0968,5680181,392
Masimo CorpCOM5747951002,44310,638SH DFND110,63800
Masimo CorpCOM5747951007,21531,415SH DFND231,41500
Masimo CorpCOM5747951005,98126,045SH DFND326,04500
Mastercard Inc-Class ACL A57636Q104467,1471,312,026SH DFND11,312,02600
Mastercard Inc-Class ACL A57636Q1041,051,6352,953,617SH DFND22,787,1280166,489
Mastercard Inc-Class ACL A57636Q104154,610434,237SH DFND3223,2630210,974
Mastercard Inc-Class ACL A57636Q104487,7341,369,847SH SOLE01,172,4880197,359
McDonald'sCOM58013510121,41995,560SH DFND195,56000
McDonald'sCOM5801351014802,141SH DFND2002,141
McDonald'sCOM580135101131584SH DFND358400
McDonald'sCOM58013510120,37390,894SH SOLE090,89400
Medifast IncCOM58470H10128134SH DFND313400
MedtronicCOMG5960L10317,592148,924SH DFND1148,92400
MedtronicCOMG5960L1033472,939SH DFND2002,939
MedtronicCOMG5960L103111938SH DFND393800
MedtronicCOMG5960L10317,156145,229SH SOLE0145,22900
MercadoLibreCOM58733R102394,877268,233SH DFND1268,23300
MercadoLibreCOM58733R1025,642,0963,832,581SH DFND23,191,8800640,701
MercadoLibreCOM58733R102162,317110,259SH DFND390,136020,123
MercadoLibreCOM58733R1029,6986,588SH DFND46,58800
MercadoLibreCOM58733R102619,581420,871SH SOLE0420,87100
Mercury Computer SystemsCOM58937810814205SH DFND320500
Meredith CorpCOM5894331019293SH DFND329300
Mettler-ToledoCOM59268810599,79086,347SH DFND186,34700
Mettler-ToledoCOM592688105535,631463,473SH DFND2324,6050138,868
Mettler-ToledoCOM5926881054,2543,681SH DFND33,68100
Mettler-ToledoCOM59268810533,30928,822SH SOLE028,82200
MiMedx GroupCOM6024961015513SH DFND351300
MicrosoftCOM594918104233,416990,014SH DFND1990,01400
MicrosoftCOM594918104751,2283,186,274SH DFND22,988,4280197,846
MicrosoftCOM594918104141,319599,394SH DFND3275,4390323,955
MicrosoftCOM594918104481,4552,042,055SH SOLE01,732,9370309,118
Mobile Telesystems ADRSPONSORED ADR60740910924829,700SH DFND129,70000
Moderna IncCOM60770K107694,4625,303,260SH DFND15,303,26000
Moderna IncCOM60770K1073,499,88526,726,883SH DFND220,353,35906,373,524
Moderna IncCOM60770K107314,8332,404,223SH DFND31,776,5510627,672
Moderna IncCOM60770K1071,427,80010,903,398SH SOLE09,542,95701,360,441
Modine Manufacturing CoCOM6078281008558SH DFND355800
MongoDB IncCOM60937P10668253SH DFND325300
Monolithic Power Systems IncCOM6098391052983SH DFND38300
Moody's CorpCOM615369105209,603701,928SH DFND1701,92800
Moody's CorpCOM615369105763,9882,558,481SH DFND22,391,1300167,351
Moody's CorpCOM615369105153,199513,039SH DFND3235,4750277,564
Moody's CorpCOM615369105481,2831,611,744SH SOLE01,346,3000265,444
NIO Inc ADRSPON ADS62914V10684,7502,174,189SH DFND12,174,18900
NIO Inc ADRSPON ADS62914V1062,366,77260,717,609SH DFND246,249,493014,468,116
NIO Inc ADRSPON ADS62914V10676,5081,962,751SH DFND31,576,2630386,488
NIO Inc ADRSPON ADS62914V1061,058,90027,165,212SH SOLE024,538,92702,626,285
NV5 GlobalCOM62945V10913138SH DFND313800
NVIDIACOM67066G104323,768606,387SH DFND1606,38700
NVIDIACOM67066G1041,558,8162,919,514SH DFND21,207,24701,712,267
NVIDIACOM67066G104162,038303,482SH DFND3245,592057,890
NVIDIACOM67066G104844,9521,582,514SH SOLE01,218,7500363,764
Nano Dimension ADRSPONS ADS63008G203141,600SH DFND31,60000
Nanobiotix ADRCOM63009J10712,780850,841SH DFND1850,84100
Nanobiotix ADRCOM63009J1078,248549,159SH SOLE0549,15900
National Instruments CorpCOM63651810222,339517,283SH DFND1517,28300
National Instruments CorpCOM63651810249911,555SH DFND20011,555
National Instruments CorpCOM6365181021353,129SH DFND33,12900
National Instruments CorpCOM63651810220,989486,023SH SOLE0486,02300
Nektar TherapeuticsCOM640268108311,542SH DFND31,54200
NetEase.com ADRSPONSORED ADR64110W10297,061939,971SH DFND1939,97100
