Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the registration statements on Form S-8 (No. 333-206521, No. 333-221184, and No. 333-231645) of our report dated March 17, 2022, with respect to the consolidated financial statements of Usio, Inc. included in the Annual Report (Form 10-K) for the year ended December 31, 2021.

We further consent to our designation as an expert in accounting and auditing.

/s/ ADKF, P.C.                                            

ADKF, P.C.

San Antonio, Texas

March 17, 2022