NetEase.com ADRSPONSORED ADR64110W102567,7525,498,281SH DFND21,636,14003,862,141
NetEase.com ADRSPONSORED ADR64110W10269,178669,944SH DFND3538,8450131,099
NetEase.com ADRSPONSORED ADR64110W102164,2811,590,947SH SOLE0703,0600887,887
Netflix IncCOM64110L106679,6491,302,858SH DFND11,302,85800
Netflix IncCOM64110L1062,229,7764,274,385SH DFND22,269,15802,005,227
Netflix IncCOM64110L106244,133467,992SH DFND3354,2790113,713
Netflix IncCOM64110L1061,117,7332,142,646SH SOLE01,671,2440471,402
Nevro CorpCOM64157F10321154SH DFND315400
New RelicCOM64829B10052840SH DFND384000
Newmont MiningCOM6516391063926,510SH DFND16,51000
NextEra EnergyCOM65339F10155,895739,248SH DFND1739,24800
NextEra EnergyCOM65339F1011131,500SH DFND21,50000
NextEra EnergyCOM65339F1013,10441,059SH DFND341,05900
Nic IncCOM62914B10027800SH DFND380000
NikeCOM65410610314105SH DFND310500
Novocure LtdORD SHSG6674U108330,0712,497,135SH DFND12,497,13500
Novocure LtdORD SHSG6674U108535,8394,053,858SH DFND23,588,8410465,017
Novocure LtdORD SHSG6674U10885,688648,265SH DFND3466,4510181,814
Novocure LtdORD SHSG6674U108220,0371,664,674SH SOLE01,498,4990166,175
Nucana Plc ADRSPONSORED ADR67022C10612,0762,420,041SH DFND12,420,04100
Nucana Plc ADRSPONSORED ADR67022C1066,1831,238,989SH SOLE01,238,98900
Nutanix IncCOM67059N10816621SH DFND362100
OneConnect Financial Technology ADRCOM68248T10530,3702,054,800SH DFND12,054,80000
OneConnect Financial Technology ADRCOM68248T1059,540645,469SH DFND2215,9510429,518
OneConnect Financial Technology ADRCOM68248T1054,339293,568SH DFND3293,56800
Opko Health IncCOM68375N103317,300SH DFND37,30000
Oscar Health IncCOM68779310935,2141,310,029SH DFND11,310,02900
Oscar Health IncCOM687793109122,4084,553,857SH DFND24,045,3430508,514
Oscar Health IncCOM68779310927,8401,035,696SH DFND3514,0020521,694
Oscar Health IncCOM68779310983,2893,098,553SH SOLE02,614,9150483,638
Oscar Health Inc - converted at IPOCOM68779310932,3511,203,533SH DFND2413,9470789,586
Oscar Health Inc - converted at IPOCOM68779310928,5801,063,253SH SOLE01,063,25300
Outset MedicalCOM69014510719346SH DFND334600
Oxford Industries IncCOM691497309673SH DFND37300
Ozon HoldingsCOM69269L10413,854247,078SH DFND1247,07800
Ozon HoldingsCOM69269L10494,0061,676,582SH DFND2872,6020803,980
Ozon HoldingsCOM69269L1043646,494SH DFND36,49400
Pacific Biosciences of CaliforniaCOM69404D10819561SH DFND356100
Pacira BioSciencesCOM69512710067,405961,697SH DFND1961,69700
Pacira BioSciencesCOM69512710035,158501,612SH DFND2215,9650285,647
Pacira BioSciencesCOM69512710019,884283,694SH DFND3252,519031,175
Pacira BioSciencesCOM69512710024,425348,478SH SOLE0348,47800
PagerDutyCOM69553P10025615SH DFND361500
PaychexCOM70432610711116SH DFND311600
Peloton Interactive IncCL A COM70614W100195,3301,737,190SH DFND11,737,19000
Peloton Interactive IncCL A COM70614W1001,141,34810,150,730SH DFND23,178,88406,971,846
Peloton Interactive IncCL A COM70614W100163,8331,457,068SH DFND31,147,7400309,328
Peloton Interactive IncCL A COM70614W100315,3352,804,477SH SOLE01,273,04101,531,436
Penumbra IncCOM70975L107136,217503,425SH DFND1503,42500
Penumbra IncCOM70975L107173,137639,873SH DFND2611,432028,441
Penumbra IncCOM70975L1076,93525,630SH DFND325,63000
Penumbra IncCOM70975L10730,970114,457SH SOLE0114,45700
PepsicoCOM71344810831,211220,650SH DFND1220,65000
PepsicoCOM7134481087105,017SH DFND2005,017
PepsicoCOM7134481081921,357SH DFND31,35700
PepsicoCOM71344810829,654209,640SH SOLE0209,64000
Petrobras Common ADRSPONSORED ADR71654V408123,19014,527,147SH DFND114,527,14700
Petrobras Common ADRSPONSORED ADR71654V408418,70949,376,054SH DFND222,495,595026,880,459
Petrobras Common ADRSPONSORED ADR71654V408106,95012,611,971SH DFND31,820,790010,791,181
Petrobras Common ADRSPONSORED ADR71654V4084,657549,189SH DFND4549,18900
Petrobras Common ADRSPONSORED ADR71654V40810,6391,254,653SH SOLE01,254,65300
Petrobras Pref ADRSP ADR NON VTG71654V10116,9401,983,615SH DFND11,983,61500
Petrobras Pref ADRSP ADR NON VTG71654V101108,47612,702,116SH DFND27,137,75805,564,358
Petrobras Pref ADRSP ADR NON VTG71654V10145052,675SH DFND352,67500
Pinduoduo Inc ADRSPONSORED ADS722304102262,5051,960,750SH DFND11,960,75000
Pinduoduo Inc ADRSPONSORED ADS7223041022,223,54316,608,476SH DFND26,569,249010,039,227
Pinduoduo Inc ADRSPONSORED ADS722304102224,7671,678,872SH DFND31,356,9490321,923
Pinduoduo Inc ADRSPONSORED ADS722304102886,1656,619,102SH SOLE04,415,36402,203,738
PinterestCOM72352L106178,5402,411,724SH DFND12,411,72400
PinterestCOM72352L106233,8773,159,215SH DFND23,018,1880141,027
PinterestCOM72352L1069,048122,226SH DFND3122,22600
PinterestCOM72352L10642,953580,211SH SOLE0580,21100
Plantronics IncCOM72749310810254SH DFND325400
PluralsightCOM CL A72941B106441,972SH DFND31,97200
Procter & GambleCOM74271810939,801293,883SH DFND1293,88300
Procter & GambleCOM7427181098846,526SH DFND2006,526
Procter & GambleCOM7427181092411,783SH DFND31,78300
Procter & GambleCOM74271810937,393276,106SH SOLE0276,10600
ProgynyCOM74340E10319436SH DFND343600
Prologis Inc REITCOM74340W10360,685572,500SH DFND1572,50000
Prologis Inc REITCOM74340W1031271,200SH DFND21,20000
Prologis Inc REITCOM74340W1032,73525,800SH DFND325,80000
Proofpoint IncCOM74342410319154SH DFND315400
Ptc Therapeutics IncCOM69366J20012246SH DFND324600
Puma BiotechnologyCOM74587V1072252SH DFND325200
Pure Storage IncCOM74624M102321,470SH DFND31,47000
Q2 Holdings IncCOM74736L10931,898318,346SH DFND1318,34600
Q2 Holdings IncCOM74736L10919,081190,434SH DFND263,4870126,947
Q2 Holdings IncCOM74736L1098,64886,306SH DFND386,30600
Q2 Holdings IncCOM74736L10912,248122,235SH SOLE0122,23500
Quaker Chemical CorpCOM7473161072186SH DFND38600
Quanterix CorpCOM74766Q10119,578334,835SH DFND1334,83500
Quanterix CorpCOM74766Q10110,476179,177SH SOLE0179,17700
QuantumScape CorpCOM CL A74767V10940,869913,279SH SOLE0913,27900
Quest DiagnosticsCOM74834L10021160SH DFND316000
Quidel CorpCOM74838J10116128SH DFND312800
Rambus IncCOM75091710614699SH DFND369900
RedfinCOM75737F108263,6223,958,889SH DFND13,958,88900
RedfinCOM75737F108318,6964,785,945SH DFND24,577,6590208,286
RedfinCOM75737F10820,496307,790SH DFND3266,193041,597
RedfinCOM75737F10856,488848,295SH SOLE0848,29500
Regeneron PharmaceuticalsCOM75886F1073063SH DFND36300
Relay Therapeutics IncCOM75943R10291126,347SH DFND126,34700
Relay Therapeutics IncCOM75943R1022,76479,950SH DFND279,95000
Relay Therapeutics IncCOM75943R1022,24764,989SH DFND364,98900
ResMedCOM76115210777,733400,642SH DFND1400,64200
ResMedCOM761152107276,3111,424,139SH DFND21,332,196091,943
ResMedCOM76115210762,871324,043SH DFND3168,1800155,863
ResMedCOM761152107184,708952,004SH SOLE0801,0580150,946
Research in MotionCOM09228F103263,082SH DFND33,08200
Rexford Industrial Realty REITCOM76169C10058,9381,169,400SH DFND11,169,40000
Rexford Industrial Realty REITCOM76169C1001262,500SH DFND22,50000
Rexford Industrial Realty REITCOM76169C1002,64652,500SH DFND352,50000
Ringcentral IncCOM76680R206129433SH DFND343300
Ritchie Bros Auctioneers (USA)COM76774410597,0321,657,249SH DFND21,545,1860112,063
Ritchie Bros. AuctioneersCOM76774410568,1591,164,258SH DFND2634,7660529,492
Ritchie Bros. AuctioneersCOM76774410522,939391,823SH SOLE0391,82300
Robert Half International IncCOM77032310310132SH DFND313200
RokuCOM CL A77543R102465,3771,428,544SH DFND11,428,54400
RokuCOM CL A77543R102584,1721,793,205SH DFND21,713,742079,463
RokuCOM CL A77543R10223,24171,343SH DFND371,34300
RokuCOM CL A77543R102102,916315,916SH SOLE0315,91600
Rollins IncCOM77571110421605SH DFND360500
Royal Caribbean CruisesCOMV7780T10322,537263,257SH DFND1263,25700
Royal Caribbean CruisesCOMV7780T1031,21014,132SH DFND314,13200
Rubius Therapeutics IncCOM78116T10323,506887,000SH DFND1887,00000
Rubius Therapeutics IncCOM78116T1034,095154,531SH DFND259,484095,047
Rubius Therapeutics IncCOM78116T1031,92972,775SH DFND372,77500
Rubius Therapeutics IncCOM78116T10394,8583,579,565SH SOLE03,579,56500
Ryanair ADRSPONSORED ADR NE78351320317,121148,877SH DFND1148,87700
Ryanair ADRSPONSORED ADR NE7835132031,155,64410,049,078SH DFND28,721,88501,327,193
Ryanair ADRSPONSORED ADR NE78351320312,641109,918SH DFND332,679077,239
Ryanair ADRSPONSORED ADR NE7835132037,52765,456SH SOLE065,45600
S&P Global IncCOM78409V10482,659234,247SH DFND1234,24700
S&P Global IncCOM78409V104311,331882,283SH DFND2826,823055,460
S&P Global IncCOM78409V10460,827172,377SH DFND379,601092,776
S&P Global IncCOM78409V104194,386550,871SH SOLE0462,430088,441
SCP Pool CorporationCOM73278L1053293SH DFND39300
SEA Ltd ADRADR81141R100517,6362,318,846SH DFND12,318,84600
SEA Ltd ADRADR81141R100982,4024,400,850SH DFND23,676,2090724,641
SEA Ltd ADRADR81141R100136,427611,149SH DFND3287,0370324,112
SEA Ltd ADRADR81141R100507,3702,272,859SH SOLE01,965,8040307,055
Sage Therapeutics IncCOM78667J10879610,632SH DFND110,63200
Sage Therapeutics IncCOM78667J1082,46132,882SH DFND232,88200
Sage Therapeutics IncCOM78667J1081,96426,235SH DFND326,23500
Sailpoint Technologies HoldingCOM78781P10520388SH DFND338800
Salesforce.comCOM79466L30294,509446,071SH DFND1446,07100
Salesforce.comCOM79466L302763,0513,601,504SH DFND21,187,70002,413,804
Salesforce.comCOM79466L30284,840400,434SH DFND3321,583078,851
Salesforce.comCOM79466L302203,438960,204SH SOLE0425,4430534,761
Sana Biotechnology IncCOM79956610457,1981,708,922SH DFND11,708,92200
Sana Biotechnology IncCOM79956610472,2022,157,230SH DFND22,157,23000
Sana Biotechnology IncCOM7995661044,199125,446SH DFND3125,44600
Sana Biotechnology IncCOM79956610430,406908,448SH SOLE0908,44800
Sana Biotechnology Inc - converted at IPOCOM799566104170,2795,087,499SH SOLE05,087,49900
Sarepta Therapeutics IncCOM80360710015205SH DFND320500
SchrodingerCOM80810D10318242SH DFND324200
Schweitzer-Maudit Int.COM80854110613265SH DFND326500
Seagen IncCOM81181C10420147SH DFND314700
SeerCOM CL A81578P10611223SH DFND322300
Service Corp.Intl.COM81756510470,2411,375,924SH DFND11,375,92400
Service Corp.Intl.COM817565104252,8834,953,630SH DFND24,626,3860327,244
Service Corp.Intl.COM81756510452,3261,024,994SH DFND3471,0610553,933
Service Corp.Intl.COM817565104168,0793,292,445SH SOLE02,752,5810539,864
Shake Shack IncCOM81904710120174SH DFND317400
Sherwin-Williams CoCOM82434810612,27416,631SH DFND216,63100
ShockWave Medical IncCOM82489T10421,673166,381SH DFND1166,38100
ShockWave Medical IncCOM82489T10426,739205,276SH DFND2121,972083,304
ShockWave Medical IncCOM82489T10415,987122,729SH DFND3122,72900
ShockWave Medical IncCOM82489T10411,18885,892SH SOLE085,89200
Shopify 'A'CL A82509L1071,269,7761,147,561SH DFND11,147,56100
Shopify 'A'CL A82509L1073,612,8143,265,083SH DFND22,266,4940998,589
Shopify 'A'CL A82509L107381,398344,689SH DFND3238,4780106,211
Shopify 'A'CL A82509L1071,229,3291,111,007SH SOLE0883,7610227,246
Silicon Laboratories IncCOM82691910218127SH DFND312700
Silicon Motion Technology ADRCOM82706C10818,690314,693SH DFND1314,69300
Silicon Motion Technology ADRCOM82706C1083465,822SH DFND2005,822
Silicon Motion Technology ADRCOM82706C1081151,937SH DFND31,93700
Silicon Motion Technology ADRCOM82706C10817,773299,259SH SOLE0299,25900
Silk Road MedicalCOM82710M10012235SH DFND323500
SiteOne Landscape SupplyCOM82982L10381,868479,490SH DFND1479,49000
SiteOne Landscape SupplyCOM82982L103288,9001,692,045SH DFND21,578,4410113,604
SiteOne Landscape SupplyCOM82982L10361,290358,969SH DFND3166,4100192,559
SiteOne Landscape SupplyCOM82982L103188,1721,102,097SH SOLE0922,3260179,771
Six Flags Entertainment CorpCOM83001A10230,799662,776SH DFND1662,77600
Six Flags Entertainment CorpCOM83001A1021,57033,775SH DFND333,77500
SmartsheetCOM83200N10323353SH DFND335300
Snap IncCL A83304A106101,3611,938,439SH DFND11,938,43900
Snap IncCL A83304A106132,8152,539,973SH DFND22,425,8900114,083
Snap IncCL A83304A1065,12798,057SH DFND398,05700
Snap IncCL A83304A10624,326465,206SH SOLE0465,20600
Snowflake IncCOM83344510981,496355,441SH DFND1355,44100
Snowflake IncCOM833445109140,280611,828SH DFND2572,359039,469
Snowflake IncCOM83344510914,07861,402SH DFND336,035025,367
Snowflake IncCOM83344510989,301389,485SH SOLE0364,481025,004
Sohu.comCOM83410S1083,146200,140SH DFND300200,140
Solaredge Technologies IncCOM83417M10457200SH DFND320000
Sorrento TherapeuticsCOM83587F202465,531SH DFND35,53100
Splunk IncCOM84863710413,675100,940SH DFND1100,94000
Splunk IncCOM84863710419,085140,866SH DFND246,703094,163
Splunk IncCOM8486371048,53763,010SH DFND363,01000
Splunk IncCOM84863710410,01073,884SH SOLE073,88400
Spotify Technology SASHSL8681T102343,8421,283,232SH DFND11,283,23200
Spotify Technology SASHSL8681T1024,253,02415,872,454SH DFND211,252,65804,619,796
Spotify Technology SASHSL8681T102144,309538,568SH DFND3397,2170141,351
Spotify Technology SASHSL8681T102893,4133,334,252SH SOLE02,773,9840560,268
Sprout SocialCOM85209W10918,545321,078SH DFND1321,07800
Sprout SocialCOM85209W10910,527182,258SH DFND260,1300122,128
Sprout SocialCOM85209W1094,57379,167SH DFND379,16700
Sprout SocialCOM85209W1098,541147,870SH SOLE0147,87000
Staar SurgicalCOM PAR $0.01852312305139,1901,320,465SH DFND11,320,46500
Staar SurgicalCOM PAR $0.01852312305146,1461,386,450SH DFND2953,2350433,215
Staar SurgicalCOM PAR $0.0185231230551,423487,836SH DFND3378,1140109,722
Staar SurgicalCOM PAR $0.01852312305102,892976,113SH SOLE0896,625079,488
Stamps.ComCOM NEW8528572001155SH DFND35500
Stanley Black & DeckerCOM8545021011577SH DFND37700
Stericycle IncCOM85891210840,479599,594SH DFND1599,59400
Stericycle IncCOM858912108149,0682,208,083SH DFND22,060,6920147,391
Stericycle IncCOM85891210830,150446,594SH DFND3204,9020241,692
Stericycle IncCOM85891210899,4941,473,773SH SOLE01,233,4410240,332
Stitch FixCOM CL A860897107108,8782,197,781SH DFND12,197,78100
Stitch FixCOM CL A860897107140,5922,837,947SH DFND22,709,1820128,765
Stitch FixCOM CL A8608971075,563112,284SH DFND3112,28400
Stitch FixCOM CL A86089710725,665518,075SH SOLE0518,07500
StoneCoCOM CL AG851581066,370104,056SH DFND2104,05600
StratasysSHSM855481015,861226,300SH DFND1226,30000
StratasysSHSM855481019,415363,520SH DFND2116,4700247,050
StratasysSHSM855481013,968153,190SH DFND3153,19000
StratasysSHSM855481013,745144,600SH SOLE0144,60000
StrykerCOM8636671011354SH DFND35400
Summit Therapeutics New ListingCOM86627T1081,074183,027SH DFND1183,02700
Summit Therapeutics New ListingCOM86627T1081,111189,234SH SOLE0189,23400
Sunpower CorpCOM867652406531,591SH DFND31,59100
SurveyMonkeyCOM78489X103201,095SH DFND31,09500
Sutro BiopharmaCOM86936710223,7261,042,428SH DFND11,042,42800
Sutro BiopharmaCOM86936710214,867653,226SH SOLE0653,22600
Symantec CorpCOM66877110810462SH DFND346200
SynopsysCOM87160710734137SH DFND313700
T. Rowe PriceCOM74144T10816,32895,149SH DFND195,14900
T. Rowe PriceCOM74144T1083732,176SH DFND2002,176
T. Rowe PriceCOM74144T108101588SH DFND358800
T. Rowe PriceCOM74144T10815,44590,006SH SOLE090,00600
TAL Education Group ADRADS REPSTG COM87408010473,7291,369,160SH DFND11,369,16000
TAL Education Group ADRADS REPSTG COM8740801041,758,08232,647,754SH DFND224,111,12508,536,629
TAL Education Group ADRADS REPSTG COM87408010467,2281,248,427SH DFND31,003,4390244,988
TAL Education Group ADRADS REPSTG COM874080104159,6282,964,316SH SOLE01,307,51901,656,797
TJX CompaniesCOM8725401098,735132,048SH DFND2132,04800
TSMC ADRSPONSORED ADR87403910051,009431,260SH DFND1431,26000
TSMC ADRSPONSORED ADR874039100710,0516,003,136SH DFND24,639,21701,363,919
TSMC ADRSPONSORED ADR8740391002,39920,279SH DFND320,27900
TSMC ADRSPONSORED ADR874039100159,0471,344,661SH SOLE01,172,5870172,074
Tabula Rasa HealthCare IncCOM87337910125,842561,175SH DFND1561,17500
Tabula Rasa HealthCare IncCOM8733791018,177177,567SH DFND258,0760119,491
Tabula Rasa HealthCare IncCOM8733791013,74081,211SH DFND381,21100
Tabula Rasa HealthCare IncCOM8733791018,854192,274SH SOLE0192,27400
Tandem Diabetes CareCOM NEW87537220317,490198,192SH DFND1198,19200
Tandem Diabetes CareCOM NEW87537220317188SH DFND318800
Tandem Diabetes CareCOM NEW87537220313,094148,377SH SOLE0148,37700
Tata Motors Ltd ADRCOM87656850285,0424,090,544SH DFND14,090,54400
Tata Motors Ltd ADRCOM87656850259,1652,845,826SH DFND22,845,82600
Tata Motors Ltd ADRCOM87656850292344,402SH DFND344,40200
Tata Motors Ltd ADRCOM87656850235,3651,701,035SH SOLE01,701,03500
TeladocCOM87918A105415,5972,286,643SH DFND12,286,64300
TeladocCOM87918A105595,0443,273,972SH DFND22,791,6080482,364
TeladocCOM87918A105164,298903,980SH DFND3639,6870264,293
TeladocCOM87918A105267,9871,474,484SH SOLE01,308,6140165,870
Telus CorpCOM87971M1038397SH DFND339700
Tenable HoldingsCOM88025T10211315SH DFND331500
Tencent Music Entertainment ADRSPONSORED ADS88034P10982,7464,038,349SH DFND14,038,34900
Tencent Music Entertainment ADRSPONSORED ADS88034P109653,44331,890,815SH DFND223,948,05707,942,758
Tencent Music Entertainment ADRSPONSORED ADS88034P10938,8591,896,502SH DFND3889,28701,007,215
Tencent Music Entertainment ADRSPONSORED ADS88034P109168,1608,206,949SH SOLE07,231,4780975,471
TeradyneCOM880770102102,207839,968SH DFND1839,96800
TeradyneCOM880770102530,8194,362,418SH DFND24,163,2690199,149
TeradyneCOM88077010274,417611,577SH DFND3281,3850330,192
TeradyneCOM880770102233,3031,917,347SH SOLE01,602,4050314,942
Tesla IncCOM88160R1011,342,7742,010,352SH DFND12,010,35200
Tesla IncCOM88160R1016,600,7519,882,400SH DFND27,158,31002,724,090
Tesla IncCOM88160R101591,142885,036SH DFND3655,1990229,837
Tesla IncCOM88160R1012,296,5253,438,272SH SOLE02,880,1820558,090
Texas Roadhouse IncCOM88268110913131SH DFND313100
The Trade DeskCOM CL A88339J105700,7701,075,362SH DFND11,075,36200
The Trade DeskCOM CL A88339J1051,398,4002,145,905SH DFND21,651,6960494,209
The Trade DeskCOM CL A88339J105148,475227,841SH DFND3155,418072,423
The Trade DeskCOM CL A88339J105443,427680,458SH SOLE0533,9470146,511
Thermo Fisher ScientificCOM88355610283,008181,883SH DFND1181,88300
Thermo Fisher ScientificCOM883556102324,343710,686SH DFND2666,739043,947
Thermo Fisher ScientificCOM88355610261,947135,736SH DFND362,627073,109
Thermo Fisher ScientificCOM883556102194,453426,077SH SOLE0356,048070,029
Thor Industries IncCOM88516010118133SH DFND313300
TransMedics GroupCOM89377M10917400SH DFND340000
Trimble NavigationCOM89623910028359SH DFND335900
Trip.com Group Sponsored ADRAMERICAN DEP SHS89677Q107141,0343,558,770SH DFND22,844,0970714,673
TrupanionCOM89820210615,059197,600SH DFND1197,60000
TrupanionCOM89820210626,602349,065SH DFND2114,9440234,121
TrupanionCOM89820210611,830155,225SH DFND3155,22500
TrupanionCOM89820210656,014735,000SH SOLE0735,00000
Twilio IncCL A90138F102510,5441,498,250SH DFND11,498,25000
Twilio IncCL A90138F102806,5382,366,881SH DFND22,254,0010112,880
Twilio IncCL A90138F10268,444200,857SH DFND3131,944068,913
Twilio IncCL A90138F102232,940683,589SH SOLE0622,585061,004
UltragenyxCOM90400D10813115SH DFND311500
United Parcel ServiceCL B91131210646,824275,450SH DFND1275,45000
United Parcel ServiceCL B9113121061,0426,129SH DFND2006,129
United Parcel ServiceCL B9113121062831,665SH DFND31,66500
United Parcel ServiceCL B91131210643,928258,418SH SOLE0258,41800
Unity Biotechnology IncCOM91381U1011,488248,000SH DFND1248,00000
Unity Biotechnology IncCOM91381U10121,3303,555,014SH SOLE03,555,01400
Upwork IncCOM91688F10497,4592,176,888SH DFND12,176,88800
Upwork IncCOM91688F10453,6461,198,258SH DFND2491,2190707,039
Upwork IncCOM91688F10428,991647,548SH DFND3588,000059,548
Upwork IncCOM91688F10454,3541,214,079SH SOLE01,214,07900
Uxin ADRADS91818X1081,4171,211,500SH DFND11,211,50000
Uxin ADRADS91818X108661564,600SH SOLE0564,60000
Vale SA ADRADR91912E10550,1242,884,021SH DFND12,884,02100
Vale SA ADRADR91912E105349,63820,117,285SH DFND210,426,79109,690,494
Vale SA ADRADR91912E1051,34477,347SH DFND377,34700
Varonis Systems IncCOM92228010233639SH DFND363900
Vedanta Ltd ADRCOM92242Y10015,1591,206,000SH DFND11,206,00000
Vedanta Ltd ADRCOM92242Y10067753,880SH DFND353,88000
Vedanta Ltd ADRCOM92242Y10018,1221,441,655SH SOLE01,441,65500
Veeco InstrumentsCOM92241710012,171586,854SH DFND1586,85400
Veeco InstrumentsCOM92241710010,674514,648SH DFND2169,0680345,580
Veeco InstrumentsCOM9224171004,753229,175SH DFND3229,17500
Veeva Systems Inc Class ACOM9224751081,2074,619SH DFND14,61900
Veeva Systems Inc Class ACOM9224751083,67914,084SH DFND214,08400
Veeva Systems Inc Class ACOM9224751083,01511,541SH DFND311,54100
Verint Systems IncCOM92343X10018395SH DFND339500
Verisk AnalyticsCOM92345Y10610,16357,521SH DFND257,52100
ViewRayCOM92672L1074911SH DFND391100
Vir Biotechnology IncCOM92764N1021,05020,477SH DFND120,47700
Vir Biotechnology IncCOM92764N1023,14361,306SH DFND261,30600
Vir Biotechnology IncCOM92764N1022,61150,928SH DFND350,92800
Vir Biotechnology IncCOM92764N102188,9013,684,437SH SOLE03,684,43700
Visa Inc-Class A SharesCOM CL A92826C83915,31672,337SH DFND272,33700
Voya Prime Rate TrustSH BEN INT92913A1002,003431,655SH DFND1431,65500
Voya Prime Rate TrustSH BEN INT92913A1001,891407,624SH DFND3407,62400
Vroom IncCOM92918V109162,6274,170,986SH DFND14,170,98600
Vroom IncCOM92918V109241,8216,202,137SH DFND25,928,2000273,937
Vroom IncCOM92918V1098,098207,694SH DFND3207,69400
Vroom IncCOM92918V10937,296956,550SH SOLE0956,55000
VuzixCOM92921W300251,000SH DFND31,00000
Vyne Therapeutics IncCOM92941V20933348,706SH DFND148,70600
Vyne Therapeutics IncCOM92941V20934350,056SH SOLE050,05600
WD-40 CoCOM9292361071858SH DFND35800
WEC Energy GroupCOM92939U1061,42615,233SH DFND115,23300
WabtecCOM92974010836,221457,572SH DFND1457,57200
WabtecCOM929740108140,1371,770,304SH DFND21,657,1250113,179
WabtecCOM92974010827,497347,362SH DFND3161,0730186,289
WabtecCOM92974010885,9891,086,273SH SOLE0905,5170180,756
Wal-Mart StoresCOM93114210314101SH DFND310100
WatersCOM9418481036,28922,132SH DFND122,13200
WatersCOM94184810317,42161,306SH DFND261,30600
WatersCOM9418481033,04510,717SH DFND37,17803,539
WatersCOM9418481038693,057SH SOLE03,05700
Watsco IncCOM942622200203,702781,217SH DFND1781,21700
Watsco IncCOM942622200238,533914,797SH DFND2877,322037,475
Watsco IncCOM94262220013,06150,091SH DFND344,13505,956
Watsco IncCOM94262220064,788248,468SH SOLE0248,46800
Wayfair Inc Class ACL A94419L101820,6682,607,366SH DFND12,607,36600
Wayfair Inc Class ACL A94419L1011,124,5783,572,924SH DFND23,323,4800249,444
Wayfair Inc Class ACL A94419L101102,603325,981SH DFND3249,986075,995
Wayfair Inc Class ACL A94419L101638,3092,027,987SH SOLE01,965,118062,869
Wheaton Precious MetalsCOM9628791023128,165SH DFND18,16500
Williams-Sonoma IncCOM9699041011476SH DFND37600
Wix ComSHSM98068105909,2673,256,453SH DFND21,854,67901,401,774
Wix ComSHSM98068105133478SH DFND347800
Workday IncCL A98138H101375,1521,510,092SH DFND11,510,09200
Workday IncCL A98138H1011,444,1095,812,942SH DFND22,634,09003,178,852
Workday IncCL A98138H101149,679602,498SH DFND3488,6200113,878
Workday IncCL A98138H101573,2212,307,373SH SOLE01,611,6880695,685
XPELCOM98379L10018342SH DFND334200
Xencor IncCOM98401F10519431SH DFND343100
Xperi Holding CorpCOM98390M103452,066SH DFND32,06600
XylemCOM98419M10082,899788,160SH DFND1788,16000
XylemCOM98419M10023,081219,441SH DFND262,1070157,334
XylemCOM98419M10054,224515,540SH DFND3372,3610143,179
XylemCOM98419M1009,33788,771SH SOLE088,77100
Yatsen Holding Ltd ADRCOM98519410917,0131,377,603SH DFND11,377,60300
Yatsen Holding Ltd ADRCOM98519410941,3203,345,774SH DFND21,734,48501,611,289
Yatsen Holding Ltd ADRCOM98519410917013,736SH DFND313,73600
YelpCOM98581710510262SH DFND326200
Yext IncCOM98585N10669,4994,799,673SH DFND14,799,67300
Yext IncCOM98585N10673,7555,093,578SH DFND23,987,66801,105,910
Yext IncCOM98585N10611,979827,273SH DFND3804,316022,957
Yext IncCOM98585N10623,1021,595,432SH SOLE01,595,43200
Zai Lab ADRADR98887Q104177,2071,328,089SH DFND11,328,08900
Zai Lab ADRADR98887Q104241,4071,809,241SH DFND2873,2960935,945
Zai Lab ADRADR98887Q10449,769372,994SH DFND3195,6120177,382
Zai Lab ADRADR98887Q10447,341354,800SH SOLE0354,80000
Zillow Group Inc Class ACL A98954M101153,0041,164,589SH DFND11,164,58900
Zillow Group Inc Class ACL A98954M101252,7241,923,612SH DFND21,746,9270176,685
Zillow Group Inc Class ACL A98954M10117,469132,964SH DFND3132,96400
Zillow Group Inc Class ACL A98954M10145,572346,869SH SOLE0346,86900
Zillow Group Inc Class CCL C CAP STK98954M200198,4261,530,592SH DFND11,530,59200
Zillow Group Inc Class CCL C CAP STK98954M200414,8963,200,368SH DFND22,496,4470703,921
Zillow Group Inc Class CCL C CAP STK98954M200105,767815,849SH DFND3533,8360282,013
Zillow Group Inc Class CCL C CAP STK98954M200283,3312,185,522SH SOLE01,914,5830270,939
Zoom Video Communications IncCL A98980L101486,9261,515,534SH DFND11,515,53400
Zoom Video Communications IncCL A98980L1011,345,9294,189,142SH DFND22,334,42701,854,715
Zoom Video Communications IncCL A98980L101121,423377,922SH DFND3312,406065,516
Zoom Video Communications IncCL A98980L101648,3832,018,062SH SOLE01,621,6660396,396
Zuora Inc Class ACOM CL A98983V10626,3251,778,724SH DFND11,778,72400
Zuora Inc Class ACOM CL A98983V10614,372971,110SH DFND2321,7980649,312
Zuora Inc Class ACOM CL A98983V1066,407432,887SH DFND3432,88700
Zuora Inc Class ACOM CL A98983V1069,801662,236SH SOLE0662,23600
ZynexCOM98986M1037437SH DFND343700
Zynga IncCOM98986T108353,427SH DFND33,42700
iQIYI Inc ADRSPON ADR46267X10826,2401,578,813SH DFND11,578,81300
iQIYI Inc ADRSPON ADR46267X1087,943477,924SH DFND2477,92400
iQIYI Inc ADRSPON ADR46267X10817210,353SH DFND310,35300
iQIYI Inc ADRSPON ADR46267X1083,049183,441SH SOLE0183,44100
iRobotCOM46272610015,246124,785SH DFND3113,997010,788
iRobotCOM46272610028,871236,300SH DFND295,1590141,141
iRobotCOM46272610024,408199,768SH DFND1199,76800
iRobotCOM46272610037,103303,674SH SOLE0303,67400
iShares Physical Silver ETCCOM46428Q10955,3772,372,000SH DFND12,372,00000
iShares Physical Silver ETCCOM46428Q1092,839121,600SH DFND3121,60000
j2 GlobalCOM48123V102973SH DFND37300
nLIGHTCOM65487K10018542SH DFND354200